百晓学者学者目录

周雪忠

博士生导师、博导、教授、硕导，山东中医药大学

精选作品

期刊论文

2026

基于深度学习的OCT/OCTA视网膜图像分析方法综述

薛静艳，夏佳楠，霍蕊莉，刘杰，周雪忠

《计算机科学》

2026

基于序贯多重分配随机试验的泽泻汤治疗痰湿型良性阵发性位置性眩晕患者疗效及动态治疗策略评价

潘知玉，姜燕华，周莎，武红莉，吕红霞，周雪忠，刘骏，吉萌萌，王忠，于亚南，权建野，荆志伟

《中医杂志》

2026

治疗糖尿病周围神经病变中药复方优化：网络药理学、机器学习和实验验证（英文）

杜阳，彭菊琴，张伏芝，于清源，周雪忠，杨扩，任钧国

Science of Traditional Chinese Medicine

2026

人工智能赋能中医药和老年医学

周雪忠，戴芯瑜，霍赛楠，常凯，何丽云，张润顺，刘保延

《老年医学与保健》

2026

中医智能处方推荐计算方法研究进展：综述（英文）

董鑫，潘格言，唐聚贤，张旭晨，侯雨桐，张鹏，茅笑寒，柯志鹏，赵宗耀，周雪忠

Science of Traditional Chinese Medicine

2026

中医临床辅助诊疗技术发展与展望：从大语言模型到智能体

潘格言，董鑫，唐聚贤，张润顺，张磊，刘保延，郭伟，曲志成，诸强，王瑞平，林威，周雪忠

《兰州大学学报(医学版)》

2026

基于因果学习模型框架探讨中药治疗慢性阻塞性肺疾病临床疗效评价研究进展

魏巍，王博冉，王佳芸，周雪忠

《中国新药杂志》

DOI

2026

Mining personalized core traditional Chinese medicine prescriptions for rheumatoid arthritis and elucidating their mechanisms via frequent closed Itemset compression and multilevel network pharmacology

Xu Chen, Jinlong Yu, Xin Dong, Zhangfan Chen, Jiang-Shan Tian, Min Zhao, Miao Jiang, Hongtao Guo, Xuezhong Zhou, Lifeng Fa, Yu-Qiu Li, Lei Zhang

Frontiers in Molecular Biosciences

DOI

2025

构建真实世界中医药临床研究人工智能技术体系：重要价值、研究问题与发展方向

鄢灯莹，郑琪光，常凯，舒梓心，花睿，王文佳，胡蕴慧，周水平，杨鹏程，魏宇，余海滨，李晓东，张润顺，刘保延，周雪忠

《上海中医药杂志》

DOI

2025

M2T-Net:基于多源数据的跨任务迁移学习舌象诊断方法

曾丽莉，夏佳楠，李韶雯，敬迈科，赵慧辉，周雪忠

《计算机科学》

2024

Deep representation learning from electronic medical records identifies distinct symptom based subtypes and progression patterns for COVID-19 prognosis

Qiguang Zheng, Qifan Shen, Zixin Shu, Kai Chang, Kunyu Zhong, Yuhang Yan, Jia Ke, Jingjing Huang, Rui Su, Jianan Xia, Xuezhong Zhou

International Journal Of Medical Informatics，Vol. 191

DOI

2024

Lingdan: enhancing encoding of traditional Chinese medicine knowledge for clinical reasoning tasks with large language models

Rui Hua, Xin Dong, Yu Wei, Zixin Shu, Pengcheng Yang, Yunhui Hu, Shuiping Zhou, He Sun, Kaijing Yan, Xijun Yan, Kai Chang, Xiaodong Li, Yuning Bai, Runshun Zhang, Wenjia Wang, Xuezhong Zhou

Journal Of The American Medical Informatics Association

DOI

2024

PresRecST: a novel herbal prescription recommendation algorithm for real-world patients with integration of syndrome differentiation and treatment planning

Xin Dong, Chenxi Zhao, Xinpeng Song, Lei Zhang, Yu Liu, Jun Wu, Yiran Xu, Ning Xu, Jialing Liu, Haibin Yu, Kuo Yang, Xuezhong Zhou

Journal Of The American Medical Informatics Association，Vol. 310, No. 6

DOI

2024

基于疾病模块分析的大株红景天注射液治疗冠心病心绞痛气虚血瘀证的研究

薛莲，董鑫，赵辰羲，于雪，张淑静，李平，周雪忠，杨阳

《南京中医药大学学报》

2024

中医药治疗射血分数保留心力衰竭的核心处方及类方分析

林静怡，郑琪光，罗小非，邓帅帅，周雪忠，樊官伟

《中国中医药信息杂志》

2023

基于病例注册登记研究平台构建针灸对卵巢低反应患者妊娠结局的临床预测模型

苏晨晨，周雪忠，许焕芳，杨莉，李佳珊，肖奇蔚，黎蔚欣，房繄恭

《中国针灸》

2023

构建中医药特色真实世界临床研究新模式的实践与思考

周雪忠，王世华，张迪，雒琳，黄杏贤，兰天，张润顺，高铸烨，李晓东，何丽云，杨卓欣，曾以德，刘保延

《科技导报》

2023

基于隐结构模型的原发性肝癌不同症状群预后差异性分析

叶俊秋，郑琪光，钟昆禹，舒梓心，周雪忠，周亚娜，吴辉坤，李晓东，卢晨霞

《世界科学技术-中医药现代化》

2023

基于核心症状群对中医疫病学病症研究的思考

董斐，周雪忠，谷晓红

《中华中医药杂志》

2023

Knowledge Graph Completion based on Tensor Decomposition for Disease Gene Prediction

Xinyan Wang, Ting Jia, Chong Wang, Kuan Xu, Zi-Xin Shu, Jian Yu, Kuo Yang, Xuezhong Zhou

arXiv.org

DOI

2023

A optimization framework for herbal prescription planning based on deep reinforcement learning

Kuo Yang, Zecong Yu, X. Su, Xiong He, Ning Wang, Qi-Guang Zheng, Fei-yun Yu, Zhuang Liu, Tiancai Wen, Xuezhong Zhou

arXiv.org

DOI

2023

Ontology characterization, enrichment analysis, and similarity calculation‐based evaluation of disease–syndrome–formula associations by applying SoFDA

Yu-Dong Liu, Jia Xu, Zecong Yu, Tong Chen, Ning Wang, Xiaowei Du, Ping Wang, Xuezhong Zhou, Hai-Yu Xu, Yan-Qiong Zhang

iMeta

DOI

2023

SympGAN: A systematic knowledge integration system for symptom-gene associations network

Ke-Zhi Lu, Kuo Yang, Hai-Long Sun, Qian Zhang, Qi-Guang Zheng, Kuan Xu, Jianxin Chen, Xuezhong Zhou

Knowledge-Based Systems

DOI

2022

SoFDA——面向精准医学的中医证候本体信息存储及“病-证-方”多维关联计算的整合平台（英文）

张彦琼，王宁，杜霞，陈同，于泽从，秦月雯，陈文佳，于梦，王萍，张华敏，周雪忠，黄璐琦，许海玉

Science Bulletin

2022

基于真实世界诊疗数据的失眠症状群分类方法研究

李凌香，李亚茹，秦宇宁，邸露瑶，刘艳骄，张润顺，黄俊山，齐向华，王松龄，郭蓉娟，王平，周雪忠，李洪皎

《世界中医药》

2022

SoFDA: an integrated web platform from syndrome ontology to network-based evaluation of disease-syndrome-formula associations for precision medicine.

