百晓学者学者目录

吴淏

副教授、教授、讲师，湖北师范大学

精选作品

期刊论文

2024

Estimating the Weight Matrix in Distributionally Weighted Least Squares Estimation: An Empirical Bayesian Solution

Han Du, Hao Wu

Structural Equation Modeling-A Multidisciplinary Journal，Vol. 310, No. 60

DOI

2024

Investigating Structural Model Fit Evaluation

Xijuan Zhang, Hao Wu

Structural Equation Modeling-A Multidisciplinary Journal，Vol. 310, No. 50

DOI

2023

A cofunctional grouping-based approach for non-redundant feature gene selection in unannotated single-cell RNA-seq analysis

Tao Deng, Siyu Chen, Ying Zhang, Yuan Xu, Da Feng, Hao Wu, Xiaobo Sun

Briefings Bioinform.

DOI

2023

Cellcano: supervised cell type identification for single cell ATAC-seq data

Wenjing Ma, Jia-Ying Lu, Hao Wu

Nature Communications

DOI

2022

Differential Methylation Analysis for Bisulfite Sequencing (BS-Seq) Data.

H. Feng, K. Conneely, Hao Wu

Methods in molecular biology

DOI

2022

CeDAR: incorporating cell type hierarchy improves cell type-specific differential analyses in bulk omics data

Luxiao Chen, Ziyi Li, Hao Wu

bioRxiv

DOI

2022

EDClust: an EM-MM hybrid method for cell clustering in multiple-subject single-cell RNA sequencing

Xin Wei, Ziyi Li, H. Ji, Hao Wu

Bioinform.

DOI

2022

Differential RNA methylation analysis for MeRIP-seq data under general experimental design

Zhenxing Guo, A. Shafik, Peng Jin, Hao Wu

Bioinform.

DOI

2022

Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors

X. Xiong, Songhai Tian, Pan Yang, F. Lebreton, Huan Bao, Kuan-Wei Sheng, L. Yin, Peng Chen, Jie Zhang, Wan-Shu Qi, J. Ruan, Hao Wu, H. Chen, D. Breault, A. Earl, M. Gilmore, J. Abraham, M. Dong

Cell

DOI

2021

Penalized Latent Dirichlet Allocation Model in Single-Cell RNA Sequencing

Xiaotian Wu, Hao Wu, Zhi-Jin Wu

Statistics in Biosciences

DOI

2021

Detecting m6A methylation regions from Methylated RNA Immunoprecipitation Sequencing

Zhenxing Guo, A. Shafik, P. Jin, Zhi-Jin Wu, Hao Wu

Bioinform.

DOI

2021

Non-linear Normalization for Non-UMI Single Cell RNA-Seq

Zhi-Jin Wu, Kenong Su, Hao Wu

Frontiers in Genetics

DOI

2021

A new graph-based clustering method with application to single-cell RNA-seq data from human pancreatic islets

Hao Wu, Disheng Mao, Yuping Zhang, Zhiyi Chi, M. Stitzel, Z. Ouyang

NAR Genomics and Bioinformatics

DOI

2021

Accurate feature selection improves single-cell RNA-seq cell clustering

Kenong Su, Tianwei Yu, Hao Wu

Briefings Bioinform.

DOI

2021

Evaluation of some aspects in supervised cell type identification for single-cell RNA-seq: classifier, feature selection, and reference construction

Wenjing Ma, Kenong Su, Hao Wu

Genome Biology

DOI

2021

Purification and cryoelectron microscopy structure determination of human V-ATPase

Long-Fei Wang, Zhen-Hang Chen, Hao Wu, T. Fu

STAR Protocols

DOI

2021

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

P. Münzer, R. Negro, S. Fukui, L. Di Meglio, Karen Aymonnier, Long Chu, Deya Cherpokova, Sarah Gutch, N. Sorvillo, Lai Shi, V. Magupalli, A. Weber, R. Scharf, Clare M. Waterman, Hao Wu, D. Wagner

Frontiers in Immunology

DOI

2021

Structures and functions of the inflammasome engine

Long-Fei Wang, H. Sharif, Setu M. Vora, Yumei Zheng, Hao Wu

Journal of Allergy and Clinical Immunology

DOI

2021

Channelling inflammation: gasdermins in physiology and disease

Xing Liu, S. Xia, Zhi-Bin Zhang, Hao Wu, J. Lieberman

Nature reviews. Drug discovery

DOI

2021

Structural mechanism of CARD8 regulation by DPP9

H. Sharif, L. R. Hollingsworth, A. R. Griswold, J. Hsiao, Qing-Hui Wang, D. Bachovchin, Hao Wu

bioRxiv

DOI

2021

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

L. R. Hollingsworth, H. Sharif, A. R. Griswold, P. Fontana, J. Mintseris, K. Dagbay, João A. Paulo, S. Gygi, D. Bachovchin, Hao Wu

Nature

DOI

2021

NLRP3 Cages Revealed by Full-length Mouse NLRP3 Structure Control Pathway Activation

L. Andreeva, L. David, S. Rawson, Chen Shen, Teerithveen Pasricha, P. Pelegrín, Hao Wu

Cell

DOI

2021

Multiple domain interfaces mediate SARM1 autoinhibition

Chen Shen, M. Vohra, Pengfei Zhang, X. Mao, Matthew D. Figley, Jian Zhu, Y. Sasaki, Hao Wu, A. Diantonio, J. Milbrandt

Proceedings of the National Academy of Sciences of the United States of America

DOI

2021

Dipeptidyl Peptidase 9 Sets a Threshold for CARD8 Inflammasome Formation by Sequestering Its Active C-terminal Fragment

H. Sharif, L. R. Hollingsworth, A. R. Griswold, J. Hsiao, Qing-Hui Wang, D. Bachovchin, Hao Wu

Immunity

DOI

2021

Correction: Wu, H.; et al. A Purified Aspartic Protease from Akkermansia Muciniphila Plays an Important Role in Degrading Muc2. Int. J. Mol. Sci. 2020, 21, 72

Xin Meng, Wencheng Wang, Tian-Qi Lan, Wanxin Yang, Da-Hai Yu, Xuexun Fang, Hao Wu

International Journal of Molecular Sciences

DOI

2021

Gasdermin D pore structure reveals preferential release of mature interleukin-1

S. Xia, Zhi-Bin Zhang, V. Magupalli, J. Pablo, Ying Dong, Setu M. Vora, Long-Fei Wang, T. Fu, Matthew P. Jacobson, A. Greka, J. Lieberman, J. Ruan, Hao Wu

Nature

DOI

2021

Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

L. Robert Hollingsworth, L. David, Yang Li, A. R. Griswold, J. Ruan, H. Sharif, P. Fontana, Elizabeth L. Orth-He, T. Fu, D. Bachovchin, Hao Wu

Nature Communications

DOI

2021

Cryo-EM structure of NLRP1-DPP9 complex

L. R. Hollingsworth, H. Sharif, A. R. Griswold, P. Fontana, J. Mintseris, K. Dagbay, J. A. Paulo, S. Gygi, D. Bachovchin, Hao Wu

DOI

2021

Phase Separation Drives RNA Virus-Induced Activation of the NLRP6 Inflammasome

Chen Shen, Run-Zhi Li, R. Negro, Jie-Wei Cheng, Setu M. Vora, T. Fu, Anmin Wang, Kaixin He, L. Andreeva, P. Gao, Z. Tian, R. Flavell, Shu Zhu, Hao Wu

Cell

DOI

2021

STING condensates on ER limit IFN response

L. Andreeva, Hao Wu

Nature Cell Biology

DOI

2021

Full-length NLRP3 forms oligomeric cages to mediate NLRP3 sensing and activation

L. Andreeva, L. David, S. Rawson, Chen Shen, Teerithveen Pasricha, P. Pelegrín, Hao Wu

bioRxiv

DOI

2020

Complete deconvolution of DNA methylation signals from complex tissues: a geometric approach

Weiwei Zhang, Hao Wu, Ziyi Li

Bioinform.

