张志文｜复旦大学｜学者主页

2026

Strategies for engineering biomimetic lipoproteins to improve drug delivery efficiency and tumor therapy.

Yuchen He, Naibo Yin, Zhiwen Zhang, Guo-Yu Lu, Jingyuan Wen

Drug Delivery and Translational Research

DOI

2026

Injectable dual-affinity self-assembling peptide hydrogels for local controlled delivery of therapeutic antibodies

Weiping Cui, Limin Zhang, Chang Yang, Bing He, Hua Zhang, Xueqing Wang, Zhiwen Zhang, Qiang Zhang, Wenbing Dai

Asian Journal of Pharmaceutical Sciences

DOI

2026

Deciphering Apolipoprotein A4 in the Protein Corona of Ligand-Modified Liposomes for Tumor Targeting and Penetration

Y I X I U Liang, Xianlu Li, Yichen Zhang, Xinyue Ding, Weimin Nie, Shuai Wang, Mingxuan Huang, Yelin Wu, Shiyang Wu, Xinyu Zhao, Yongping Li, Zhiwen Zhang

ACS Nano

DOI

2026

Pleural Mesothelioma: Current Therapeutic Strategies and Future Directions

Haoxuan Tang, Xingchen Lu, Shiyang Wu, Guo‐Liang Lu, Jingyuan Wen, Ming Qian Wei, Xianyi Sha, Zhiwen Zhang

Current Oncology Reports

DOI

2026

The impact of chemotherapy on floating vs. attached colorectal cancer cells: An in-vitro study

Veria Khosrawipour, Agata Mikołajczyk‐Martinez, Carolina Khosrawipour, Patrycja Salata, Zdzisław Kiełbowicz, Ewa Nicpon, Przemysław Prządka, Zhiwen Zhang, Wojciech Kielan, Shiri Li, Jacek Bania, Kamila Kuzniak, Kacper Zielinski, Mouhamed El-Aita, Wolfram Trudo Knoefel

Frontiers in Oncology

DOI

2026

An elegant fluorinated liposome for enhanced tumor penetration

Hong Wang, X X Xu, Yi Shen, Li Y, Xiangshi Sun, Yi Chen, Zhang Zhiwen, Li Y

Nano Today

DOI

2026

A precision nitric oxide-releasing hydrogel promoting nanoparticles permeation for comprehensive nerve-vessel recovery and microenvironment regulation in diabetic wounds

Lu Enhao, Huang Xueli, Zhang Qi, Kuankuan Luo, Yan Xin, Nie Weimin, Zhang Lingmin, Hu Ruining, Bian Jing, Yue Li, Luo Yu, Zhang Zhiwen, Zhao Jing, Xianyi Sha

Journal of Controlled Release

DOI

2025

Progress in peptide and protein therapeutics: Challenges and strategies

Mengyang Liu, D. Svirskis, T. Proft, J. Loh, Naibo Yin, Hao Li, Danhui Li, Yongzhi Zhou, Shuo Chen, Li Song, Guanyu Chen, Wei-Yue Lu, Zhiwen Zhang, Zhou Zhou, Lian Li, Yuan Huang, C. Bunt, Gui-Ju Sun, Paul W R Harris, M. Brimble, Jing-Yuan Wen

Acta Pharmaceutica Sinica B

DOI

2025

Strategies of designing lymph nodes-targeting nanoparticles for cancer immunotherapy

Zhiyuan Huang, Fangqiu Fu, Chaoqiang Deng, Shiyang Wu, Mingxuan Huang, Xianyi Sha, Ming Qian Wei, Zhiwen Zhang, Yang Zhang

Chinese Chemical Letters

DOI

2025

Phosphatidylcholine Chain-Length of Bioinspired Lipoprotein Modulates Interactions with Collagen for Intratumor Delivery in Pancreatic Cancer

Guodong Li, Yichen Zhang, Jinhua Wang, Yiyu Liang, Yuan Zhang, Yifei Chi, Carter Sun, Zixin Hu, Shiyang Wu, Guo‐Liang Lu, Jingyuan Wen, Zhiwen Zhang

ACS Nano

DOI

2025

Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance

Xinyue Ding, Yiyu Liang, Siyuan Zhou, Yao Wu, Patricia Sałata, Agata Mikołajczyk‐Martinez, Veria Khosrawipour, Zhiwen Zhang

Journal of Controlled Release

DOI

2025

Rational Design of Bioinspired Lipoprotein System to Improve Penetration in Colorectal Peritoneal Metastases

Yifei Chi, Yi Lü, Jingbo Wu, Guodong Li, Xianlu Li, Yao Wu, Xiao Zhao, Jingyuan Wen, Xianyi Sha, Guo‐Liang Lu, Kaili Hu, Zhiwen Zhang

Nano Letters

DOI

2025

Inhalable biomimetic polyunsaturated fatty acid-based nanoreactors for peroxynitrite-augmented ferroptosis potentiate radiotherapy in lung cancer

Yi-Ting Chen, Xueli Huang, Ruining Hu, Enhao Lu, Kuankuan Luo, Xin Yan, Zhiwen Zhang, Yan Ma, Minghe Zhang, Xianyi Sha

Journal of Nanobiotechnology

DOI

2024

Biomimetic nanoreactor of catalase and nitric oxide enhance peroxynitrite generation for radiosensitization

Yao Wu, Yongping Li, Yongping Li, Honglei Xie, Yichen Zhang, Yichen Zhang, Xinyue Bao, Xianyi Sha, Jingyuan Wen, Yaping Li, Yaping Li, Zhiwen Zhang

Nano Today

DOI

2024

Glutathione-Disrupting Nanotherapeutics Potentiate Ferroptosis for Treating Luminal Androgen Receptor-Positive Triple-Negative Breast Cancer

Jie Li, Yao Wu, Yongping Li, Yongping Li, Hongbo Zhu, Zhiwen Zhang, Yaping Li, Yaping Li

ACS Nano

DOI

2024

Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke

Kuankuan Luo, Yong Wang, Enhao Lu, Weimin Nie, Xin Yan, Qi Zhang, Yumei Luo, Zhiwen Zhang, Jing Zhao, Xianyi Sha

ACS Applied Materials & Interfaces

DOI

2024

Biomimetic Integrated Nanozyme for Flare and Recurrence of Gouty Arthritis

Rui Wang, Tongyao Liu, Xinhong Li, Enhao Lu, Yi‐Ting Chen, Kuankuan Luo, Tao Wang, Xueli Huang, Zhiwen Zhang, Shilin Du, Xianyi Sha

Asian Journal of Pharmaceutical Sciences

DOI

2024

Extracellular Matrix‐Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity

Yao Wu, Yongping Li, Yongping Li, Zixin Hu, Yuan Li, Yuan Li, Shixuan Zhang, Xinyue Bao, Yu Jerry Zhou, Yuan Gao, Yaping Li, Yaping Li, Zhiwen Zhang

Advanced Materials

DOI

2023

Corrigendum to "Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy" [Journal of Controlled Release 353 (2023) 447-461].

Xin-di Qian, Yuqi Wang, Honglei Xie, Chen Wang, Jie Li, Ying Lei, H. Liu, Yao Wu, Ya-Ping Li, Zhiwen Zhang

Journal of Controlled Release

DOI

2023

Nitric Oxide-Loaded Bioinspired Lipoprotein Normalizes Tumor Vessels To Improve Intratumor Delivery and Chemotherapy of Albumin-Bound Paclitaxel Nanoparticles.