Yanqiong Zhang, Ning Wang, X. Du, Tong Chen, Zecong Yu, Yuewen Qin, Wen-Jia Chen, Meng Yu, Ping Wang, Hua-Ming Zhang, Xuezhong Zhou, Luqi Huang, Hai-Yu Xu

Science Bulletin

DOI

2022

Research and Implementation of Real World Traditional Chinese Medicine Clinical Scientific Research Information Electronic Medical Record Sharing System

Yuliang Tian, Qi Xie, Run-Shun Zhang, Xuezhong Zhou, Tiancai Wen, Lei Zhang, Xingping Zhang, Bin Wang, Xu Miao, Jie Yang, Baoyan Liu

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2022

Add-on Chinese medicine for hospitalized chronic obstructive pulmonary disease (CHOP): A cohort study of hospital registry.

Ning Xu, Kunyu Zhong, Haibin Yu, Zi-Xin Shu, Kai Chang, Qi-Guang Zheng, Haoyu Tian, Ling-Li Zhou, Wen Wang, Yunyan Qu, Baoyan Liu, Xuezhong Zhou, Kam-Wa Chan, Jian-Sheng Li

Phytomedicine

DOI

2022

Phenonizer: A Fine-Grained Phenotypic Named Entity Recognizer for Chinese Clinical Texts

Qunsheng Zou, Kuo Yang, Zi-Xin Shu, Kai Chang, Qi-Guang Zheng, Yi Zheng, Ke-Zhi Lu, Ning Xu, Hao-Yu Tian, Xiao-Meng Li, Yu-Xia Yang, Ya-Na Zhou, Hai-Bin Yu, Xiaoping Zhang, Jia-Nan Xia, Qiang Zhu, Josiah Poon, Simon K. Poon, Run-Shun Zhang, Xiao-Dong Li, Xuezhong Zhou

BioMed Research International

DOI

2022

The mechanisms of Qizhu Tangshen formula in the treatment of diabetic kidney disease: Network pharmacology, machine learning, molecular docking and experimental assessment.

Juqin Peng, Kuo Yang, Haoyu Tian, Ya-Li Lin, M. Hou, Yunxiao Gao, Xuezhong Zhou, Zhu-Ye Gao, Junguo Ren

Phytomedicine

DOI

2022

Link Prediction based on Tensor Decomposition for the Knowledge Graph of COVID-19 Antiviral Drug

Ting Jia, Yu-Xia Yang, Xi Lu, Qiang Zhu, Kuo Yang, Xuezhong Zhou

Data Intelligence

DOI

2022

DRONet: effectiveness-driven drug repositioning framework using network embedding and ranking learning

Kuo Yang, Yu-Xia Yang, Shu-Yue Fan, Jia-Nan Xia, Qi-Guang Zheng, Xin Dong, Jun Liu, Qiong Liu, Lei Lei, Yingying Zhang, Bing Li, Zhu-Ye Gao, Run-Shun Zhang, Baoyan Liu, Zhong Wang, Xuezhong Zhou

Briefings Bioinform.

DOI

2022

Editorial: Network pharmacology and traditional medicine: Setting the new standards by combining In silico and experimental work

Xin Wang, Yuan-Jia Hu, Xuezhong Zhou, Shao Li

Frontiers in Pharmacology

DOI

2022

RESurv: A Deep Survival Analysis Model to Reveal Population Heterogeneity by Individual Risk

Qi-Guang Zheng, Q. Shen, Xin Su, Kuo Yang, Zi-Xin Shu, Xuezhong Zhou

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2022

Network medicine framework reveals generic herb-symptom effectiveness of traditional Chinese medicine

Xiaohui Gan, Zi-Xin Shu, Xinyan Wang, D. Yan, Jun Yu Li, Shany Ofaim, R. Albert, Xiaodong Li, Baoyan Liu, Xuezhong Zhou, A. Barabási

Science Advances

DOI

2022

Identification of Cirrhosis Subtypes Through Heterogeneous Medical Information Network

Jun Yu Li, Xin Dong, Ya-Na Zhou, Hui-Kun Wu, Xiaodong Li, Xuezhong Zhou

Gastroenterology & Hepatology Research

DOI

2021

中医知识库的应用需求与构建方法分析

牟梓君，何丽云，周雪忠，张磊，刘保延

《中国数字医学》

2021

基于复杂网络的国医大师沈宝藩治疗冠心病用药规律分析

省格丽，刘晶晶，于泽丛，周雪忠，杨颐

《湖南中医药大学学报》

2021

基于复杂网络的特发性肺纤维化病证结合人群分型研究

许宁，董鑫，钟昆禹，郑琪光，舒梓心，周玲，屈云艳，王伟，许玉龙，周雪忠，余海滨

《世界科学技术-中医药现代化》

2021

基于相似性网络技术挖掘丁书文教授治疗冠心病的处方用药规律

王怡斐，郇家铭，焦华琛，周雪忠，李运伦

《世界科学技术-中医药现代化》

2021

基于文献计量学分析症状群生物学机制的研究现状

李凌香，刘保延，周雪忠，舒梓心，牟梓君，何丽云

《中国中医基础医学杂志》

DOI

2021

基于数据挖掘分析林慧娟教授诊治心系疾病的中药配伍研究

韩松君，郇家铭，周雪忠，李伟，苏文革，王怡斐

《世界科学技术-中医药现代化》

2021

Add-on Chinese Medicine for Coronavirus Disease 2019 (COVID-19): A Retrospective Cohort

Kam-Wa Chan, Zi-Xin Shu, Kai Chang, Bao-Yan Liu, Xuezhong Zhou, Xiaodong Li

European Journal of Integrative Medicine

DOI

2021

2021 Integrative Medicine & Health Symposium Abstracts

Zi-Xin Shu, Kai Chang, Ya-Na Zhou, Chaoan Peng, Xu-Gui Li, W. Cai, Li Wei, Boli Zhang, X. Tong, Baoyan Liu, Xuezhong Zhou, Kam-Wa Chan, Xiao-Dong Li

Global Advances in Health and Medicine

DOI

2021

Longitudinal clinical trajectory analysis of individuals before and after diagnosis of Type 2 Diabetes Mellitus (T2DM) indicates that vascular problems start early

A. Heald, Kai Chang, Ting Jia, Hai-Long Sun, Qi-Guang Zheng, Xinyan Wang, Jia-Nan Xia, M. Stedman, H. Fachim, M. Gibson, Xuezhong Zhou, S. Anderson, Yonghong Peng, W. Ollier

International journal of clinical practice

DOI

2021

AIM in Alternative Medicine

Zi-Xin Shu, Ting Jia, Haoyu Tian, D. Yan, Yu-Xia Yang, Xuezhong Zhou

Artificial Intelligence in Medicine

DOI

2021

TMNP: a transcriptome-based multi-scale network pharmacology platform for herbal medicine

Peng Li, Haoran Zhang, Wuxia Zhang, Yuan-Yuan Zhang, Lingmin Zhan, Ning Wang, Caiping Chen, Bangze Fu, Jin-Zhong Zhao, Xuezhong Zhou, Shuzhen Guo, Jianxin Chen

Briefings Bioinform.

