翁小成｜武汉大学｜学者主页

2026

核酸修饰驱动的分子医学:现状、挑战与机遇

黄艳，朱凌，翁小成，陈鹏，周翔，杨俊林

《中国科学:化学》

2026

Competitive biofunctionalized Au@Pt nanoprobe-based electrochemical biosensor for signal-amplified detection of m6A in gastric cancer

Xi Cheng, Huiyan Cao, Li Huang, Yang Ww, Ziyi Liu, Ziyi Liu, Xiaocheng Weng, Xiang Li, Song‐Mei Liu, Fang Wang

Sensors and Actuators B Chemical

DOI

2026

Simultaneous single-base resolution profiling of 5mC and 5hmC using BRIGHT-seq

Xiaochen Xue, Ziang Lu, Wei Yang, Shaoqing Han, Zhiying Wang, Yifan Jin, Xingxing Li, Xiang Zhou, Yafen Wang, Xiaocheng Weng

National Science Review

DOI

2026

Conductive Cu-MOF synergizing with enzyme-free catalytic cascade amplification for ultrasensitive electrochemical detection of miRNA-21

Li Huang, Ziyi Liu, Huiyan Cao, 董国芃, Wenjun Yang, Weikai Yan, Xiaocheng Weng, Song-Mei Liu, Yanqin Li, Fang Wang

Analytica Chimica Acta

DOI

2026

Photocatalytic Proximity Labeling Maps RNA and Protein Subcellular Landscapes

Meihan Hou, Linao Ren, Xi Xin, Rongjie Zhu, Shengda Xie, Yaqian Liu, Xiaocheng Weng, Xiang Zhou, Yuhao Du

JACS Au

DOI

2026

Development of the First YTHDC1 Degrader with Improved Antileukemia Activity

Zhongpao Xie, Yuanyuan Zhang, Weicai Song, Qianqian Qi, Wei Xiong, Xingyu Liu, Xiaocheng Weng, Xiang Zhou, Tian Tian

JACS Au

DOI

2026

A 5-hydroxymethylcytosine-based noninvasive model for acute myocardial infarction in type 2 diabetes: implications in cardiovascular outcomes from a 5-year median follow-up study

KUN YU YANG, Shanshan Qin, Shaohua Xu, Xiaolong Cui, Zhou Zhang, Jianlei Cao, Meng-Yao Xiao, Ying Yang, Chuan He, Xiang Zhou, Xiaocheng Weng, Wei Zhang, Song-Mei Liu

Cardiovascular Diabetology

DOI

2026

Nanobody-Tethered Transposition for Dual Profiling of Histone Modification and DNA Methylation

Jizhou Liu, Jindi Zhou, Ziang Lu, Guorun Tang, Zhiying Wang, Yelin Lan, Xiang Zhou, Guan‐Zheng Luo, Wang Yc, Xiaocheng Weng

JACS Au

DOI

2026

A gold nanostars-based electrochemical biosensor for sensitive detection of RNA pseudouridine

Li Huang, Xi Cheng, Huiyan Cao, Shouquan Dong, Xiaocheng Weng, Hongling Wang, Yanqin Li, Fang Wang

Sensors and Actuators B Chemical

DOI

2026

Targeted detection method for locus-specific m 6 A modifications in low-abundance transcripts based on chemical conversion

Ting Liu, Xin Fang, Yue Lu, Xiumin Liu, Ruiqi Zhao, Xiang Zhou, Xiaocheng Weng

Chemical Communications

DOI

2026

Molecular medicine driven by nucleic acid modifications: state of the field, challenges, and opportunities

Yan Huang, Ling Zhu, Xiao-Cheng Weng, Penghui Chen, Xiang Zhou, Jun-Lin Yang

Scientia Sinica Chimica

DOI

2025

RNA修饰的检测和定点干预

唐恒，邵静怡，江欣，闫卫凯，骆观正，翁小成

《中国科学:化学》

2025

Unveiling the clinical significance of RNA pseudouridine in colorectal cancer

Jiehua Li, Xuanfei Li, Xiaole Zhao, Xiaochen Xue, Panpan Xia, Lilan Fan, Hongling Wang, Xiaocheng Weng, Yafen Wang, Shaoqing Han, Xiang Zhou

Science China Life Sciences

DOI

2025

Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines

Cong Ding, Zipeng Wang, Bingwen Li, Jiangtian Shao, Ying Chun Tang, Wei Yang, Xiaocheng Weng, Zhi‐Xiang Yu, Xiang Zhou, Yibin Liu

Journal of the American Chemical Society

DOI

2025

A highly sensitive magnetic separation-assisted electrochemical sensor for detection of m6A-microRNA-17–5p based on rolling circle amplification and N3-kethoxal labeling strategy at LIG electrodes

Xi Cheng, Jingyi Guo, Huiyan Cao, Haiyue Bi, Shouquan Dong, Hongling Wang, Xiaocheng Weng, Fang Wang

Analytica Chimica Acta

DOI

2025

Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features

Bingqian Lin, Zhenna Jiao, Shouquan Dong, Weikai Yan, Jinting Jiang, DU Yan-fang, Xiaocheng Weng, Hongling Wang, Zhiyuan Hu, Yibin Liu, Xiang Zhou

Nature Communications

DOI

2025

Author Correction: In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Jing Mo, Zonggui Chen, Manman Cui, Xin Fang, Ruichao Li, Shanshan Qin, Zhenlin Zhou, Mei Sun, Jinjun Wu, Chuan He, Fang Wang, Haojian Zhang, Xiang Zhou, Xiaocheng Weng