Yao Wu, Honglei Xie, Yong-Ping Li, Xinyue Bao, Guo-Liang Lu, Jingyuan Wen, Yuan Gao, Yaping Li, Zhiwen Zhang

Nano letters (Print)

DOI

2023

Spatial-Drug-Laden Protease-Activatable M1 Macrophage System Targets Lung Metastasis and Potentiates Antitumor Immunity.

Xiaoxuan Xu, Qianqian Wang, Xin-di Qian, Yao Wu, Jiaoying Wang, Jie Li, Ya-Ping Li, Zhiwen Zhang

ACS Nano

DOI

2023

Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma

Hong Luo, H. Zhang, Jinning Mao, Hui Cao, Yihao Tao, Guan-Jian Zhao, Zhiwen Zhang, Nan Zhang, Zao-bin Liu, Jian Zhang, P. Luo, Yuguo Xia, Yuan Cheng, Zongyi Xie, Q. Cheng, Guo-Dong Liu

Cell Death and Disease

DOI

2023

Bioinspired Lipoproteins of Furoxans–Gemcitabine Preferentially Targets Glioblastoma and Overcomes Radiotherapy Resistance

Maoyuan Sun, Honglei Xie, Wenli Zhang, Xianlu Li, Zhan Jiang, Yiyu Liang, Guanjian Zhao, Ning Huang, Jinning Mao, Guodong Liu, Zhiwen Zhang

Advanced Science

DOI

2023

Allomelanin-based biomimetic nanotherapeutics for orthotopic glioblastoma targeted photothermal immunotherapy

Maoyuan Sun, Yan Li, Wenli Zhang, Xiang Gu, Rong Wen, Ke Zhang, Jinning Mao, Chengyao Huang, Xiong Zhang, Mao Nie, Zhiwen Zhang, Chao Qi, Kaiyong Cai, Guodong Liu

Acta Biomaterialia

DOI

2023

Drug‐Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia‐Reperfusion Therapy in Stroke

Wenxiu He, Xiao‐Yong Zhang, Xiang Gong, Kuankuan Luo, Xuening Mao, Enhao Lu, Yi-Ting Chen, Rui Wang, Zhiwen Zhang, Jing Zhao, Xianyi Sha

Advanced Functional Materials

DOI

2023

Biomimetic Thermo‐Sensitive Hydrogel Encapsulating Hemangiomas Stem Cell Derived Extracellular Vesicles Promotes Microcirculation Reconstruction in Diabetic Wounds

Enhao Lu, Xi Yang, Tao Wang, Xueli Huang, Yi‐Ting Chen, Rui Wang, Kuankuan Luo, Zhiwen Zhang, Xiaoxi Lin, Xianyi Sha

Advanced Functional Materials

DOI

2022

Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy.

Xin-di Qian, Yuqi Wang, Honglei Xie, Chen Wang, Jie Li, Ying Lei, H. Liu, Yao Wu, Ya-Ping Li, Zhiwen Zhang

Journal of Controlled Release

DOI

2022

Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity.

Xiang Gong, Jie Li, Xiaoxuan Xu, Yao Wu, Ying Lei, H. Liu, Xin-di Qian, Ya-Ping Li, Zhiwen Zhang

Biomaterials

DOI

2022

Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function.

Jie Li, Yao Wu, Jiaoying Wang, Xiaoxuan Xu, Ao Zhang, Ya-Ping Li, Zhiwen Zhang

ACS Nano

DOI

2022

Strategies of engineering nanomedicines for tumor retention.

Xin-di Qian, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Jie Li, Shuo Chen, Jingyuan Wen, Ya-Ping Li, Zhiwen Zhang

Journal of Controlled Release

DOI

2022

Current approaches of nanomedicines in the market and various stage of clinical translation

Xiaoting Shan, Xiang Gong, Jie Li, Jingyuan Wen, Ya-Ping Li, Zhiwen Zhang

Acta Pharmaceutica Sinica B

DOI

2022

Bioinspired Lipoproteins of Furoxans–Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T‐Cell Infiltration

Yuqi Wang, Honglei Xie, Yao Wu, Shuzhou Xu, Yong-Ping Li, Jie Li, Xiaoxuan Xu, Si-Ling Wang, Yaping Li, Zhiwen Zhang

Advances in Materials

DOI

2022

ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity.

Jiaoying Wang, Jie Li, Yao Wu, Xiaoxuan Xu, Xin-di Qian, Ying Lei, H. Liu, Zhiwen Zhang, Ya-Ping Li

Nano letters (Print)

DOI

2022

Full factorial design, physicochemical characterization, ex vivo investigation, and biological assessment of glutathione-loaded solid lipid nanoparticles for topical application

Mengyang Liu, Manisha Sharma, Guo‐Liang Lu, Zhiwen Zhang, Naibo Yin, Jingyuan Wen

International Journal of Pharmaceutics

DOI

2021

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Si-Ling Wang, Ya-Ping Li, Zhiwen Zhang

Journal of Nanobiotechnology

DOI

2021

Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy

Xiaoxuan Xu, Yao Wu, Xin-di Qian, Yuqi Wang, Jiaoying Wang, Jie Li, Ya-Ping Li, Zhiwen Zhang

Advanced Healthcare Materials

DOI

2021

Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity.

Zhiwan Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Ya-Ping Li, X. Sha, Zhiwen Zhang

ACS Nano

DOI

2020

Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy

Junjing Yin, Haiqiang Cao, Hong Wang, Kao-Xiang Sun, Ya-Ping Li, Zhiwen Zhang

Acta Pharmaceutica Sinica B

DOI

2020

Reprogramming Tumor Associated Macrophages toward M1 Phenotypes with Nanomedicine for Anticancer Immunotherapy

Xiaoxuan Xu, Xiang Gong, Yuqi Wang, Jie Li, Hong Wang, Jiaoying Wang, X. Sha, Ya-Ping Li, Zhiwen Zhang

Advances in Therapy

DOI

2020

Orally delivered legumain-activated nanovehicles improve tumor accumulation and penetration for combinational photothermal-chemotherapy.

Jing Wang, Yuqi Wang, Haiqiang Cao, Hong Wang, Jie Li, You-Xin Li, Ya-Ping Li, Zhiwen Zhang

Journal of Controlled Release

DOI

2020

Corrigendum to "Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem-like cells in vitro" [Int. J. Pharm. 553 (2018) 201-209].

Tao Tan, Yuqi Wang, Hong Wang, Haiqiang Cao, Zhiwan Wang, Jing Wang, Jie Li, Ya-Ping Li, Zhiwen Zhang, Si-Ling Wang

International journal of pharmaceutics

DOI

2020

Corrigendum to "Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery" [Journal of Controlled Release 151 (2011) 35-44].