DOI

2021

Common Network Pharmacology Software

Xuezhong Zhou, Ning Wang, X. Zhai

Network Pharmacology

DOI

2021

Identifying Protein Complexes With Clear Module Structure Using Pairwise Constraints in Protein Interaction Networks

Guangming Liu, Bo Liu, Aimin Li, Xiaofan Wang, Jian Yu, Xuezhong Zhou

Frontiers in Genetics

DOI

2021

TCMPR: TCM Prescription Recommendation Based on Subnetwork Term Mapping and Deep Learning

Xin Dong, Y. Zheng, Zi-Xin Shu, Kai Chang, D. Yan, Jia-Nan Xia, Qiang Zhu, Kunyu Zhong, Xinyan Wang, Kuo Yang, Xuezhong Zhou

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2021

Add-On Chinese Medicine for Coronavirus Disease 2019 (ACCORD): A Retrospective Cohort Study of Hospital Registries.

Zi-Xin Shu, Kai Chang, Ya-Na Zhou, Chaoan Peng, Xu-Gui Li, W. Cai, Li Wei, Qi-Guang Zheng, H. Tian, J. Xia, Kuo Yang, Ning Wang, Jifen Liu, X. Min, D. Yan, Jing Sun, Huan-gan Wu, Xiao-Meng Li, Yi Zheng, Zecong Yu, Xi Lu, Yu-Xia Yang, Ting Jia, Jinghui Ji, Q. Zou, Yinyan Wang, M. Xiao, Qing Zhang, Y. Xiong, F. Sun, Qiang Zhu, Xingxing Jiang, Guodong Wang, S. Tang, Jun-Hua Zhang, Xiuyang Li, N. Zhang, Bo-Li Zhang, X. Tong, Baoyan Liu, Xuezhong Zhou, K. W. Chan, Xiaodong Li

The American Journal of Chinese Medicine

DOI

2021

Network Patterns of Herbal Combinations in Traditional Chinese Clinical Prescriptions

Ning Wang, Ninglin Du, Yong-Hong Peng, Kuo Yang, Zi-Xin Shu, Kai Chang, Di Wu, Jian Yu, Caiyan Jia, Ya-Na Zhou, Xiaodong Li, Baoyan Liu, Zhu-Ye Gao, Run-Shun Zhang, Xuezhong Zhou

Frontiers in Pharmacology

DOI

2021

Diversity and molecular network patterns of symptom phenotypes

Zi-Xin Shu, Jingjing Wang, Hailong Sun, N. Xu, Chen-Xia Lu, Run-Shun Zhang, Xiaodong Li, Baoyan Liu, Xuezhong Zhou

npj Systems Biology and Applications

DOI

2021

A network-based machine-learning framework to identify both functional modules and disease genes

Kuo Yang, Ke-Zhi Lu, Yang Wu, Jian Yu, Baoyan Liu, Yi Zhao, Jianxin Chen, Xuezhong Zhou

Human Genetics

DOI

2020

全国名中医丁书文益气活血解毒法治疗心房颤动的处方用药规律挖掘

郇家铭，王宁，李运伦，焦华琛，周雪忠，王怡斐

《世界科学技术-中医药现代化》

2020

一种中医辨证多标记学习算法的设计及实现

杨涛，孙鑫亮，朱垚，胡孔法，周雪忠

《世界科学技术-中医药现代化》

2020

针刺治疗脑瘫儿童的症状分类特征和用穴经验分析

牟梓君，何丽云，郑琪光，成秋，舒梓心，杨杰，周雪忠，刘保延

《世界科学技术-中医药现代化》

2020

冠状动脉粥样硬化性心脏病心力衰竭不同兼症及合并病中医治疗方案优化研究

冯妍，王以新，马涵英，高杰，康晨瑜，徐浩，周雪忠

《中国医药》

2020

Prediction of the Network Pharmacology-Based Mechanism for Attenuation of Atherosclerosis in Apolipoprotein E Knockout Mice by Panax notoginseng Saponins

Lin-Zi Long, Zi-Kai Yu, Hua Qu, Ning Wang, M. Guo, Xuezhong Zhou, Changgeng Fu, Zhu-Ye Gao

Evidence-Based Complementary and Alternative Medicine

DOI

2020

Network-based gene prediction for TCM symptoms

Yinyan Wang, Kuo Yang, Zi-Xin Shu, D. Yan, Xuezhong Zhou

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2020

Analysis of diabetic comorbidities and their interrelationships in 5227 Chinese patients with type 2 diabetes

Yifei Wang, Y. Xing, Min Pi, Run-Shun Zhang, Xiong He, Xuezhong Zhou, M. Qiu, Tiancai Wen

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2020

PDGNet: Predicting Disease Genes Using a Deep Neural Network With Multi-View Features

Kuo Yang, Y. Zheng, Ke-Zhi Lu, Kai Chang, Ning Wang, Zi-Xin Shu, Jian Yu, Baoyan Liu, Zhu-Ye Gao, Xuezhong Zhou

IEEE/ACM Transactions on Computational Biology & Bioinformatics

DOI

2020

Disease phenotype synonymous prediction through network representation learning from PubMed database

Shiwen Ma, Kuo Yang, Ning Wang, Qiang Zhu, Zhu-Ye Gao, Run-Shun Zhang, Baoyan Liu, Xuezhong Zhou

Artif. Intell. Medicine

DOI

2020

Identification of herbal categories active in pain disorder subtypes by machine learning help reveal novel molecular mechanisms of algesia.

