陈秀杰｜哈尔滨医科大学｜学者主页

2026

Study on tumor ecology and precision medicine strategy of oral squamous cell carcinoma based on multi-omics cell atlas

Qingkang Meng, Diwei Huo, Fei Xu, Naiqiang Liu, Muchen Fan, Yewen Wu, Xiujie Chen

Frontiers in Immunology

DOI

2026

Lineage-Specific CagA Binding Mechanics and Microenvironmental Rewiring in East Asian Gastric Carcinogenesis

Hongbo Xie, Denan Zhang, Lei Liu, Qing Jin, Xiujie Chen

Molecules

DOI

2026

Deciphering the Leading-Edge Spatiotemporal Microenvironment of Hepatocellular Carcinoma for Targeted Drug Discovery Using SpaPred

S Zhang, Ziqiao Li, Kexin Yu, Guang Shi, Yangguang Su, Xin Hu, Xiujie Chen

International Journal of Molecular Sciences

DOI

2026

KAN-PROSPECT: a Kolmogorov–Arnold Networks–integrated framework for predicting the effects and adverse reactions of natural products via transfer learning

Zhenshun Du, Zi Wang, Yuehua Chen, Boyou Li, Xin Wan, Tianyi Ren, Haowei Chen, Lei Liu, Qing Jin, Yongle Zhang, Yanan Zhang, Junge Bai, Hongbo Xie, Xiujie Chen, Xuekun Ren, Denan Zhang

Scientific Reports

DOI

2026

GRIP-Lung: Generative Model of Response to Drug-Induced Perturbation in Lung Cancer

Zhijin Fu, Yanjiao Li, Zhenshun Du, D. X. Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie

International Journal of Molecular Sciences

DOI

2025

Increased antiandrogen enzalutamide sensitivity via altering prostate cancer stem cell traits through modulating the androgen receptor-mediated CDR1/circCDR1-AS/miR-1290/BMP4 signaling

Diwei Huo, Minggui Si, Ke‐Xin Yu, Xiaoxue Fang, Hongbo Liu, D P Li, Zhengxing Chen, Jinguo Li, Ruicong Xu, X. Su, Yongfeng Du, Xuebin Ma, Xunwei Wang, Pengbo Li, Huike Yang, Xiujie Chen, Keliang Wang

Oncogene

DOI

2025

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Meizhu Xiao, Zhijin Fu, Yanjiao Li, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie

Discover Oncology

DOI

2025

Integrating Hypoxia Signatures from scRNA-seq and Bulk Transcriptomes for Prognosis Prediction and Precision Therapy in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

Kexin Yu, S Zhang, Jiali Shen, Meini Yu, Yangguang Su, Ying Wang, Kun Zhou, Lei Liu, Xiujie Chen

International Journal of Molecular Sciences

DOI

2024

Single cell landscape of potential mechanisms in primary and metastatic hepatocellular carcinoma

Shibo Zhang, Yi Li, Meihan Chu, Kexin Yu, Yangguang Su, Kun Zhou, Ying Wang, Xin Zhang, Xiujie Chen

Scientific Reports

DOI

2024

Impact of Hashimoto’s thyroiditis on the tumor microenvironment in papillary thyroid cancer: insights from single-cell analysis

Hongzhe Ma, Guoqi Li, Diwei Huo, Yangguang Su, Qing Jin, Yangxu Lu, Yanyan Sun, Denan Zhang, Xiujie Chen

Frontiers in Endocrinology

DOI

2024

Construction of an immune-related gene prognostic model for obese endometrial cancer patients based on bioinformatics analysis

Yun Tong, Tao Zhu, Fei Xu, Wenjun Yang, Yakun Wang, Xianze Zhang, Xiujie Chen, Lei Liu

Heliyon

DOI

2024

A deep learning drug screening framework for integrating local-global characteristics: A novel attempt for limited data

Ying Wang, Yangguang Su, Kairui Zhao, Diwei Huo, Zhenshun Du, Zhiju Wang, Hongbo Xie, Lei Liu, Qing Jin, Xuekun Ren, Xiujie Chen, Denan Zhang

Heliyon

DOI

2024

Decoding temporal heterogeneity in NSCLC through machine learning and prognostic model construction

Junpeng Cheng, Meizhu Xiao, Qingkang Meng, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Zhijin Fu, Yanjiao Li, Xiujie Chen, Hongbo Xie

World Journal of Surgical Oncology

DOI

2024

Crosstalk of different cell-death patterns predicts prognosis and drug sensitivity in glioma

Meini Yu, Diwei Huo, Kexin Yu, Kun Zhou, Fei Xu, Qingkang Meng, Yiyang Cai, Xiujie Chen

Computers in Biology and Medicine

DOI

2024

Predicting drug synergy using a network propagation inspired machine learning framework