Qi Yin, Yu Gao, Zhiwen Zhang, Pengcheng Zhang, Ya-Ping Li

Journal of Controlled Release

DOI

2020

Tumor‐Activated Size‐Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti‐Tumor Immune Responses

Jie Li, Hong Wang, Yuqi Wang, Xiang Gong, Xiaoxuan Xu, X. Sha, Ao Zhang, Zhiwen Zhang, Ya-Ping Li

Advances in Materials

DOI

2020

Cancer Cell Membrane‐Coated Gold Nanocages with Hyperthermia‐Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer

Hui-Ping Sun, Jing-Han Su, Qing-Shuo Meng, Qi Yin, Ling-Li Chen, Wang-Wen Gu, Zhiwen Zhang, Haijun Yu, Pengcheng Zhang, Si-Ling Wang, Ya-Ping Li

Advanced Functional Materials

DOI

2020

Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy.

Hong Wang, Jie Li, Zhiwan Wang, Yuqi Wang, Xiaoxuan Xu, Xiang Gong, Jiaoying Wang, Zhiwen Zhang, Ya-Ping Li

Biomaterials

DOI

2019

The Application of Pre-clinical Animal Models to Optimise Nanoparticulate Drug Delivery for Hepatocellular Carcinoma.

Zhiwen Zhang, Liu Song, Jianfeng Guo

Pharmaceutical Nanotechnology

DOI

2019

Correction to Codelivery of Sorafenib and Curcumin by Directed Self-Assembled Nanoparticles Enhances Therapeutic Effect on Hepatocellular Carcinoma.

Haiqiang Cao, Yixin Wang, Xinyu He, Zhiwen Zhang, Qi Yin, Yi Chen, Haijun Yu, Yongzhuo Huang, Ling-Li Chen, Minghua Xu, Wang-Wen Gu, Ya-Ping Li

Molecular Pharmaceutics

DOI

2019

Correction to Bioengineered Macrophages Can Responsively Transform into Nanovesicles to Target Lung Metastasis.

Haiqiang Cao, Hong Wang, Xinyu He, Tao Tan, Haiyan Hu, Zhiwan Wang, Jing Wang, Jie Li, Zhiwen Zhang, Ya-Ping Li

Nano letters (Print)

DOI

2019

Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor

Tao Tan, Yuqi Wang, Jing Wang, Zhiwan Wang, Hong Wang, Haiqiang Cao, Jie Li, Ya-Ping Li, Zhiwen Zhang, Si-Ling Wang

Acta Pharmaceutica Sinica B

DOI

2019

Emerging Approaches of Cell‐Based Nanosystems to Target Cancer Metastasis

Xiang Gong, Jie Li, Tao Tan, Zhiwan Wang, Hong Wang, Yuqi Wang, Xiaoxuan Xu, Zhiwen Zhang, Ya-Ping Li

Advanced Functional Materials

DOI

2019

Ly6C hi Monocytes Delivering pH‐Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer

Tianqun Lang, Xin-Yue Dong, Yan Huang, Wei Ran, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

Advanced Functional Materials

DOI

2019

Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles

Tao Tan, Haiyan Hu, Hong Wang, Jie Li, Zhiwan Wang, Jing Wang, Si-Ling Wang, Zhiwen Zhang, Ya-Ping Li

Nature Communications

DOI

2019

Nanoparticles-mediated reoxygenation strategy relieve tumor hypoxia for enhanced cancer therapy.

Hong Wang, Jie Li, Yuqi Wang, Xiang Gong, Xiaoxuan Xu, Jiaoying Wang, Ya-Ping Li, X. Sha, Zhiwen Zhang

Journal of Controlled Release

DOI

2018

Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis.

Haiqiang Cao, Hong Wang, Xinyu He, Tao Tan, Haiyan Hu, Zhiwan Wang, Jing Wang, Jie Li, Zhiwen Zhang, Ya-Ping Li

Nano letters (Print)

DOI

2018

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Zhiwen Zhang, Hong Wang, Tao Tan, Jie Li, Zhiwan Wang, Ya-Ping Li

Advanced Functional Materials

DOI

2018

Deep Tumor‐Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal‐Chemotherapy of Breast Cancer Metastasis

Tao Tan, Hong Wang, Haiqiang Cao, Li-Juan Zeng, Yuqi Wang, Zhiwan Wang, Jing Wang, Jie Li, Si-Ling Wang, Zhiwen Zhang, Ya-Ping Li

Advancement of science

DOI

2018

Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem‐like cells in vitro

Tao Tan, Yuqi Wang, Hong Wang, Haiqiang Cao, Zhiwan Wang, Jing Wang, Jie Li, Ya-Ping Li, Zhiwen Zhang, Si-Ling Wang

International journal of pharmaceutics

DOI

2018

Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy

Hai-Yan Hu, Jing Wang, Hong Wang, Tao Tan, Jie Li, Zhiwan Wang, Kao-Xiang Sun, Ya-Ping Li, Zhiwen Zhang

Theranostics

DOI

2018

Rational Design of Tumor Microenvironment‐Activated Micelles for Programed Targeting of Breast Cancer Metastasis

Bin He, Tao Tan, Hong Wang, Hai-Yan Hu, Zhiwan Wang, Jing Wang, Jie Li, Kao-Xiang Sun, Zhiwen Zhang, Ya-Ping Li

DOI

2017

光敏感型盐酸多柔比星脂质体逆转乳腺癌耐药

孟庆硕，张鹏程，尹琦，张志文，于海军，李亚平

《药学学报》

2017

Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer.

Shan Tang, Qing-Shuo Meng, Hui-Ping Sun, Jing-Han Su, Qi Yin, Zhiwen Zhang, Haijun Yu, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

Biomaterials

DOI

2017

転移性乳癌の相乗的治療のためのアルブミン生体模倣Nanocoronaを改善する腫瘍標的化と浸透【Powered by NICT】

Haiqiang Cao, Li-Li Zou, Bin He, Li-Juan Zeng, Yongzhuo Huang, Haijun Yu, Pengcheng Zhang, Qi Yin, Zhiwen Zhang, Ya-Ping Li

2017

Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy

Yihui Zhai, Jing-Han Su, Wei Ran, Pengcheng Zhang, Qi Yin, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

Theranostics

DOI

2017

Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer

Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Qing-Shuo Meng, J. Zeng, Zhiwen Zhang, Si-Ling Wang, Haijun Yu, Ya-Ping Li

DOI

2017

Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles

Tao Zhong, Bin He, Haiqiang Cao, Tao Tan, Hai-Yan Hu, Ya-Ping Li, Zhiwen Zhang

Acta Pharmacologica Sinica

DOI

2017

Cancer Therapy: Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer (Adv. Funct. Mater. 20/2017)

Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Qing-Shuo Meng, J. Zeng, Zhiwen Zhang, Si-Ling Wang, Haijun Yu, Ya-Ping Li

DOI

2017

Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Zhirui Cui, Si-Ling Wang, Chunyong Ding, Zhiwen Zhang, Jian Liu, Haijun Yu, Ya-Ping Li

DOI

2017

IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice

Bin He, Haiyan Hu, Tao Tan, H. Wang, Kao-Xiang Sun, Ya-Ping Li, Zhiwen Zhang

Acta Pharmacologica Sinica

DOI

2017

Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy.

Xinyu He, Haiqiang Cao, Hong Wang, Tao Tan, Haijun Yu, Pengcheng Zhang, Qi Yin, Zhiwen Zhang, Ya-Ping Li

Nano letters (Print)

DOI

2017

温熱療法誘発薬物放出による癌細胞膜被覆金ナノケージと乳癌の同型標的を阻害する増殖と転移【Powered by NICT】

Hui-Ping Sun, Jing-Han Su, Qing-Shuo Meng, Qi Yin, Ling-Li Chen, Wang-Wen Gu, Zhiwen Zhang, Haijun Yu, Pengcheng Zhang, Si-Ling Wang, Ya-Ping Li

2017

Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors.