DOI

2020

Accounting for cell type hierarchy in evaluating single cell RNA-seq clustering

Zhi-Jin Wu, Hao Wu

Genome Biology

DOI

2020

Simulation, power evaluation and sample size recommendation for single-cell RNA-seq

Kenong Su, Zhi-Jin Wu, Hao Wu

Bioinform.

DOI

2020

Robust partial reference-free cell composition estimation from tissue expression

Ziyi Li, Zhenxing Guo, Ying Cheng, P. Jin, Hao Wu

Bioinform.

DOI

2020

Pan-cancer analysis of differential DNA methylation patterns

Mai Shi, S. Tsui, Hao Wu, Ying-Ying Wei

BMC Medical Genomics

DOI

2020

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

V. Magupalli, R. Negro, Yuzi Tian, Arthur V. Hauenstein, G. Di Caprio, Wesley Skillern, Qiu-Fang Deng, Pontus Orning, H. Alam, Z. Maliga, H. Sharif, J. Hu, C. Evavold, J. Kagan, F. Schmidt, K. Fitzgerald, Tom Kirchhausen, Yongqing Li, Hao Wu

Science

DOI

2020

Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma.

J. Hatcher, Guang Yang, Li Wang, Scott B. Ficarro, S. Buhrlage, Hao Wu, Jarred Marto, S. Treon, N. Gray

ACS Medicinal Chemistry Letters

DOI

2020

METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing

Hao Chen, Lei Gu, Esteban A. Orellana, Yuanyuan Wang, Jiaojiao Guo, Qi Liu, Long-Fei Wang, Zhang-Fei Shen, Hao Wu, R. Gregory, Yi Xing, Yang Shi

Cell Research

DOI

2020

Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development.

Kai Song, Xiaofeng Cai, Yun-Zhou Dong, Hao Wu, Yong Wei, U. Shankavaram, Kui Cui, Yang Lee, Bo Zhu, Sudarshan Bhattacharjee, Beibei Wang, Kun Zhang, Aiyun Wen, Scott W. Wong, Lili Yu, Lijun Xia, A. Welm, D. Bielenberg, K. Camphausen, Yi-Bin Kang, Hong Chen

Journal of Clinical Investigation

DOI

2020

TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation

Long-Fei Wang, R. Negro, Hao Wu

Current Opinion in Immunology

DOI

2020

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

J. Hu, Xing Liu, S. Xia, Zhi-Bin Zhang, Ying Zhang, Jing-Xia Zhao, J. Ruan, Xuemei Luo, Xiwen Lou, Yang Bai, Junhong Wang, L. R. Hollingsworth, V. Magupalli, Li Zhao, Hongbo R. Luo, Justin Kim, J. Lieberman, Hao Wu

Nature Immunology

DOI

2020

Abstract B58: Gasdermin E suppresses tumor growth by activating antitumor immunity

Zhi-Bin Zhang, Ying Zhang, S. Xia, Qing Kong, Shun-Ying Li, Xing Liu, Caroline Junqueira, James A Ansara, Satyaki Sengupta, Yan-Dan Yao, Hao Wu, J. Lieberman

DOI

2020

Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis.

Ratnakar Potla, Mariko Hirano-Kobayashi, Hao Wu, Hong Chen, Akiko Mammoto, Benjamin D. Matthews, D. Ingber

Journal of Cell Science

DOI

2020

CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

Lei Gu, Long-Fei Wang, Hao Chen, Jiaxu Hong, Zhang-Fei Shen, A. Dhall, T. Lao, Chaozhong Liu, Zaoxia Wang, Yifan Xu, Hong-Wen Tang, Damayanti Chakraborty, Jie-Kai Chen, Zhihua Liu, Dragana Rogulja, N. Perrimon, Hao Wu, Yang Shi

Cell Discovery

DOI

2020

Epsin-mediated degradation of IP3R1 fuels atherosclerosis

Yun-Zhou Dong, Yang Lee, Kui Cui, Ming He, Beibei Wang, Sudarshan Bhattacharjee, Bo Zhu, T. Yago, Kun Zhang, Lin Deng, Kunfu Ouyang, Aiyun Wen, Douglas B. Cowan, Kai Song, Lili Yu, Megan L. Brophy, Xiaolei Liu, Jill Wylie-Sears, Hao Wu, Scott W. Wong, Guang-Lin Cui, Y. Kawashima, H. Matsumoto, Y. Kodera, R. Wojcikiewicz, S. Srivastava, J. Bischoff, Da-Zhi Wang, K. Ley, Hong Chen

Nature Communications

DOI

2020

Homogeneous Oligomers of Pro-Apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization

Zachary J. Hauseman, Edward P. Harvey, C. Newman, T. Wales, Joel C. Bucci, J. Mintseris, Devin K. Schweppe, L. David, Li-Xin Fan, Daniel T. Cohen, H. D. Herce, Rida Mourtada, Yael Ben-Nun, Noah B. Bloch, S. Hansen, Hao Wu, S. Gygi, J. Engen, L. Walensky

Molecules and Cells

DOI

2020

Gasdermin E suppresses tumor growth by activating anti-tumor immunity

Zhi-Bin Zhang, Ying Zhang, S. Xia, Qing Kong, Shun-Ying Li, Xing Liu, Caroline Junqueira, K. Meza-Sosa, T. M. Mok, James A Ansara, Satyaki Sengupta, Yan-Dan Yao, Hao Wu, J. Lieberman

Nature

DOI

2020

SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism

Ming Shi, Long-Fei Wang, P. Fontana, Setu M. Vora, Ying Zhang, T. Fu, J. Lieberman, Hao Wu

bioRxiv

DOI

2020

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

Hao Wu, V. Estrella, M. Beatty, D. Abrahams, Asmaa El-Kenawi, Shonagh Russell, Arig Ibrahim-Hashim, D. Longo, Y. Reshetnyak, A. Moshnikova, O. Andreev, K. Luddy, Mehdi Damaghi, K. Kodumudi, S. Pillai, P. Enríquez-Navas, S. Pilon-Thomas, P. Swietach, R. Gillies

Nature Communications

DOI

2020

Higher-order assemblies in innate immune and inflammatory signaling: a general principle in cell biology?

Ming Shi, Pengfei Zhang, Setu M. Vora, Hao Wu

Current Opinion in Cell Biology

DOI

2020

Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly

J. Stinson, Batsukh Dorjbal, Dennis P. McDaniel, L. David, Hao Wu, A. Snow

Cellular Immunology

DOI

2020

Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs

Meng Zhang, M. Gui, Zi-Fu Wang, C. Gorgulla, James Yu, Hao Wu, Zhen-Yu J. Sun, C. Klenk, L. Merklinger, L. Morstein, F. Hagn, A. Plückthun, Alan Brown, M. Nasr, G. Wagner

Nature Structural & Molecular Biology

DOI

2020

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-associated Chronic Inflammation and Insulin Resistance

M. He, Hou-Hsien Chiang, Hanzhi Luo, Zhifang Zheng, Q. Qiao, Li Wang, Ming-Sheng Tan, Rika Ohkubo, Wei-Chieh Mu, Shimin Zhao, Hao Wu, Danica Chen

Cell Metabolism

DOI

2020

PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema.

