郝海平｜中国药科大学｜学者主页

2026

创新药物研发新范式：靶标组与原创组合药物

杨华，曾昊，杨志敏，蒋建东，李佳，王广基，王洪，李萍，郝海平

《中国科学基金》

2026

表面蛋白表征方法及其在疾病靶标发现中的应用

张越阳，邵畅，郝海平，叶慧

《中国药科大学学报》

2026

专业力量赋能共筑健康中国新时代

郝海平

《群言》

DOI

2026

聚焦慢病靶标组构筑原创药物新范式

郝海平

《中国科学基金》

2026

以体系化攻关推进生物医药科技自立自强

郝海平

《群众》

2026

CM-TRAP: A chemoproteomic workflow for profiling circulating metabolites and their protein targets in Alzheimer's disease.

Xin-Miao Wang, Xiang-Dong He, Xiao Pu, Xingchao Yang, Yi Li, Han-Qing Zhang, Haiping Hao, Chang Shao, Hui Ye

Analytica Chimica Acta

DOI

2026

DT-TRAP enables accurate target recognition via simplified dosing and low-temperature incubation

Han-Qing Zhang, Wenjie Yuan, Yi Li, Chunyu Li, Yizhou Xie, Ning Wan, Haiping Hao, Hui Ye

Journal of Pharmaceutical Analysis

DOI

2026

MAPLE: interpretable deep learning identifies selective antimicrobial peptides using joint evolutionary–physicochemical analysis

Hao Liu, Yi Shi, Fei Guo, Jinyi Wang, Jiaqian Li, Guangji Wang, De-Chuan Zhan, Haiping Hao, Guo Yu

Briefings Bioinform.

DOI

2026

Protein-Corona-Based Nanomagnetic Enrichment Strategy for In-Depth Secretome Profiling of Lung Adenocarcinoma Organoids.

Wenhui Wu, Yuebo Zhang, Zi-Zhang Guo, Han-Qing Zhang, Yi Li, Haiping Hao, Hui Ye

Analytical Chemistry

DOI

2026

Deoxycholic acid impairs mitochondrial fitness and suppresses mitophagy through Parkin ubiquitination driving CD8+ T cell Exhaustion in Colorectal Cancer

Gao Y, Jiaxin Wang, Shihui Lai, Mingwei Li, Shi Jl, Xianjun Li, Ying Guo, Sainan Ma, Xinxin Wang, Shule Zhang, Tianyu He, Yu Hong, Shuang Li, Caiqi Liu, Lijuan Cao, Haiping Hao, Chujie Ding

Redox Biology

DOI

2026

GPR35 in host–microbe interaction: Mechanisms and translational prospects

Jian Chen, Xiaoying Cai, Qingyun Ma, Haiping Hao, Xiao Zheng

Trends in Pharmacological Sciences

DOI

2026

SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth

Mengyao Qin, Longcheng Shang, Hao Chen, Li Shi, Chan Liu, Ming Ding, Dandan He, Chang Shao, Shengtao Yuan, Hong Yu, Haiping Hao, Yong Ma, Jing Xiong

Science Advances

DOI

2026

A Novel FXR-Targeted DUBTAC and Its Applications in Cholestasis Therapy

Ming Cui, Bin Tang, Tingting Yao, Wenbin Shao, Qiuling Zheng, Huiyong Sun, Haiping Hao, Hao Wang, Xiaowei Xu

Journal of Medicinal Chemistry

DOI

2026

Hepatocyte CEBPA-ORM1 axis restricts alcohol-associated liver disease

Nana Yan, Yangliu Xia, Yang Zhang, Vorthon Sawaswong, Xi Xu, Yoshifumi Saito, Ravikanth Nanduri, Mengge Dai, Daisuke Aibara, Kristopher W. Krausz, Shogo Takahashi, Brandon J. Peiffer, Maria A. Parra, Zhaoli Sun, Haiping Hao, Tingting Yan, Frank J. Gonzalez

Hepatology

DOI

2026

Predicting cerebral acetylcholine dynamics with huperzine A pharmacokinetics in blood via mPBPK-PD modeling

Jiaying Wang, Yangfan Zhang, Haoqian Wu, Siqi Yu, Xiaoying Cai, Youying Zhang, Jian Chen, Zixing Chen, Xiao Zheng, Haiping Hao

Chinese Journal of Natural Medicines

DOI

2026

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Jiawei Wu, Shule Zhang, Ruofan Du, L I N A Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao

Advanced Science

DOI

2026

Discovery of Novel and Potent Dual PARP1/ERK Inhibitors as a Promising Strategy for Cancer Therapy

Ying Bai, Shiqi Wu, Wenhui Zhang, Yuehua Chen, Wenxin Yan, Lei Huang, Jing Liu, Zhaohui. Guan, Yupei Su, Dongqing Guo, Yuchen Bian, Kaiyuan Cong, Yi Zou, Haiping Hao, Qihua Zhu, Hao Wang, Yungen Xu

Journal of Medicinal Chemistry

DOI

2026

Ketogenic Diet Modulates Depressive‐Like Behavior via Gut Bacterial Metabolism of Tyrosine

Youying Zhang, Xuanyao Li, Xuanshuang Zhang, Xuanshuang Zhang, Ying Wang, Zixin Chen, Xuan Lin, Xiao Zheng, Haiping Hao, Xueli Zhang, Xueli Zhang

The FASEB Journal

DOI

2025

Time-shifting oriented balanced time perspective in college students with dysphoria: An exploration with the text reading and writing tasks

Xuchen Yu, Lei Jin, Ya Wang, Yaxuan Zhao, Junru Gong, Jinglin Sun, Xiaobao Li, Haiping Hao, Siyan Wen, Houchao Lyu, Y. Wang

Personality And Individual Differences，Vol. 245

DOI

2025

Admiration and Malicious Envy Among Chinese Adolescents: Differences in Retrospection and Anticipation

Haiping Hao, Qiao Hu, Lieketseng Joyce Rakoro, Wei Liao, Tingting Huang, Houchao Lyu

International Journal Of Psychology，Vol. 60, No. 2

DOI

2025

我国非处方药市场准入优化路径现状调研及国际经验应用建议

卢娜，郝海平，丁佐奇

《中国药房》

2025

Navigating drug discovery with Targetome

Haiping Hao, F. Kirchhoff

Targetome

DOI

2025

Targetome-guided combination drug discovery as next-generation therapeutics

Pan Liu, Fu-Yue Huang, Xiao Zheng, Haiping Hao

Targetome

DOI

2025

Combination of silybin and carvedilol synergistically alleviates liver fibrosis by inhibiting Wnt/β-catenin signaling

An Chen, Xiao-Chai Zhu, Houzhe Jiang, M. Gong, Shuang Cui, Guangji Wang, Hong Wang, Haiping Hao

Targetome

DOI

2025

In situ global mapping of protein perturbations via protein abundance and conformation analysis.