Tingting Wang, Dangge Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Qi Yin, Zhiwen Zhang, Zhonglian Cao, Haijun Yu, Ya-Ping Li

Nano letters (Print)

DOI

2017

Theranostics: Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer (Adv. Funct. Mater. 46/2017)

Fangyuan Zhou, Bing Feng, Tingting Wang, Dangge Wang, Zhirui Cui, Si-Ling Wang, Chunyong Ding, Zhiwen Zhang, Jian Liu, Haijun Yu, Ya-Ping Li

DOI

2017

Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer.

Chunhua Hu, Xiaoyu Liu, Wei Ran, Jia Meng, Yihui Zhai, Pengcheng Zhang, Qi Yin, Haijun Yu, Zhiwen Zhang, Ya-Ping Li

Biomaterials

DOI

2017

Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer

Haiqiang Cao, Li-Li Zou, Bin He, Li-Juan Zeng, Yongzhuo Huang, Haijun Yu, Pengcheng Zhang, Qi Yin, Zhiwen Zhang, Ya-Ping Li

DOI

2017

転移性乳癌治療のための細胞取込および薬物放出制御のための電荷スイッチを用いた二重pH感受性ミセル【Powered by NICT】

Shan Tang, Qing-Shuo Meng, Hui-Ping Sun, Jing-Han Su, Qi Yin, Zhiwen Zhang, Haijun Yu, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

2017

Ly6Chi Monocytes Delivering pH‐Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer

Tianqun Lang, Xin-Yue Dong, Yan Huang, Wei Ran, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

DOI

2016

Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics

Li-Li Zou, Hong Wang, Bin He, Li-Juan Zeng, Tao Tan, Haiqiang Cao, Xinyu He, Zhiwen Zhang, Sheng-Rong Guo, Ya-Ping Li

Theranostics

DOI

2016

Treatment of Malignant Brain Tumor by Tumor‐Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration

Li-Juan Zeng, Li-Li Zou, Haijun Yu, Xinyu He, Haiqiang Cao, Zhiwen Zhang, Qi Yin, Pengcheng Zhang, Wang-Wen Gu, Ling-Li Chen, Ya-Ping Li

DOI

2016

酸誘発正確なイメージングとオルガネラ特異的併用癌治療向け汎用性プロドラッグナノ粒子【Powered by NICT】

Bing Feng, Fangyuan Zhou, Zhi-Ai Xu, Tingting Wang, Dangge Wang, Jianping Liu, Yuan-Lei Fu, Qi Yin, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

2016

Long Circulation Red‐Blood‐Cell‐Mimetic Nanoparticles with Peptide‐Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer

Jing-Han Su, Hui-Ping Sun, Qing-Shuo Meng, Qi Yin, Shan Tang, Pengcheng Zhang, Yi Chen, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

Advanced Functional Materials

DOI

2016

Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer

Fangyuan Zhou, Bing Feng, Haijun Yu, Dangge Wang, Tingting Wang, Jianping Liu, Qing-Shuo Meng, Si-Ling Wang, Pengcheng Zhang, Zhiwen Zhang, Ya-Ping Li

Theranostics

DOI

2016

Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro

Hui-Ping Sun, Jing-Han Su, Qing-Shuo Meng, Qi Yin, Zhiwen Zhang, Hai-Jun Yu, Peng-Cheng Zhang, Si-Ling Wang, Ya-Ping Li

Acta Pharmacologica Sinica

DOI

2016

Versatile Prodrug Nanoparticles for Acid‐Triggered Precise Imaging and Organelle‐Specific Combination Cancer Therapy

Bing Feng, Fangyuan Zhou, Zhi-Ai Xu, Tingting Wang, Dangge Wang, Jianping Liu, Yuan-Lei Fu, Qi Yin, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

DOI

2016

腫瘍微小環境適応ナノ粒子CodeliverパクリタキセルおよびsiRNA乳癌の増殖を阻害すると肺転移へ【Powered by NICT】

Shan Tang, Qing-Shuo Meng, Hui-Ping Sun, Jing-Han Su, Qi Yin, Zhiwen Zhang, Haijun Yu, Ling-Li Chen, Yi Chen, Wang-Wen Gu, Ya-Ping Li

2016

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy.

Dangge Wang, Tingting Wang, Jianping Liu, Haijun Yu, S. Jiao, Bing Feng, Fangyuan Zhou, Yuan-Lei Fu, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Zhaocai Zhou, Ya-Ping Li

Nano letters (Print)

DOI

2016

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer.

Haiqiang Cao, Zhaoling Dan, Xinyu He, Zhiwen Zhang, Haijun Yu, Qi Yin, Ya-Ping Li

ACS Nano

DOI

2016

Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor.

Tingting Wang, Dangge Wang, Haijun Yu, Ming-Wei Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Yongzhuo Huang, Ya-Ping Li

ACS Nano

DOI

2016

A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer

Zhaoling Dan, Haiqiang Cao, Xinyu He, Zhiwen Zhang, Li-Li Zou, Li-Juan Zeng, Yan Xu, Qi Yin, Minghua Xu, D. Zhong, Haijun Yu, Qi Shen, Pengcheng Zhang, Ya-Ping Li

Theranostics

DOI

2016

Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer

Haijun Yu, Chengyue Guo, Bing Feng, Jianping Liu, Xianzhi Chen, Dangge Wang, Lesheng Teng, You-Xin Li, Qi Yin, Zhiwen Zhang, Yaping Li

Theranostics

DOI

2016

転移性乳癌の相乗化学光熱治療のためのNIR制御された薬剤放出を持つバイオインスパイアードナノ粒子【Powered by NICT】

Jing-Han Su, Hui-Ping Sun, Qing-Shuo Meng, Qi Yin, Peng-Cheng Zhang, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

2016

Tumor‐Microenvironment‐Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer

Shan Tang, Qing-Shuo Meng, Hui-Ping Sun, Jing-Han Su, Qi Yin, Zhiwen Zhang, Haijun Yu, Ling-Li Chen, Yi Chen, Wang-Wen Gu, Ya-Ping Li

DOI

2016

Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA.

Dangge Wang, Tingting Wang, Zhi-Ai Xu, Haijun Yu, Bing Feng, Jun-Ying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Ya-Ping Li

Small

DOI

2016

Bioinspired Nanoparticles with NIR‐Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer

Jing-Han Su, Hui-Ping Sun, Qing-Shuo Meng, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

DOI

2016

pH‐Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer

Xinyu He, Haijun Yu, Xiaoyue Bao, Haiqiang Cao, Qi Yin, Zhiwen Zhang, Ya-Ping Li

Advanced Healthcare Materials

DOI

2016

Cancer‐Cell‐Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

Hui-Ping Sun, Jing-Han Su, Qing-Shuo Meng, Qi Yin, Ling-Li Chen, Wang-Wen Gu, Pengcheng Zhang, Zhiwen Zhang, Haijun Yu, Si-Ling Wang, Ya-Ping Li

Advances in Materials

DOI

2015

Tumor‐Penetrating Nanotherapeutics Loading a Near‐Infrared Probe Inhibit Growth and Metastasis of Breast Cancer

Xinyu He, Xiaoyue Bao, Haiqiang Cao, Zhiwen Zhang, Qi Yin, Wang-Wen Gu, Ling-Li Chen, Haijun Yu, Ya-Ping Li

DOI

2015

Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy.