Nature Chemical Biology

DOI

2025

Targeted RNA base editing for therapeutic: mechanisms and advances

Weikai Yan, Xiaocheng Weng

Pharmaceutical Science Advances

DOI

2025

In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Jing Mo, Zonggui Chen, Manman Cui, Xin Fang, Ruichao Li, Shanshan Qin, Zhenlin Zhou, Mei Sun, Jinjun Wu, Chuan He, Fang Wang, Haojian Zhang, Xiang Zhou, Xiaocheng Weng

Nature Chemical Biology

DOI

2025

Enhanced or reversible RNA N6-methyladenosine editing by red/far-red light induction

Heng Yuan Tang, Shaoqing Han, Yang Jie, Xin Quan Jiang, Yi Zhang, Junran Peng, Fang Wang, Xiang Li, Xiang Zhou, Wei Jiang, Xiaocheng Weng

Nucleic Acids Research

DOI

2025

Advances in the detection of RNA modification

Ruiqi Zhao, Xin Fang, Xiaocheng Weng

Chemical Communications

DOI

2024

A bisulfite-assisted and ligation-based qPCR amplification technology for locus-specific pseudouridine detection at base resolution

Xin Fang, Ruiqi Zhao, Yafen Wang, Mei Sun, Jin Xu, Shengrong Long, Jing Mo, Hudan Liu, Xiang Li, Fang Wang, Xiang Zhou, Xiaocheng Weng

Nucleic Acids Research

DOI

2024

Exonuclease-assisted enrichment and base resolution analysis of pseudouridine in single-stranded RNA

Xin Fang, Ziang Lu, Yafen Wang, Ruiqi Zhao, Jing Mo, Wei Yang, Mei Sun, Xiang Zhou, Xiaocheng Weng

Chemical Science

DOI

2024

Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex

Ziang Lu, Jinglei Xu, Yuqi Chen, Yuanyuan Zhou, Xiaolu Zhou, Xiaolu Zhou, Qi Wang, Qi Wei, Shaoqing Han, Ruiqi Zhao, Xiaocheng Weng, Xiao‐Lian Zhang, Xiang Zhou, Xiang Zhou

Aggregate

DOI

2024

RNA modifications identification based on chemical reactions

Zhengjia Zhao, Weikai Yan, Xiaocheng Weng

Bioorganic & Medicinal Chemistry

DOI

2024

Single-cell epigenomics and proteomics methods integrated in multiomics

Haiyue Bi, Xiaocheng Weng

Fundamental Research

DOI

2024

Locus-specific detection of pseudouridine with CRISPR-Cas13a

Mei Sun, Xin De Fang, Bingqian Lin, Jing Mo, Fang Wang, Xiang Zhou, Xiaocheng Weng

Chemical Communications

DOI

2024

Steric hindrance of N 6 -methyl in m 6 A and its application for specific loci detection

Xiaoyi Xie, Qi Wei, Jingyu Han, Xin Fang, Wei Yang, Xiang Zhou, Yafen Wang, Xiaocheng Weng

Chemical Communications

DOI

2024

Ultrasensitive Method Enables Liquid Biopsy for the Precise Detection of Circulating MicroRNAs.

Zhaoxin Chen, Han-Fei Zhang, Feng Xiao, Shen Yan, Lin-Ao Ren, Song-Mei Liu, Xiao-Cheng Weng, Xiang Zhou, Yu-Hao Du

Analytical Chemistry

DOI

2023

检测核酸表观遗传修饰的测序方法

方鑫，赵瑞奇，莫婧，王雅芬，翁小成

《高等学校化学学报》

2023

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

Yuqing Sun, Haixin Yu, Shaoqing Han, Ruoxi Ran, Ying Zhen Yang, Yongling Tang, Yuhao Wang, Wenhao Zhang, Heng Yuan Tang, Boqiao Fu, Boshi Fu, Xiaocheng Weng, Song‐Mei Liu, Hexiang Deng, Shuang Peng, Xiang Zhou

National Science Review

DOI

2023

Preface: special issue celebrating the 130th anniversary of Wuhan University

Xiang Zhou, Zhen Li, Xiaocheng Weng, Qianqian Li

Science China Chemistry

2023

Sequencing-based methods for single-cell multi-omics studies

Shanshan Qin, Songmei Liu, Xiaocheng Weng

Science China Chemistry

DOI

2023

Antibody-Free Fluorine-Assisted Metabolic Sequencing of RNA N 4‑Acetylcytidine

Shen Yan, Ziang Lu, Wei Yang, Jinglei Xu, Yafen Wang, Wei Xiong, Rongjie Zhu, Linao Ren, Zhaoxin Chen, Qi Wei, Song‐Mei Liu, Tian Feng, Bi‐Feng Yuan, Xiaocheng Weng, Yuhao Du, Xiang Zhou

Journal of the American Chemical Society

DOI

2023

Detection, Clinical Application, and Manipulation of RNA Modifications

Jing Mo, Xiaocheng Weng, Xiang Zhou

Accounts of Chemical Research

DOI

2023

Transcriptome-wide profiling of A-to-I RNA editing by Slic-seq

Qi Wei, Shaoqing Han, Kexin Yuan, Zhiyong He, Yuqi Chen, Xi Xin, Jingyu Han, Shen Yan, Yingying Chen, Bi‐Feng Yuan, Xiaocheng Weng, Xiang Zhou

Nucleic Acids Research

DOI

2023

Transcriptome-wide identification of single-stranded RNA binding proteins

Ruiqi Zhao, Xin Fang, Zhibiao Mai, Xi Chen, Jing Mo, Yingying Lin, Rui Xiao, Xichen Bao, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2023