A. Adini, Hao Wu, Duy T. Dao, Victoria H. Ko, Lu-Meng J. Yu, A. Pan, M. Puder, Selome Mitiku, Ratnakar Potla, Hong Chen, James M. Rice, Benjamin D. Matthews

American Journal of Respiratory Cell and Molecular Biology

DOI

2020

A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7

Chun-Xiao Yu, Long-Fei Wang, R. G. Rowe, Areum Han, Wanying Ji, C. McMahon, Alexander S. Baier, Yu-Chung Huang, William Marion, Daniel S Pearson, A. Kruse, George Q. Daley, Hao Wu, P. Śliż

Proceedings of the National Academy of Sciences of the United States of America

DOI

2020

425-P: Mechanisms Regulating VEGF Receptors in Diabetic Angiogenesis

Sudarshan Bhattacharjee, Hao Wu, Jian Xu, Hong Chen

Diabetes

DOI

2020

Epsins in Vascular Development, Function, and Disease

Sudarshan Bhattacharjee, Yang Lee, Bo Zhu, Hao Wu, Ya-Bing Chen, Hong Chen

Cellular and Molecular Life Sciences

DOI

2020

Akkermansia muciniphila Aspartic Protease Amuc_1434* Inhibits Human Colorectal Cancer LS174T Cell Viability via TRAIL-Mediated Apoptosis Pathway

Xin Meng, Jinrui Zhang, Hao Wu, Da-Hai Yu, Xuexun Fang

International Journal of Molecular Sciences

DOI

2020

Genome-wide CRISPR screen identifies semaphorin 6A and 6B as receptors for Paeniclostridium sordellii toxin TcsL

Songhai Tian, Yang Liu, Hao Wu, Hao Liu, Ji Zeng, M. Choi, Hong Chen, R. Gerhard, M. Dong

Cell Host and Microbe

DOI

2019

TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis

Ziyi Li, Hao Wu

Genome Biology

DOI

2019

Disease prediction by cell-free DNA methylation

H. Feng, P. Jin, Hao Wu

Briefings Bioinform.

DOI

2019

Differential methylation analysis for bisulfite sequencing using DSS

H. Feng, Hao Wu

Quantitative Biology

DOI

2019

Combined Immunodeficiency due to a loss of function mutation in DNA Polymerase Delta 1

Ye Cui, S. Keleş, L. Charbonnier, Amélie M. Julé, L. Henderson, Ş. Çelik, I. Reisli, Chen Shen, Wen-Jun Xie, K. Schmitz-Abe, Hao Wu, T. Chatila

Journal of Allergy and Clinical Immunology

DOI

2019

Molecular mechanism for NLRP6 inflammasome assembly and activation

Chen Shen, A. Lu, Wen-Jun Xie, J. Ruan, R. Negro, E. Egelman, T. Fu, Hao Wu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2019

Mimicry by a viral RHIM

M. Mompeán, G. Bozkurt, Hao Wu

EMBO Reports

DOI

2019

Peptide-based covalent inhibitors of MALT1 paracaspase

J. Hatcher, Guang-Yan Du, L. Fontán, I. Us, Q. Qiao, Spandan Chennamadhavuni, J. Shao, Hao Wu, A. Melnick, N. Gray, David A. Scott

Bioorganic & Medicinal Chemistry Letters

DOI

2019

Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation

Younho Choi, Stephanie Kim, Younho Choi, T. Nielsen, Jun Yan, A. Lu, J. Ruan, Hye-Ra Lee, Hao Wu, B. Spellberg, Jae U. Jung

Nature Immunology

DOI

2019

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Zsofia Bittner, Xiao Liu, María Mateo-Tórtola, Ana Tapia-Abellán, S. Shankar, L. Andreeva, M. Mangan, M. Spalinger, H. Kalbacher, P. Düwell, M. Lovotti, Karlotta Bosch, Sabine Dickhöfer, A. Marcu, S. Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, M. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, J. Kuemmerle-Deschner, Samuel Wagner, Anita Delor, B. Grimbacher, Oliver Hantschel, M. Scharl, Hao Wu, E. Latz, A. Weber

bioRxiv

DOI

2019

Keeping the Death Protein in Check

Long-Fei Wang, Hao Wu

Immunity

DOI

2019

Mechanism and Regulation of Gasdermin-Mediated Cell Death.

S. Xia, L. R. Hollingsworth, Hao Wu

Cold Spring Harbor Perspectives in Biology

DOI

2019

Quinoline and thiazolopyridine allosteric inhibitors of MALT1.

David A. Scott, J. Hatcher, Hongyan Liu, Ming-Peng Fu, Guang-Yan Du, L. Fontán, I. Us, Gabriella Casalena, Q. Qiao, Hao Wu, A. Melnick, N. Gray

Bioorganic & Medicinal Chemistry Letters

DOI

2019

Structure of the RSC complex bound to the nucleosome

You-Pi Ye, Hao Wu, Kangjing Chen, Cedric R. Clapier, N. Verma, Wen-Hao Zhang, H. Deng, B. Cairns, N. Gao, Zhu-Cheng Chen

Science

DOI

2019

Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4)

Li Wang, R. Ferrao, Qiu-Bai Li, J. Hatcher, H. Choi, S. Buhrlage, N. Gray, Hao Wu

Journal of Biological Chemistry

DOI

2019

Gasdermin D activity in inflammation and host defense

J. Lieberman, Hao Wu, J. Kagan

Science immunology

DOI

2019

Crystal structure of the WD40 domain dimer of LRRK2

Pengfei Zhang, Ying Fan, H. Ru, Li Wang, V. Magupalli, Susan S. Taylor, D. Alessi, Hao Wu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2019

Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.

Hao Wu, Lingyun Li, Kuan-Ming Chen, D. Homolka, P. Gos, F. Fleury-Olela, A. McCarthy, R. Pillai

Cell Reports

DOI

2019

Abstract A132: Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D

J. Hu, Xing Liu, Jing-Xia Zhao, S. Xia, J. Ruan, Xuemei Luo, Justin Kim, J. Lieberman, Hao Wu

Maintenance of Immune Balance: Effects of Targeted and Immune Therapies

DOI

2019

Structural mechanism for NEK7-licensed NLRP3 inflammasome activation

H. Sharif, Li Wang, Wei-Li Wang, V. Magupalli, L. Andreeva, Q. Qiao, Arthur V. Hauenstein, Zhao-Long Wu, G. Núñez, You-Dong Mao, Hao Wu

Nature

DOI

2019

Publisher Correction: Structures of the ISWI–nucleosome complex reveal a conserved mechanism of chromatin remodeling

Lijuan Yan, Hao Wu, Xue-Mei Li, N. Gao, Zhu-Cheng Chen

Nature Structural & Molecular Biology

DOI

2019

the crosslinked complex of ISWI-nucleosome in the ADP-bound state

Lijuan Yan, Hao Wu, Xue-Mei Li, N. Gao, Zhu-Cheng Chen

DOI

2019

Structural and mechanistic elucidation of inflammasome signaling by cryo-EM

Chen Shen, H. Sharif, S. Xia, Hao Wu

Current Opinion in Structural Biology

DOI

2019

Structures of the ISWI–nucleosome complex reveal a conserved mechanism of chromatin remodeling

Lijuan Yan, Hao Wu, Xue-Mei Li, N. Gao, Zhu-Cheng Chen

Nature Structural & Molecular Biology

DOI

2019

Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation

Megan L. Brophy, Yun-Zhou Dong, H. Tao, P. Yancey, Kai Song, Kun Zhang, Aiyun Wen, Hao Wu, Yang Lee, M. Malovichko, Srinivas D. Sithu, Scott W. Wong, Lili Yu, O. Kocher, J. Bischoff, S. Srivastava, M. Linton, K. Ley, Hong Chen

Circulation Research

DOI

2019

A Purified Aspartic Protease from Akkermansia Muciniphila Plays an Important Role in Degrading Muc2

Xin Meng, Wencheng Wang, Tian-Qi Lan, Wanxin Yang, Da-Hai Yu, Xuexun Fang, Hao Wu

International Journal of Molecular Sciences

DOI

2019

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

L. Fontán, J. Hatcher, D. Scott, Q. Qiao, I. Us, Guang-Yan Du, Matthew Durant, Jimmy P. Wilson, Hao Wu, N. Gray, A. Melnick

Blood

DOI

2019

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Yu-Ru Lee, Ming Chen, Jonathan D. Lee, Jinfang Zhang, Shu-Yu Lin, T. Fu, Hao Chen, Tomoki Ishikawa, Shang-Yin Chiang, Jesse Katon, Yang Zhang, Yulia V. Shulga, A. Bester, Jacqueline Fung, Emanuele Monteleone, L. Wan, Chen Shen, Chih-Hung Hsu, A. Papa, J. Clohessy, J. Teruya-Feldstein, Suresh Jain, Hao Wu, L. Matesic, Ruey-Hwa Chen, Wenyi Wei, P. Pandolfi