Zhaoling Dan, Haiqiang Cao, Xinyu He, Li-Juan Zeng, Li-Li Zou, Qi Shen, Zhiwen Zhang

International journal of pharmaceutics

DOI

2015

Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel.

Shan Tang, Qi Yin, Jing-Han Su, Hui-Ping Sun, Qing-Shuo Meng, Yi Chen, Ling-Li Chen, Yongzhuo Huang, Wang-Wen Gu, Minghua Xu, Haijun Yu, Zhiwen Zhang, Ya-Ping Li

Biomaterials

DOI

2015

Bioreducible Micelles with Endosomal Buffering and Multidrug Resistance-Reversing Function Enhance Anti-Tumor Efficacy of Doxorubicin.

Qi Yin, Jia-Nan Shen, Haijun Yu, Yongzhuo Huang, Zhiwen Zhang, Ya-Ping Li

Journal of Biomedical Nanotechnology

DOI

2015

Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent.

Chong-Shen Guo, Haijun Yu, Bing Feng, Wei-Dong Gao, Mei Yan, Zhiwen Zhang, Ya-Ping Li, Shaoqin Liu

Biomaterials

DOI

2015

Inhibition of Breast Cancer Metastasis by Pluronic Copolymers with Moderate Hydrophilic-Lipophilic Balance.

Hui-Ping Sun, Qing-Shuo Meng, Shan Tang, Jing-Han Su, Qi Yin, Ling-Li Chen, Wang-Wen Gu, Haijun Yu, Zhiwen Zhang, Si-Ling Wang, Ya-Ping Li

Molecular Pharmaceutics

DOI

2015

Near infrared light-actuated gold nanorods with cisplatin-polypeptide wrapping for targeted therapy of triple negative breast cancer.

Bing Feng, Zhi-Ai Xu, Fangyuan Zhou, Hai-Jun Yu, Qianqian Sun, Dangge Wang, Zhao-Hui Tang, Hai-Yang Yu, Qi Yin, Zhiwen Zhang, Ya-Ping Li

Nanoscale

DOI

2015

Photothermal Therapy: Tumor‐Penetrating Nanotherapeutics Loading a Near‐Infrared Probe Inhibit Growth and Metastasis of Breast Cancer (Adv. Funct. Mater. 19/2015)

Xinyu He, Xiaoyue Bao, Haiqiang Cao, Zhiwen Zhang, Qi Yin, Wang-Wen Gu, Ling-Li Chen, Haijun Yu, Ya-Ping Li

DOI

2015

Codelivery of sorafenib and curcumin by directed self-assembled nanoparticles enhances therapeutic effect on hepatocellular carcinoma.

Haiqiang Cao, Yixin Wang, Xinyu He, Zhiwen Zhang, Qi Yin, Yi Chen, Haijun Yu, Yongzhuo Huang, Ling-Li Chen, Minghua Xu, Wang-Wen Gu, Ya-Ping Li

Molecular Pharmaceutics

DOI

2015

Micelles: pH‐ and NIR Light‐Responsive Micelles with Hyperthermia‐Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer (Adv. Funct. Mater. 17/2015)

Haijun Yu, Zhirui Cui, Peng-Cheng Yu, Chengyue Guo, Bing Feng, Tongying Jiang, Si-Ling Wang, Qi Yin, D. Zhong, Xiang-Liang Yang, Zhiwen Zhang, Ya-Ping Li

DOI

2015

Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer.

Pengfei Xu, Qing-Shuo Meng, Hui-Ping Sun, Qi Yin, Haijun Yu, Zhiwen Zhang, Mi Cao, Yingyi Zhang, Ya-Ping Li

Biomaterials

DOI

2015

pH‐ and NIR Light‐Responsive Micelles with Hyperthermia‐Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

Haijun Yu, Zhirui Cui, Peng-Cheng Yu, Chengyue Guo, Bing Feng, Tongying Jiang, Si-Ling Wang, Qi Yin, D. Zhong, Xiang-Liang Yang, Zhiwen Zhang, Ya-Ping Li

DOI

2015

Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression.

Haiqiang Cao, Zhiwen Zhang, Shuang Zhao, Xinyu He, Haijun Yu, Qi Yin, Zhiping Zhang, Wang-Wen Gu, Ling-Li Chen, Ya-Ping Li

Journal of Controlled Release

DOI

2014

Nanoassembly of probucol enables novel therapeutic efficacy in the suppression of lung metastasis of breast cancer.

Zhiwen Zhang, Haiqiang Cao, Shi-Jun Jiang, Zeying Liu, Xinyu He, Haijun Yu, Ya-Ping Li

Small

DOI

2014

Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram

Xiaopin Duan, Ji-Sheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shi-Rui Mao, Ya-Ping Li

Nanotechnology

DOI

2014

Reversal of lung cancer multidrug resistance by pH-responsive micelleplexes mediating co-delivery of siRNA and paclitaxel.

Haijun Yu, Zhi-Ai Xu, Xianzhi Chen, Leilei Xu, Qi Yin, Zhiwen Zhang, Ya-Ping Li

Macromolecular Bioscience

DOI

2014

Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis.

Pengfei Xu, Haijun Yu, Zhiwen Zhang, Qing-Shuo Meng, Hui-Ping Sun, Xianzhi Chen, Qi Yin, Ya-Ping Li

Biomaterials

DOI

2014

Directed Self-assembled Nanoparticles of Probucol Improve Oral Delivery: Fabrication, Performance and Correlation

Zhiwen Zhang, Shi-Jun Jiang, Zeying Liu, Baohua Niu, Wang-Wen Gu, Ya-Ping Li, Jing-Bin Cui

Pharmaceutical Research

DOI

2014

iRGD conjugated TPGS mediates codelivery of paclitaxel and survivin shRNA for the reversal of lung cancer resistance.

Jia-Nan Shen, Qing-Shuo Meng, Huiping Sui, Qi Yin, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

Molecular Pharmaceutics

DOI

2014

Irinotecan hydrochloride composite phospholipid composition, preparation method and applications thereof

Ya-Ping Li, Ling-Li Chen, Zhao-Lei Zheng, Zhiwen Zhang, Wang-Wen Gu

2014

Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods.

Dangge Wang, Zhi-Ai Xu, Haijun Yu, Xianzhi Chen, Bing Feng, Zhirui Cui, Bin Lin, Qi Yin, Zhiwen Zhang, Chunying Chen, Jun Wang, Wen Zhang, Ya-Ping Li

Biomaterials

DOI

2014

Simultaneous inhibition of tumor growth and angiogenesis for resistant hepatocellular carcinoma by co-delivery of sorafenib and survivin small hairpin RNA.

Jia-Nan Shen, Hui-Ping Sun, Qing-Shuo Meng, Qi Yin, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

Molecular Pharmaceutics

DOI

2014

Co-delivery of doxorubicin and RNA using pH-sensitive poly (β-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer.

Shan Tang, Qi Yin, Zhiwen Zhang, Wang-Wen Gu, Ling-Li Chen, Haijun Yu, Yongzhuo Huang, Xianzhi Chen, Minghua Xu, Ya-Ping Li

Biomaterials

DOI

2014

A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer.