Intracellular RNA Labeling Technologies for the Analysis of RNA Biology†

Ruiqi Zhao, Xin Fang, Xiaocheng Weng

Chinese Journal of Chemistry

DOI

2023

A CRISPR-Cas and Tat Peptide with Fluorescent RNA Aptamer System for Signal Amplification in RNA Imaging

Heng Yuan Tang, Junran Peng, Xin Quan Jiang, Shuang Peng, Fang Wang, Xiaocheng Weng, Xiang Zhou

Biosensors

DOI

2023

N6‐methyladenine profiling of low‐input multiplex clinical samples on transcriptome reveals RNA modifications implicated in type 2 diabetes and acute myocardial infarction

Shanshan Qin, Kun Yang, Shaoqing Han, Yushu Yuan, Jing Mo, Meng-Yao Xiao, Yin Yang, Yafen Wang, Xin Fang, Fang Wang, Wei Zhang, Song‐Mei Liu, Xiaocheng Weng, Xiang Zhou

Clinical and Translational Medicine

DOI

2022

Inert Pepper aptamer-mediated endogenous mRNA recognition and imaging in living cells

Qi Wang, Feng Xiao, Haomiao Su, Hui Liu, Jinglei Xu, Heng Yuan Tang, Shanshan Qin, Zhentian Fang, Ziang Lu, Jian Wu, Xiaocheng Weng, Xiang Zhou

Nucleic Acids Research

DOI

2022

KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal–assisted labeling

Ruitu Lyu, Tong Wu, Allen C. Zhu, Diana C. West-Szymanski, Xiaocheng Weng, Mengjie Chen, Chuan He

Nature Protocols

DOI

2022

Live-cell RNA imaging using the CRISPR-dCas13 system with modified sgRNAs appended with fluorescent RNA aptamers

Heng Yuan Tang, Junran Peng, Shuang Peng, Qi Wang, Xin Quan Jiang, Xiaocheng Xue, Yanxin Tao, Limin Xiang, Quanjiang Ji, Song‐Mei Liu, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2022

Transcriptome-wide profiling of N 6 -methyladenosine via a selective chemical labeling method

Yalun Xie, Shaoqing Han, Qiming Li, Zhentian Fang, Wei Yang, Qi Wei, Yafen Wang, Yu Zhou, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2021

RNA化学标记技术

方振天，卢子昂，方鑫，翁小成，周翔

《生命科学》

DOI

2021

A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome

Yafen Wang, Shaoqing Han, Ruoxi Ran, Anling Li, Huanyu Liu, Mingjun Liu, Yongwei Duan, Xiong Zhang, Zhigang Zhao, Shihui Song, Xiaocheng Weng, Song‐Mei Liu, Xiang Zhou

Nature Communications

DOI

2021

Base-Resolution Analysis of Deoxyuridine at the Genome Scale Based on the Artificial Incorporation Modified Nucleobase

Yafen Wang, Xiong Zhang, Shaoqing Han, Wei Yang, Zonggui Chen, Fan Wu, Jizhou Liu, Xiaocheng Weng, Xiang Zhou

ACS Central Science

DOI

2021

Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation

Qing Wang, Kaiyue Tan, Hong Wang, Jinhua Shang, Yeqing Wan, Xiaoqing Liu, Xiaocheng Weng, Fuan Wang

Journal of the American Chemical Society

DOI

2021

Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharomyces cerevisiae mRNAs

Yafen Wang, Zonggui Chen, Xiong Zhang, Xiaocheng Weng, Jikai Deng, Wei Yang, Fan Wu, Shaoqing Han, Chao Xia, Yu Zhou, Yu Zheng Chen, Xiang Zhou

ACS Chemical Biology

DOI

2021

Cover Feature: N3‐Kethoxal‐Based Bioorthogonal Intracellular RNA Labeling (ChemBioChem 9/2021)

Jinguo Huang, Ruiqi Zhao, Jing Mo, Fang Wang, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2021

N3‐Kethoxal‐Based Bioorthogonal Intracellular RNA Labeling

Jinguo Huang, Ruiqi Zhao, Jing Mo, Fang Wang, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2021

One-pot fluorescent assay for sensitive detection of APOBEC3A activity

Bingyao Wang, Xiong Zhang, Yafen Wang, Kun Chen, Fang Wang, Xiaocheng Weng, Xiang Zhou

RSC Chemical Biology

DOI

2021

Highly sensitive detection of 6mA at single-base resolution based on A–C mismatch

Wei Li, Hongmei Yang, Yafen Wang, Xiaocheng Weng, Fang Wang

The Analyst

DOI

2021

A far-red emissive two-photon fluorescent probe for quantification of uracil in genomic DNA

Bingyao Wang, Yi Chen, Xiong Zhang, Zhuoran Jiang, Yafen Wang, Kun Chen, Fang Wang, Xiaocheng Weng, Xiang Zhou

Chemical Communications

DOI

2020

A m6A Sensing Method by Its Impact on the Stability of RNA Double Helix

Shixi Yang, Fan Wu, Shuang Peng, Fang Wang, Yi Chen, Yushu Yuan, Xiaocheng Weng, Xiang Zhou

Chemistry & Biodiversity

DOI

2020

Keth-seq for transcriptome-wide RNA structure mapping

Xiaocheng Weng, Jing Gong, Yi Chen, Tong Wu, Fang Wang, Shixi Yang, Yushu Yuan, Guan‐Zheng Luo, Kai Chen, Lulu Hu, Honghui Ma, Pingluan Wang, Qiangfeng Cliff Zhang, Xiang Zhou, Chuan He