Xue Xu, Kuo Yang, Feilong Zhang, Wenwen Liu, Yinyan Wang, Changyin Yu, Junyao Wang, Keke Zhang, Chao Zhang, G. Nenadic, Dacheng Tao, Xuezhong Zhou, H. Shang, Jian-Xin Chen

Pharmacological Research

DOI

2020

Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases

Zi-Xin Shu, Ya-Na Zhou, Kai Chang, Jifen Liu, X. Min, Qing Zhang, Jing Sun, Y. Xiong, Qunsheng Zou, Qi-Guang Zheng, Jinghui Ji, Josiah Poon, Baoyan Liu, Xuezhong Zhou, Xiaodong Li

Frontiers in Medicine

DOI

2020

Integrated network analysis of symptom clusters across disease conditions

Ke-Zhi Lu, Kuo Yang, Edouard Niyongabo, Zi-Xin Shu, Jingjing Wang, Kai Chang, Qunsheng Zou, Jiyue Jiang, Caiyan Jia, Baoyan Liu, Xuezhong Zhou

Journal of Biomedical Informatics

DOI

2020

Topological Analysis of the Language Networks of Ancient Traditional Chinese Medicine Books

Qunsheng Zou, Yinyan Wang, Zi-Xin Shu, Kuo Yang, Jingjing Wang, Ke-Zhi Lu, Qiang Zhu, Baoyan Liu, Run-Shun Zhang, Xuezhong Zhou

Evidence-Based Complementary and Alternative Medicine

DOI

2019

急性心肌梗死不同兼症及合并病中医治疗方案优化研究

冯妍，王以新，马涵英，康晨瑜，徐浩，周雪忠

《中国医药》

2019

HerGePred: Heterogeneous Network Embedding Representation for Disease Gene Prediction

Kuo Yang, Ruyu Wang, Guangming Liu, Zi-Xin Shu, Ning Wang, Run-Shun Zhang, Jian Yu, Jianxin Chen, Xiaodong Li, Xuezhong Zhou

IEEE journal of biomedical and health informatics

DOI

2019

Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Run-Shun Zhang, Z. Ni, Xiao-Ying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tian-Tian Huang, Gui-Hua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

Frontiers in Medicine

DOI

2019

Symptom-based network classification identifies distinct clinical subgroups of liver diseases with common molecular pathways

Zi-Xin Shu, Wenwen Liu, Hui-Kun Wu, Ming-Zhong Xiao, Deng Wu, T. Cao, Meng Ren, Jun-Xiu Tao, Chu-Hua Zhang, Tangqing He, Xiaodong Li, Run-Shun Zhang, Xuezhong Zhou

Comput. Methods Programs Biomed.

DOI

2019

Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network

Ning Wang, Peng Li, Xiao-Chen Hu, Kuo Yang, Yong-Hong Peng, Qiang Zhu, Run-Shun Zhang, Zhu-Ye Gao, Hao Xu, Baoyan Liu, Jianxin Chen, Xuezhong Zhou

Computational and Structural Biotechnology Journal

DOI

2019

SNFM: A semi-supervised NMF algorithm for detecting biological functional modules.

Yutong Man, Guangming Liu, Kuo Yang, Xuezhong Zhou

Mathematical biosciences and engineering : MBE

DOI

2018

Heterogeneous network embedding for identifying symptom candidate genes

Kuo Yang, Ning Wang, Guangming Liu, Ruyu Wang, Jian Yu, Runshun Zhang, Jianxin Chen, Xuezhong Zhou

Journal Of The American Medical Informatics Association，Vol. 250, No. 11

DOI

2018

基于原型范畴理论名老中医诊治肺癌认知模型优化思路与方法

庞博，徐心瑶，周培培，耿嘉伟，张红，周雪忠，郑红刚，朴炳奎，花宝金

《北京中医药》

2018

基于深度表示的中医病历症状表型命名实体抽取研究

原旎，卢克治，袁玉虎，舒梓心，杨扩，张润顺，李晓东，周雪忠

《世界科学技术-中医药现代化》

2018

基于症状—中药—诊断模型2型糖尿病及并发症中医证治特征分析

陈世波，刘保延，周雪忠，倪青，张小平

《世界中西医结合杂志》

2018

Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model

Xiao-Han Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiao-Feng Zhou, Changkai Sun, Li-Ying Wu, Shu-Hong Liu, Yong-Qi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, F. Jin

Frontiers in Medicine

DOI

2018

Discovery of Xuantoujiedu Decoction and its Molecular Mechanisms Using Integrated Network Analysis

Li-Li Xu, Weilian Kong, Yinghui Wang, Xiao-Feng Sun, Xuezhong Zhou, Run-Shun Zhang, Yan-Xing Xue, Wei-Bin Wang

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2018

Prediction of Molecular Mechanisms for LianXia NingXin Formula: A Network Pharmacology Study

Yang Yang, Kuo Yang, Teng Hao, Guo-Dong Zhu, Ruby Ling, Xuezhong Zhou, Ping Li

Frontiers in Physiology

DOI

2018

Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease

Wei-Ming Xu, Kuo Yang, Li-jie Jiang, Jing-Qing Hu, Xuezhong Zhou

Frontiers in Physiology

DOI

2018

Analysis of disease comorbidity patterns in a large-scale China population

Mengfei Guo, Yanan Yu, Tiancai Wen, Xiaoping Zhang, Baoyan Liu, Jin Zhang, Run-Shun Zhang, Yanning Zhang, Xuezhong Zhou

BMC Medical Genomics

DOI

2018

Heterogeneous network propagation for herb target identification

Kuo Yang, Guangming Liu, Ning Wang, Run-Shun Zhang, Jian Yu, Jianxin Chen, Xuezhong Zhou

BMC Medical Informatics and Decision Making

DOI

2018

Risk factors associated with 31-day unplanned readmission in 50,912 discharged patients after stroke in China

Tiancai Wen, Baoyan Liu, X. Wan, Xiaoping Zhang, Jin Zhang, Xuezhong Zhou, A. Lau, Yanning Zhang

BMC Neurology

DOI

2018

SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping

Yang Wu, Feilong Zhang, Kuo Yang, Shuangsang Fang, D. Bu, Hui Li, Liang Sun, Hai Hu, Kuo Gao, Wei Wang, Xuezhong Zhou, Yi Zhao, Jian-Xin Chen

Nucleic Acids Res.