Yi Li, Xing Yang, Fei Zheng, Han-Qing Zhang, Chang Shao, Ning Wan, Haiping Hao, Hui Ye

Analytica Chimica Acta

DOI

2025

Emerging trends in chemoproteomics: Mapping the landscape of protein-metabolite interactions.

Ning Wan, Chen-Guang Liu, Haiping Hao, Hui Ye

Current Opinion in Chemical Biology

DOI

2025

Preclinical Efficacy of TSL2109 in Prostate Cancer Treatment and Overcoming Enzalutamide Resistance

Kai Yuan, Wanqi Wang, Tong Chen, Huanaoyu Yang, Weijiao Chen, Xiaoyu Zhang, Genbei Wang, Guixia Li, Yuanyuan Chen, Xujie Zhuang, Wenjian Min, Haiping Hao, Yibei Xiao, Xiaohui Ma, Peng Yang

Journal of Medicinal Chemistry

DOI

2025

Tryptophan metabolites at the service of neuroimmune sensing of microbes

Ying Wang, Jiajie Li, Zhengqi Lian, Haiping Hao, Xiao Zheng

Trends in Molecular Medicine

DOI

2025

Targeting Protein Tyrosine Phosphatase Nonreceptor Type 2 with a Novel Inhibitor for the Treatment of Melanoma

Wenbin Kuang, Qiannan Li, Wenmu Wang, Dawei Wang, Tong Chen, Mingge Song, Kailin Han, Jianing Liu, Anyan Chen, Yangchao Chen, Liping Wang, Haiping Hao, Xiao Wang, Yibei Xiao, Peng Yang

Journal of Medicinal Chemistry

DOI

2025

Galnt2 neurons in the ventromedial hypothalamus counterregulate hypoglycemia via a brain-liver neurocircuit

Junjie Wang, Xinyuan Sun, Xiangfei Gong, Wenling Dai, Hao Hong, Li Jiang, Zhonglong Wang, Zhiyuan Tang, Xiaobo Wu, Peng Sun, Yongjie Zhang, Kun Hao, Kun Hao, Fang Zhou, Ying Jun Cui, Tianyu Tang, Xiao Zheng, Lanqun Mao, Guangji Wang, Haiping Hao, Hao Xie

Cell Metabolism

DOI

2025

Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma

Dawei Wang, Mingge Song, Tong Chen, Wenmu Wang, Qiannan Li, Jianing Liu, Anyan Chen, Yangchao Chen, Liping Wang, Haiping Hao, Xiao Wang, Kailin Han, Yibei Xiao, Wenbin Kuang, Peng Yang

Journal of Medicinal Chemistry

DOI

2025

The X-Age Project to construct a Chinese aging clock

Jiaming Li, Mengmeng Jiang, Qiaoran Wang, Zikai Zheng, Jianghua Shen, Jingyi Li, Muzhao Xiong, Yandong Zheng, Xiaoyong Lu, Yusheng Cai, Yanling Fan, Lingling Geng, Qianzhao Ji, Qianqian Peng, Shuhui Sun, Yuan Yuan Wang, Zijuan Xin, Kaowen Yan, Yuanhan Yang, Jun Yu, Haoteng Yan, Ding Ai, Yongping Bai, Yan Bi, Xiu‐Wu Bian, Pengcheng Bu, Jian‐Ping Cai, Chun-Mei Cao, Feng Cao, Zhongwei Cao, Renjie Chai, Piu Chan, Chang Chen, Chengshui Chen, Chunying Chen, Di Chen, Hou‐Zao Chen, Lin Chen, Quan Chen, Xiao Chen, Xiaochun Chen, Yu Chen, Zi‐Jiang Chen, Weimin Ci, Zhe Dai, Qiurong Ding, Birong Dong, Jiahong Dong, Jian‐Gao Fan, Shiqing Feng, Xin Feng, Yun Feng, Xiaobing Fu, Xiaolong Fu, Feng Gao, Jiangang Gao, Qiang Gao, Shaorong Gao, Yonghao Gu, Youfei Guan, Feifan Guo, Jing‐Dong J. Han, Haiping Hao, Jihui Hao, Fuchu He, Mingguang He, Mingguang He, Mingguang He, Qiyang He, Zhiying He, Zuhong He, Huashan Hong, Jiaxu Hong, Shengping Hou, Cheng Hu, Ping Hu, Zhibin Hu, Canhua Huang, Jun Huang, Kai Huang, Pengyu Huang, Xunming Ji, Yong Hua Ji, Shunji Jia, Hong Fu Jiang, Wenjian Jiang, Lingjing Jin, Zi‐Bing Jin, Shenghong Ju, Zhenyu Ju, Qing‐Peng Kong, Wei Kong, Weijia Kong, Xiangqing Kong, Guanghua Lei, Geng‐Lin Li, Ji Li, Jian Li, Mengfeng Li, Rong Li

Nature Aging

DOI

2025

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Lichen Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan

Pharmacological Research

DOI

2025

Integrated Microbiota–Bile Acid Analysis as Potential NonInvasive Biomarkers for Ulcerative Colitis Staging Diagnose

Tianyu He, Yun Wang, Liang Zhao, Yuan Che, Lu Zhang, Yuming Zeng, Hong Shen, Haiping Hao, Lijuan Cao

The FASEB Journal

DOI

2025

Transient Cross-linking Mass Spectrometry: Taking Conformational Snapshots of Proteins

Yuxin Xie, Jiawen Wang, Lei Yang, Junjun Tao, Yuanyuan Xu, Yang Hu, Guiqing Zou, Yu Su, Meijun Liu, Huiyong Sun, Haiping Hao, Xiaowei Xu, Qiuling Zheng

Analytical Chemistry

DOI

2025

Metabolic insights into gut microbiota in the pharmacology of natural medicines

Zixin Chen, Junchi Zhou, Xiao Zheng, Hao Xie, Haiping Hao

Chinese Journal of Natural Medicines

DOI

2025

SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis

Li Shi, Hao Chen, Yuxin Zhang, Donghao An, Mengyao Qin, Wanting Yu, Bin Wen, Dandan He, Haiping Hao, Jing Xiong

The EMBO Journal

DOI

2024

The relationship of self-concept clarity, future time perspective, grit, and life satisfaction among Chinese adolescents: A cross-sectional and longitudinal study

Zhengpai Chen, Lei Jin, Haiping Hao, Yaxuan Zhao, Rakoro Lieketseng Joyce, Houchao Lyu