Nature Chemical Biology

DOI

2020

NEase-based amplification for detection of miRNA, multiple miRNAs and circRNA

Yajun Zhang, Qiuyang Zhang, Xiaocheng Weng, Yuhao Du, Xiang Zhou

Analytica Chimica Acta

DOI

2020

Cover Feature: 4‐Thiouridine‐Enhanced Peroxidase‐Generated Biotinylation of RNA (ChemBioChem 1/2021)

Jinguo Huang, Ruiqi Zhao, Shanshan Qin, Shixi Yang, Wei Li, Jing Mo, Fang Wang, Yuhao Du, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2020

4‐Thiouridine‐Enhanced Peroxidase‐Generated Biotinylation of RNA

Jinguo Huang, Ruiqi Zhao, Shanshan Qin, Shixi Yang, Wei Li, Jing Mo, Fang Wang, Yuhao Du, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2020

TRADES: Targeted RNA Demethylation by SunTag System

Jing Mo, Zonggui Chen, Shanshan Qin, Shu Li, Chuangang Liu, Lu Zhang, Ruoxi Ran, Ying Kong, Fang Wang, Song‐Mei Liu, Yu Zhou, Xiao‐Lian Zhang, Xiaocheng Weng, Xiang Zhou

Advanced Science

DOI

2020

Acrylonitrile‐Mediated Nascent RNA Sequencing for Transcriptome‐Wide Profiling of Cellular RNA Dynamics

Yuqi Chen, Fan Wu, Zonggui Chen, Zhiyong He, Qi Wei, Weiwu Zeng, Kun Chen, Feng Xiao, Yushu Yuan, Xiaocheng Weng, Yu Zhou, Xiang Zhou

Advanced Science

DOI

2019

N 1-Methyladenosine detection with CRISPR-Cas13a/C2c2

Yi Chen, Shixi Yang, Shuang Peng, Wei Li, Fan Wu, Qian Yao, Fang Wang, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2019

Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification

Yaqian Liu, Xiong Zhang, Min Liu, Fa Xu, Qiuyang Zhang, Yajun Zhang, Xiaocheng Weng, Song‐Mei Liu, Yuhao Du, Xiang Zhou

Analytica Chimica Acta

DOI

2019

A sensitive and radiolabeling-free method for pseudouridine detection

Wei Li, Fang Wang, Yi Chen, Xiaocheng Weng, Xiang Zhou

Analytical Biochemistry

DOI

2019

Photocaged probes for spatiotemporal imaging

Guangrong Zou, Chaoxing Liu, Zhentian Fang, Shaokang Jia, Wei Yang, Xiong Zhang, Mingkai Chen, Tian Tian, Xiaocheng Weng, Xiang Zhou

Sensors and Actuators B Chemical

DOI

2019

Biotinylation and isolation of an RNA G-quadruplex based on its peroxidase-mimicking activity

Wei Li, Weiwu Zeng, Yi Chen, Fang Wang, Fan Wu, Xiaocheng Weng, Xiang Zhou

The Analyst

DOI

2019

Correction to "Application of the N-Halogeno-N-sodiobenzenesulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences".

Tianlu Wang, Ting-Ting Hong, Tun Tang, Qianqian Zhai, Xiwen Xing, Wu-Xiang Mao, Xiaolong Zheng, Liang Xu, Jinjun Wu, Xiao-Cheng Weng, Shao-Run Wang, Tian Tian, Bifeng Yuan, Bing-Shun Huang, Lin Zhuang, Xiang Zhou

Journal of the American Chemical Society

DOI

2018

Luminescence Sensing for Qualitative and Quantitative Detection of 5-Methylcytosine

Yushu Yuan, Tingting Hong, Yi Chen, Yafen Wang, Xueping Qiu, Fang Zheng, Xiaocheng Weng, Xiang Zhou

Analytical Chemistry

DOI

2018

Precise Antibody-Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution

Tingting Hong, Yushu Yuan, Zonggui Chen, Kun Xi, Tianlu Wang, Yalun Xie, Zhiyong He, Haomiao Su, Yu Zhou, Zhi-Jie Tan, Xiaocheng Weng, Xiang Zhou

Journal of the American Chemical Society

DOI

2018

Gene specific-loci quantitative and single-base resolution analysis of 5-formylcytosine by compound-mediated polymerase chain reaction

Yafen Wang, Chaoxing Liu, Xiong Zhang, Wei Yang, Fan Wu, Guangrong Zou, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2018

Highly Selective 5-Formyluracil Labeling and Genome-wide Mapping Using (2-Benzimidazolyl)Acetonitrile Probe

Yafen Wang, Chaoxing Liu, Fan Wu, Xiong Zhang, Sheng Liu, Zonggui Chen, Weiwu Zeng, Wei Yang, Xiao‐Lian Zhang, Yu Zhou, Xiaocheng Weng, Zhiguo Wu, Xiang Zhou

iScience

DOI

2018

Existence of Diverse Modifications in Small‐RNA Species Composed of 16–28 Nucleotides

Meng‐Dan Lan, Jun Xiong, Xue‐Jiao You, Xiaocheng Weng, Xiang Zhou, Bi‐Feng Yuan, Yu‐Qi Feng