DOI

2018

Overlapping functional modules detection in PPI network with pair‐wise constrained non‐negative matrix tri‐factorisation

Guangming Liu, Bian-Fang Chai, Kuo Yang, Jian Yu, Xuezhong Zhou

IET Systems Biology

DOI

2017

辨证论治失眠疗效评价医生队列研究

孙亚男，于长禾，袁玉虎，周雪忠，刘岩，闫世艳，黄小波，陈文强，何丽云，刘保延

《辽宁中医药大学学报》

2017

面向中医临床现病史文本的命名实体抽取方法研究

袁玉虎，周雪忠，张润顺，李晓东

《世界科学技术-中医药现代化》

2017

基于路志正医案数据挖掘清化湿热法核心用药研究

杨凤珍，张小平，刘宗莲，周雪忠，郭宇丹，董聪霞，刘松松

《世界中医药》

2017

本体对齐技术概述及其在中医领域的应用探讨

郝伟学，于剑，周雪忠

《世界科学技术-中医药现代化》

2017

中医师个体化辨证论治失眠诊疗数据预处理方法研究

李新龙，刘岩，王宁，侯爱娟，王世华，周雪忠，张润顺，刘保延，何丽云

《中国中医药信息杂志》

2017

基于复杂网络的薛伯寿教授临床处方用药规律分析研究

孔维莲，徐丽丽，薛燕星，刘保延，王映辉，周雪忠，张润顺

《世界科学技术-中医药现代化》

2017

Functional diversity of topological modules in human protein-protein interaction networks

Guangming Liu, Hui-Xin Wang, Hongwei Chu, Jian Yu, Xuezhong Zhou

Scientific Reports

DOI

2017

Multistage analysis method for detection of effective herb prescription from clinical data

Kuo Yang, Run-Shun Zhang, Liyun He, Yubing Li, Wenwen Liu, Changhe Yu, Yanhong Zhang, Xin-Long Li, Yan Liu, Wei-Ming Xu, Xuezhong Zhou, Baoyan Liu

Frontiers in Medicine

DOI

2017

Network-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic Stroke

Yiwei Wang, Hai-Long Liu, Yongzhong Lin, Guangming Liu, Hongwei Chu, Pengyao Zhao, Xiao-Han Yang, Tiezheng Zheng, Ming Fan, Xuezhong Zhou, Jun Meng, Changkai Sun

Scientific Reports

DOI

2017

Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies

Hongwei Chu, P. Sun, Jiahui Yin, Guangming Liu, Yiwei Wang, Pengyao Zhao, Yizhun Zhu, Xiao-Han Yang, Tiezheng Zheng, Xuezhong Zhou, Wei-Lin Jin, Changkai Sun

PLoS ONE

DOI

2017

HEMnet: Integration of Electronic Medical Records with Molecular Interaction Networks and Domain Knowledge for Survival Analysis

Edward W. Huang, Sheng Wang, Bingxue Li, Ran Zhang, Baoyan Liu, Run-Shun Zhang, Jie Liu, Xuezhong Zhou, Hongsheng Lin, ChengXiang Zhai

ACM International Conference on Bioinformatics, Computational Biology and Biomedicine

DOI

2017

An analysis of human microbe‐disease associations

Wei Ma, Lu Zhang, Pan Zeng, Chuanbo Huang, Jian-Wei Li, B. Geng, Ji-Chun Yang, W. Kong, Xuezhong Zhou, Qing-Hua Cui

Briefings Bioinform.

DOI

2017

Framing Electronic Medical Records as Polylingual Documents in Query Expansion

Edward W. Huang, Sheng Wang, Doris Jung Lin Lee, Run-Shun Zhang, Baoyan Liu, Xuezhong Zhou, ChengXiang Zhai

American Medical Informatics Association Annual Symposium

2017

A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks

Xuezhong Zhou, Lei Lei, Jun Liu, A. Halu, Yingying Zhang, Bing Li, Zhi-li Guo, Guangming Liu, Changkai Sun, J. Loscalzo, Amitabh Sharma, Zhong Wang

bioRxiv

DOI

2016

Extracting relations from traditional Chinese medicine literature via heterogeneous entity networks

Huaiyu Wan, Marie-Francine Moens, Walter Luyten, Xuezhong Zhou, Qiaozhu Mei, Lu Liu, Jie Tang

Journal Of The American Medical Informatics Association，Vol. 230, No. 2

DOI

2016

中医医疗与临床科研信息共享系统——《中医临床术语字典》的构建

周霞继，谢琪，刘保延，郭玉峰，曹馨宇，张润顺，周雪忠，张小平，宋观礼，胡延杰

《中国数字医学》

2016

老年公寓中医药健康管理系统设计与应用

周洪伟，谢琪，刘保延，王斌，于琦，杨杰，李敬华，马剑，周雪忠，邱恒

《世界科学技术-中医药现代化》

2016

基于可视化图方法的体征时间序列数据分类分析研究

焦晓宇，周雪忠，胡镜清，谢琪，周洪伟

《世界科学技术-中医药现代化》

2016

A conditional probabilistic model for joint analysis of symptoms, diseases, and herbs in traditional Chinese medicine patient records

Sheng Wang, Edward W. Huang, Run-Shun Zhang, Xiaoping Zhang, Baoyan Liu, Xuezhong Zhou, ChengXiang Zhai

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2016

PaReCat: Patient Record Subcategorization for Precision Traditional Chinese Medicine

Edward W. Huang, Sheng Wang, Run-Shun Zhang, Baoyan Liu, Xuezhong Zhou, ChengXiang Zhai

ACM International Conference on Bioinformatics, Computational Biology and Biomedicine

DOI

2016

Similarity-based algorithms for Disease Terminology Mapping

Shiwen Ma, Kuo Yang, Xuezhong Zhou, Xue Xu, Wenwen Liu

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2015

基于机器学习的名老中医诊治肺癌认知模型构建方法

庞博，刘刚，周雪忠，王玉亮，朴炳奎，花宝金

《北京中医药》

2015

国际临床表型的本体研究概述及问题探讨

刘林，周雪忠，周霞继，张润顺，郭玉峰，王映辉，谢琪，刘保延

《世界科学技术-中医药现代化》

2015

基于多区域处方的中药数据规范化整理的问题及对策

周霞继，张润顺，王映辉，刘保延，张静茹，杨辉，王建升，郭琦，宋观礼，徐丽丽，周雪忠

《世界科学技术-中医药现代化》

2015

Complex Networks Approach for Analyzing the Correlation of Traditional Chinese Medicine Syndrome Evolvement and Cardiovascular Events in Patients with Stable Coronary Heart Disease

Zhu-Ye Gao, Si-Wei Li, Qinghua Shang, Yang Jiao, Xuezhong Zhou, Changgeng Fu, Hao Xu, Da-Zhuo Shi, Ke-Ji Chen

Evidence-Based Complementary and Alternative Medicine

DOI

2015

Detection of Herb-Symptom Associations from Traditional Chinese Medicine Clinical Data

Yubing Li, Xuezhong Zhou, Run-shun Zhang, Yinghui Wang, Yong-Hong Peng, Jingqing Hu, Qi Xie, Yan Xue, Li-Li Xu, Xiaofang Liu, Bao-Yan Liu

Evidence-Based Complementary and Alternative Medicine

DOI

2015

Integrating herb effect similarity for network-based herb target prediction

Kuo Yang, Xuezhong Zhou, Run-Shun Zhang, Baoyan Liu, Lei Lei, Xiaoping Zhang, Hongwei Chu, Changkai Sun, Zhu-Ye Gao, Hao Xu