Science

DOI

2019

Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling

L. Pan, T. Fu, Wen-Yi Zhao, Linlin Zhao, Wen Chen, Chixiao Qiu, Wen-hui Liu, Zhi-Jun Liu, A. Piai, Q. Fu, Shu-Qing Chen, Hao Wu, J. Chou

Cell

DOI

2019

Cardosin A endocytosis mediated by integrin leads to lysosome leakage and apoptosis of epithelial cells

Hao Wu, P. Castanheira, C. Faro, Jordan Tang

Proteins: Structure, Function, and Bioinformatics

DOI

2019

Abstract A022: Gasdermin E suppresses tumor growth by activating antitumor immunity

Zhi-Bin Zhang, Ying Zhang, S. Xia, Qing Kong, Shun-Ying Li, Xing Liu, Caroline Junqueira, James A Ansara, Satyaki Sengupta, Yan-Dan Yao, Hao Wu, J. Lieberman

Apoptosis, Necrosis, and Autophagy

DOI

2018

Parameter Uncertainty in Structural Equation Models: Confidence Sets and Fungible Estimates

Jolynn Pek, Hao Wu

Psychological Methods，Vol. 230, No. 40

DOI

2018

Approximations to the distribution of a test statistic in covariance structure analysis: A comprehensive study

Hao Wu

British Journal Of Mathematical & Statistical Psychology，Vol. 710, No. 2

DOI

2018

Dissecting differential signals in high-throughput data from complex tissues

Ziyi Li, Zhi-Jin Wu, P. Jin, Hao Wu

bioRxiv

DOI

2018

Two-phase differential expression analysis for single cell RNA-seq

Zhi-Jin Wu, Yi Zhang, M. Stitzel, Hao Wu

Bioinform.

DOI

2018

InfiniumPurify: An R package for estimating and accounting for tumor purity in cancer methylation research

Yu-Fang Qin, H. Feng, Ming Chen, Hao Wu, Xiaoqi Zheng

Genes and Diseases

DOI

2018

A comprehensive review of computational prediction of genome-wide features.

Tianlei Xu, Xiaoqi Zheng, Ben Li, P. Jin, Z. Qin, Hao Wu

Briefings in Bioinformatics

DOI

2018

Mechanism of ubiquitin transfer promoted by TRAF6

T. Fu, Chen Shen, Qiu-Bai Li, Pengfei Zhang, Hao Wu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2018

Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth

L. Fontán, Q. Qiao, J. Hatcher, Gabriella Casalena, I. Us, Matt Teater, Matthew Durant, Guang-Yan Du, M. Xia, Natalia Bilchuk, Spandan Chennamadhavuni, G. Palladino, G. Inghirami, U. Philippar, Hao Wu, David A. Scott, N. Gray, A. Melnick

Journal of Clinical Investigation

DOI

2018

INAUGURAL ARTICLE by a Recently Elected Academy Member:Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1

Yang Li, T. Fu, A. Lu, K. Witt, J. Ruan, Chen Shen, Hao Wu

DOI

2018

Pathogen blockade of TAK1 triggers caspase-8 dependent cleavage of Gasdermin D and cell death

Pontus Orning, D. Weng, K. Starheim, D. Ratner, Z. Best, Bettina L. Lee, A. Brooks, S. Xia, Hao Wu, M. Kelliher, Scott B. Berger, P. Gough, J. Bertin, Megan M Proulx, J. Goguen, N. Kayagaki, K. Fitzgerald, E. Lien

Science

DOI

2018

Structures and gating mechanism of human TRPM2

Long-Fei Wang, T. Fu, Yiming Zhou, S. Xia, A. Greka, Hao Wu

Science

DOI

2018

Ectopic lipid accumulation: potential role in tubular injury and inflammation in diabetic kidney disease.

Wen-xia Yang, Ying Luo, Shi-Kun Yang, Mengru Zeng, Shu-Min Zhang, Jia-lu Liu, Yu-zhang Han, Yu Liu, Xue-Jing Zhu, Hao Wu, Fu-You Liu, Lin Sun, Li Xiao

Clinical science

DOI

2018

Abstract 231: The Role of Epsin in Regulating SR-B1 Function and Lipid Metabolism in Atherosclerosis

Kai Song, Megan L. Brophy, Yun-Zhou Dong, Hao Wu, A. F. M. Moshiur Rahman, Hong Chen

DOI

2018

Mutation analysis of the ADAR1 gene in a pedigree with dyschromatosis symmetrica hereditaria

Yuanhaoqi Chen, Ya-Ning Jiao, Biao Yang, Hui Dong, Hao Wu, Nan Yu, Xin-Hong Ge

DOI

2018

The Structure of the Necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex

M. Mompeán, Wenbo Li, Ji-Xi Li, Ségolène Laage, Ansgar B. Siemer, G. Bozkurt, Hao Wu, A. McDermott

Cell

DOI

2018

Gene expression profiles of rat MMECs with different glucose levels and fgl2 gene silencing

Zhen-Zhong Zheng, Fan Zhang, Deng-Peng Gao, Yu-Jing Wu, Hao Wu

Diabetes/Metabolism Research Reviews

DOI

2018

Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome

L. David, Yang Li, Jun Ma, E. Garner, Xinzheng Zhang, Hao Wu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2018

Fibrinogen‐like protein‐2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death‐1 and inflammatory cytokines

Zhen-Zhong Zheng, Yinghui Yu, Ratnakar Potla, Yu-Jing Wu, Hao Wu

Immunology

DOI

2018

Inflammation NODs to Antagonists of RIP2-XIAP Interaction

S. Xia, T. Fu, Hao Wu

Molecules and Cells

DOI

2018

Structural gymnastics of RAG-mediated DNA cleavage in V(D)J recombination

H. Ru, Pengfei Zhang, Hao Wu

Current Opinion in Structural Biology

DOI

2018

Cryo-EM structure of the gasdermin A3 membrane pore

J. Ruan, S. Xia, Xing Liu, J. Lieberman, Hao Wu

Nature

DOI

2018

RING finger protein 38 induces gastric cancer cell growth by decreasing the stability of the protein tyrosine phosphatase SHP‐1

Jigang Zhang, Hao Wu, Bin Yi, Jian Zhou, Lu-Xin Wei, Yan Chen, Lifeng Zhang

FEBS Letters

DOI

2018

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential

R. Feltham, K. Jamal, T. Tenev, G. Liccardi, I. Jaco, C. Domingues, O. Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J. Kearney, Danielle M. Clancy, P. Elliott, Timo Glatter, Q. Qiao, A. Thompson, A. Nesvizhskii, A. Schmidt, D. Komander, Hao Wu, Seamus J. Martin, P. Meier

Cell Reports

DOI

2018

Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes

Hao Wu, H. N. Ashiqur Rahman, Yun-Zhou Dong, Xiaolei Liu, Yang Lee, Aiyun Wen, K. H. To, Li Xiao, A. Birsner, L. Bazinet, Scott W. Wong, Kai Song, Megan L. Brophy, M. R. Mahamud, Baojun Chang, Xiaofeng Cai, Satish Pasula, Sukyoung Kwak, Wen-xia Yang, J. Bischoff, Jian Xu, D. Bielenberg, J. B. Dixon, R. D'Amato, R. Srinivasan, Hong Chen

Journal of Clinical Investigation

DOI

2018

Rescue of Fragile X syndrome neurons by DNA methylation editing of the FMR1 gene

X. S. Liu, Hao Wu, Marine Krzisch, Xue-Bing Wu, J. Graef, J. Muffat, Denes Hnisz, Charles H. Li, Bingbing Yuan, Chuan-Yun Xu, Yun Li, Dan Vershkov, A. Cacace, R. Young, R. Jaenisch

Cell

DOI

2018

DNA melting initiates the RAG catalytic pathway

H. Ru, W. Mi, Pengfei Zhang, F. Alt, D. Schatz, M. Liao, Hao Wu

Nature Structural & Molecular Biology

DOI

2018

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1.