Qing Jin, Xianze Zhang, Diwei Huo, Hongbo Xie, Denan Zhang, Lei Liu, Yashuang Zhao, Xiujie Chen

Briefings in Functional Genomics

DOI

2024

DAPredict: a database for drug action phenotype prediction

Qingkang Meng, Yiyang Cai, Kun Zhou, Fei Xu, Diwei Huo, Hongbo Xie, Meini Yu, Denan Zhang, Xiujie Chen

Database

DOI

2023

Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population

Yangguang Su, Ying Wang, Zhuo Qu, Jiaxin Liu, Xuekun Ren, Denan Zhang, Xiujie Chen

Frontiers in Pharmacology

DOI

2023

Network Propagation-based Identification of Oligometastatic Biomarkers in Metastatic Colorectal Cancer

Qing Jin, Ke‐Xin Yu, Xianze Zhang, Diwei Huo, Denan Zhang, Lei Liu, Hongbo Xie, Binhua Liang, Xiujie Chen

Current Bioinformatics

DOI

2023

Integrating multiple machine learning algorithms for prognostic prediction of gastric cancer based on immune-related lncRNAs

Guoqi Li, Diwei Huo, Naifu Guo, Yi Li, Hongzhe Ma, Lei Liu, Hongbo Xie, Denan Zhang, Bo Qu, Xiujie Chen

Frontiers in Genetics

DOI

2022

Exploring Precise Medication Strategies for OSCC Based on Single-Cell Transcriptome Analysis from a Dynamic Perspective

Qingkang Meng, Feng Wu, Guoqi Li, Fei Xu, Lei Liu, Denan Zhang, Yangxu Lu, Hongbo Xie, Xiujie Chen

Cancers

DOI

2022

Concepts and applications of chemical fingerprint for hit and lead screening

Jingbo Yang, Yiyang Cai, Kairui Zhao, Hongbo Xie, Xiujie Chen

Drug Discovery Today

DOI

2022

Identification of Warning Transition Points from Hepatitis B to Hepatocellular Carcinoma Based on Mutation Accumulation for the Early Diagnosis and Potential Drug Treatment of HBV‐HCC

Fei Xu, Qingkang Meng, Feng Wu, Yakun Wang, Wenjun Yang, Yun Tong, Lei Liu, Xiujie Chen

Oxidative Medicine and Cellular Longevity

DOI

2021

Precision treatment exploration of breast cancer based on heterogeneity analysis of lncRNAs at the single-cell level

Yan Zhang, Denan Zhang, Qingkang Meng, Ziqi Liu, Hongbo Xie, Lei Liu, Fei Xu, Xiujie Chen

BMC Cancer

DOI

2021

Computational Drug Repositioning for Ischemic Stroke: Neuroprotective Drug Discovery

Yunong Li, Jingbo Yang, Yan Zhang, Qingkang Meng, Andreas Bender, Xiujie Chen

Future Medicinal Chemistry

DOI

2021

Identification of Risk Molecular Subtype of Colon Cancer with Lymphovascular Invasion

Qing Jin, Binhua Liang, Xiujie Chen, Huiwen Liu

Current Bioinformatics

DOI

2021

New insights for precision treatment of glioblastoma from analysis of single-cell lncRNA expression

Qingkang Meng, Yan Zhang, Guoqi Li, Yunong Li, Hongbo Xie, Xiujie Chen

Journal of Cancer Research and Clinical Oncology

DOI

2020

Computational drug repositioning based on the relationships between substructure–indication

Jingbo Yang, Denan Zhang, Lei Liu, Guoqi Li, Yiyang Cai, Yan Zhang, Hongbo Jin, Xiujie Chen

Briefings in Bioinformatics

DOI

2020

Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis

Lei Liu, Zhuo Shao, Jiaxuan Lv, Fei Xu, Sibo Ren, Qing Jin, Jingbo Yang, Weifang Ma, Hongbo Xie, Denan Zhang, Xiujie Chen

Frontiers in Bioengineering and Biotechnology

DOI

2020

CHG: A Systematically Integrated Database of Cancer Hallmark Genes

Denan Zhang, Diwei Huo, Hongbo Xie, Lingxiang Wu, Juan Zhang, Lei Liu, Qing Jin, Xiujie Chen

Frontiers in Genetics

DOI

2018

Discovering Proangiogenic Drugs in Ischemic Stroke Based on the Relationship between Protein Domain and Drug Substructure

Yunong Li, Haixia Zhu, Jingbo Yang, Kehui Ke, Yanmei Zhu, Yanmei Zhu, Li Chen, Youyang Qu, Rui Suo, Xiujie Chen, Yulan Zhu, Yulan Zhu

ACS Chemical Neuroscience

DOI

2018

Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network

Lei Liu, Xiujie Chen, Chunyu Hu, Denan Zhang, Zhuo Shao, Qing Jin, Jingbo Yang, Hongbo Xie, Bo Liu, Mingming Hu, Kehui Ke