International Conference on BioMedical Engineering and Informatics

DOI

2014

基于共享系统的真实世界中医临床研究范式初步实施方案的设计

张润顺，王映辉，刘保延，周雪忠，何丽云，宋观礼

《中医杂志》

2014

基于复杂网络的不稳定型心绞痛中药配伍应用规律研究

罗静，徐浩，周雪忠，陈可冀，高蕊

《中国中西医结合杂志》

2014

基于主题模型的消渴病痹痿症药关系研究

霍蕊莉，刘保延，何丽云，倪青，周雪忠，庞博

《北京中医药》

2014

基于计算的中药靶点预测研究探讨与实验分析

孟志昌，周雪忠，雷蕾，刘保延，张润顺，王映辉，谢琪

《世界科学技术-中医药现代化》

2014

Regularity of herbal formulae for HIV/AIDS patients with syndromes based on complex networks

Jian Wang, Xiaoping Zhang, B. Liang, Xuezhong Zhou, Jia-Ming Lu, Liran Xu, Xin Deng, Xiu-Hui Li, Li Wang, Xing-Hua Tan, Yuxiang Mao, Guo-Liang Zhang, Jun-Wen Wang, Xiao-Dong Li, Yu-Guang Wang

Symposium on Computational Intelligence in Big Data

DOI

2014

Methods and technologies of traditional Chinese medicine clinical information datamation in real world

G. Song, Yinghui Wang, Run-Shun Zhang, Baoyan Liu, Xuezhong Zhou, Guan-Bo Song, Liang Xie, Xinghua Huang

Symposium on Computational Intelligence in Big Data

DOI

2014

Development of large-scale TCM corpus using hybrid named entity recognition methods for clinical phenotype detection: An initial study

Lizhi Feng, Xuezhong Zhou, Haixun Qi, Run-Shun Zhang, Yinghui Wang, Baoyan Liu

Symposium on Computational Intelligence in Big Data

DOI

2014

Data Mining in Real-World Traditional Chinese Medicine Clinical Data Warehouse

Xuezhong Zhou, Baoyan Liu, Xiaoping Zhang, Qi Xie, Run-Shun Zhang, Yinghui Wang, Yong-Hong Peng

DOI

2014

Human symptoms–disease network

Xuezhong Zhou, Jörg Menche, A. Barabási, Amitabh Sharma

Nature Communications

DOI

2014

Network Based Integrated Analysis of Phenotype-Genotype Data for Prioritization of Candidate Symptom Genes

Xing Li, Xuezhong Zhou, Yong-Hong Peng, Baoyan Liu, Run-Shun Zhang, Jingqing Hu, Jian Yu, Caiyan Jia, Changkai Sun

BioMed Research International

DOI

2014

Clinical phenotype network: the underlying mechanism for personalized diagnosis and treatment of traditional Chinese medicine

Xuezhong Zhou, Yubing Li, Yong-Hong Peng, Jingqing Hu, Run-Shun Zhang, Liyun He, Yinghui Wang, Lijie Jiang, Shi-Yan Yan, Peng Li, Qi Xie, Baoyan Liu

Frontiers in Medicine

DOI

2013

中医临床科研数据西医疾病诊断规范的研究分析

宋红梅，刘保延，张润顺，何丽云，宋观礼，周雪忠

《中国数字医学》

2013

中医药(临床)信息学学科概况

周霞继，王映辉，刘保延，张润顺，周雪忠，张红，樊俊芝，郭玉峰，宋观礼

《中国数字医学》

2013

中医药(临床)信息学学科的建设思路

周霞继，王映辉，刘保延，张润顺，周雪忠，张红，樊俊芝，郭玉峰，宋观礼

《中国数字医学》

2013

Exploring effective core drug patterns in primary insomnia treatment with Chinese herbal medicine: study protocol for a randomized controlled trial

Shi-Yan Yan, Run-Shun Zhang, Xuezhong Zhou, Peng Li, Liyun He, Baoyan Liu

Trials

DOI

2013

Integrating phenotype-genotype data for prioritization of candidate symptom genes

Xing Li, Xuezhong Zhou, Yong-Hong Peng, Run-Shun Zhang, Jingqing Hu, Jian Yu, Baoyan Liu

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2013

Modelling traditional Chinese medicine therapy planning with POMDP

Qi Feng, Xuezhong Zhou, Houkuan Huang, Xiaoping Zhang, Run-Shun Zhang

Int. J. Funct. Informatics Pers. Medicine

DOI

2013

Investigation into the Influence of Physician for Treatment Based on Syndrome Differentiation

Li-Jie Jiang, Baoyan Liu, Qi Xie, Shuhong Yang, Liyun He, Run-Shun Zhang, Shi-Yan Yan, Xuezhong Zhou, Jia Liu

Evidence-Based Complementary and Alternative Medicine

DOI

2013

Complex network approach for analyzing TCM clinical herb-symptom relationships

Yubing Li, Xuezhong Zhou, Run-Shun Zhang, Yinghui Wang, Jingqing Hu, Qi Xie, Baoyan Liu

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2013

Frequent itemsets compressing based on minimum cover: An efficient method for mining medication law of Chinese herbs

Lei Zhang, Yi-Guo Wang, Qiming Zhang, Xuezhong Zhou, Jian Yu, Xiuhua Guo, Xia Li

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2012

“医疗与临床科研信息共享系统”中医电子病历系统信息基本要求

刘保延，周雪忠，张润顺，王映辉，谢琪，郭玉峰，张小平，周霞继，何丽云，张磊，宋观礼，张艳虹，张红，李宝顺，赵书君

《中国数字医学》

2012

中医规范术语在结构化电子病历中应用体系的研究

刘保延，尹爱宁，张润顺，谢琪，郭玉峰，周雪忠，张小平，黄兴彦，赵书君，胡延杰，曹海波

《中国数字医学》

2012

Multidimensional analysis for Traditional Chinese Medicine diagnosis and treatment on hepatitis diseases

Lanxin Bi, Xuezhong Zhou, Lei Zhang, Run-Shun Zhang

International Conference on e-Health Networking, Applications and Services

DOI

2012

Thought and Practice of Study of Tumor Treatments by Traditional Chinese Medicine Based on Collection and Analysis Platform of Known TCM Veteran Physicians

Run-shun Zhang, Xuezhong Zhou, Yinghui Wang, Baoyan Liu, Hong-Gang Zheng, Jie Wu, Dao-Rui Li

DOI

2012

Discovery of regularities in the use of herbs in chinese medicine prescriptions

Tao Chen, Xuezhong Zhou, Run-Shun Zhang, Lian-Wen Zhang

Chinese Journal of Integrative Medicine

DOI

2012

Using link topic model to analyze traditional Chinese Medicine Clinical symptom-herb regularities

Zai-Xing Jiang, Xuezhong Zhou, Xiaoping Zhang, Shibo Chen

International Conference on e-Health Networking, Applications and Services

DOI

2012

Enhanced data extraction, transforming and loading processing for Traditional Chinese Medicine clinical data warehouse