Personality And Individual Differences，Vol. 230

DOI

2024

Temporal Asymmetry of Pleasant and Unpleasant Feelings Among Chinese Adolescents

Haiping Hao, Qiao Hu, Xi Shen, Yiqiao Hu, Houchao Lyu

Journal Of Psychology，Vol. 1580, No. 7

DOI

2024

Family functioning and adolescent self-concept clarity: The mediating roles of balanced time perspective and depression

Xuchen Yu, Xiaobao Li, Junru Gong, Haiping Hao, Lei Jin, Houchao Lyu

Personality And Individual Differences，Vol. 220

DOI

2024

Reciprocal relationships between future time perspective and self-control among adolescents in China: a longitudinal study

Haiping Hao, Xiaobao Li, Xi Shen, Hong Jiang, Haoyue Xiao, Houchao Lyu

Current Psychology，Vol. 430, No. 12

DOI

2024

高中生网络成瘾与未来时间洞察力的纵向关系：抑郁的中介作用

肖皓月，张杉，郝海平，吕厚超

《心理与行为研究》，Vol. 22, No. 5

下载原文

2024

场域理论视角下同行评议公平信度提升路径研究

卢娜，孙劲楠，丁佐奇，郝海平

《编辑学报》

2024

代谢仿生导向的中西医融升路径

郑啸，郝海平

《中国科学基金》

2024

发展新质生产力生物医药行业如何抓住机遇

郝海平

《中国卫生》

2024

Carbene Footprinting Directs Design of Genetically Encoded Proximity-Reactive Protein Binders.

Hui Ye, Yinxue Zhu, Ying Kong, Hongtao Wen, Wenjie Lu, Dexiang Wang, Shuo Tang, Mengru Zhan, Gao-Yuan Lu, Chang Shao, Nanxi Wang, Haiping Hao

Analytical Chemistry

DOI

2024

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein function

Chang Shao, Shuo Tang, Si-Min Yu, Chen-Guang Liu, Tianyan Wan, Zimeng He, Qi Yuan, Yueyang Zhang, Mengru Zhan, Han-Qing Zhang, Ning Wan, Shihan Wu, Ren-Xiang Tan, Haiping Hao, Hui Ye, Nanxi Wang

bioRxiv

DOI

2024

Indole-3-Carboxaldehyde Alleviates LPS-Induced Intestinal Inflammation by Inhibiting ROS Production and NLRP3 Inflammasome Activation

Ji Cao, Qiuyu Bao, Haiping Hao

Antioxidants

DOI

2024

Lactyllysine Esterification Enables Efficient Lactylprotein Expression via Genetic Code Expansion and Supports Functional Proteomics Studies.

Dexiang Wang, Chen-Guang Liu, Jingzhuo Chen, Yueyang Zhang, Rui Han, Shuo Tang, Nanxi Wang, Haiping Hao, Chang Shao, Hui Ye

Journal of Proteome Research

DOI

2024

Subcellular Proteomic Mapping of Lysine Lactylation.

Qiuyu Bao, Ning Wan, Zimeng He, Ji Cao, Wenjie Yuan, Haiping Hao, Hui Ye

Journal of the American Society for Mass Spectrometry

DOI

2024

Ginsenoside Rg1 enriches gut microbial indole-3-acetic acid to alleviate depression-like behavior in mice via oxytocin signaling

Siqi Yu, Zhe Yin, Ming Ling, Zhuo Chen, Yangfan Zhang, Yarui Pan, Youying Zhang, Xiaoying Cai, Zeyu Chen, Haiping Hao, Xiao Zheng

Phytomedicine

DOI

2024

Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination

Munire Maimaiti, Chenhui Li, Mingxing Cheng, Ziwei Zhong, Jiameng Hu, Lei Yang, Lele Zhang, Ze Hong, Jinyi Song, Mingyu Pan, Xiaonan Ma, Shufang Cui, Peng Zhang, Haiping Hao, Chen Wang, Hai Hu

Med

DOI

2024

Reverse metabolomics as a novel strategy to annotate the human metabolome

Tingting Yan, Liangliang NIE, Haiping Hao

Chinese Journal of Natural Medicines

DOI

2024

Front Cover Image, Volume 44, Issue 2

Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang

Medicinal Research Reviews

DOI

2024

Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment

Wei Wei, Yali Liu, Yuanlong Hou, Shuqi Cao, Zhuo Chen, Youying Zhang, Xiaoying Cai, Qingyuan Yan, Ziguang Li, Yonggui Yuan, Guangji Wang, Xiao Zheng, Haiping Hao

Cell Metabolism

DOI

2024

A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior

Lingsha Cheng, Haoqian Wu, Xiaoying Cai, Youying Zhang, Siqi Yu, Yuanlong Hou, Zhe Yin, Qingyuan Yan, Qiong Wang, Taipeng Sun, Guangji Wang, Yonggui Yuan, Xueli Zhang, Haiping Hao, Xiao Zheng

Cell Host & Microbe

DOI

2023

情绪的时间不对称性及其与道德判断和价值评估的关系

谢如月，金磊，郝海平，杜刚，李小保，吕厚超

《心理科学》，Vol. 46, No. 3

下载原文

2023

遗传密码子拓展技术在赖氨酸酰化修饰研究中的应用

孔影，叶慧，邵畅，郝海平

《中国药科大学学报》

2023

癌症领域的人工智能应用综述

卢娜，孙劲楠，丁佐奇，郝海平

《药物生物技术》

2023

中医药人才发展现状与人才政策实施效果探究

王崴，刘宇舸，关晨，孙劲楠，李楚威，丁佐奇，郝海平

《世界科学技术-中医药现代化》

2023

Mapping a comprehensive targetome of glycolytic metabolites in cancer cells

Hui Ye, Haiping Hao

Nature Chemical Biology

DOI

2023

FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid

Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang

Medicinal Research Reviews

DOI

2023

Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism

Junchi Zhou, Qilin Fan, Xiaoying Cai, Youying Zhang, Yuanlong Hou, Shuqi CAO, Z. Li, Mengzhen FENG, Qingqing WANG, Jianbing ZHANG, Guangji Wang, Xiao Zheng, Haiping Hao

Chinese Journal of Natural Medicines

DOI

2023

Gut microbiome at the crossroad of genetic variants and behavior disorders

Lingsha Cheng, Haoqian Wu, Zhuo Chen, Haiping Hao, Xiao Zheng

Gut Microbes

DOI

2022

产学研合作模式下长三角生物医药产业一体化协同创新发展研究——基于专利合作及基金项目合作

万里，孙劲楠，丁佐奇，郝海平

《中国药科大学学报》

2022

基因编码非天然氨基酸技术及其在生物医学领域的应用

朱银雪，王德祥，孔影，陆文捷，叶慧，郝海平

《中国药科大学学报》

2022

JoVE科教视频数据库在药物代谢动力学实验教学改革中的应用

胡巍，郑啸，何华，刘昊晨，刘李，郝海平

《药学教育》

2022

基于政策文本分析的医药“揭榜挂帅”制度实施策略研究

万里，孙劲楠，丁佐奇，郝海平

《药学教育》

2022

Cooperation of structural motifs controls drug selectivity in cyclin-dependent kinases: an advanced theoretical analysis

Lingling Wang, Lei Xu, Zhe Wang, Tingjun Hou, Haiping Hao, Hui-Yong Sun

Briefings Bioinform.