A. Koh, A. Molinaro, M. Ståhlman, Muhammad Tanweer Khan, C. Schmidt, L. Mannerås-Holm, Hao Wu, A. Carreras, Heeyoon Jeong, L. Olofsson, Per-Olof Bergh, Victor Gerdes, A. Hartstra, M. D. de Brauw, R. Perkins, Max Nieuwdorp, G. Bergström, F. Bäckhed

Cell

DOI

2018

Bad germs are trapped

Li-Man Zhang, Hao Wu

Cell Research

DOI

2017

Confidence Intervals of Fit Indexes by Inverting a Bootstrap Test

Chuchu Cheng, Hao Wu

Structural Equation Modeling-A Multidisciplinary Journal，Vol. 240, No. 60

DOI

2017

PLEMT: A NOVEL PSEUDOLIKELIHOOD BASED EM TEST FOR HOMOGENEITY IN GENERALIZED EXPONENTIAL TILT MIXTURE MODELS

Chuan Hong, Yang Ning, Shuang Wang, Hao Wu, R. Carroll, Yong Chen

Journal of the American Statistical Association

DOI

2017

Differential Gene Network Analysis from Single Cell RNA-Seq

Yikai Wang, Hao Wu, Tianwei Yu

Journal of genetics and genomics = Yi chuan xue bao

DOI

2017

Accounting for tumor purity improves cancer subtype classification from DNA methylation data

Weiwei Zhang, H. Feng, Hao Wu, Xiaoqi Zheng

Bioinform.

DOI

2017

Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studies

Xiaoqi Zheng, Naiqian Zhang, Hua-Jun Wu, Hao Wu

Genome Biology

DOI

2017

FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats

Zhen-Zhong Zheng, Long-Hui Yu, Yu-Jing Wu, Hao Wu

Immunologic research

DOI

2017

CIDE domains form functionally important higher-order assemblies for DNA fragmentation

Jae Young Choi, Q. Qiao, Se-hoon Hong, Chang Min Kim, Jae-Hee Jeong, Y. Kim, Yong-Keun Jung, Hao Wu, Hyun Ho Park

Proceedings of the National Academy of Sciences of the United States of America

DOI

2017

Analysis on the correlation of HSP-70 with brain’s promoting angiogenesis molecules or α5β1, αVβ3 in acute atherosclerosis cerebral infarction

Hao Wu, Chaowen Sun, Congli Jin, Wan-Xin Jie

DOI

2017

Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling

Yun-Zhou Dong, Hao Wu, Jerry Dong, Kai Song, H. N. Rahman, R. Towner, Hong Chen

Vessel Plus

DOI

2017

Eating the Dead to Keep Atherosclerosis at Bay

Megan L. Brophy, Yun-Zhou Dong, Hao Wu, H. N. Ashiqur Rahman, Kai Song, Hong Chen

Frontiers in Cardiovascular Medicine

DOI

2017

Evidence for M1-linked Polyubiquitin-Mediated Conformational Change in NEMO

Arthur V. Hauenstein, Guozhou Xu, V. Kabaleeswaran, Hao Wu

Journal of Molecular Biology

DOI

2017

Cryo-EM structure of the DNA-PK holoenzyme

H. Sharif, Yang Li, Yuanchen Dong, Liyi Dong, Wei-Li Wang, You-Dong Mao, Hao Wu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2017

Instant Hydrogelation Inspired by Inflammasomes

Huai-Min Wang, Zhaoqianqi Feng, A. Lu, Yujie Jiang, Hao Wu, Bing Xu

Angewandte Chemie

DOI

2017

Crystal structure of human IRAK1

Li Wang, Q. Qiao, R. Ferrao, Chen Shen, J. Hatcher, S. Buhrlage, N. Gray, Hao Wu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2017

Sirolimus for the treatment of progressive kaposiform hemangioendothelioma: A multicenter retrospective study

Yi Ji, Si-Yuan Chen, B. Xiang, Kai Li, Zhi-Cheng Xu, W. Yao, Guo-Yan Lu, Xingtao Liu, Chuncao Xia, Qi Wang, Yanan Li, Chuan Wang, Kai-Ying Yang, Gang Yang, Xueyang Tang, Ting Xu, Hao Wu

International Journal of Cancer

DOI

2017

Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT)

L. Yi, G. Bozkurt, Qiu-Bai Li, Stanley M. Lo, A. Menon, Hao Wu

Scientific Reports

DOI

2017

Ruxolitinib reverses Dysregulated T Helper Cell Responses and controls Autoimmunity caused by a Novel STAT1 Gain of Function Mutation

Katja G. Weinacht, L. Charbonnier, Fayhan J. Alroqi, Ashley Plant, Q. Qiao, Hao Wu, Clement Ma, T. Torgerson, S. Rosenzweig, T. Fleisher, L. Notarangelo, I. Hanson, L. Forbes, T. Chatila

Journal of Allergy and Clinical Immunology

DOI

2017

Abstract LB-303: Substrate-mimetic covalent inhibitor of MALT1 is most effective against CARD11 mutant ABC-DLBCL

L. Fontán, D. Scott, J. Hatcher, Q. Qiao, I. Us, Gabriella Casalena, M. Bekkers, U. Philippar, Matthew Durant, Spandan Chennamadhavuni, Hao Wu, N. Gray, A. Melnick

DOI

2017

Abstract 94: Deficiency of Epsins in Macrophages Ameliorates Atherosclerosis by Attenuating Inflammation

Megan L. Brophy, Yun-Zhou Dong, Hao Wu, Kai Song, A. F. M. Moshiur Rahman, Aiyun Wen, Sukyoung Kwak, Scott W. Wong, K. Krygier, K. Ley, Hong Chen

2017

Understanding CARD Tricks in Apoptosomes

Li Wang, Q. Qiao, Hao Wu

Structure

DOI

2017

AID Recognizes Structured DNA for Class Switch Recombination

Q. Qiao, Li Wang, Fei-Long Meng, Joyce K. Hwang, F. Alt, Hao Wu

Molecules and Cells

DOI

2017

Tailoring the binding properties of SpA Ig binding domains by in vitro molecular evolution

Li-Li Wang, Ying-Ying Ding, Ziyu Lin, J. Bai, Chun-Yan Zhao, Caixia Gao, Jiaojiao Feng, Jin-Hong Wang, Bing Rui, Xiang-Yu Li, Hao Wu, Bao-Hua Qian, W. Pan

2017

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer

Y. Zhai, E. Cheng, Hao Wu, Ning-Ning Li, P. Yung, N. Gao, B. Tye

Nature Structural &Molecular Biology

DOI

2017

The pore forming protein gasdermin D regulates interleukin-1 secretion from living macrophages

C. Evavold, J. Ruan, Yun-Hao Tan, S. Xia, Hao Wu, J. Kagan

Immunity

DOI

2017

Abstract 212: Endothelium-Specific Deletion of Epsins Attenuates Atherosclerosis in ApoE-deficient Mouse Model Through Stabilization of IP3 Receptor 1 and Maintaining ER Homeostasis

Yun-Zhou Dong, Megan L. Brophy, Aiyun Wen, Lili Yu, Hao Wu, Kai Song, A. F. M. Moshiur Rahman, Scott W. Wong, Sukyoung Kwak, K. Krygier, Hong Chen

2016

A Note on the Identifiability of Fixed-Effect 3PL Models

Hao Wu

Psychometrika，Vol. 810, No. 4

DOI

2016

Identification of Confirmatory Factor Analysis Models of Different Levels of Invariance for Ordered Categorical Outcomes

Hao Wu, Ryne Estabrook

Psychometrika，Vol. 810, No. 4

DOI

2016

Raw Data Maximum Likelihood Estimation for Common Principal Component Models: A State Space Approach

Fei Gu, Hao Wu

Psychometrika，Vol. 810, No. 3

DOI

2016

A Scaled F Distribution as an Approximation to the Distribution of Test Statistics in Covariance Structure Analysis

Hao Wu, Johnny Lin

Structural Equation Modeling-A Multidisciplinary Journal，Vol. 230, No. 30

DOI

2016

Differential methylation analysis for BS-seq data under general experimental design

Yongseok Park, Hao Wu

Bioinform.