Scientific Reports

DOI

2018

Predicting hepatocellular carcinoma through cross-talk genes identified by risk pathways

Lei Liu, Lin Pang, Yunfeng Wang, Ming Hu, Zhuo Shao, Diwei Huo, Denan Zhang, Hongbo Xie, Jingbo Yang, Qiuqi Liu, Xiujie Chen

Oncotarget

DOI

2017

药学本科学生学习药物基因组学课程的必要性和教学内容探索

刘磊，解鸿波，张德楠，庞林，陈秀杰

《科技创新导报》

2017

Biological evaluation and energetic analyses of novel GSK‐3 β inhibitors

Denan Zhang, Lei Liu, Lin Pang, Qing Jin, Kehui Ke, Ming Hu, Jingbo Yang, Wei-fang Ma, Hongbo Xie, Xiujie Chen

Journal of Cellular Biochemistry

DOI

2017

Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins

Hongbo Xie, Diheng Zeng, Xiujie Chen, Diwei Huo, Lei Liu, Denan Zhang, Qing Jin, Kehui Ke, Ming Hu

Oncotarget

DOI

2017

Complex integrated analysis of lncRNAs-miRNAs-mRNAs in oral squamous cell carcinoma

Simin Li, Xiujie Chen, Xiangqiong Liu, Yang Yu, Hongying Pan, Rainer Haak, Jana Schmidt, Dirk Ziebolz, Gerhard Schmalz

Oral Oncology

DOI

2017

Large-Scale Analysis of Drug Side Effects via Complex Regulatory Modules Composed of microRNAs, Transcription Factors and Gene Sets

Xiaodong Jia, Qing Jin, Xiangqiong Liu, Xiusen Bian, Yunfeng Wang, Lei Liu, Hongzhe Ma, Fujian Tan, Mingliang Gu, Xiujie Chen

Scientific Reports

DOI

2017

Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening andin vitrobiological activities study

Hongbo Xie, Haixia Wen, Denan Zhang, Lei Liu, Bo Liu, Qiuqi Liu, Qing Jin, Kehui Ke, Ming Hu, Xiujie Chen

Oncotarget

DOI

2016

刍议化学信息软件在药物设计学教学中的应用

解鸿波，张德楠，刘磊，庞林，陈秀杰

《知音励志》

2016

IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering

Lingxiang Wu, Xiujie Chen, Denan Zhang, Wubing Zhang, Lei Liu, Hongzhe Ma, Jingbo Yang, Hongbo Xie, Бо Лю, Qing Jin

PLoS ONE

DOI

2016

Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues

Xiujie Chen, Lei Liu, Yunfeng Wang, Bo Liu, Diheng Zeng, Qing Jin, Mengjian Li, Denan Zhang, Qiuqi Liu, Hongbo Xie

Oncotarget

DOI

2016

In silico drug repositioning for the treatment of Alzheimer's disease using molecular docking and gene expression data

Hongbo Xie, Haixia Wen, Mingze Qin, Jie Xia, Denan Zhang, Lei Liu, Бо Лю, Qiuqi Liu, Qing Jin, Xiujie Chen

RSC Advances

DOI

2015

Identifying the causative proteins of similar side effect pairs to explore the common molecular basis of these side effects

Yunfeng Wang, Xiujie Chen, Lei Liu, Yuelong Chen, Hongzhe Ma, Ruizhi Yang, Xiangqiong Liu

Molecular BioSystems

DOI

2014

Drug repositioning by applying ‘expression profiles’ generated by integrating chemical structure similarity and gene semantic similarity

Fujian Tan, Ruizhi Yang, Xiaoxue Xu, Xiujie Chen, Yunfeng Wang, Hongzhe Ma, Xiangqiong Liu, Xin Wu, Yuelong Chen, Lei Liu, Xiaodong Jia

Molecular BioSystems

DOI

2013

Network Characteristic Analysis of ADR-related Proteins and Identification of ADR-ADR Associations

Xiujie Chen, Xiangqiong Liu, Xiaodong Jia, Fujian Tan, Ruizhi Yang, Sheng Chen, Lei Liu, Yunfeng Wang, Yuelong Chen

Scientific Reports

DOI

2012

A sensitive method for computing GO-based functional similarities among genes with ‘shallow annotation’

Xiujie Chen, Ruizhi Yang, Jiankai Xu, Hongzhe Ma, Sheng Chen, Xiusen Bian, Lei Liu

Gene

DOI

2012

Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses

Wei Jiang, Xiaowen Chen, Mingzhi Liao, Wei Li, Baofeng Lian, Lihong Wang, Fanlin Meng, Xinyi Liu, Xiujie Chen, Yan Jin, Xia Li