DOI

2022

Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis

Keisuke Hamada, Ping Wang, Yang-Liu Xia, Nana Yan, Shogo Takahashi, K. Krausz, Haiping Hao, Tingting Yan, F. Gonzalez

Food and Chemical Toxicology

DOI

2022

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Kai Yuan, Zhao-dong Li, Wen Kuang, Xiao Wang, Minghui Ji, Weijiao Chen, Jia-Yu Ding, Jiaxing Li, Wenjian Min, Cheng-Liang Sun, Xiu-Juan Ye, Meiling Lu, Li-Ping Wang, Hai-Xia Ge, Yu-Zhang Jiang, Haiping Hao, Yi-Bei Xiao, Peng Yang

Nature Communications

DOI

2022

Living Cell-Target Responsive Accessibility Profiling Reveals Silibinin Targeting ACSL4 for Combating Ferroptosis.

Wenchao Yan, Dexiang Wang, Ning Wan, Shunyi Wang, Chang Shao, Han-Qing Zhang, Zhou Zhao, Wenjie Lu, Yang Tian, Hui Ye, Haiping Hao

Analytical Chemistry

DOI

2022

Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2

Wenying Yu, Yu-Cheng Zhao, Hui Ye, N. Wu, Yixian Liao, Nan-nan Chen, Zhiling Li, Ning Wan, Haiping Hao, Hong-Gao Yan, Yi-Bei Xiao, Mao-De Lai

Journal of Medicinal Chemistry

DOI

2022

Determination of Molecule Category of Ligands Targeting the Ligand-Binding Pocket of Nuclear Receptors with Structural Elucidation and Machine Learning

Qinghua Wang, Zhe Wang, Sheng Tian, Lingling Wang, Rongfan Tang, Yang Yu, Jing-Xuan Ge, Tingjun Hou, Haiping Hao, Hui-Yong Sun

Journal of Chemical Information and Modeling

DOI

2022

Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS

Xunxun Wu, Lian Liu, Qiu-Ling Zheng, Hui Ye, Hua Yang, Haiping Hao, Ping Li

Acta Pharmaceutica Sinica B

DOI

2022

Characterizing the stabilization effects of stabilizers in protein-protein systems with end-point binding free energy calculations

Rongfan Tang, Pengcheng Chen, Zhe Wang, Lingling Wang, Haiping Hao, Tingjun Hou, Hui-Yong Sun

Briefings Bioinform.

DOI

2022

Evaluation of Untargeted Metabolomic Strategy for the Discovery of Biomarker of Breast Cancer

Xujun Ruan, Yan Wang, LiRong Zhou, Qiu-Ling Zheng, Haiping Hao, Dan-Dan He

Frontiers in Pharmacology

DOI

2022

Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect

Wenjie Lu, Lingfei Yu, Lujun Wang, Songlin Liu, Manman Li, Zijun Wu, Shengqi Chen, Rongfeng Hu, Haiping Hao

AAPS PharmSciTech

DOI

2022

Identifying the core concepts of pharmacology education: A global initiative

Paul James White, Clare Guilding, Thomas Anthony Angelo, John P. Kelly, Laurel Gorman, Steven John Tucker, Ashleigh Fun, Jae Han, Guanliang Chen, Yassmin O. Samak, Anna‐Marie Babey, Fabiana A. Caetano, Sudhir Chandra Sarangi, Jennifer Koenig, Haiping Hao, Joseph Goldfarb, Kelly Dowhower Karpa, Luciene Bruno Vieira, Carolina Baraldi A. Restini, Margaret Cunningham, Patrik Aronsson, Roisin F. Kelly-Laubscher, Mark J. Hernandez, Patangi K. Rangachari, Janet Mifsud, Fatima Mraiche, Ramzi Sabra, Octavio Piñeros, Xuechu Zhen, Helen Ochuko Kwanashie, Betty Exintaris, Nilushi S. Karunaratne, Kuniaki Ishii, Yannee Liu

British Journal of Pharmacology

DOI

2022

Selective Photoaffinity Probe for Monitoring Farnesoid X Receptor Expression in Cultured Cells

Xiaowei Xu, Ya Zhu, Jiang-Zhou Song, Guiqing Zou, Haiping Hao, Qiuling Zheng, Lijuan Cao, Guangji Wang, Hong Wang, Haiping Hao

Analytical Chemistry

DOI

2022

Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome

Ning Wan, Nian Wang, Nian Wang, Siqin Yu, Hanqing Zhang, Dexiang Wang, Dexiang Wang, Wenjie Lu, Huanhuan Li, Daniel G. Delafield, Ying Kong, Xinmiao Wang, Chang Shao, Langlang Lv, Guangji Wang, Ren Xiang Tan, Nanxi Wang, Nanxi Wang, Haiping Hao, Hui Ye

Nature Methods

DOI

2022

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer

Kuojun Zhang, Kaizhen Wang, Xiangyu Zhang, Zhenlong Qian, Wenbo Zhang, Xiao Zheng, Jiaying Wang, Yin Jiang, Wanheng Zhang, Zhiyu Lu, Haiping Hao, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2022

Emerging targetome and signalome landscape of gut microbial metabolites

Xiao Zheng, Xiaoying Cai, Haiping Hao

Cell Metabolism

DOI

2021

基于Z指数模型的药学科研人员代表作评析

丁佐奇，李芙蓉，孙劲楠，郝海平

《中国药科大学学报》

2021

我国代谢调控与药物靶标发现研究的进展与展望

郝海平

《中国临床药理学与治疗学》

2021

未来中医药论坛“中药高质量发展·成都共识”

张伯礼，邬贺铨，陈凯先，王广基，胡镜清，赵军宁，杨明，程翼宇，王一涛，陈士林，李大宁，石上梅，彭成，郝海平，谢春光，林志健，叶甜春，尤肖虎，杜晓黎，詹榜华，李昕欣，徐鸿，陈俊江，刘耕，张春晖，富军，朱永宏，赵海，游洪涛，刘雳，朱雅宁，周厚成，孙继林，何晓蓉，耿福能，任强

《中药药理与临床》

DOI

2021

基于文献计量学的药学领域国家重点实验室评价

李芙蓉，郝海平，丁佐奇

《南京中医药大学学报(社会科学版)》

2021

Boronic derivatization-based strategy for monoacylglycerol identification, isomer annotation and quantification.