DOI

2016

Measuring the spatial correlations of protein binding sites

Ying-Ying Wei, Hao Wu

Bioinform.

DOI

2016

ROC Curve Analysis in the Presence of Imperfect Reference Standards

Pei-Zhou Liao, Hao Wu, Tianwei Yu

Statistics in Biosciences

DOI

2016

Statistical challenges in analyzing methylation and long-range chromosomal interaction data

Z. Qin, Ben Li, K. Conneely, Hao Wu, Ming Hu, D. Ayyala, Yongseok Park, Victor X. Jin, Fangyuan Zhang, Han Zhang, Li Li, Shili Lin

Statistics in Biosciences

DOI

2016

Network-Based Method for Inferring Cancer Progression at the Pathway Level from Cross-Sectional Mutation Data

Hao Wu, Lin Gao, N. Kasabov

IEEE/ACM Transactions on Computational Biology & Bioinformatics

DOI

2016

Experimental Design and Power Calculation for RNA-seq Experiments

Zhi-Jin Wu, Hao Wu

Statistical Genomics

DOI

2016

Tumor purity and differential methylation in cancer epigenomics.

Fayou Wang, Naiqian Zhang, Jun Wang, Hao Wu, Xiaoqi Zheng

Briefings in Functional Genomics

DOI

2016

NanoStringDiff: a novel statistical method for differential expression analysis based on NanoString nCounter data

Hong Wang, C. Horbinski, Hao Wu, Yin-Xing Liu, Shaoyi Sheng, Jin-Peng Liu, H. Weiss, A. Stromberg, Chi Wang

Nucleic Acids Research

DOI

2016

Differential analyses with DSS

Hao Wu

2016

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

I. Zanoni, Yun-Hao Tan, Marco di Gioia, A. Broggi, J. Ruan, Jianjin Shi, C. Donado, F. Shao, Hao Wu, James R. Springstead, J. Kagan

Science

DOI

2016

Abstract A174: Mechanistic elucidation of activation-induced deaminase (AID) in immunity and cancer

Q. Qiao, Li Wang, Fei-Long Meng, Hao Wu

DOI

2016

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death Inducing Signaling Complex

T. Fu, Yang Li, A. Lu, Zongli Li, P. Vajjhala, Anthony C. Cruz, D. B. Srivastava, F. DiMaio, P. Penczek, R. Siegel, K. J. Stacey, E. Egelman, Hao Wu

Molecules and Cells

DOI

2016

Abstract B073: Structural basis of the 12-23 rule in V(D)J recombination

H. Ru, M. Chambers, M. Liao, Hao Wu

DOI

2016

Abstract 257: Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-mediated Angiogenesis

H. N. Rahman, Hao Wu, Satish Pasula, Yun-Zhou Dong, Aiyun Wen, Ye Sun, Megan L. Brophy, K. L. Tessneer, Xiaofeng Cai, John R. McManus, Baojun Chang, Sukyoung Kwak, Hong Chen

2016

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

E. Janssen, Mira Tohmé, M. Hedayat, Marion Leick, Sudha Kumari, N. Ramesh, M. Massaad, Sumana Ullas, V. Azcutia, C. Goodnow, Katrina L. Randall, Q. Qiao, Hao Wu, W. Al-Herz, D. Cox, J. Hartwig, D. Irvine, F. Luscinskas, R. Geha

Journal of Clinical Investigation

DOI

2016

Inflammasome - activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu, Zhi-Bin Zhang, J. Ruan, You-Dong Pan, V. Magupalli, Hao Wu, J. Lieberman

Nature

DOI

2016

Abstract B122: Molecular mechanism of V(D)J recombination from synaptic RAG1-RAG2 complex structures

H. Ru, M. Chambers, T. Fu, Alexander B. Tong, M. Liao, Hao Wu

DOI

2016

Molecular basis of caspase-1 polymerization and its inhibition by a novel capping mechanism

A. Lu, Yang Li, F. Schmidt, Q. Yin, Shuobing Chen, T. Fu, Alexander B. Tong, H. Ploegh, You-Dong Mao, Hao Wu

Nature Structural &Molecular Biology

DOI

2016

Parent-of-origin DNA methylation dynamics during mouse development

Y. Stelzer, Hao Wu, Yue-Lin Song, C. Shivalila, S. Markoulaki, R. Jaenisch

Cell Reports

DOI

2016

Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis

Yun-Zhou Dong, Conrad Fernandes, Yan-Jun Liu, Yong Wu, Hao Wu, Megan L. Brophy, Lin Deng, Kai Song, Aiyun Wen, Scott W. Wong, Daoguang Yan, R. Towner, Hong Chen

Diabetes & vascular disease research

DOI

2016

Editing DNA methylation in the mammalian genome

X. Liu, Hao Wu, Xiong Ji, Y. Stelzer, Xue-Bing Wu, Szymon Czauderna, J. Shu, D. Dadon, R. Young, R. Jaenisch

Cell

DOI

2016

A Structure and Dynamics Continuum of Higher-Order Assemblies: Amyloids, Signalosomes and Granules

Hao Wu, M. Fuxreiter

Cell

DOI

2016

DOCK8 Regulates STAT3 Activation and Promotes Th17 Cell Differentiation

S. Keleş, L. Charbonnier, V. Kabaleeswaran, I. Reisli, F. Genel, N. Gulez, W. Al-Herz, N. Ramesh, A. Perez-Atayde, N. Karaca, N. Kutukculer, Hao Wu, R. Geha, T. Chatila

Journal of Allergy and Clinical Immunology

DOI

2016

Structural Elucidation of Innate Immunity

Hao Wu

DOI

2016

Characterization of T and B cell repertoire diversity in patients with RAG deficiency

Yu-Nee Lee, Francesco Frugoni, K. Dobbs, I. Tirosh, Li-Kun Du, F. Ververs, H. Ru, Lisa Ott de Bruin, Mehdi M. Adeli, Jacob H. Bleesing, D. Buchbinder, M. Butte, C. Cancrini, Karin Chen, S. Choo, Reem Elfeky, A. Finocchi, R. Fuleihan, A. Gennery, D. El-Ghoneimy, L. Henderson, W. Al-Herz, E. Hossny, R. Nelson, S. Pai, N. Patel, S. Reda, P. Soler-Palacín, R. Somech, A. Palma, Hao Wu, S. Giliani, J. Walter, L. Notarangelo

Science immunology

DOI

2016

Abstract A183: Molecular elucidation of the CBM complex in NF-kappaB activation by using single molecule imaging and structural studies

L. David, Hao Wu

DOI

2016

Abstract 607: Modulating VEGFR3 Signaling by Epsins Regulates Lymphatic Dysfuntion in Diabetes

Hong Chen, Hao Wu, Ashiqur Rhaman

2016

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

Q. Fu, T. Fu, Anthony C. Cruz, Prabuddha Sengupta, S. Thomas, Shuqing Wang, R. Siegel, Hao Wu, J. Chou

Molecules and Cells

DOI

2016

Abstract B134:Cryo-EMstructure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

Li-Man Zhang, Shuobing Chen, J. Ruan, L. David, You-Dong Mao, Hao Wu

DOI

2015

Profile Likelihood-Based Confidence Intervals and Regions for Structural Equation Models

Jolynn Pek, Hao Wu

Psychometrika，Vol. 800, No. 4

DOI

2015

Quantifying Adventitious Error in a Covariance Structure as a Random Effect

Hao Wu, Michael W. Browne

Psychometrika，Vol. 800, No. 3

DOI

2015

Random Model Discrepancy: Interpretations and Technicalities (A Rejoinder)

Hao Wu, Michael W. Browne

Psychometrika，Vol. 800, No. 3

DOI

2015

Inference of cancer progression from somatic mutation data

Hao Wu, Lin Gao, N. Kasabov

DOI

2015

Predicting tumor purity from methylation microarray data

N. Zhang, Hua-Jun Wu, Weiwei Zhang, Jun Wang, Hao Wu, Xiaoqi Zheng

Bioinform.

DOI

2015

PROPER: comprehensive power evaluation for differential expression using RNA-seq

Hao Wu, Chi Wang, Zhi-Jin Wu

Bioinform.

