周杰超｜厦门大学｜学者主页

2026

TRIM32–UBQLN2–p62 axis promotes TDP-43 inclusion formation and amyloid aggregation through shuttle condensates

Zi-Yan He, Jiechao Zhou, Rong-Zhen Zhang, F. Meng, David W. Nauen, Juan C. Troncoso, P. F. Worley, Wen-Chi Zhang

bioRxiv

2025

Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer's disease

Yan-Bing Chen, Bo Jiang, Kai Zhuang, He Wang, Hui-Min Peng, Bo-Wen Zhong, Wen-Ting Xie, Kai-Wei Chen, Ting-Ting Zou, Ya Wang, Hui-Li Yang, Qingwei Yang, Jiechao Zhou, Li Zhong, Li-Hua Zhang, Jie Zhang

Molecular Psychiatry，Vol. 300, No. 120

DOI

2025

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Kai Zhuang, Liu Zi, Xiao Su, Chen Hu, Xin-Rui Li, Shuzhong Wang, Yujun Xia, Bo Wu, Yuemin Su, Shaokun Chen, Hao-Jie Li, Silv Wang, Meng-Dan Wang, Jieyin Li, Wenting Xie, Yanbing Chen, Lige Leng, Hui-Fang Li, Li Zhong, Jiechao Zhou, Yan Liu, Qingsong Liu, Karl Herrup, Jie Zhang

Nature Aging

DOI

2025

Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer’s disease

Shaokun Chen, Jiechao Zhou, Shuzhong Wang, Erqu Chen, Kai Zhuang, Raozhou Lin, Chensi Liang, Can Dan, Huifang Li, Jing Li, Jie Zhang

PLoS Biology

DOI

2025

Analysis of the causal relationship between five chosen factors and early-onset Alzheimer's disease: A Mendelian randomization study

Chun-li Lu, Jiechao Zhou

Journal of Alzheimer's Disease

DOI

2024

The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation

Jiechao Zhou, Yang-An Chuang, Javier Redding-Ochoa, Rong-Zhen Zhang, Alexander J. Platero, Alexander H. Barrett, Juan C. Troncoso, P. F. Worley, Wen-Chi Zhang

Nature Cell Biology

DOI

2023

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

Jiechao Zhou, Sarah D. Wade, David Graykowski, Mei-Fang Xiao, Binhui Zhao, Lucia A. A. Giannini, Jesse E. Hanson, J. V. van Swieten, Morgan Sheng, P. Worley, Borislav Dejanovic

Science Translational Medicine

DOI

2023

STRENGTH OF LEC EXCITATORY INPUTS ONTO DENTATE GYRUS PV-INS CORRELATED WITH COGNITIVE PERFORMANCE IN AGED RATS

Cristián Moreno, Daniel Severin, M. Koh, Jiechao Zhou, Michelle C. D. Bridi, Paul Worley, Micehela Gallagher, Alfredo Kirkwood

IBRO Neuroscience Reports

DOI

2022

Neuronal pentraxin Nptx2 regulates complement activity in the brain

Jiechao Zhou, Sarah D. Wade, David Graykowski, Mei-Fang Xiao, Binhui Zhao, Lucia A. A. Giannini, Jesse E. Hanson, J. V. van Swieten, Morgan Sheng, P. Worley, Borislav Dejanovic

bioRxiv

DOI

2021

A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function

Mei-Fang Xiao, Seung-Eon Roh, Jiechao Zhou, Chun-Che Chien, B. Lucey, M. T. Craig, L. Hayes, Jennifer M. Coughlin, F. Leweke, Min Jia, De-Sheng Xu, Weiqiang Zhou, C. Talbot, Don B. Arnold, Melissa Staley, Cindy Jiang, I. Reti, A. Sawa, K. Pelkey, C. McBain, A. Savonenko, P. Worley

Science Advances

DOI

2021

All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity

Daniel Severin, Su Z. Hong, Seung-Eon Roh, Shi-Yong Huang, Jiechao Zhou, Michelle C. D. Bridi, Ingie Hong, S. Murase, Sarah E. Robertson, Rebecca P. Haberman, R. Huganir, M. Gallagher, E. Quinlan, P. Worley, A. Kirkwood

Proceedings of the National Academy of Sciences of the United States of America

DOI

2020

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang

Biological Psychiatry，Vol. 87, No. 8

DOI

2019

Arc oligomerization is regulated by CaMKII phosphorylation of GAG domain; an essential mechanism for plasticity and memory formation.