Mengle Zhu, Ke-Gui Lu, Yi-Ting Jin, Xiao-Wei Xu, Chengyu Chu, Haiping Hao, Qiu-Ling Zheng

Analytica Chimica Acta

DOI

2021

Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2

Xunxun Wu, Lian Liu, Qiu-Ling Zheng, Haiping Hao, Hui Ye, Ping Li, Hua Yang

Acta Pharmaceutica Sinica B

DOI

2021

TEPP-46-Based AIE Fluorescent Probe for Detection and Bioimaging of PKM2 in Living Cells.

Dong Wang, Chunmiao Li, Ya Zhu, Yunxia Song, Sheng Lu, Hui-Yong Sun, Haiping Hao, Xiao-Wei Xu

Analytical Chemistry

DOI

2021

Discovery of Signature Cyclic Immonium Ion for Lactyllysine Reveals Widespread and Functional Lactylation on Non-histone Proteins

Hui Ye, Ning Wan, Nian Wang, Yingyi Kong, Xin-Miao Wang, Dexiang Wang, Si-Min Yu, Wenjie Lu, Yinxue Zhu, Chenxi Yang, Chang Shao, Run-Bin Sun, Nan Wang, Haiping Hao

DOI

2021

Targeting ADAR1 with a Novel Small-Molecule for the Treatment of Prostate Cancer

Xiao Wang, Jiaxing Li, Yasheng Zhu, T. Zeng, Ji-Chao Ding, Wenjian Min, Fei Huang, Shun-Qing Liang, Kai Yuan, Wen Kuang, Minghui Ji, Cheng-Liang Sun, Yi Hou, Li-Ping Wang, Yu-Zhang Jiang, Haiping Hao, Y. Xiao, Peng Yang

DOI

2021

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

Danyu Du, Chan Liu, Mengyao Qin, Xiao Zhang, T. Xi, S. Yuan, Haiping Hao, Jing Xiong

Acta Pharmaceutica Sinica B

DOI

2021

Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights

Yangliu Xia, Mingrui Yan, Ping Wang, Keisuke Hamada, Nana Yan, Haiping Hao, Frank J. Gonzalez, Tingting Yan

Drug Metabolism and Disposition

DOI

2021

St. John’s Wort alleviates dextran sodium sulfate‐induced colitis through pregnane X receptor‐dependent NFκB antagonism

Tingting Yan, Yuhong Luo, Yangliu Xia, Keisuke Hamada, Qiong Wang, Nana Yan, Kristopher W. Krausz, Jerrold Michael Ward, Haiping Hao, Ping Wang, Frank J. Gonzalez

The FASEB Journal

DOI

2021

Ginsenosides regulation of lysophosphatidylcholine profiles underlies the mechanism of Shengmai Yin in attenuating atherosclerosis

Yun Wang, Yun Wang, Jia‐Ying Zhu, Jiaying Zhu, Chujie Ding, Wanfeng Xu, Haiping Hao, Jun Zhang, Guangji Wang, Lijuan Cao

Journal of Ethnopharmacology

DOI

2021

Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals

Xiaojing Guan, You-Ying Zhang, Xiao Zheng, Haiping Hao

Trends in Molecular Medicine

DOI

2021

A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

Yuanlong Hou, Wei Wei, Xiaojing Guan, Yali Liu, Gaorui Bian, Dandan He, Qilin Fan, Xiaoying Cai, Youying Zhang, Guangji Wang, Xiao Zheng, Haiping Hao

Nature Communications

DOI

2020

基于代谢组学研究糖尿病状态下阿司匹林治疗中血小板高反应的发生机制

张浩文，朱业锦，武相，陈寒昱，宋玉磊，卞尧尧，郝海平，陈晓虎

《中国临床药理学与治疗学》

2020

高校一流期刊培育和“双一流”建设互融共生的相关思考

丁佐奇，郝海平

《中国科技期刊研究》

2020

新型冠状病毒肺炎治疗中应关注肝损伤及防治中药概述

褚扬，周王谊，吴江，乔淼，王婉琦，马晓慧，周水平，郝海平

《世界中医药》

2020

“双一流”建设背景下我国医药类高校ESI潜力学科识别及预测方法实践

王雅棋，丁佐奇，郝海平

《药学教育》

DOI

2020

脂质代谢与降脂药物研究进展

蔡东成，刘红霞，刘丹媚，郝海平，何朝勇

《药学进展》

2020

Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis

Chang Shao, Wenjie Lu, Ye Du, Wenchao Yan, Qiuyu Bao, Yang Tian, Guangji Wang, Hui Ye, Haiping Hao

Redox Biology

DOI

2020

Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs

Kai Yuan, Xiao Wang, Haojie Dong, Wenjian Min, Haiping Hao, Peng Yang

Acta Pharmaceutica Sinica B

DOI

2020

Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host–Microbe Interplay

Yali Liu, Yuanlong Hou, Guangji Wang, Xiao Zheng, Haiping Hao

Trends in Endocrinology and Metabolism

DOI

2020

Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule

Xiangjiang Nie, Bin Wang, Rongfeng Hu, Wenjie Lu, Jiayi Chen, Songlin Liu, Dong Jin, Chaojie Sun, Song Gao, Yuxing Guo, Wenyou Fang, Haiping Hao

AAPS PharmSciTech

DOI

2019

反应模式对时间空间一致性效应的影响

郝海平，范宁

《心理与行为研究》，Vol. 17, No. 2

下载原文

2019

炎症性肠病中的自噬异常与中药干预研究进展

范淇淋，郑啸，王淑美，郝海平，李萍

《中国临床药理学与治疗学》

2019

内源性代谢物靶标发现及其在精准靶向肿瘤治疗中的应用前景

叶慧，郝海平

《医学研究与战创伤救治》

DOI

2019

Correction: A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells

Ya Zhu, Jialing Han, Qian Zhang, Zhou Zhao, Jin Wang, Xiao-Wei Xu, Haiping Hao, Jun Zhang

RSC Advances

DOI

2019

Recent advances in chromo-fluorogenic probes for fluoride detection

Jialing Han, Jun Zhang, Ming-Xin Gao, Haiping Hao, Xiao-Wei Xu

Dyes and pigments

DOI

2019

A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells

Ya Zhu, Jialing Han, Qian Zhang, Zhou Zhao, Jin Wang, Xiao-Wei Xu, Haiping Hao, Jun Zhang

RSC Advances

DOI

2019

Boronic Derivatization of Monoacylglycerol and Monitoring in Biofluids.