DOI

2015

Base-resolution methylation patterns accurately predict transcription factor bindings in vivo

Tianlei Xu, Ben Li, Meng Zhao, Keith E. Szulwach, R. Street, Li Lin, Bing Yao, Fei-Ran Zhang, P. Jin, Hao Wu, Z. Qin

Nucleic Acids Research

DOI

2015

Local false discovery rate estimation using feature reliability in LC/MS metabolomics data

Elizabeth Y. Chong, Yijian Huang, Hao Wu, N. Ghasemzadeh, K. Uppal, A. Quyyumi, Dean P. Jones, Tianwei Yu

Scientific Reports

DOI

2015

Identifying overlapping mutated driver pathways by constructing gene networks in cancer

Hao Wu, Lin Gao, Feng Li, Fei Song, Xiaofei Yang, N. Kasabov

BMC Bioinformatics

DOI

2015

Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates

Hao Wu, Tianlei Xu, H. Feng, Li Chen, Ben Li, Bing Yao, Z. Qin, P. Jin, K. Conneely

Nucleic Acids Research

DOI

2015

Motif mimetic of epsin perturbs tumor growth and metastasis.

Yun-Zhou Dong, Hao Wu, H. N. Rahman, Yanjun Liu, Satish Pasula, K. L. Tessneer, Xiaofeng Cai, Xiaolei Liu, Baojun Chang, John R. McManus, Scott A. Hahn, Jiali Dong, Megan L. Brophy, Lili Yu, Kai Song, R. Silasi-Mansat, D. Saunders, Charity Njoku, Hoogeun Song, Padmaja Mehta-D’souza, R. Towner, F. Lupu, R. McEver, Lijun Xia, D. Boerboom, R. Srinivasan, Hong Chen

Journal of Clinical Investigation

DOI

2015

A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation

Benoît Laurent, Rui-Tu Lv, J. Murn, Kristina Hempel, R. Ferrao, Yang Xiang, Shi-Chong Liu, B. Garcia, Hao Wu, Fei-Zhen Wu, Hanno Steen, Yang Shi

Molecules and Cells

DOI

2015

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2

A. Lu, Yang Li, Q. Yin, J. Ruan, Xiong Yu, E. Egelman, Hao Wu

Cell Discovery

DOI

2015

Epsin is required for Dishevelled stability and Wnt signaling activation in colon cancer development

Baojun Chang, K. L. Tessneer, John R. McManus, Xiaolei Liu, Scott A. Hahn, Satish Pasula, Hao Wu, Hoogeun Song, Yi-Yuan Chen, Xiaofeng Cai, Yun-Zhou Dong, Megan L. Brophy, Ruby Rahman, Jian-Xing Ma, Lijun Xia, Hong Chen

Nature Communications

DOI

2015

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

H. Ru, M. Chambers, T. Fu, Alexander B. Tong, M. Liao, Hao Wu

Cell

DOI

2015

Structural Biology of Innate Immunity

Q. Yin, T. Fu, Ji-Xi Li, Hao Wu

Annual Review of Immunology

DOI

2015

Abstract A19: MALT1 inhibition as an anchor for combinatorial therapy of ABC-DLBCL.

L. Fontán, Cheng-Hua Yang, Himaly Shinglot, V. Kabaleeswaran, V. Laurent, M. J. Osborne, E. Beltrán, Monica Rosen, R. Shaknovich, Shao N. Yang, R. Gascoyne, L. Cerchietti, J. Martinez-Climent, J. F. Glickman, K. Borden, Hao Wu, A. Melnick

DOI

2015

Abstract 141: The Role of Macrophage Epsins in the Regulation of LRP-1 in Atherosclerosis

Megan L. Brophy, Yun-Zhou Dong, K. L. Tessneer, Hoogeun Song, Satish Pasula, Xiaofeng Cai, Baojun Chang, Hao Wu, K. Ley, Hong Chen

Arteriosclerosis, Thrombosis and Vascular Biology

DOI

2015

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

Li-Man Zhang, Shuobing Chen, J. Ruan, Jiayi Wu, Alexander B. Tong, Q. Yin, Yang Li, L. David, A. Lu, Wei-Li Wang, Carolyn B. Marks, Q. Ouyang, Xin-Zheng Zhang, You-Dong Mao, Hao Wu

Science

DOI

2015

The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines

Arthur V. Hauenstein, Li-Man Zhang, Hao Wu

Current Opinion in Structural Biology

DOI

2015

Abstract 33: Role of Epsins in Regulating LPS-Induced Sepsis

Satish Pasula, Megan L. Brophy, K. L. Tessneer, Scott A. Hahn, John R. McManus, Hua Zhu, Baojun Chang, Yun-Zhou Dong, Xiaofeng Cai, Hoogeun Song, Hao Wu, Hong Chen

Arteriosclerosis, Thrombosis and Vascular Biology

DOI

2015

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments*

P. Vajjhala, A. Lu, Darren L. Brown, S. Pang, V. Sagulenko, D. Sester, S. Cridland, J. Hill, K. Schroder, J. Stow, Hao Wu, K. J. Stacey

Journal of Biological Chemistry

DOI

2014

A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

Xiaofei Yang, Lin Gao, Xing-Li Guo, Xing-Hua Shi, Hao Wu, Fei Song, Bing-Bo Wang

PLoS ONE

DOI

2014

A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data

H. Feng, K. Conneely, Hao Wu

Nucleic Acids Research

DOI

2014

PolyaPeak: Detecting Transcription Factor Binding Sites from ChIP-seq Using Peak Shape Information

Hao Wu, H. Ji

PLoS ONE

DOI

2014

Incorporating feature reliability in false discovery rateestimation improves statistical power to detect differentially expressed features

Elizabeth Y. Chong, Yijian Huang, Hao Wu, Tianwei Yu, N. Ghasemzadeh, K. Uppal, A. Quyyumi, Dean P. Jones

International Conference on Systems Biology

DOI

2014

What’s Your Favorite Crystal Structure?

Hao Wu

Cell

DOI

2014

Single aromatic residue location alters nucleic acid binding and chaperone function of FIV nucleocapsid protein

Hao Wu, Wen Wang, N. Naiyer, Eric J Fichtenbaum, D. Qualley, Micah J. McCauley, R. Gorelick, I. Rouzina, K. Musier-Forsyth, Mark C. Williams

Virus Research

DOI

2014

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

Hao Wu, Yi Zhang

Cell

DOI

2014

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

W. Yue, Zi-Heng Chen, Hai-Yang Liu, Chen Yan, Ming Chen, D. Feng, Chao-Jun Yan, Hao Wu, Lei Du, Yueying Wang, Jin-Hua Liu, Xiaohu Huang, Laixin Xia, Lei Liu, Xiaohui Wang, Haijing Jin, Jun Wang, Zhiyin Song, X. Hao, Quan Chen

Cell Research

DOI

2014

Abstract 15705: Novel Epsin-VEGFR2 Interactions Facilitated by c-Cbl Ubiquitination of Epsin and VEGFR2 Regulate VEGFR2 Signaling and Physiological and Pathological Angiogenesis

Hoogeun Song, Satish Pasula, Megan L. Brophy, K. L. Tessneer, Hao Wu, Yun-Zhou Dong, Hong Chen

2014

Structural Study of the RIPoptosome Core Reveals a Helical Assembly for Kinase Recruitment

T. Jang, Chao Zheng, Ji-Xi Li, Claire Richards, Yu-Shan Hsiao, T. Walz, Hao Wu, Hyun Ho Park

Biochemistry

DOI

2014

Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of its Self-association to DED/DED Interactions

A. Lu, V. Kabaleeswaran, T. Fu, V. Magupalli, Hao Wu

Journal of Molecular Biology

DOI

2014

N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment

B. Soh, Kristina Buac, Huansheng Xu, Edward B. Li, Shi-Yan Ng, Hao Wu, J. Chmielowiec, Xin Jiang, Lei Bu, Ronald A. Li, C. Cowan, K. Chien

Cell Research

DOI

2014

IRAK4 Dimerization and Trans-autophosphorylation are Induced by Myddosome Assembly

R. Ferrao, Hao Zhou, Y. Shan, Qun Liu, Qiu-Bai Li, D. E. Shaw, Xiao-Xia Li, Hao Wu

Molecules and Cells

DOI

2014

Unified Polymerization Mechanism for the Assembly of ASC-dependent Inflammasomes

A. Lu, V. Magupalli, J. Ruan, Q. Yin, M. Atianand, M. Vos, G. Schröder, K. Fitzgerald, Hao Wu, E. Egelman

Cell

DOI

2014

SMOCs: supramolecular organizing centres that control innate immunity

J. Kagan, V. Magupalli, Hao Wu

Nature reviews. Immunology

DOI

2014

Extraluminal distraction enterogenesis using shape-memory polymer.