Scientific Reports

DOI

2010

A sub-pathway-based approach for identifying drug response principal network

Xiujie Chen, Jiankai Xu, Bangqing Huang, Jin Li, Xin Wu, Ling Ma, Xiaodong Jia, Xiusen Bian, Fujian Tan, Lei Liu, Sheng Chen, Xia Li

Bioinformatics

DOI

2009

The analysis of the drug–targets based on the topological properties in the human protein–protein interaction network

Mingzhu Zhu, Lei Gao, Xia Li, Zhicheng Liu, Chun Xu, Yuqing Yan, Erin J. Walker, Wei Jiang, Bin Su, Xiujie Chen, Hui‐Yi Lin

Journal of drug targeting

DOI

精选作品

期刊论文

Study on tumor ecology and precision medicine strategy of oral squamous cell carcinoma based on multi-omics cell atlas

Lineage-Specific CagA Binding Mechanics and Microenvironmental Rewiring in East Asian Gastric Carcinogenesis

Deciphering the Leading-Edge Spatiotemporal Microenvironment of Hepatocellular Carcinoma for Targeted Drug Discovery Using SpaPred

KAN-PROSPECT: a Kolmogorov–Arnold Networks–integrated framework for predicting the effects and adverse reactions of natural products via transfer learning

GRIP-Lung: Generative Model of Response to Drug-Induced Perturbation in Lung Cancer

Increased antiandrogen enzalutamide sensitivity via altering prostate cancer stem cell traits through modulating the androgen receptor-mediated CDR1/circCDR1-AS/miR-1290/BMP4 signaling

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Integrating Hypoxia Signatures from scRNA-seq and Bulk Transcriptomes for Prognosis Prediction and Precision Therapy in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

Single cell landscape of potential mechanisms in primary and metastatic hepatocellular carcinoma

Impact of Hashimoto’s thyroiditis on the tumor microenvironment in papillary thyroid cancer: insights from single-cell analysis

Construction of an immune-related gene prognostic model for obese endometrial cancer patients based on bioinformatics analysis

A deep learning drug screening framework for integrating local-global characteristics: A novel attempt for limited data

Decoding temporal heterogeneity in NSCLC through machine learning and prognostic model construction

Crosstalk of different cell-death patterns predicts prognosis and drug sensitivity in glioma

Predicting drug synergy using a network propagation inspired machine learning framework

DAPredict: a database for drug action phenotype prediction

Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population

Network Propagation-based Identification of Oligometastatic Biomarkers in Metastatic Colorectal Cancer

Integrating multiple machine learning algorithms for prognostic prediction of gastric cancer based on immune-related lncRNAs

Exploring Precise Medication Strategies for OSCC Based on Single-Cell Transcriptome Analysis from a Dynamic Perspective

Concepts and applications of chemical fingerprint for hit and lead screening

Identification of Warning Transition Points from Hepatitis B to Hepatocellular Carcinoma Based on Mutation Accumulation for the Early Diagnosis and Potential Drug Treatment of HBV‐HCC

Precision treatment exploration of breast cancer based on heterogeneity analysis of lncRNAs at the single-cell level

Computational Drug Repositioning for Ischemic Stroke: Neuroprotective Drug Discovery

Identification of Risk Molecular Subtype of Colon Cancer with Lymphovascular Invasion

New insights for precision treatment of glioblastoma from analysis of single-cell lncRNA expression

Computational drug repositioning based on the relationships between substructure–indication

Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis

CHG: A Systematically Integrated Database of Cancer Hallmark Genes

Discovering Proangiogenic Drugs in Ischemic Stroke Based on the Relationship between Protein Domain and Drug Substructure

Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network

Predicting hepatocellular carcinoma through cross-talk genes identified by risk pathways

药学本科学生学习药物基因组学课程的必要性和教学内容探索

Biological evaluation and energetic analyses of novel GSK‐3 β inhibitors

Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins

Complex integrated analysis of lncRNAs-miRNAs-mRNAs in oral squamous cell carcinoma

Large-Scale Analysis of Drug Side Effects via Complex Regulatory Modules Composed of microRNAs, Transcription Factors and Gene Sets

Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening andin vitrobiological activities study

刍议化学信息软件在药物设计学教学中的应用

IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering

Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues

In silico drug repositioning for the treatment of Alzheimer's disease using molecular docking and gene expression data

Identifying the causative proteins of similar side effect pairs to explore the common molecular basis of these side effects

Drug repositioning by applying ‘expression profiles’ generated by integrating chemical structure similarity and gene semantic similarity

Network Characteristic Analysis of ADR-related Proteins and Identification of ADR-ADR Associations

A sensitive method for computing GO-based functional similarities among genes with ‘shallow annotation’

Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses

A sub-pathway-based approach for identifying drug response principal network

The analysis of the drug–targets based on the topological properties in the human protein–protein interaction network