Mengle Zhu, Xiao-Wei Xu, Yuanlong Hou, Jialing Han, Jin Wang, Qiu-Ling Zheng, Haiping Hao

Analytical Chemistry

DOI

2019

Intestinal mucosal metabolites-guided detection of trace-level ginkgo biloba extract metabolome

Guoxiu Cao, Nian Wang, Dandan He, Xinmiao Wang, Yang Tian, Ning Wan, Wenchao Yan, Hui Ye, Haiping Hao

Journal of Chromatography A

DOI

2019

Integrative Omics Analysis Revealed that Metabolic Intervention Combined with Metronomic Chemotherapy Selectively Kills Cancer Cells

Chang Shao, Wenjie Lu, Ning Wan, Mengqiu Wu, Qiuyu Bao, Yang Tian, Gaoyuan Lu, Nian Wang, Haiping Hao, Hui Ye

Journal of Proteome Research

DOI

2019

HIF-1α Preconditioning Potentiates Antioxidant Activity in Ischemic Injury: The Role of Sequential Administration of Dihydrotanshinone I and Protocatechuic Aldehyde in Cardioprotection

Lifeng Jiang, Hao Zeng, Lihong Ni, Li‐Feng‐Rong Qi, Yanmin Xu, Ludan Xia, Yinghua Yu, Baolin Liu, Hua Qiang Yang, Haiping Hao, Ping Li

Antioxidants and Redox Signaling

DOI

2018

气相色谱-质谱联用法分析肠炎小鼠短链脂肪酸代谢

孟拓，邓珊珊，郝海平，曹丽娟

《药物评价研究》

2018

基于高分辨质谱和代谢组学技术对不同银杏叶制剂差异成分的快速分析

曹国秀，陆文捷，叶慧，田扬，郝海平

《中国药科大学学报》

2018

中西医结合防治代谢性疾病的关键科学问题

孔令东，郝海平，郭淑贞，郭姣，孟庆峰，张凤珠

《中国科学基金》

2018

Meet Our Editorial Board Member

Haiping Hao

Current Drug Metabolism

DOI

2018

Ligand–protein target screening from cell matrices using reactive desorption electrospray ionization-mass spectrometry via a native-denatured exchange approach

Qiuling Zheng, Xujun Ruan, Yang Tian, Jiaojiao Hu, Ning Wan, Wenjie Lu, Xiaowei Xu, Guangji Wang, Haiping Hao, Hui Ye

The Analyst

DOI

2017

抑郁症中的免疫代谢调控异常与药物干预研究进展

郑啸，王广基，郝海平

《药学学报》

2017

反向药物动力学导向的中药药物靶标发现及机制研究（英文）

郝海平

《中国药理学与毒理学杂志》

2017

Regulation of proinflammatory monocyte activation by the kynurenine–AhR axis underlies immunometabolic control of depressive behavior in mice

Xiaojie Zang, Xiao Zheng, Yuanlong Hou, Miaomiao Hu, Hong Wang, Xiaoqiang Bao, Fang Zhou, Guangji Wang, Haiping Hao

The FASEB Journal

DOI

2017

Corrigendum to “A novel intestinal-restricted FXR agonist” [Bioorg Med Chem Lett 27 (2017) 3386–3390]

Hong Wang, Haiping Hao, Jiyu Zhou, Yitong Guo, Guangji Wang, Haiping Hao, Xiaowei Xu

Bioorganic & Medicinal Chemistry Letters

DOI

2017

A novel intestinal-restricted FXR agonist

Hong Wang, Haiping Hao, Jiyu Zhou, Yitong Guo, Guangji Wang, Haiping Hao, Xiaowei Xu

Bioorganic & Medicinal Chemistry Letters

DOI

2017

PPARα MAY play a key role in the hepatoprotective effect of silybin against NASH

Hong Wang, Jiyu Zhou, Tingting Yan, Min Zhao, Yuan Che, Guangji Wang, Haiping Hao

Drug Metabolism and Pharmacokinetics

DOI

2016

参麦注射液对脓毒症小鼠炎症的抑制作用

柴营营，曹丽娟，张浩文，陈寒昱，王广基，郝海平

《中国药科大学学报》

2016

药物代谢和药物动力学国家自然科学基金项目分析及其基础研究的发展与展望

余露山，毕惠嫦，郝海平，黄民，曾苏，吴镭

《药学进展》

2016

Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats

Min Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju, Ping Li

Drug Metabolism and Disposition

DOI

2016

A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines

Hui‐Peng Song, Siqi Wu, Haiping Hao, Jun Chen, Jun Lu, Xiaojun Xu, Li P, Hua Qiang Yang

Scientific Reports

DOI

2015

基于生物质谱的蛋白质定量技术及其在药代动力学研究中的应用

吴梦秋，陆高远，邵畅，王单单，孙迪，郝海平，王广基，叶慧

《中国药科大学学报》

2015

高血压病肝火亢盛证型代谢组学的初步研究

宁澄，王广基，阿基业，郝海平，陈晓虎，范群丽

《中西医结合心脑血管病杂志》

2015

Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium–Induced Colitis

Jun Zhang, Lijuan Cao, Hong Wang, Xuefang Cheng, Lin Wang, Lin Zhu, Tingting Yan, Yang Xie, Yuzheng C. Wu, Min Zhao, Sijing Ma, Mengqiu Wu, Guangji Wang, Haiping Hao

Drug Metabolism and Disposition

DOI

2015

Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder

Xiao Zheng, Xueli Zhang, Guangji Wang, Haiping Hao

Drug Discovery Today

DOI

2014

阿司匹林抵抗机制研究进展

张浩文，柴营营，陈寒昱，郑啸，郝海平，陈晓虎

《中国药科大学学报》

2014

中药注射剂药物代谢动力学研究现状

申汉元，郝海平，王广基

《中国临床药理学与治疗学》

2014

糖尿病状态下阿司匹林抵抗的研究进展

谢昊，朱语眉，郝海平，郑啸，马思静，王广基

《中国临床药理学与治疗学》

2014

中药代谢组学研究进展

吴昱铮，王广基，郝海平

《中国药科大学学报》

2014

核受体FXR代谢调控作用及肿瘤细胞增殖机制研究进展

谢杨，周雪妍，郝海平，王广基

《生理学报》

2014

A strategy for screening of high-quality enzyme inhibitors from herbal medicines based on ultrafiltration LC-MS and in silico molecular docking

Hui‐Peng Song, Jun Chen, Jia-Ying Hong, Haiping Hao, Lian‐Wen Qi, Jun Lu, Yu Fu, Bin Wu, Hua Qiang Yang, Ping Li

Chemical Communications

DOI

2014

Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?