J. Fisher, Eric A. Sparks, Faraz A. Khan, B. Dionigi, Hao Wu, Joseph A. Brazzo, D. Fauza, Biren P. Modi, D. Safranski, T. Jaksic

Journal of Pediatric Surgery

DOI

2014

A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination

Julie R. Wilkerson, Nien-Pei Tsai, M. A. Maksimova, Hao Wu, Nicole P Cabalo, K. Loerwald, J. Dictenberg, Jay R. Gibson, K. Huber

Cell Reports

DOI

2014

Structural mechanisms of inflammasome assembly

A. Lu, Hao Wu

The FEBS Journal

DOI

2014

Abstract 2693: Harnessing MALT1 inhibition for rational combinatorial therapy of ABC-DLBCL

L. Fontán, Cheng-Hua Yang, V. Kabaleeswaran, L. Volpon, M. J. Osborne, E. Beltrán, Monica Rosen, R. Shaknovich, Shao N. Yang, R. Gascoyne, L. Cerchietti, J. Martinez-Climent, J. F. Glickman, K. Borden, Hao Wu, A. Melnick

DOI

2014

Promiscuity Is Not Always Bad

H. Ru, Pengfei Zhang, Hao Wu

Molecules and Cells

DOI

2014

Temporal and Spatial Regulation of Epsin Abundance and VEGFR3 Signaling are Required for Lymphatic Valve Formation and Function

Xiaolei Liu, Satish Pasula, Hoogeun Song, K. L. Tessneer, Yun-Zhou Dong, Scott A. Hahn, T. Yago, Megan L. Brophy, Baojun Chang, Xiaofeng Cai, Hao Wu, John R. McManus, Hirotake Ichise, C. Georgescu, J. Wren, Courtney T. Griffin, Lijun Xia, R. Srinivasan, Hong Chen

Science Signaling

DOI

2013

On the likelihood ratio tests in bivariate acde models

Hao Wu, Michael C. Neale

Psychometrika，Vol. 780, No. 3

DOI

2013

Exploring the Cooccurrence Patterns of Multiple Sets of Genomic Intervals

Hao Wu, Z. Qin

BioMed Research International

DOI

2013

Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme

Timothy T Lu, Michio Onizawa, G. Hammer, Emre E. Turer, Q. Yin, Ermelinda Damko, Alexander Agelidis, N. Shifrin, R. Advincula, Julio Barrera, Barbara A. Malynn, Hao Wu, A. Ma

Immunity

DOI

2013

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

Q. Qiao, Cheng-Hua Yang, Chao Zheng, L. Fontán, L. David, Xiong Yu, Clay Bracken, Monica Rosen, A. Melnick, E. Egelman, Hao Wu

Molecules and Cells

DOI

2013

Molecular Basis of NF-κB Signaling

Johanna Napetschnig, Hao Wu

Annual Review of Biophysics

DOI

2013

Molecular Mechanism for p202-mediated Specific Inhibition of AIM2 Inflammasome Activation

Q. Yin, D. Sester, Yuan Tian, Yu-Shan Hsiao, A. Lu, Jasmyn A. Cridland, V. Sagulenko, S. Thygesen, D. Choubey, V. Hornung, T. Walz, K. J. Stacey, Hao Wu

Cell Reports

DOI

2013

Differential contribution of basic residues to HIV-1 nucleocapsid protein’s nucleic acid chaperone function and retroviral replication

Hao Wu, Mithun Mitra, M. N. Naufer, Micah J. McCauley, R. Gorelick, I. Rouzina, K. Musier-Forsyth, Mark C. Williams

Nucleic Acids Research

DOI

2013

Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics

Li Shen, Hao Wu, D. Dinh, Shinpei Yamaguchi, A. D'Alessio, A. Fung, Kun Zhang, Yi Zhang

Cell

DOI

2013

Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism

Hao Wu, D. Downs, K. Ghosh, A. Ghosh, P. Staib, M. Monod, Jordan Tang

The FASEB Journal

DOI

2013

The CBM signalosome: Potential therapeutic target for aggressive lymphoma?

Cheng-Hua Yang, L. David, Q. Qiao, Ermelinda Damko, Hao Wu

Cytokine & growth factor reviews

DOI

2013

Structural Basis of Signal Transduction in the TNF Receptor Superfamily

Ji-Xi Li, Q. Yin, Hao Wu

Advances in Immunology

DOI

2013

Higher-Order Assemblies in a New Paradigm of Signal Transduction

Hao Wu

Cell

DOI

2013

Crystal structure and versatile functional roles of the COP9 signalosome subunit 1

Jung-Hoon Lee, L. Yi, Ji-Xi Li, Katrin Schweitzer, Marc Borgmann, M. Naumann, Hao Wu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2013

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics

Li Shen, Hao Wu, D. Dinh, A. D'Alessio, A. Fung, Kun Zhang, Yi Zhang

Epigenetics & Chromatin

DOI

2012

Adjusted Confidence Intervals for a Bounded Parameter

Hao Wu, Michael C. Neale

Behavior Genetics，Vol. 420, No. 60

DOI

2012

JAMIE: A software tool for jointly analyzing multiple ChIP-chip experiments.

Hao Wu, H. Ji

Methods in molecular biology

DOI

2012

A new shrinkage estimator for dispersion improves differential expression detection in RNA-seq data

Hao Wu, Chi Wang, Zhi-Jin Wu

Biostatistics

DOI

2012

Structural Insights in the Assembly of Large Oligomeric Signalosomes in the Toll-like Receptor/IL-1 Receptor Superfamily

R. Ferrao, Ji-Xi Li, E. Bergamin, Hao Wu

Science Signaling

DOI

2012

Helical assembly in the death domain (DD) superfamily

R. Ferrao, Hao Wu

Current Opinion in Structural Biology

DOI

2012

Nucleic Acid Chaperone Activity of Wild Type and Mutant FIV Nucleocapsid Proteins

Hao Wu, Micah J. McCauley, R. Gorelick, I. Rouzina, K. Musier-Forsyth, Mark C. Williams

DOI

2012

Regulation and function of mammalian DNA methylation patterns: a genomic perspective.

Hao Wu, Ji-Fang Tao, Y. Sun

Briefings in Functional Genomics

DOI

2012

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

Ji-Xi Li, T. McQuade, Ansgar B. Siemer, Johanna Napetschnig, Kenta Moriwaki, Yu-Shan Hsiao, Ermelinda Damko, D. Moquin, T. Walz, A. McDermott, F. K. Chan, Hao Wu

Cell

DOI

2012

Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein’s nucleic acid chaperone activity and retroviral replication

Hao Wu, Mithun Mitra, Micah J. McCauley, James A. Thomas, I. Rouzina, K. Musier-Forsyth, Mark C. Williams, R. Gorelick

Virus Research

DOI

2011

Tet1 and 5-hydroxymethylation

Hao Wu, Yi Zhang

Cell Cycle

DOI

2003

R/qtl: QTL Mapping in Experimental Crosses

K. Broman, Hao Wu, Ś. Sen, G. Churchill

Bioinform.

DOI

2003

MAANOVA: A Software Package for the Analysis of Spotted cDNA Microarray Experiments

Hao Wu, M. Kerr, Xiangqin Cui, G. Churchill

DOI

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