Xishui Pan, Xuezhong Zhou, Hong-Mei Song, Run-Shun Zhang, Tingting Zhang

International Conference on e-Health Networking, Applications and Services

DOI

2012

Clinical data preprocessing and case studies of POMDP for TCM treatment knowledge discovery

Kai Liu, Xuezhong Zhou, Yan Feng, Jie Liu

International Conference on e-Health Networking, Applications and Services

DOI

2012

Data processing and analysis in real‐world traditional Chinese medicine clinical data: challenges and approaches

Baoyan Liu, Xuezhong Zhou, Yin-Hui Wang, Jingqing Hu, Liyun He, Run-Shun Zhang, Shibo Chen, Yu-Feng Guo

Statistics in Medicine

DOI

2012

Real-world clinical data mining on TCM clinical diagnosis and treatment: A survey

Xiaoping Zhang, Xuezhong Zhou, Run-Shun Zhang, Baoyan Liu, Qi Xie

International Conference on e-Health Networking, Applications and Services

DOI

2011

电子病历中医科研数据采集过程中质量问题及对策

宋红梅，刘保延，何丽云，张润顺，周霞继，周雪忠

《中国中医基础医学杂志》

DOI

2011

2型糖尿病主诉逻辑构成及其科研意义研究

周霞继，刘保延，王映辉，郭玉峰，闫秀峰，陈世波，周雪忠

《中国数字医学》

2011

利用复杂网络与点式互信息法分析挖掘名老中医用药经验研究

王映辉，周雪忠，张润顺，刘保延，姚乃礼，薛燕星，饶向荣，李文泉，吴洁，郑红刚，谢京红

《中国数字医学》

2011

Analysis of herbal formulation in TCM: Infertility as a case study

Simon K. Poon, Kei Fan, Josiah Poon, Clement Loy, Kelvin Chan, P. Kwan, Xuezhong Zhou, Junbin Gao, Runsun Zhang, Yinghui Runshun, D. Sze

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

DOI

2011

Multiscale backbone based network comparison algorithm for effective herbal interaction analysis

Ninglin Du, Xuezhong Zhou, Run-Shun Zhang, Caiyan Jia, Jian Yu, Baoyan Liu

International Conference on BioMedical Engineering and Informatics

DOI

2011

Topic model for Chinese medicine diagnosis and prescription regularities analysis: Case on diabetes

Xiaoping Zhang, Xuezhong Zhou, Houkuan Huang, Qi Feng, Shibo Chen, Bao-Yan Liu

Chinese Journal of Integrative Medicine

DOI

2011

SHP-VI: A Shortest Hamiltonian Path-Based POMDP Value Iteration Algorithm

Qi Feng, Xuezhong Zhou, Houkuan Huang, Xiaoping Zhang

2011

Thinking and practice of accelerating transformation of traditional Chinese medicine from experience medicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Frontiers in Medicine

DOI

2011

A novel approach in discovering significant interactions from TCM patient prescription data

Simon K. Poon, Josiah Poon, Martin McGrane, Xuezhong Zhou, P. Kwan, Runsun Zhang, Baoyan Liu, Junbin Gao, Clement Loy, Kelvin Chan, D. Sze

International Journal of Data Mining and Bioinformatics

DOI

2011

Co-evolutionary genetic algorithm in symptom-herb relationship discovery

Josiah Poon, Dawei Yin, Simon K. Poon, Xuezhong Zhou, Run-Shun Zhang, Baoyan Liu, D. Sze

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

DOI

2010

中医临床术语集在临床科研信息采集系统中的应用

周霞继，刘保延，郭玉峰，闫秀峰，张润顺，周雪忠

《中国数字医学》

2010

中药方剂药物配伍网络构建程序的并行化实现及其应用

刘红，涂强，周雪忠，赵东升，亢力

《中国数字医学》

2010

基于词相似性与CRP的主题模型

张小平，周雪忠，黄厚宽，冯奇，陈世波

《模式识别与人工智能》

2010

Text mining for traditional Chinese medical knowledge discovery: A survey

Xuezhong Zhou, Yong-Hong Peng, Baoyan Liu

Journal of Biomedical Informatics

DOI

2010

Studying herb-herb interaction for insomnia through the theory of complementarities

Josiah Poon, Simon K. Poon, Dawei Yin, Kelvin Chan, Clement Loy, Xuezhong Zhou, Run-Shun Zhang, Baoyan Liu, P. Kwan, D. Sze, Junbin Gao

2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

DOI

2010

Empirical study on treatment of Coronary Heart Disease with famous doctors' method of regulating spleen and stomach based on simplified point-wise mutual information

Ping Li, Xuezhong Zhou, Rong-Lin Gao, Sanmang Wu

2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

DOI

2010

A MDP solution for Traditional Chinese medicine treatment planning

Qi Feng, Xuezhong Zhou, Houkuan Huang, Jian Yu, Yin Zhang, X. Tong, Run-Shun Zhang, Yinghui Wang, Baoyan Liu

International Conference on BioMedical Engineering and Informatics

DOI

2010

Development of traditional Chinese medicine clinical data warehouse for medical knowledge discovery and decision support

Xuezhong Zhou, Shibo Chen, Baoyan Liu, Runsun Zhang, Yinghui Wang, Ping Li, Yu-Feng Guo, Hua Zhang, Zhu-Ye Gao, Xiufeng Yan

Artif. Intell. Medicine

DOI

2010

Analysis of synergistic and antagonistic effects of TCM: Cases on diabetes and insomnia

Martin McGrane, Simon K. Poon, Josiah Poon, Kelvin Chan, Clement Loy, Xuezhong Zhou, Run-Shun Zhang, Baoyan Liu, P. Kwan, D. Sze, Junbin Gao

2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)

DOI

2010

A hierarchical symptom-herb topic model for analyzing traditional Chinese medicine clinical diabetic data

Xiaoping Zhang, Xuezhong Zhou, Houkuan Huang, Shibo Chen, Baoyan Liu

International Conference on BioMedical Engineering and Informatics

DOI

2010

Novel Two-Stage Analytic Approach in Extraction of Strong Herb-Herb Interactions in TCM Clinical Treatment of Insomnia

Xuezhong Zhou, Josiah Poon, P. Kwan, Runsun Zhang, Yinghui Wang, Simon K. Poon, Baoyan Liu, D. Sze

International Conference on Medical Biometrics

DOI

2009

以“症”为依据的2型糖尿病人群分类原理探讨

刘保延，陈世波，周雪忠，倪青，何丽云

《北京中医药》

2009

Network Analysis System for Traditional Chinese Medicine Clinical Data

Xuezhong Zhou, Baoyan Liu

International Conference on BioMedical Engineering and Informatics

DOI

2009

Network Analysis for Core Herbal Combination Knowledge Discovery from Clinical Chinese Medical Formulae