Chemistry - A European Journal

DOI

2018

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation

X. Zhong, Jiayao Yu, Katya Frazier, Xiao-Cheng Weng, Yi Li, C. Cham, K. Dolan, Xiaorong Zhu, N. Hubert, Y. Tao, F. Lin, Kristina Martinez-Guryn, Yong Huang, Tian Wang, Jianzhao Liu, Chuan He, E. Chang, V. Leone

Cell Reports

DOI

2018

N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA

Guan-Zheng Luo, Ziyang Hao, Liangzhi Luo, Ming-Ren Shen, Daniela Sparvoli, Yuqing Zheng, Zijie Zhang, Xiao-Cheng Weng, Kai Chen, Q. Cui, A. Turkewitz, Chuan He

Genome Biology

DOI

2017

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Jun Su, Lei Dong, Chenying Li, Sigrid Nachtergaele, Mark Wunderlich, Ying Qing, Xiaolan Deng, Yungui Wang, Xiaocheng Weng, Chao Hu, Mengxia Yu, Jennifer R. Skibbe, Qing Dai, Dongling Zou, Tong Wu, Kang‐Kang Yu, Hengyou Weng, Huilin Huang, Kyle Ferchen, Xi Qin, Bin Zhang, Jun Qi, Atsuo T. Sasaki, David R. Plas, James E. Bradner, Minjie Wei, Guido Marcucci, Xi Jiang, James C. Mulloy, Jie Jin, Chuan He, Jianjun Chen

Cell

DOI

2017

Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA

Chaoxing Liu, Yafen Wang, Wei Yang, Fan Wu, Weiwu Zeng, Zonggui Chen, Jinguo Huang, Guangrong Zou, Xiong Zhang, Shaoru Wang, Xiaocheng Weng, Zhiguo Wu, Yu Zhou, Xiang Zhou

Chemical Science

DOI

2016

Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing

Guan‐Zheng Luo, Fang Wang, Xiaocheng Weng, Kai Chen, Ziyang Hao, Miao Yu, Xin Deng, Jianzhao Liu, Chuan He

Nature Communications

DOI

2016

Fto Plays an Oncogenic Role in Acute Myeloid Leukemia As a N6-Methyladenosine RNA Demethylase

R. Su, Ze-Juan Li, Hengyou Weng, Xiao-Cheng Weng, Z. Zuo, Chen-Ying Li, Huilin Huang, Chao Hu, Xi Qin, Li-Juan Tang, Yun-Gui Wang, Gia-ming Hong, Hao Huang, Xiao Wang, Ping Chen, S. Gurbuxani, S. Arnovitz, Yuan-Yuan Li, Shenglai Li, J. Strong, M. Neilly, R. Larson, Xi Jiang, Pu-Min Zhang, Jie Jin, Chuan He, Jianjun Chen

DOI

2016

Corrigendum: Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy

Libo Yuan, Tian Tian, Yu-Qi Chen, Shengyong Yan, Xiwen Xing, Zhen-Gan Zhang, Qianqian Zhai, Liang Xu, Shao-Run Wang, Xiao-Cheng Weng, Bifeng Yuan, Yuqi Feng, Xiang Zhou

Scientific Reports

DOI

2015

Enantioselective Diels–Alder reactions using a G-triplex DNA-based catalyst

Xiaowei Xu, Wuxiang Mao, Feng Lin, Jianlin Hu, Zhiyong He, Xiaocheng Weng, Chun‐Jiang Wang, Xiang Zhou

Catalysis Communications

DOI

2015

DNA methyltransferase activity detection based on fluorescent silver nanocluster hairpin-shaped DNA probe with 5’-C-rich/G-rich-3’ tails

Wenting Liu, Han Lai, Rong Huang, Chuntao Zhao, Yimo Wang, Xiaocheng Weng, Xiang Zhou

Biosensors and Bioelectronics

DOI

2015

Widespread occurrence of N6-methyladenosine in bacterial mRNA

Xin Deng, Kai Chen, Guan-Zheng Luo, Xiao-Cheng Weng, Q. Ji, Tianhong Zhou, Chuan He

Nucleic Acids Research

DOI

2015

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang, B. Zhao, I. A. Roundtree, Zhike Lu, Dali Han, Honghui Ma, Xiao-Cheng Weng, Kai Chen, Hailing Shi, Chuan He

Cell

DOI

2015

N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas

Ye Fu, Guan-Zheng Luo, Kai Chen, Xin Deng, Miao Yu, Dali Han, Ziyang Hao, Jianzhao Liu, Xingyu Lu, L. Doré, Xiao-Cheng Weng, Q. Ji, L. Mets, Chuan He

Cell

DOI

2014

Corrigendum to “Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling” [Bioorg. Med. Chem. Lett. 24 (2014) 294–297]

Jianlin Hu, Yuqi Chen, Xiaowei Xu, Fan Wu, Xiwen Xing, Zhenghao Xu, Jiahui Xu, Xiaocheng Weng, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2014

A novel aggregation-induced emission fluorescent probe for nucleic acid detection and its applications in cell imaging

Xiaowei Xu, Shengyong Yan, Yimin Zhou, Rong Huang, Yuqi Chen, Jiaqi Wang, Xiaocheng Weng, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2014

ChemInform Abstract: One‐Step to Get 5‐Azidomethyl‐2′‐deoxyuridine from 5‐Hydroxymethyl‐2′‐deoxyuridine and Detection of It Through Click Reaction.