Huihui Bu, Xinyu He, Zhiwen Zhang, Qi Yin, Haijun Yu, Ya-Ping Li

International journal of pharmaceutics

DOI

2014

Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis.

Ji-Sheng Xiao, Xiaopin Duan, Qing-Shuo Meng, Qi Yin, Zhiwen Zhang, Haijun Yu, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

Acta Biomaterialia

DOI

2014

The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer.

Zhiwen Zhang, Baohua Niu, Jian Chen, Xinyu He, Xiaoyue Bao, Jianhua Zhu, Haijun Yu, Ya-Ping Li

Biomaterials

DOI

2013

Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles.

Jia-Nan Shen, Hui-Ping Sun, Pengfei Xu, Qi Yin, Zhiwen Zhang, Si-Ling Wang, Haijun Yu, Ya-Ping Li

Biomaterials

DOI

2013

Paclitaxel loaded self-assembled nanocarrier reduces multidrug resistance in lung cancer

Zhiwen Zhang, Huihui Bu, Zeying Liu, Yixin Wang, Baohua Niu, Ya-Ping Li

DOI

2013

The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles.

Ji-Sheng Xiao, Xiaopin Duan, Qi Yin, Ze-Hong Miao, Haijun Yu, Chunying Chen, Zhiwen Zhang, Jun Wang, Ya-Ping Li

Biomaterials

DOI

2013

Photothermal ablation cancer therapy using homogeneous CsxWO3 nanorods with broad near-infra-red absorption.

Chong-Shen Guo, S. Yin, Haijun Yu, Shaoqin Liu, Q. Dong, T. Goto, Zhiwen Zhang, Ya-Ping Li, Tsugio Sato

Nanoscale

DOI

2013

Bioreducible Poly ( β-amino esters ) / RNA Complex Nanoparticles Sensitize Drug Resistant Cells

Qi Yin, Ji-Sheng Xiao, Pengfei Xu, Zhiwen Zhang, Ya-Ping Li

2013

Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles.

Haijun Yu, Yonglong Zou, Lei Jiang, Qi Yin, Xinyu He, Ling-Li Chen, Zhiwen Zhang, Wang-Wen Gu, Ya-Ping Li

Biomaterials

DOI

2013

Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram.

Xiaopin Duan, Ji-Sheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shi-Rui Mao, Ya-Ping Li

ACS Nano

DOI

2013

Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats.

Zhiwen Zhang, Fang Gao, Shi-Jun Jiang, Ling-Li Chen, Zeying Liu, Haijun Yu, Ya-Ping Li

International journal of pharmaceutics

DOI

2013

Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS.

Pengfei Xu, Qi Yin, Jia-Nan Shen, Ling-Li Chen, Haijun Yu, Zhiwen Zhang, Ya-Ping Li

International journal of pharmaceutics

DOI

2013

A high-drug-loading self-assembled nanoemulsion enhances the oral absorption of probucol in rats.

Zhiwen Zhang, Jian Huang, Shi-Jun Jiang, Zeying Liu, Wang-Wen Gu, Haijun Yu, Ya-Ping Li

Journal of Pharmacy and Science

DOI

2013

Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug.

Zhiwen Zhang, Jian Huang, Shi-Jun Jiang, Zeying Liu, Wang-Wen Gu, Haijun Yu, Ya-Ping Li

International journal of pharmaceutics

DOI

2013

Reversal of multidrug resistance by mitochondrial targeted self-assembled nanocarrier based on stearylamine.

Zhiwen Zhang, Zeying Liu, Li Ma, Shi-Jun Jiang, Yixin Wang, Haijun Yu, Qi Yin, Jing-Bin Cui, Ya-Ping Li

Molecular Pharmaceutics

DOI

2013

A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor.

Zhiwen Zhang, Li Ma, Shi-Jun Jiang, Zeying Liu, Jian Huang, Ling-Li Chen, Haijun Yu, Ya-Ping Li

Journal of Controlled Release

DOI

2013

Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor.

Qi Yin, Jia-Nan Shen, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

Advanced Drug Delivery Reviews

DOI

2013

Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer.

Ji-Sheng Xiao, Xiaopin Duan, Qi Yin, Zhiwen Zhang, Haijun Yu, Ya-Ping Li

Biomaterials

DOI

2013

pH-Responsive wormlike micelles for intracellular delivery of hydrophobic drugs

Haijun Yu, Xuetao Shi, Peng-Cheng Yu, Jian-Hua Zhou, Zhiwen Zhang, Hong-Kai Wu, Ya-Ping Li

DOI

2013

Multifunctional nanoparticles improve therapeutic effect for breast cancer by simultaneously antagonizing multiple mechanisms of multidrug resistance.

Qi Yin, Jia-Nan Shen, Zhiwen Zhang, Haijun Yu, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

Biomacromolecules

DOI

2013

Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

Haijun Yu, Zhi-Ai Xu, Dangge Wang, Xianzhi Chen, Zhiwen Zhang, Qi Yin, Ya-Ping Li

DOI

2013

A mitochondrial targeted paclitaxel loaded self-assembled nanocarrier reduces the multidrug resistance of breast cancer

Zhiwen Zhang, Ji-Sheng Xiao, Xinyu He, Ya-Ping Li

2013

Reversal of paclitaxel-chemoresistance by mixed Pluronic P105/L101 micelles in human ovarian cancer SKOV-3/PTX cells

Yongzhong Wang, Zhiwen Zhang, Xianyi Sha, Limei Han, Xiaoling Fang

Journal of Drug Delivery Science and Technology

DOI

2012

Nano-based drug delivery system enhances the oral absorption of lipophilic drugs with extensive presystemic metabolism.

Zhiwen Zhang, Fang Gao, Shi-Jun Jiang, Li Ma, Ya-Ping Li

Current drug metabolism

DOI

2012

Overcoming multidrug resistance by co-delivery of Mdr-1 and survivin-targeting RNA with reduction-responsible cationic poly(β-amino esters).

Qi Yin, Jia-Nan Shen, Ling-Li Chen, Zhiwen Zhang, Wang-Wen Gu, Ya-Ping Li

Biomaterials

DOI

2012

Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance.

Xiu-Feng Ji, Yu Gao, Ling-Li Chen, Zhiwen Zhang, Yi-Hui Deng, Ya-Ping Li

International journal of pharmaceutics

DOI

2012

Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer.

Jia-Nan Shen, Qi Yin, Ling-Li Chen, Zhiwen Zhang, Ya-Ping Li

Biomaterials

DOI

2012

Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics.

Ji-Sheng Xiao, Xiaopin Duan, Qi Yin, Ling-Li Chen, Zhiwen Zhang, Ya-Ping Li

Bioconjugate chemistry

DOI

2012

Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats.

Zhiwen Zhang, Fang Gao, Huihui Bu, Ji-Sheng Xiao, Ya-Ping Li

Nanomedicine: Nanotechnology, Biology and Medicine

DOI

2012

Amphiphilic graft copolymer based on poly(styrene-co-maleic anhydride) with low molecular weight polyethylenimine for efficient gene delivery

Xiaopin Duan, Ji-Sheng Xiao, Qi Yin, Zhiwen Zhang, Shi-Rui Mao, Ya-Ping Li

International Journal of Nanomedicine

DOI

2012

Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: synthesis, preparation and in vivo evaluation.