Xiao Zheng, Xueli Zhang, Kang An, Chongzhao Ran, Guangji Wang, Haiping Hao

Neuropharmacology

DOI

2014

Identification of effective combinatorial markers for quality standardization of herbal medicines

Zi‐Qi Shi, De-Fang Song, Ruo-Qian Li, Hua Qiang Yang, Lian‐Wen Qi, Gui-Zhong Xin, Ding-Qian Wang, Hui‐Peng Song, Jun Chen, Haiping Hao, Ping Li

Journal of Chromatography A

DOI

2014

UDP‐glucuronosyltransferase 1 (UGT1) knockdown in colon epithelial cells causes inactivation of P53 mediated apoptosis and increases colon tumorigenesis (LB599)

Miao Liu, Shujuan Chen, Haiping Hao, Guangji Wang, Robert H. Tukey

The FASEB Journal

DOI

2013

基于血浆和心肌内小分子的代谢组学方法评价心肌缺血大鼠模型

严蓓，阿基业，郝海平，王广基，刘林生，查伟斌，张颖，顾胜华

《药学学报》

2013

姜黄素对洛伐他汀在非酒精性脂肪肝大鼠体内药代动力学行为的影响

谢媛，王洪，冯冬，郝海平，王广基

《中国药科大学学报》

2013

大鼠静脉注射丹酚酸B后代谢产物的鉴定及血浆药动学研究(英文)

亓蕖，郝琨，李飞燕，曹丽娟，王广基，郝海平

Chinese Journal of Natural Medicines

2013

甘草酸二铵对恩替卡韦在大鼠体内药代动力学的影响(英文)

李飞燕，郝海平，郝琨，颜婷婷，王广基

Chinese Journal of Natural Medicines

2013

水飞蓟宾对硫代乙酰胺所致肝损伤状态下CYP3A的调节作用及机制(英文)

谢媛，郝海平，王洪，王兆先，王广基

Chinese Journal of Natural Medicines

2012

细胞内p53蛋白LC-MS/MS定量方法及其应用

李盈淳，汤志远，吴梦秋，王广基，郝海平

《中国药科大学学报》

2012

靶向NQO1抗肿瘤醌构效关系研究进展(英文)

廖珂，牛芳，郝海平，王广基

Chinese Journal of Natural Medicines

2012

NQO1介导的丹参酮IIA的代谢转化与细胞毒(英文)

刘芳，郝海平，王广基

Chinese Journal of Natural Medicines

2012

Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients

Xiao-Man Chu, Lifang Zhang, Guangji Wang, Shen-Ning Zhang, Jia-Hui Zhou, Haiping Hao

European Journal of Clinical Pharmacology

DOI

2011

基于药物体内代谢过程的中药配伍禁忌研究思路与方法

郭建明，段金廒，郝海平，唐于平，钱大玮，刘培

《中草药》

2011

尿苷二磷酸葡萄糖醛酸转移酶介导的药物相互作用的研究进展

张艳，郝海平，王广基

《中国临床药理学与治疗学》

2011

气阴两虚证心肌缺血模型方证对应的代谢组学表征

严蓓，阿基业，郝海平，王广基，刘林生，查伟斌，张颖，顾胜华

《药学学报》

2011

厄贝沙坦敏感与不敏感高血压患者的血清代谢谱差异分析

陈晓虎，方祝元，王广基，阿基业，郝海平，范群丽，黄丹

《现代预防医学》

2011

咖啡酸逆转非甾体抗炎药对阿司匹林活性的拮抗作用(英文)

孙世顷，郝海平，史海波，陈晓虎，ZHA Beth S，王广基

Chinese Journal of Natural Medicines

2011

代谢组学策略评价银杏提取物对高脂诱导动脉粥样硬化金黄地鼠代谢紊乱的药效作用(英文)

查伟斌，阿基业，王广基，朱萱萱，顾胜华，曹蓓，严蓓，ZHA S.Beth，郝海平，黄青，刘林生，石建，孙建国

Chinese Journal of Natural Medicines

2010

松果菊苷药动/药效研究进展与思考

戴亮，郝海平，汪玉馨，王广基

《中国临床药理学与治疗学》

2010

基于中医药特点的中药体内外药效物质组生物/化学集成表征新方法

齐炼文，周建良，郝海平，李会军，闻晓东，陈君，杨中林，李萍，王广基

《中国药科大学学报》

2010

Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship

Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Li Wu, Ping Gong, Guangji Wang

Drug Metabolism and Disposition

DOI

2009

葡萄糖醛酸转移酶(UGTs)诱导羧酸药物代谢激活的研究进展

谢彤，梁艳，郝海平，谢林，王广基

《药学学报》

2009

多组分、多靶点中药整体药代动力学研究的思考与探索

郝海平，郑超湳，王广基

《药学学报》

2009

肝损状态下尿苷二磷酸葡萄糖醛酸转移酶研究进展

姜杉，郝海平，王广基

《中国临床药理学与治疗学》

2008

临床前药物代谢动力学关键技术与研究体系

郝海平，王广基

《中国药科大学学报》

2008

代谢组学技术在疾病诊断中的应用

管恩泽，朱萱萱，王广基，郝海平，丁杨

《中国临床药理学与治疗学》

2008

脉络宁注射液酚酸类成分在大鼠体内的药代动力学研究(英文)

王玮，王广基，郝海平，崔楠，孙璇嵘

《中国临床药理学与治疗学》

2008

Global Detection and Identification of Nontarget Components from Herbal Preparations by Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry and a Strategy

Haiping Hao, Nan Cui, Guangji Wang, Binren Xiang, Yan Liang, Xiangyang Xu, Hui Zhang, Jun Yang, Chaonan Zheng, Liang Wu, Ping Gong, Wei Wang

Analytical Chemistry

DOI

2008

Orthogonal Design-Directed Optimization of an LC Method for Fingerprinting Mai-Luo-Ning Injection, and Validation of the Method