Xiaowei Xu, Shengyong Yan, Jianlin Hu, Pu Guo, Lai Wei, Xiaocheng Weng, Xiang Zhou

ChemInform

DOI

2014

Symmetric cyanovinyl-pyridinium triphenylamine: a novel fluorescent switch-on probe for an antiparallel G-quadruplex

Hai Lai, Yijie Xiao, Shengyong Yan, Fang-Fang Tian, Cheng Zhong, Yi Liu, Xiaocheng Weng, Xiang Zhou

The Analyst

DOI

2014

Nonlinear optical dye TSQ1 as an efficiently selective fluorescent probe for G-quadruplex DNA

Yuqi Chen, Shengyong Yan, Libo Yuan, Yimin Zhou, Yanyan Song, Heng Xiao, Xiaocheng Weng, Xiang Zhou

Organic Chemistry Frontiers

DOI

2013

Application of N-Halogeno-N-sodiobenzenesulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences

Tianlu Wang, Tingting Hong, Tun Tang, Qianqian Zhai, Xiwen Xing, Wuxiang Mao, Xiaolong Zheng, Liang Xu, Jinjun Wu, Xiaocheng Weng, Shaoru Wang, Tian Tian, Bi‐Feng Yuan, Bing Huang, Lin Zhuang, Xiang Zhou

Journal of the American Chemical Society

DOI

2013

Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling

Jianlin Hu, Yuqi Chen, Xiaowei Xu, Fan Wu, Xiwen Xing, Zhenghao Xu, Jiahui Xu, Xiaocheng Weng, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2013

One-step to get 5-azidomethyl-2′-deoxyuridine from 5-hydroxymethyl-2′-deoxyuridine and detection of it through click reaction

Xiaowei Xu, Shengyong Yan, Jianlin Hu, Pu Guo, Lai Wei, Xiaocheng Weng, Xiang Zhou

Tetrahedron

DOI

2013

Selective Detection of 5-Formyl-2′-deoxycytidine in DNA Using a Fluorogenic Hydroxylamine Reagent

Pu Guo, Shengyong Yan, Jianlin Hu, Xiwen Xing, Changcheng Wang, Xiaowei Xu, Xiaoyu Qiu, Wen Ma, Chunjiang Lu, Xiaocheng Weng, Xiang Zhou

Organic Letters

DOI

2013

Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy

Libo Yuan, Tian Tian, Yuqi Chen, Shengyong Yan, Xiwen Xing, Zhengan Zhang, Qianqian Zhai, Liang Xu, Shaoru Wang, Xiaocheng Weng, Bi‐Feng Yuan, Yuqi Feng, Xiang Zhou

Scientific Reports

DOI

2013

Selective Chemical Labelling of 5‐Formylcytosine in DNA by Fluorescent Dyes

Jianlin Hu, Xiwen Xing, Xiaowei Xu, Fan Wu, Pu Guo, Shengyong Yan, Zhenghao Xu, Jiahui Xu, Xiaocheng Weng, Xiang Zhou

Chemistry - A European Journal

DOI

2013

Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2′-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives

Pu Guo, Xiaowei Xu, Xiaoyu Qiu, Yimin Zhou, Shengyong Yan, Changcheng Wang, Chunjiang Lu, Wen Ma, Xiaocheng Weng, Xian‐Zheng Zhang, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2013

Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

Jun Wu, Rong Huang, Tianlu Wang, Xi Zhao, Wanyi Zhang, Xiaocheng Weng, Tian Tian, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2013

Graphene oxide-based fluorescent detection of DNA and enzymes using Hoechst 33258 and its use for dual-output fluorescent logic gates

Wenting Liu, Ling‐Yu Wu, Shengyong Yan, Rong Huang, Xiaocheng Weng, Xiang Zhou

Analytical Methods

DOI

2013

A selective turn-on fluorescence strategy for the detection of 5-hydroxymethyl-2′-deoxycytidine

Shengyong Yan, Xiaowei Xu, Pu Guo, Jianlin Hu, Changcheng Wang, Rong Huang, Xiaocheng Weng, Yuhao Du, Xiang Zhou

RSC Advances

DOI

2012

基于小分子的核酸结构探针最新研究进展

田沺，肖珩，翁小成，王少儒，周翔

《中国科学:化学》

2012

Selective cleavage of DNA at guanosine bases which locate in DNA non-duplex portions within duplexes by ruthenium(II) complexes

Lin Liu, Qianqian Zhai, Tingting Hong, Yushu Ge, Peng Hu, Xiaocheng Weng, Yi Liu, Xiang Zhou

Inorganica Chimica Acta

DOI

2012

Ag+ and cysteine detection by Ag+–guanine interaction based on graphene oxide and G-quadruplex DNA

Lin Liu, Wenting Liu, Tingting Hong, Xiaocheng Weng, Qianqian Zhai, Xiang Zhou

Analytical Methods

DOI

2012

Studies of the Activity of Peroxidase‐Like DNAzyme by Modifying 3′‐ or 5′‐End of Aptamers

Ming Zhang, Haiqun Li, Ming‐Gang Deng, Xiaocheng Weng, Heng Ma, Shuo Feng, Yangyang Zhou, Xiang Zhou

Chemistry & Biodiversity

DOI

2012

Recent progress of nucleic acid probes based on small molecules

Tian Tian, Heng Xiao, Xiao-Cheng Weng, Shao-Run Wang, Xiang Zhou

DOI

2011

Formation of sequence-independent Z-DNA induced by a ruthenium complex at low salt concentrations.