Xuezhong Zhou, Runsun Zhang, Yinghui Wang, Ping Li, Baoyan Liu

2009 First International Workshop on Database Technology and Applications

DOI

2009

An Uncertainty-Based Belief Selection Method for POMDP Value Iteration

Qi Feng, Xuezhong Zhou, Houkuan Huang, Xiaoping Zhang

European Conference on Symbolic and Quantitative Approaches to Reasoning and Uncertainty

DOI

2008

谢海洲“治痹三要四宜”学术思想之信息化研究

张华东，赵冰，王映辉，王波，刘保延，李大奇，张润顺，朱建贵，焦拥政，周雪忠

《湖北中医杂志》

2008

以数据为导向研究模式的路志正教授临床核心方药初步探讨

李平，周雪忠，王映辉，张润顺，高荣林，路志正，刘保延

《中国数字医学》

2008

2型糖尿病中医诊疗临床路径建立的几个关键问题分析

陈世波，刘保延，王永炎，周雪忠，倪青，何丽云

《辽宁中医杂志》

2008

基于支持向量机的名老中医治疗冠心病证候要素研究

王阶，吴荣，周雪忠

《北京中医药大学学报》

2008

Building Clinical Data Warehouse for Traditional Chinese Medicine Knowledge Discovery

Xuezhong Zhou, Baoyan Liu, Yinghui Wang, Runsun Zhang, Ping Li, Shibo Chen, Yu-Feng Guo, Zhu-Ye Gao, Hua Zhang

International Conference on BioMedical Engineering and Informatics

DOI

2007

名老中医电子病历中病史动态结构化数据录入规范

张润顺，王映辉，姚乃礼，刘保延，姜在旸，周雪忠，田琳

《中国中医药信息杂志》

2007

基于关联规则的名老中医冠心病用药规律研究

吴荣，刘晛，王阶，周雪忠

《中国中药杂志》

2007

基于结构化临床信息采集系统的2型糖尿病用药规律研究

姜兆顺，倪青，周雪忠，邢万佳，林兰，刘保延

《山东中医药大学学报》

2007

Integrative mining of traditional Chinese medicine literature and MEDLINE for functional gene networks

Xuezhong Zhou, Baoyan Liu, Zhao-Hui Wu, Yi Feng

Artif. Intell. Medicine

DOI

2006

Knowledge discovery in traditional Chinese medicine: State of the art and perspectives

Yi Feng, Zhao-Hui Wu, Xuezhong Zhou, Zhong-Mei Zhou, Weiyu Fan

Artif. Intell. Medicine

DOI

2005

Text Mining for Clinical Chinese Herbal Medical Knowledge Discovery

Xuezhong Zhou, Baoyan Liu, Zhao-Hui Wu

IFIP Working Conference on Database Semantics

DOI

2004

Ontology development for unified traditional Chinese medical language system

Xuezhong Zhou, Zhao-Hui Wu, Ai-Ning Yin, Lancheng Wu, Weiyu Fan, Ru-En Zhang

Artif. Intell. Medicine

DOI

2004

Text Mining for Finding Functional Community of Related Genes Using TCM Knowledge

Zhao-Hui Wu, Xuezhong Zhou, Baoyan Liu, Junli Chen

European Conference on Principles of Data Mining and Knowledge Discovery

DOI

2001

TCMMDB: a distributed multidatabase query system and its key technique implemention

Xuezhong Zhou, Zhao-Hui Wu, Wei Lu

2001 IEEE International Conference on Systems, Man and Cybernetics. e-Systems and e-Man for Cybernetics in Cyberspace (Cat.No.01CH37236)

DOI

会议论文

2021

预测并验证连夏宁心方通过抑制环氧化酶2阻断心梗后大鼠交感神经重构的研究

杨阳，李平，戴方圆，李赛赛，林恬恬，韩飞，范倩，娄序笙，马鑫，于雪，路迎冬，王宁，周雪忠

《第七届中国中医药信息大会》

DOI

2009

基于临床科研一体化理念的中西医结合肿瘤结构化电子病历的研究现状

闫秀峰，刘保延，陈世波，郭玉峰，周雪忠，关天宇，胡向禹

《2009年首届全国中西医肿瘤博士及中青年医师论坛》

预印本

2026

LingShu: A Large-Scale Symptom-Centric Contextualized Knowledge Graph Bridging Traditional Chinese Medicine and Modern Biomedicine

Rui Hua, Zixin Shu, Kai Chang, Dengying Yan, Jianan Xia, Hui Zhu, Shujie Song, Shurui Yang, Tongxin Wang, Yue Yin, Yu Wei, Lijuan Pei, Yunhui Hu, Hao Xu, Mingzhong Xiao, Xiaodong Li, Haibin Yu, Runshun Zhang, Wenjia Wang, Baoyan Liu, Xuezhong Zhou

arXiv preprint

2026

LingLanMedBench: A Unified Benchmark for Evaluating Large Language Models in Traditional Chinese Medicine

Rui Hua, Yu Wei, Zixin Shu, Kai Chang, Dengying Yan, Jianan Xia, Hui Zhu, Xiaodong Li, Dongmei Jia, Zhuye Gao, Yanyan Meng, Haibin Yu, Fei Dong, Kan Ding, Runshun Zhang, Jian Yu, Jiansheng Li, Baoyan Liu, Wenjia Wang, Xuezhong Zhou

arXiv preprint

2026

Lingdan-V2: Large language models for clinically grounded reasoning in traditional Chinese medicine

Rui Hua, Yu Wei, Ziri Jin, Zhuo Sun, Kai Chang, Jianan Xia, Zixin Shu, Xiaodong Li, Dongmei Jia, Fei Dong, Runshun Zhang, Jian Yu, Hao Xu, Haibin Yu, Jiansheng Li, Baoyan Liu, Wenjia Wang, Xuezhong Zhou

arXiv preprint

2025

OEMA: Ontology-Enhanced Multi-Agent Collaboration Framework for Zero-Shot Clinical Named Entity Recognition

Xinli Tao, Xin Dong, Xuezhong Zhou

arXiv preprint

DOI

2024

ISPO: An Integrated Ontology of Symptom Phenotypes for Semantic Integration of Traditional Chinese Medical Data

Zixin Shu, Rui Hua, Dengying Yan, Chenxia Lu, Ning Xu, Jun Li, Hui Zhu, Jia Zhang, Dan Zhao, Chenyang Hui, Junqiu Ye, Chu Liao, Qi Hao, Wen Ye, Cheng Luo, Xinyan Wang, Chuang Cheng, Xiaodong Li, Baoyan Liu, Xiaji Zhou, Runshun Zhang, Min Xu, Xuezhong Zhou

arXiv preprint

2024

TCM-FTP: Fine-Tuning Large Language Models for Herbal Prescription Prediction

Xingzhi Zhou, Xin Dong, Chunhao Li, Yuning Bai, Yulong Xu, Ka Chun Cheung, Simon See, Xinpeng Song, Runshun Zhang, Xuezhong Zhou, Nevin L. Zhang

arXiv preprint

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