Pengcheng Zhang, Luojuan Hu, Qi Yin, Zhiwen Zhang, Lin-Yin Feng, Ya-Ping Li

Journal of Controlled Release

DOI

2012

Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors

Yongzhong Wang, Junguo Hao, Yajuan Li, Zhiwen Zhang, Xianyi Sha, Limei Han, Xiaoling Fang

Biomaterials

DOI

2011

Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery.

Qi Yin, Yu Gao, Zhiwen Zhang, Pengcheng Zhang, Ya-Ping Li

Journal of Controlled Release

DOI

2011

A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance.

Zhiwen Zhang, Yan Huang, Fang Gao, Zhi-wei Gao, Huihui Bu, Wang-Wen Gu, Ya-Ping Li

Nanomedicine

DOI

2011

Controlled intracellular release of doxorubicin in multidrug-resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles.

Yu Gao, Yu Chen, Xiu-Feng Ji, Xinyu He, Qi Yin, Zhiwen Zhang, Jian-Lin Shi, Ya-Ping Li

ACS Nano

DOI

2011

Probucol nano-suspension prepared by using mixing micelle technology, and preparation method thereof

Zhiwen Zhang, Ya-Ping Li, Shi-Jun Jiang, Wang-Wen Gu, Fang Gao, Jian Huang

2011

Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles.

Yu Gao, Ling-Li Chen, Zhiwen Zhang, Yi Chen, Ya-Ping Li

Biomaterials

DOI

2011

Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism.

Fang Gao, Zhiwen Zhang, Huihui Bu, Yan Huang, Zhi-wei Gao, Jia-Nan Shen, Chun-Jie Zhao, Ya-Ping Li

Journal of Controlled Release

DOI

2011

A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance.

Qianjun He, Yu Gao, Ling-Xia Zhang, Zhiwen Zhang, Fang Gao, Xiu-Feng Ji, Ya-Ping Li, Jian-Lin Shi

Biomaterials

DOI

2011

Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal

Yu Gao, Rong-Fu Yang, Zhiwen Zhang, Ling-Li Chen, Zuyue Sun, Ya-Ping Li

Nanotoxicology

DOI

2011

Linear cationic click polymers/DNA nanoparticles: in vitro structure-activity relationship and in vivo evaluation for gene delivery.

Yu Gao, Qi Yin, Ling-Li Chen, Zhiwen Zhang, Ya-Ping Li

Bioconjugate chemistry

DOI

2011

Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats.

Zhiwen Zhang, Yan Huang, Fang Gao, Huihui Bu, Wang-Wen Gu, Ya-Ping Li

Nanoscale

DOI

2010

The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model.

Zheng-Hong Xu, Zhiwen Zhang, Yi Chen, Ling-Li Chen, Li-Ping Lin, Ya-Ping Li

Biomaterials

DOI

2010

Urocanic acid improves transfection efficiency of polyphosphazene with primary amino groups for gene delivery.

Yongxin Yang, Zhiwen Zhang, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

Bioconjugate chemistry

DOI

2010

Linear cationic click polymer for gene delivery: synthesis, biocompatibility, and in vitro transfection.

Yu Gao, Ling-Li Chen, Zhiwen Zhang, Wang-Wen Gu, Ya-Ping Li

Biomacromolecules

DOI

2010

The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats.

Zhiwen Zhang, Huihui Bu, Zhi-wei Gao, Yan Huang, Fang Gao, Ya-Ping Li

International journal of pharmaceutics

DOI

2010

Effect of multifold charge groups and imidazole-4-carboxaldehyde on physicochemical characteristics and transfection of cationic polyphosphazenes/DNA complexes.

Yongxin Yang, Zhiwen Zhang, Ling-Li Chen, Ya-Ping Li

International journal of pharmaceutics

DOI

2010

Candesartan cilexetil nanoemulsion and preparation method thereof

Zhiwen Zhang, Ya-Ping Li, Wang-Wen Gu, Fang Gao

2010

Pharmacokinetics in rats and efficacy in murine ovarian cancer model for solid lipid nanoparticles loading docetaxel.

Pengcheng Zhang, Ling-Li Chen, Zhiwen Zhang, Li-Ping Lin, Ya-Ping Li

Journal of Nanoscience and Nanotechnology

DOI

2010

Folate-PEG modified poly(2-(2-aminoethoxy)ethoxy)phosphazene/DNA nanoparticles for gene delivery: synthesis, preparation and in vitro transfection efficiency.

Pengcheng Zhang, Zhiwen Zhang, Yongxin Yang, Ya-Ping Li

International journal of pharmaceutics

DOI

2010

Galactosylated poly(2-(2-aminoethyoxy)ethoxy)phosphazene/DNA complex nanoparticles: in vitro and in vivo evaluation for gene delivery.

Yongxin Yang, Zhiwen Zhang, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

Biomacromolecules

DOI

2010

Preparation of Daidzein-Phospholipid Complex and Its Bioavailability Study in Rats

Zhiwen Zhang

2010

"Intelligent" nanoassembly for gene delivery: in vitro transfection and the possible mechanism.

Zheng-Hong Xu, Ling-Li Chen, Zhiwen Zhang, Wang-Wen Gu, Ya-Ping Li

International journal of pharmaceutics

DOI

2009

The performance of docetaxel-loaded solid lipid nanoparticles targeted to hepatocellular carcinoma.

Zheng-Hong Xu, Ling-Li Chen, Wang-Wen Gu, Yu Gao, Li-Ping Lin, Zhiwen Zhang, Yong Xi, Ya-Ping Li

Biomaterials

DOI

2009

Chitosan N-betainates/DNA self-assembly nanoparticles for gene delivery: in vitro uptake and transfection efficiency.

Yu Gao, Zhiwen Zhang, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

International journal of pharmaceutics

DOI

2009

Synthesis of 6-N,N,N-trimethyltriazole chitosan via "click chemistry" and evaluation for gene delivery.

Yu Gao, Zhiwen Zhang, Ling-Li Chen, Wang-Wen Gu, Ya-Ping Li

Biomacromolecules

DOI

2009

Enhanced transfection of polyplexes based on pluronic-polypropylenimine dendrimer for gene transfer

Junguo Hao, Xianyi Sha, Yuanjia Tang, Ye Jiang, Zhiwen Zhang, Wei Zhang, Yajuan Li, Xiaoling Fang

Archives of Pharmacal Research

DOI

2009

Establishment of an LC-Based Assay to Determine Caffeic Acid Tetramer in Rat Plasma and Its Application to a Pharmacokinetic Study

Yajuan Li, Yuanqing Gu, Junguo Hao, Zhiwen Zhang, Xiaoling Fang, Xianyi Sha

Chromatographia

DOI

2008

A smart nanoassembly consisting of acid-labile vinyl ether PEG-DOPE and protamine for gene delivery: preparation and in vitro transfection.

Zheng-Hong Xu, Wang-Wen Gu, Ling-Li Chen, Yu Gao, Zhiwen Zhang, Ya-Ping Li

Biomacromolecules

DOI

2008

ChemInform Abstract: Synthesis and Antitumor Activities of 3‐Substituted 1‐(5‐Formylfurfuryl)indolin‐2‐one Derivatives.