Zhi-Guo Wu, Tian Tian, Junping Yu, Xiao-Cheng Weng, Yi Liu, Xiang Zhou

Angewandte Chemie

DOI

2010

Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives

Minghui Bai, Jing Huang, Xiaolong Zheng, Zhibin Song, Miru Tang, Wuxiang Mao, Libo Yuan, Jun Wu, Xiaocheng Weng, Xiang Zhou

Journal of the American Chemical Society

DOI

2010

Conformational Switching of G‐Quadruplex DNA by Photoregulation

Xiaolin Wang, Jing Huang, Yangyang Zhou, Shengyong Yan, Xiaocheng Weng, Xiaojun Wu, Ming‐Gang Deng, Xiang Zhou

Angewandte Chemie

DOI

2009

Pyridyl‐Substituted Corrole Isomers: Synthesis and their Regulation to G‐quadruplex Structures

Heng Ma, Ming Zhang, Dan Zhang, Rong Huang, Yang Zhao, Hao Yang, Yijing Liu, Xiaocheng Weng, Yangyang Zhou, Ming‐Gang Deng, Liang Xu, Xiang Zhou

Chemistry - An Asian Journal

DOI

2009

Specific Recognition of DNA by Small Molecules

Yan-Rong Du, Jing Huang, Xiaocheng Weng, Xiaodong Zhou

Current Medicinal Chemistry

DOI

2009

Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA

Yuhao Du, Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou, Jean‐François Constant

Bioorganic & Medicinal Chemistry

DOI

2009

Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission

Jing Huang, Ming Wang, Yangyang Zhou, Xiaocheng Weng, Liang Shuai, Xiang Zhou, Deqing Zhang

Bioorganic & Medicinal Chemistry

DOI

2009

Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomereG-quadruplex

Jing Huang, Guorui Li, Zhiguo Wu, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou, Guang‐Fu Yang

Chemical Communications

DOI

2009

Some cationic porphyrins: synthesis, stabilization of G-quadruplexes, and down-regulation of c-myc in Hep G2 cells

Shaoru Wang, Dan Zhang, Feng Luo, Lin Liu, Xiao-Cheng Weng, Jin-Guo Huang, Guorui Li, Xiao Zhang, Xiang Zhou

DOI

2008

Cationic Metal–Corrole Complexes: Design, Synthesis, and Properties of Guanine‐Quadruplex Stabilizers

Boqiao Fu, Dan Zhang, Xiaocheng Weng, Ming Zhang, Heng Ma, Yuzhi Ma, Xiang Zhou

Chemistry - A European Journal

DOI

2008

Synthesis and Oxidation‐Induced DNA Cross‐Linking Capabilities of Bis(catechol) Quaternary Ammonium Derivatives

Zhibin Song, Xiaocheng Weng, Liwei Weng, Jing Huang, Xiaolin Wang, Minghui Bai, Yangyang Zhou, Guang‐Fu Yang, Xiang Zhou

Chemistry - A European Journal

DOI

2008

Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand

Guorui Li, Jing Huang, Ming Zhang, Yangyang Zhou, Dan Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang Zhou, Guang‐Fu Yang

Chemical Communications

DOI

2008

Synthesis and DNA‐Recognition and ‐Cleavage Properties of Multiply Charged Porphyrin Esters

Lin Wu, Peng Hu, Ying Xiao, Ming Zhang, Lixia Zhang, Xiaocheng Weng, Xiaojun Wu, Xiang Zhou, Xiao‐Ping Cao

Chemistry & Biodiversity

DOI

2007

可诱导核酸交联剂的研究进展

翁小成，翁立伟，白明慧，周泱泱，周翔

《化学进展》

2007

Specific Recognition of Loop DNA by Dicationic Porphyrins

Xiaocheng Weng, Jing Huang, Song Wu, Lige Ren, Liwei Weng, Shugao Zhu, Xiang Zhou

Chemistry & Biodiversity

DOI

2007

Quaternary Ammonium Zinc Phthalocyanine: Inhibiting Telomerase by Stabilizing G quadruplexes and Inducing G‐Quadruplex Structure Transition and Formation

Lige Ren, Anming Zhang, Jing Huang, Ping Wang, Xiaocheng Weng, Lixia Zhang, Feng Liang, Zheng Tan, Xiang Zhou

ChemBioChem

DOI

2007

A Water‐Soluble, Octacationic Zinc Phthalocyanine as Molecular Probe for Nucleic Acid Secondary Structure

An‐Ming Zhang, Jing Huang, Xiaocheng Weng, Jin‐Xi Li, Lige Ren, Zhi‐Bin Song, Xiaoqin Xiong, Xiang Zhou, Xiao‐Ping Cao, Yan Zhou

Chemistry & Biodiversity

DOI

2007

Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands

Boqiao Fu, Jing Huang, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du, Xiaojun Wu, Xiang Zhou, Guang‐Fu Yang

Chemical Communications

DOI

2007

Synthesis and Biological Studies of Inducible DNA Cross‐Linking Agents

Xiaocheng Weng, Lige Ren, Liwei Weng, Jing Huang, Shugao Zhu, Xiang Zhou, Linhong Weng

Angewandte Chemie

DOI

2003

A Potent, Water-Soluble and Photoinducible DNA Cross-Linking Agent

Ping Wang, Renpeng Liu, Xiaojun Wu, MA Hong-juan, Xiao‐Ping Cao, Ping Zhou, Jiangye Zhang, Xiaocheng Weng, Xiao‐Lian Zhang, Jun Qi, Xiang Zhou, Linhong Weng

Journal of the American Chemical Society

DOI

精选作品

期刊论文

核酸修饰驱动的分子医学:现状、挑战与机遇

Competitive biofunctionalized Au@Pt nanoprobe-based electrochemical biosensor for signal-amplified detection of m6A in gastric cancer