Nan Cui, Haiping Hao, Guangji Wang, Wei Wang, Yuxin Wang

Chromatographia

DOI

2008

Anti-Inflammatory Effects of Scopoletin and Underlying Mechanisms

Zuoqi Ding, Yue Dai, Haiping Hao, Rong Pan, Xiujuan Yao, Zhengtao Wang

Pharmaceutical Biology

DOI

2007

超高效液相色谱在现代药代动力学中的应用

艾华，王广基，顾轶，孙建国，郝海平

《中国药科大学学报》

2007

新型促吸收剂研究进展——以细胞间紧密连接为靶点

康安，梁艳，郝海平，谢林，王广基

《药学学报》

2007

多组分中药血塞通注射液在脑缺血患者体内的群体药动学及药效学研究

李晓宇，王广基，熊玉卿，孙建国，郝海平，邹浪，郑媛婷，严蓓，夏春华，刘皋林

《中国临床药理学与治疗学》

2007

代谢组学分析技术平台和数据处理的新进展

任洪灿，王广基，阿基业，郝海平，孙建国，查伟斌，严蓓

《中国临床药理学与治疗学》

2006

人参总皂苷中Rg1的吸收特性研究

吕天，孙建国，吕华，许美娟，谢海棠，李昊，郝海平，王广基

《中国临床药理学与治疗学》

2003

山茱萸环烯醚萜苷对糖尿病大鼠胸主动脉血管内皮的保护作用

许惠琴，刘洪，郝海平，项晓人

《中国药理学通报》

2002

心律安口服液抗心律失常作用的实验研究

申春梯，朱雄华，曹伟春，许惠琴，卢金福，郝海平，金艳

《中国实验方剂学杂志》

精选作品

期刊论文

创新药物研发新范式：靶标组与原创组合药物

表面蛋白表征方法及其在疾病靶标发现中的应用

专业力量赋能 共筑健康中国新时代

聚焦慢病靶标组 构筑原创药物新范式

以体系化攻关推进生物医药科技自立自强

CM-TRAP: A chemoproteomic workflow for profiling circulating metabolites and their protein targets in Alzheimer's disease.

DT-TRAP enables accurate target recognition via simplified dosing and low-temperature incubation

MAPLE: interpretable deep learning identifies selective antimicrobial peptides using joint evolutionary–physicochemical analysis

Protein-Corona-Based Nanomagnetic Enrichment Strategy for In-Depth Secretome Profiling of Lung Adenocarcinoma Organoids.

Deoxycholic acid impairs mitochondrial fitness and suppresses mitophagy through Parkin ubiquitination driving CD8+ T cell Exhaustion in Colorectal Cancer

GPR35 in host–microbe interaction: Mechanisms and translational prospects

SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth

A Novel FXR-Targeted DUBTAC and Its Applications in Cholestasis Therapy

Hepatocyte CEBPA-ORM1 axis restricts alcohol-associated liver disease

Predicting cerebral acetylcholine dynamics with huperzine A pharmacokinetics in blood via mPBPK-PD modeling

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Discovery of Novel and Potent Dual PARP1/ERK Inhibitors as a Promising Strategy for Cancer Therapy

Ketogenic Diet Modulates Depressive‐Like Behavior via Gut Bacterial Metabolism of Tyrosine

Time-shifting oriented balanced time perspective in college students with dysphoria: An exploration with the text reading and writing tasks

Admiration and Malicious Envy Among Chinese Adolescents: Differences in Retrospection and Anticipation

我国非处方药市场准入优化路径现状调研及国际经验应用建议

Navigating drug discovery with Targetome

Targetome-guided combination drug discovery as next-generation therapeutics

Combination of silybin and carvedilol synergistically alleviates liver fibrosis by inhibiting Wnt/β-catenin signaling

In situ global mapping of protein perturbations via protein abundance and conformation analysis.

Emerging trends in chemoproteomics: Mapping the landscape of protein-metabolite interactions.

Preclinical Efficacy of TSL2109 in Prostate Cancer Treatment and Overcoming Enzalutamide Resistance

Tryptophan metabolites at the service of neuroimmune sensing of microbes

Targeting Protein Tyrosine Phosphatase Nonreceptor Type 2 with a Novel Inhibitor for the Treatment of Melanoma

Galnt2 neurons in the ventromedial hypothalamus counterregulate hypoglycemia via a brain-liver neurocircuit

Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma

The X-Age Project to construct a Chinese aging clock

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Integrated Microbiota–Bile Acid Analysis as Potential NonInvasive Biomarkers for Ulcerative Colitis Staging Diagnose

Transient Cross-linking Mass Spectrometry: Taking Conformational Snapshots of Proteins

Metabolic insights into gut microbiota in the pharmacology of natural medicines

SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis

The relationship of self-concept clarity, future time perspective, grit, and life satisfaction among Chinese adolescents: A cross-sectional and longitudinal study

Temporal Asymmetry of Pleasant and Unpleasant Feelings Among Chinese Adolescents

Family functioning and adolescent self-concept clarity: The mediating roles of balanced time perspective and depression

Reciprocal relationships between future time perspective and self-control among adolescents in China: a longitudinal study

高中生网络成瘾与未来时间洞察力的纵向关系：抑郁的中介作用

场域理论视角下同行评议公平信度提升路径研究

代谢仿生导向的中西医融升路径

发展新质生产力 生物医药行业如何抓住机遇

Carbene Footprinting Directs Design of Genetically Encoded Proximity-Reactive Protein Binders.

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein function

Indole-3-Carboxaldehyde Alleviates LPS-Induced Intestinal Inflammation by Inhibiting ROS Production and NLRP3 Inflammasome Activation

Lactyllysine Esterification Enables Efficient Lactylprotein Expression via Genetic Code Expansion and Supports Functional Proteomics Studies.

Subcellular Proteomic Mapping of Lysine Lactylation.

Ginsenoside Rg1 enriches gut microbial indole-3-acetic acid to alleviate depression-like behavior in mice via oxytocin signaling

Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination

Reverse metabolomics as a novel strategy to annotate the human metabolome

Front Cover Image, Volume 44, Issue 2

Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment

A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior

情绪的时间不对称性及其与道德判断和价值评估的关系

遗传密码子拓展技术在赖氨酸酰化修饰研究中的应用

癌症领域的人工智能应用综述

中医药人才发展现状与人才政策实施效果探究

Mapping a comprehensive targetome of glycolytic metabolites in cancer cells

FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid

Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism

Gut microbiome at the crossroad of genetic variants and behavior disorders

产学研合作模式下长三角生物医药产业一体化协同创新发展研究——基于专利合作及基金项目合作

基因编码非天然氨基酸技术及其在生物医学领域的应用

JoVE科教视频数据库在药物代谢动力学实验教学改革中的应用

基于政策文本分析的医药“揭榜挂帅”制度实施策略研究

Cooperation of structural motifs controls drug selectivity in cyclin-dependent kinases: an advanced theoretical analysis

Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Living Cell-Target Responsive Accessibility Profiling Reveals Silibinin Targeting ACSL4 for Combating Ferroptosis.

Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2

Determination of Molecule Category of Ligands Targeting the Ligand-Binding Pocket of Nuclear Receptors with Structural Elucidation and Machine Learning

Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS

Characterizing the stabilization effects of stabilizers in protein-protein systems with end-point binding free energy calculations

Evaluation of Untargeted Metabolomic Strategy for the Discovery of Biomarker of Breast Cancer

Metformin Hydrochloride Mucosal Nanoparticles-Based Enteric Capsule for Prolonged Intestinal Residence Time, Improved Bioavailability, and Hypoglycemic Effect

专业力量赋能共筑健康中国新时代

聚焦慢病靶标组构筑原创药物新范式

发展新质生产力生物医药行业如何抓住机遇