Wen-Chi Zhang, Yang-An Chuang, Youn Na, Zengyou Ye, Liuqing Yang, R. Lin, Jiechao Zhou, Jing Wu, Jessica Qiu, A. Savonenko, D. Leahy, R. Huganir, D. Linden, P. Worley

Molecules and Cells

DOI

2018

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death

Dong Guo, Wenting Xie, Pan Xiong, Huifang Li, Siqi Wang, Guimiao Chen, Yue Gao, Jiechao Zhou, Ye Zhang, Guo-Jun Bu, Maoqiang Xue, Jie Zhang

Cell Death and Disease

DOI

2016

Emodin Attenuates The Neurotoxicity Induced by Nitric Oxide Through Inhibiting FOXO1 Transcriptional Activity

Sui-Ling Chen, Jiechao Zhou, Jie Zhang, Jiang-xing Zhuang, Ya Liu

2016

エモジンはFOXO1活性を阻害することによりNOの神経細胞への損傷を軽減する。【JST・京大機械翻訳】

Sui-Ling Chen, Jiechao Zhou, Jie Zhang, Jiang-xing Zhuang, Ya Liu

2015

The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

Jiechao Zhou, Huifang Li, Xiaoping Li, Guan-Yun Zhang, Yaqiong Niu, Zeng-Qiang Yuan, K. Herrup, Yun-Wu Zhang, Guo-Jun Bu, Hua-Xi Xu, Jie Zhang

Journal of Neuroscience

DOI

2014

CDK5 activator protein p25 preferentially binds and activates GSK3β

Hei‐Man Chow, Dong Sheng Guo, Jiechao Zhou, Guan-Yun Zhang, Huifang Li, Karl Herrup, Jie Zhang

Proceedings of the National Academy of Sciences

DOI

2012

Cdk5 Levels Oscillate during the Neuronal Cell Cycle

Jie Zhang, Huifang Li, Tingwen Zhou, Jiechao Zhou, K. Herrup

Journal of Biological Chemistry

DOI

2012

Cdk 5 Levels Oscillate during the Neuronal Protein Synthesis and Degradation :

Jie Zhang, Huifang Li, Tingwen Zhou, Jiechao Zhou, K. Herrup

周杰超

精选作品

期刊论文

TRIM32–UBQLN2–p62 axis promotes TDP-43 inclusion formation and amyloid aggregation through shuttle condensates

Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer's disease

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer’s disease

Analysis of the causal relationship between five chosen factors and early-onset Alzheimer's disease: A Mendelian randomization study

The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

STRENGTH OF LEC EXCITATORY INPUTS ONTO DENTATE GYRUS PV-INS CORRELATED WITH COGNITIVE PERFORMANCE IN AGED RATS

Neuronal pentraxin Nptx2 regulates complement activity in the brain

A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function

All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Arc oligomerization is regulated by CaMKII phosphorylation of GAG domain; an essential mechanism for plasticity and memory formation.

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death

Emodin Attenuates The Neurotoxicity Induced by Nitric Oxide Through Inhibiting FOXO1 Transcriptional Activity

エモジンはFOXO1活性を阻害することによりNOの神経細胞への損傷を軽減する。【JST・京大機械翻訳】

The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

CDK5 activator protein p25 preferentially binds and activates GSK3β

Cdk5 Levels Oscillate during the Neuronal Cell Cycle

Cdk 5 Levels Oscillate during the Neuronal Protein Synthesis and Degradation :

研究方向