Simultaneous single-base resolution profiling of 5mC and 5hmC using BRIGHT-seq

Conductive Cu-MOF synergizing with enzyme-free catalytic cascade amplification for ultrasensitive electrochemical detection of miRNA-21

Photocatalytic Proximity Labeling Maps RNA and Protein Subcellular Landscapes

Development of the First YTHDC1 Degrader with Improved Antileukemia Activity

A 5-hydroxymethylcytosine-based noninvasive model for acute myocardial infarction in type 2 diabetes: implications in cardiovascular outcomes from a 5-year median follow-up study

Nanobody-Tethered Transposition for Dual Profiling of Histone Modification and DNA Methylation

A gold nanostars-based electrochemical biosensor for sensitive detection of RNA pseudouridine

Targeted detection method for locus-specific m 6 A modifications in low-abundance transcripts based on chemical conversion

Molecular medicine driven by nucleic acid modifications: state of the field, challenges, and opportunities

RNA修饰的检测和定点干预

Unveiling the clinical significance of RNA pseudouridine in colorectal cancer

Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines

A highly sensitive magnetic separation-assisted electrochemical sensor for detection of m6A-microRNA-17–5p based on rolling circle amplification and N3-kethoxal labeling strategy at LIG electrodes

Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features

Author Correction: In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Targeted RNA base editing for therapeutic: mechanisms and advances

In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Enhanced or reversible RNA N6-methyladenosine editing by red/far-red light induction

Advances in the detection of RNA modification

A bisulfite-assisted and ligation-based qPCR amplification technology for locus-specific pseudouridine detection at base resolution

Exonuclease-assisted enrichment and base resolution analysis of pseudouridine in single-stranded RNA

Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex

RNA modifications identification based on chemical reactions

Single-cell epigenomics and proteomics methods integrated in multiomics

Locus-specific detection of pseudouridine with CRISPR-Cas13a

Steric hindrance of N 6 -methyl in m 6 A and its application for specific loci detection

Ultrasensitive Method Enables Liquid Biopsy for the Precise Detection of Circulating MicroRNAs.

检测核酸表观遗传修饰的测序方法

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

Preface: special issue celebrating the 130th anniversary of Wuhan University

Sequencing-based methods for single-cell multi-omics studies

Antibody-Free Fluorine-Assisted Metabolic Sequencing of RNA N 4‑Acetylcytidine

Detection, Clinical Application, and Manipulation of RNA Modifications

Transcriptome-wide profiling of A-to-I RNA editing by Slic-seq

Transcriptome-wide identification of single-stranded RNA binding proteins

Intracellular RNA Labeling Technologies for the Analysis of RNA Biology†

A CRISPR-Cas and Tat Peptide with Fluorescent RNA Aptamer System for Signal Amplification in RNA Imaging

N6‐methyladenine profiling of low‐input multiplex clinical samples on transcriptome reveals RNA modifications implicated in type 2 diabetes and acute myocardial infarction

Inert Pepper aptamer-mediated endogenous mRNA recognition and imaging in living cells

KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal–assisted labeling

Live-cell RNA imaging using the CRISPR-dCas13 system with modified sgRNAs appended with fluorescent RNA aptamers

Transcriptome-wide profiling of N 6 -methyladenosine via a selective chemical labeling method

RNA化学标记技术

A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome

Base-Resolution Analysis of Deoxyuridine at the Genome Scale Based on the Artificial Incorporation Modified Nucleobase

Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation

Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharomyces cerevisiae mRNAs

Cover Feature: N3‐Kethoxal‐Based Bioorthogonal Intracellular RNA Labeling (ChemBioChem 9/2021)

N3‐Kethoxal‐Based Bioorthogonal Intracellular RNA Labeling

One-pot fluorescent assay for sensitive detection of APOBEC3A activity

Highly sensitive detection of 6mA at single-base resolution based on A–C mismatch

A far-red emissive two-photon fluorescent probe for quantification of uracil in genomic DNA

A m6A Sensing Method by Its Impact on the Stability of RNA Double Helix

Keth-seq for transcriptome-wide RNA structure mapping

NEase-based amplification for detection of miRNA, multiple miRNAs and circRNA

Cover Feature: 4‐Thiouridine‐Enhanced Peroxidase‐Generated Biotinylation of RNA (ChemBioChem 1/2021)

4‐Thiouridine‐Enhanced Peroxidase‐Generated Biotinylation of RNA

TRADES: Targeted RNA Demethylation by SunTag System

Acrylonitrile‐Mediated Nascent RNA Sequencing for Transcriptome‐Wide Profiling of Cellular RNA Dynamics

N 1-Methyladenosine detection with CRISPR-Cas13a/C2c2

Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification

A sensitive and radiolabeling-free method for pseudouridine detection

Photocaged probes for spatiotemporal imaging

Biotinylation and isolation of an RNA G-quadruplex based on its peroxidase-mimicking activity

Correction to "Application of the N-Halogeno-N-sodiobenzenesulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences".

Luminescence Sensing for Qualitative and Quantitative Detection of 5-Methylcytosine

Precise Antibody-Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution

Gene specific-loci quantitative and single-base resolution analysis of 5-formylcytosine by compound-mediated polymerase chain reaction

Highly Selective 5-Formyluracil Labeling and Genome-wide Mapping Using (2-Benzimidazolyl)Acetonitrile Probe

Existence of Diverse Modifications in Small‐RNA Species Composed of 16–28 Nucleotides

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation

N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA

Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing

Fto Plays an Oncogenic Role in Acute Myeloid Leukemia As a N6-Methyladenosine RNA Demethylase