Fusheng Zhou, Jianbin Zheng, Xiaochun Dong, Zhiwen Zhang, Lingling Zhao, Xianyi Sha, Lin Li, Wen Ren

ChemInform

DOI

2008

Polycation nanostructured lipid carrier, a novel nonviral vector constructed with triolein for efficient gene delivery

Zhiwen Zhang, Xianyi Sha, Anle Shen, Yongzhong Wang, Zhaogui Sun, Zheng Gu, Xiaoling Fang

Biochemical and Biophysical Research Communications

DOI

2008

Synthesis of 1,2,3,4-Tetrahydroeudistomin U Derivatives and PreliminaryIn Vitro. Antitumor Evaluation

Jianbin Zheng, Zhiwen Zhang, Lingling Zhao, Xianyi Sha, Xiaochun Dong, Wen Ren

Pharmaceutical Biology

DOI

2007

Pharmacokinetics and Bioequivalence Studies of Galantamine Hydrobromide Dispersible Tablet in Healthy Male Chinese Volunteers

Lijun Zhang, Xiaoling Fang, Xuening Li, Qingsong Wang, Limei Han, Zhiwen Zhang, Xianyi Sha

Drug Development and Industrial Pharmacy

DOI

精选作品

期刊论文

Strategies for engineering biomimetic lipoproteins to improve drug delivery efficiency and tumor therapy.

Injectable dual-affinity self-assembling peptide hydrogels for local controlled delivery of therapeutic antibodies

Deciphering Apolipoprotein A4 in the Protein Corona of Ligand-Modified Liposomes for Tumor Targeting and Penetration

Pleural Mesothelioma: Current Therapeutic Strategies and Future Directions

The impact of chemotherapy on floating vs. attached colorectal cancer cells: An in-vitro study

An elegant fluorinated liposome for enhanced tumor penetration

A precision nitric oxide-releasing hydrogel promoting nanoparticles permeation for comprehensive nerve-vessel recovery and microenvironment regulation in diabetic wounds

Progress in peptide and protein therapeutics: Challenges and strategies

Strategies of designing lymph nodes-targeting nanoparticles for cancer immunotherapy

Phosphatidylcholine Chain-Length of Bioinspired Lipoprotein Modulates Interactions with Collagen for Intratumor Delivery in Pancreatic Cancer

Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance

Rational Design of Bioinspired Lipoprotein System to Improve Penetration in Colorectal Peritoneal Metastases

Inhalable biomimetic polyunsaturated fatty acid-based nanoreactors for peroxynitrite-augmented ferroptosis potentiate radiotherapy in lung cancer

Biomimetic nanoreactor of catalase and nitric oxide enhance peroxynitrite generation for radiosensitization

Glutathione-Disrupting Nanotherapeutics Potentiate Ferroptosis for Treating Luminal Androgen Receptor-Positive Triple-Negative Breast Cancer

Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke

Biomimetic Integrated Nanozyme for Flare and Recurrence of Gouty Arthritis

Extracellular Matrix‐Trapped Bioinspired Lipoprotein Prolongs Tumor Retention to Potentiate Antitumor Immunity

Corrigendum to "Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy" [Journal of Controlled Release 353 (2023) 447-461].

Nitric Oxide-Loaded Bioinspired Lipoprotein Normalizes Tumor Vessels To Improve Intratumor Delivery and Chemotherapy of Albumin-Bound Paclitaxel Nanoparticles.

Spatial-Drug-Laden Protease-Activatable M1 Macrophage System Targets Lung Metastasis and Potentiates Antitumor Immunity.

Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma

Bioinspired Lipoproteins of Furoxans–Gemcitabine Preferentially Targets Glioblastoma and Overcomes Radiotherapy Resistance

Allomelanin-based biomimetic nanotherapeutics for orthotopic glioblastoma targeted photothermal immunotherapy

Drug‐Free Biomimetic Oxygen Supply Nanovehicle Promotes Ischemia‐Reperfusion Therapy in Stroke

Biomimetic Thermo‐Sensitive Hydrogel Encapsulating Hemangiomas Stem Cell Derived Extracellular Vesicles Promotes Microcirculation Reconstruction in Diabetic Wounds

Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy.

Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity.

Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function.

Strategies of engineering nanomedicines for tumor retention.

Current approaches of nanomedicines in the market and various stage of clinical translation

Bioinspired Lipoproteins of Furoxans–Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T‐Cell Infiltration

ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity.

Full factorial design, physicochemical characterization, ex vivo investigation, and biological assessment of glutathione-loaded solid lipid nanoparticles for topical application

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy

Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity.

Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy

Reprogramming Tumor Associated Macrophages toward M1 Phenotypes with Nanomedicine for Anticancer Immunotherapy

Orally delivered legumain-activated nanovehicles improve tumor accumulation and penetration for combinational photothermal-chemotherapy.

Corrigendum to "Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem-like cells in vitro" [Int. J. Pharm. 553 (2018) 201-209].

Corrigendum to "Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery" [Journal of Controlled Release 151 (2011) 35-44].

Tumor‐Activated Size‐Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti‐Tumor Immune Responses

Cancer Cell Membrane‐Coated Gold Nanocages with Hyperthermia‐Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer

Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy.

The Application of Pre-clinical Animal Models to Optimise Nanoparticulate Drug Delivery for Hepatocellular Carcinoma.

Correction to Codelivery of Sorafenib and Curcumin by Directed Self-Assembled Nanoparticles Enhances Therapeutic Effect on Hepatocellular Carcinoma.

Correction to Bioengineered Macrophages Can Responsively Transform into Nanovesicles to Target Lung Metastasis.

Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor

Emerging Approaches of Cell‐Based Nanosystems to Target Cancer Metastasis

Ly6C hi Monocytes Delivering pH‐Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer

Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles

Nanoparticles-mediated reoxygenation strategy relieve tumor hypoxia for enhanced cancer therapy.

Bioengineered Macrophages Can Responsively Transform into Nanovesicles To Target Lung Metastasis.

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Deep Tumor‐Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal‐Chemotherapy of Breast Cancer Metastasis

Apoferritin nanocages loading mertansine enable effective eradiation of cancer stem‐like cells in vitro

Cell-penetrating peptide-based nanovehicles potentiate lymph metastasis targeting and deep penetration for anti-metastasis therapy

Rational Design of Tumor Microenvironment‐Activated Micelles for Programed Targeting of Breast Cancer Metastasis

光敏感型盐酸多柔比星脂质体逆转乳腺癌耐药

Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer.

転移性乳癌の相乗的治療のためのアルブミン生体模倣Nanocoronaを改善する腫瘍標的化と浸透【Powered by NICT】

Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy

Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer

Treating breast cancer metastasis with cabazitaxel-loaded polymeric micelles

Cancer Therapy: Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple‐Negative Breast Cancer (Adv. Funct. Mater. 20/2017)

Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice

Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy.

温熱療法誘発薬物放出による癌細胞膜被覆金ナノケージと乳癌の同型標的を阻害する増殖と転移【Powered by NICT】

Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors.

Theranostics: Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer (Adv. Funct. Mater. 46/2017)

Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer.

Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer

転移性乳癌治療のための細胞取込および薬物放出制御のための電荷スイッチを用いた二重pH感受性ミセル【Powered by NICT】

Ly6Chi Monocytes Delivering pH‐Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer

Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics

Treatment of Malignant Brain Tumor by Tumor‐Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration