张林琦｜清华大学｜学者主页

2026

创新型治疗用生物制品CMC加速开发与注册的国内外法规现状与分析

吕香霖，王雅英，张小华，陈明，张林琦

《中国医药工业杂志》

2026

A potent human neutralizing antibody targeting the receptor-binding site in the glycoprotein gp350 of Epstein-Barr virus

Qingtai Liang, Qian‐Ying Zhu, Xin‐Yan Fang, Jing Wei, Yi-En Xu, Yanan Zuo, Guo‐Long Bu, Chu Xie, Sisi Shan, Cong Sun, Zheng Liu, Linqi Zhang, Mu‐Sheng Zeng

Science China Life Sciences

DOI

2026

Decoding antibody response to MERS-CoV in wild dromedary camels

Faten Idoudi, Ruoke Wang, Long Tian, Ziqing Yang, Kenn Ka‐Heng Chik, Peng Chen, Rahma Ben Abderrazek, Lili Fu, Ruijie Tan, Sayda Dhaouadi, Zakaria Benlasfar, Mahmoud Somia, Qi Zhang, Xuanling Shi, Jasper Fuk‐Woo Chan, Kwok-Yung Yuen, Xinquan Wang, Balkiss Bouhaouala‐Zahar, Linqi Zhang

Proceedings of the National Academy of Sciences

DOI

2026

Rational Design and Identification of Highly Selective TLR8 Agonists as Potent HIV-1 Latency Reversal Agents

Z. Wang, Yangyang Li, Jie Wang, Shuhao Sun, Yixuan Zhang, Linqi Zhang, Xuebin Liao

Journal of Medicinal Chemistry

DOI

2026

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection

Qi Zhang, Peng Chen, Fenglin Guo, Runhong Zhou, Ruihan Guo, Xiaofei Ge, Qianqian Yang, Xin Xie, Wei Xia, Junping Fan, Ziqing Yang, Yan Xu, Huiyu Huang, Jinqian Li, Han Wang, Huiyu Liao, Xuanling Shi, Na Liu, Yuting Chen, Zhiwei Chen, Jianzhu Ma, Xinquan Wang, Tong Zhang, Linqi Zhang

Immunity

DOI

2026

Broad and durable protection against SARS-CoV-2 and SARS-CoV by an intranasal chimpanzee adenovirus vaccine expressing tandem RBDs and nucleocapsid

Yaping Liu, Runhong Zhou, Tian Zhao, Ruoke Wang, Kun Zhu, Junxian Hong, Ziqing Yang, Qianqian Yang, Yuqing Lei, Yang Bai, Jing Wei, Peng Chen, Xinyu Fan, Qi Zhang, Xuanling Shi, Peng Liu, Zhiwei Chen, Linqi Zhang

PLoS Pathogens

DOI

2026

Bruton's tyrosine kinase inhibitor BTKi-2 inhibits mpox virus and vaccinia virus infection

Chen Yang, Runchu Zhao, Shuting Huo, Yu Zhang, Jingxi Feng, Mingli Gong, L C Zhu, Conggang Zhang, Linqi Zhang, Jing Xue, Rong Zhang, Qihui Wang, Qiang Ding

Virologica Sinica

DOI

2026

Identification and characterization of bone marrow plasma cells producing IFN-γ-neutralizing autoantibodies in adult-onset immunodeficiency

Han Wang, Qianqian Yang, Tian Zhao, Jinfang Yu, Yuqing Lei, Yuhan Yang, Siqi Pan, Xin Wang, Xin Wang, Junxian Hong, Zimeng Wei, Xinyu Fan, Jiaxiang Li, Yaqi Wang, Haodi Dong, Panpan Zhou, Qi Zhang, Xuanling Shi, Jinglan Wang, Xinquan Wang, Xinquan Wang, Peng Liu, Junping Fan, Linqi Zhang

Cell Reports Medicine

DOI

2026

Decoding antibody response to MERS-CoV in wild dromedary camels

Faten Idou, Ruoke Wang, Long Tian, Ziqing Yang, Kenn Ka‐Heng Chik, P Chen, Rahma Benabderra, Lili Fu, Ruijie Tan, Say Dhaouad, Zakaria Benlasfar, Mahmoud Somia, Zh, Qi, Xuanling Shi, Jasper Fuk-Woo, Kwok‐Yung Yuen, Xinquan Wang, Balkiss Bouhaouala‐Zahar, Linqi Zhang

INRIA a CCSD electronic archive server

DOI

2025

Grand Challenges on HIV/AIDS in China – The 5th Symposium, Yunnan 2024

Zhiwei Chen, Jianqing Xu, Xia Jin, Jian‐Hua Wang, Jinghe Huang, Hui Zhang, Ling Chen, Kai Deng, Weiping Cai, Linghua Li, Fusheng Wang, Zhiwei Wu, Hong Shang, Hao Wu, Linqi Zhang

Emerging Microbes & Infections

DOI

2025

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang

Advanced Science

DOI

2025

Organoid-based neutralization assays reveal a distinctive profile of SARS-CoV-2 antibodies and recapitulate the real-world efficacy

Zhixin Wan, Cun Li, Ying Zhou, Yifei Yu, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Wei Xue, Chengfan Jiang, Jiali Wu, Zijun Zhao, Jian‐Piao Cai, Lin Huang, Yong Zhang, Xiaojuan Liu, Zheng Zhang, Hin Chu, Linqi Zhang, Zhiwei Chen, Kelvin Kai‐Wang To, Kwok-Yung Yuen, Hans C. Clevers, Jie Zhou

Proceedings of the National Academy of Sciences

DOI

2025

Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections

Cuifeng Li, Yuxin Li, Bini Zhou, Tong Li, Xiaohui Wei, Kun Chen, Wenlong Chen, Ziwei Shi, Xiaobin Dai, Jiachen Zhang, Yang Chen, Zhenglin Ji, Wenbo Sun, Ji Gao, Jing Wu, Bin-Bin Zhao, Xin Min, Yujie Li, Lin Lin, Wei Yang, Min Wang, Zezhong Liu, Yaping Liu, Chenyou Zhu, Bo Kyung Yang, Jiang‐Fei Xu, Li‐Tang Yan, Yi Shi, Lu Lu, Linqi Zhang, Qiang Ding, Jing Xue, Baidong Hou, Hai Qi, Jiangning Liu, Yuhe Renee Yang, Dongsheng Liu, Wanli Liu

Nature Biomedical Engineering

DOI

2025

FlowDesign: Improved design of antibody CDRs through flow matching and better prior distributions

Jun Wu, Xiangzhe Kong, Ningguan Sun, Jing Wei, Sisi Shan, Fuli Feng, Feng WU, Jian Xun Peng, Linqi Zhang, Yang Liu, Jianzhu Ma

Cell Systems

DOI

2025

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

Tian Zhao, Yuqing Lei, Chang Liu, Dong Zhang, Kaiyi Li, Sisi Shan, Chenyu Li, Zimeng Wei, Yuhan Yang, Ting Zhang, Kai Sun, Haoran Sun, Linqi Zhang, Peng Liu

Advanced Science

DOI

2024

Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration

Linjing Zhu, Bilian Huang, Xiangyao Wang, Fengfeng Ni, Mingjun Ao, Ruoke Wang, Bin Zheng, Chen Chen, Jing Xue, Lin Zhu, Chenbo Yang, Lingen Shi, Shengya Geng, Jia‐Qian Hu, Mengshi Yang, Doudou Zhang, Ping Yang, Miaomiao Li, Yuncheng Li, Qinxue Hu, Sheng Ye, Peng Zheng, Hongxia Wei, Zhiwei Wu, Linqi Zhang, Yaxin Wang, Yalan Liu, Xilin Wu

Nature Communications

DOI

2024

The Fourth Symposium of Grand Challenges on HIV (2023.12.28)

Fu‐Sheng Wang, Linqi Zhang

Infectious Diseases & Immunity

DOI

2024

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

Yiling Yang, Ruoke Wang, Fenglin Guo, Tian Zhao, Yuqing Lei, Qianqian Yang, Yige Zeng, Ziqing Yang, Tatchapon Ajavavarakula, Ruijie Tan, Mingxi Li, Haodi Dong, Mengyue Niu, Keyan Bao, Hao Geng, Qining Lv, Qi Zhang, Xuanling Shi, Peng Liu, Jiwan Ge, Xinquan Wang, Linqi Zhang

npj Vaccines

DOI

2024

Pandemic research: the need for a paradigm shift

Lin‐Fa Wang, Sharon R. Lewin, Nanshan S Zhong, Linqi Zhang, Zhiwei Chen, Kwok‐Yung Yuen, David D. Ho

The Lancet Microbe

DOI

2024

Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies

Xuanyu Nan, Yujie Li, Rui Zhang, Ruoke Wang, Niannian Lv, Jiayi Li, Yuanfang Chen, Bini Zhou, Yangjunqi Wang, Ziyi Wang, Jiayi Zhu, Jing Chen, Jinqian Li, Wenlong Chen, Qi Zhang, Xuanling Shi, Changwen Zhao, Chunying Chen, Zhihua Liu, Yuliang Zhao, Dongsheng Liu, Xinquan Wang, Li‐Tang Yan, Taisheng Li, Linqi Zhang, Yuhe Renee Yang

Nature Communications

DOI

2024

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

Xianbin Tian, Yanni Liu, Kun Zhu, Haoran An, Jie Feng, Linqi Zhang, Jing‐Ren Zhang

The Journal of Experimental Medicine

DOI

2024

Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1

Haodi Dong, Runhong Zhou, Jing Chen, Jing Wei, Zimeng Wei, Ziqing Yang, Kun Zhu, Yufan Yang, Qianqian Yang, Na Liu, Yuting Chen, Yuhan Wu, Yan Liang, Yige Zeng, Qile Guo, Mingxi Li, Sisi Shan, Han Wang, Mengyue Niu, Isabella Yunfei Zeng, Xuanling Shi, Qi Zhang, Xinquan Wang, Zhiwei Chen, Linqi Zhang

PLoS Pathogens

DOI

2024

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms

Wenbo Sun, Tingyu Yang, Fengming Sun, Panhong Liu, Ji Gao, Xianmei Lan, Wei Xu, Yuhong Pang, Tong Li, Cuifeng Li, Qingtai Liang, Haoze Chen, Xiaohang Liu, Wenting Tan, Huanhuan Zhu, Fang Wang, Fanjun Cheng, Weiwei Zhai, Han‐Na Kim, Jing‐Ren Zhang, Linqi Zhang, Lu Lu, Qiaoran Xi, Guohong Deng, Yanyi Huang, Xin Jin, Xiangjun Chen, Wanli Liu

Nature Immunology

DOI

2024

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

Yifeng Wang, Wen Shao, Xin Liu, Qingtai Liang, Jiaqi Lei, Wenjuan Shi, Miao Mei, Ying Li, Xu Tan, Guocan Yu, Li Yu, Linqi Zhang, Hai Qi

Immunity

DOI

2023

Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells

Yangyang Li, Zhisong Wang, Ying Hou, Xiaoyu Liu, Junxian Hong, Xuanling Shi, Xiaojie Huang, Tong Zhang, Xuebin Liao, Linqi Zhang

Frontiers in Microbiology

DOI

2023

Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria

Juanjuan Wang, Haoran An, Ming Ding, Yanhong Liu, Shaomeng Wang, Jin Qian, Qi Wu, Haodi Dong, Qile Guo, Xianbin Tian, Jiankai Liu, Jingfei Zhang, Jingfei Zhang, Tao Zhu, Junqiang Li, Zhujun Shao, David E. Briles, Jan‐Willem Veening, Haifa Zheng, Linqi Zhang, Jing-Ren Zhang, Jing-Ren Zhang

Science Translational Medicine

DOI

2023

Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection

Ruoke Wang, Yang Han, Rui Zhang, Jiayi Zhu, Xuanyu Nan, Yaping Liu, Ziqing Yang, Bini Zhou, Jinfang Yu, Zichun Lin, Jinqian Li, Peng Chen, Yangjunqi Wang, Yujie Li, Dongsheng Liu, Xuanling Shi, Xinquan Wang, Qi Zhang, Yuhe Renee Yang, Taisheng Li, Linqi Zhang

Immunity

DOI

2023

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1

Biao Zhou, Runhong Zhou, Jasper Fuk‐Woo Chan, Jianwei Zeng, Qi Zhang, Shuofeng Yuan, Li Liu, Rémy Robinot, Sisi Shan, Na Liu, Jiwan Ge, Hugo Yat-Hei Kwong, Dongyan Zhou, Haoran Xu, Chris Chung‐Sing Chan, Vincent Kwok‐Man Poon, Hin Chu, Ming Yue, Ka‐Yi Kwan, Chun-Yin Chan, Chris Chun-Yiu Chan, Kenn Ka‐Heng Chik, Zhenglong Du, Ka‐Kit Au, Haode Huang, Hiu-On Man, Jianli Cao, Cun Li, Ziyi Wang, Jie Zhou, You‐Qiang Song, Man Lung Yeung, Kelvin Kai‐Wang To, David D. Ho, Lisa A. Chakrabarti, Xinquan Wang, Linqi Zhang, Kwok‐Yung Yuen, Zhiwei Chen

Emerging Microbes & Infections

DOI

2023

Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody

Yosuke Toyoda, Angqi Zhu, Fang Kong, Sisi Shan, Jiawei Zhao, Nan Wang, Xiaoou Sun, Linqi Zhang, Chuangye Yan, Brian K. Kobilka, Xiangyu Liu

Nature Communications

DOI

2023

Editorial: AIDS 40th Year

Jiasheng Zhou, Shibo Jiang, Tongqing Zhou, Zhiwei Chen, Xia Jin, Wenyan Zhang, Supachai Rerks‐Ngarm, Anna Kramvis, Kai Deng, Linqi Zhang

Frontiers in Microbiology

DOI

2023

Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

Bin Ju, Qi Zhang, Ziyi Wang, Zhen Qin Aw, Peng Chen, Bing Zhou, Ruoke Wang, Xiangyang Ge, Qining Lv, Lin Cheng, Rui Zhang, Yi Hao Wong, Huixin Chen, Haiyan Wang, Sisi Shan, Xuejiao Liao, Xuanling Shi, Lei Liu, Justin Jang Hann Chu, Xinquan Wang, Zheng Zhang, Linqi Zhang

Nature Immunology

DOI

2022

安巴韦单抗注射液（BRII-196）及罗米司韦单抗注射液（BRII-198）——中国首个自主知识产权新冠病毒中和抗体联合治疗药物

单思思，王若珂，张绮，张林琦

《中国医药导刊》

2022

美国FDA紧急使用授权（EUA）批准的新冠病毒抗体药物研发进展

单思思，杨子卿，张林琦

《中国医药导刊》

2022

Broadly neutralizing antibodies against SARS-CoV-2 variants

Linqi Zhang

National Science Open

2022

A commentary of “‘Shock and Kill’ of Latent HIV” : 10 remarkable discoveries from 2020 in Nature

Yangyang Li, Linqi Zhang

Fundamental Research

DOI

2022

The Rational Combination Strategy of Immunomodulatory Latency Reversing Agents and Novel Immunotherapy to Achieve HIV-1 Cure

Yangyang Li, Junxian Hong, Linqi Zhang

Infectious Diseases & Immunity

DOI

2022

Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses

Mingxi Li, Yifei Ren, Zhen Qin Aw, Bo Chen, Ziqing Yang, Yuqing Lei, Lin Cheng, Qingtai Liang, Junxian Hong, Yiling Yang, Jing Chen, Yi Hao Wong, Jing Wei, Sisi Shan, Senyan Zhang, Jiwan Ge, Ruoke Wang, Jay Zengjun Dong, Yuxing Chen, Xuanling Shi, Qi Zhang, Zheng Zhang, Justin Jang Hann Chu, Xinquan Wang, Linqi Zhang

Nature Communications

DOI

2022

Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein

Shuyuan Zhang, Wenxv Jia, Jianwei Zeng, Mingxi Li, Ziyi Wang, Haixia Zhou, Linqi Zhang, Xinquan Wang

Frontiers in Microbiology

DOI

2022

Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2

Yun Ji, Qi Zhang, Lin Cheng, Jiwan Ge, Ruoke Wang, Mengqi Fang, Eric M. Mucker, Peng Chen, Ji Ma, Rui Zhang, Chunming Li, Holly Hammond, Lauren Baracco, Michael R. Holbrook, Matthew B. Frieman, Zheng Zhang, Xinquan Wang, Jay W. Hooper, Linqi Zhang, Qing Zhu

Frontiers in Immunology

DOI

2022

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

Xiaoman Li, Yongbing Pan, Qiangling Yin, Zejun Wang, Sisi Shan, Laixing Zhang, Jinfang Yu, Yuanyuan Qu, Lina Sun, Fang Gui, Jia Lu, Zhaofei Jing, Wei Wu, Tao Huang, Xuanling Shi, Jiandong Li, Xinguo Li, Dexin Li, Shiwen Wang, Maojun Yang, Linqi Zhang, Kai Duan, Mifang Liang, Xiaoming Yang, Xinquan Wang

Cell Discovery

DOI

2022

Identification and semisynthesis of (−)-anisomelic acid as oral agent against SARS-CoV-2 in mice

Hai‐Xin Yu, Nan Zheng, Chi‐Tai Yeh, Chien‐Ming Lee, Qi Zhang, Wenlv Zheng, Qing Chang, Yuanhe Li, Yujun Li, Guizhen Wu, Junmin Quan, Linqi Zhang, Yew‐Min Tzeng, Zhen Jun Yang

National Science Review

DOI

2022

Case report: Drug rash with eosinophilia and systemic symptoms syndrome in a patient with anti–interferon-γ autoantibody–associated immunodeficiency

Yuxue Nie, Han Wang, Xiying Dong, Siqi Pan, Ting Zhang, Jun Ran, Ying Zhang, Junping Fan, Linqi Zhang, Jinglan Wang

Frontiers in Immunology

DOI

2022

Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2

Jun Lan, Peng Chen, Weiming Liu, Wenlin Ren, Linqi Zhang, Qiang Ding, Qi Zhang, Xinquan Wang, Jiwan Ge

Structure

DOI

2022

The humoral response and antibodies against SARS-CoV-2 infection

Hai Qi, Bo Liu, Xinquan Wang, Linqi Zhang

Nature Immunology

DOI

2022

SARS-CoV-2 Omicron Variants Reduce Antibody Neutralization and Acquire Usage of Mouse ACE2

Ruoke Wang, Qi Zhang, Rui Zhang, Zhen Qin Aw, Peng Chen, Yi Hao Wong, Junxian Hong, Bin Ju, Xuanling Shi, Qiang Ding, Zheng Zhang, Justin Jang Hann Chu, Linqi Zhang

Frontiers in Immunology

DOI

2022

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

Jun Lan, Xinheng He, Yifei Ren, Ziyi Wang, Huan Zhou, Shilong Fan, Chenyou Zhu, Dongsheng Liu, Bin Shao, Tie‐Yan Liu, Qisheng Wang, Linqi Zhang, Jiwan Ge, Tong Wang, Xinquan Wang

Cell Research

DOI

2022

RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Qingtai Liang, Yifeng Wang, Shuyuan Zhang, Jing Sun, Wenbo Sun, Jizhou Li, Yaping Liu, Mingxi Li, Lin Cheng, Yuhang Jiang, Ruoke Wang, Rui Zhang, Zihan Yang, Yifei Ren, Peng Chen, Peng Gao, Huayuan Yan, Zheng Zhang, Qi Zhang, Xuanling Shi, Jianbin Wang, Wanli Liu, Xinquan Wang, Bo Ying, Jincun Zhao, Hai Qi, Linqi Zhang

iScience

DOI

2022

Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization

Sisi Shan, Shitong Luo, Ziqing Yang, Junxian Hong, Yufeng Su, Fan Ding, Lili Fu, Chenyu Li, Peng Chen, Jianzhu Ma, Xuanling Shi, Qi Zhang, Bonnie Berger, Linqi Zhang, Jian Xun Peng

Proceedings of the National Academy of Sciences

DOI

2022

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

Shuyuan Zhang, Qingtai Liang, Xinheng He, Chongchong Zhao, Wenlin Ren, Ziqing Yang, Ziyi Wang, Qiang Ding, Haiteng Deng, Tong Wang, Linqi Zhang, Xinquan Wang

Cell Research

DOI

2021

潜伏的HIV病毒被“激杀”

张林琦，李杨阳

《中国科学基金》

DOI

2021

美国食品药品监督管理局接受不确定性:治疗多重耐药的人类免疫缺陷病毒感染的单克隆抗体加速获批

李冠乔，卢希，孟醒，陈晓媛，张绮，王涛，张林琦

《中国临床药理学杂志》

2021

新冠病毒变异，可怕吗

陈鹏，张林琦

《大众健康》

2021

疫苗接种可以阻断新冠传播吗

杨依凌，张林琦

《大众健康》

2021

Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques

Ruoheng Yang, Qingwei Liu, Wei Pang, Fei Gao, Huabin Liang, Wei Zhang, Yalong Lin, Min Li, Zhihua Liu, George F. Gao, Linqi Zhang, Hui Qing Xiao, Yong‐Tang Zheng, Zhong Wei Huang, Xia Jin

Vaccine

DOI

2021

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

Jiwan Ge, Ruoke Wang, Bin Ju, Qi Zhang, Jing Sun, Peng Chen, Senyan Zhang, Yuling Tian, Sisi Shan, Lin Cheng, Bing Zhou, Shuo Song, Juanjuan Zhao, Haiyan Wang, Xuanling Shi, Qiang Ding, Lei Liu, Jincun Zhao, Zheng Zhang, Xinquan Wang, Linqi Zhang

Nature Communications

DOI

2021

SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape

Qianqian Li, Jianhui Nie, Jiajing Wu, Li Zhang, Ruxia Ding, Haixin Wang, Yue Zhang, Tao Li, Shuo Liu, Mengyi Zhang, Chenyan Zhao, Huan Liu, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Junkai Liu, Haoyu Liang, Yi Shi, Yuelei Shen, Liangzhi Xie, Linqi Zhang, Xiaowang Qu, Wenbo Xu, Weijin Huang, Youchun Wang

Cell

DOI

2021

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

Dongyan Zhou, Jasper Fuk‐Woo Chan, Biao Zhou, Runhong Zhou, Shuang Li, Sisi Shan, Li Liu, Jinxia Zhang, Serena J. Chen, Chris Chung‐Sing Chan, Haoran Xu, Vincent Kwok‐Man Poon, Shuofeng Yuan, Cun Li, Kenn Ka‐Heng Chik, Chris Chun-Yiu Chan, Jianli Cao, Chun-Yin Chan, Ka‐Yi Kwan, Zhenglong Du, Thomas Tsz-Kan Lau, Qi Zhang, Jie Zhou, Kelvin Kai‐Wang To, Linqi Zhang, David D. Ho, Kwok‐Yung Yuen, Zhiwei Chen

Cell Host & Microbe

DOI

2021

Tandem bispecific antibody prevents pathogenic SHIVSF162P3CN infection and disease progression

Mengyue Niu, Yik Chun Wong, Hui Wang, Xin Li, Chun-Yin Chan, Qi Zhang, Lijun Ling, Lin Cheng, Ruoke Wang, Yanhua Du, Lok Yan Yim, Xia Jin, Haoji Zhang, Linqi Zhang, Zhiwei Chen

Cell Reports

DOI

2021

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

Jiaojiao Liu, Kun Xu, Man Xing, Yue Zhuo, Jingao Guo, Meng Du, Qi Ming Wang, Yaling An, Jinhe Li, Ping Gao, Yihan Wang, Furong He, Yingying Guo, Mingxi Li, Yuchao Zhang, Linqi Zhang, George F. Gao, Lianpan Dai, Dongming Zhou

Cell Discovery

DOI

2021

A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants

Sisi Shan, Chee Keng Mok, Shuyuan Zhang, Jun Lan, Jizhou Li, Ziqing Yang, Ruoke Wang, Lin Cheng, Mengqi Fang, Zhen Qin Aw, Jinfang Yu, Qi Zhang, Xuanling Shi, Tong Zhang, Zheng Zhang, Jianbin Wang, Xinquan Wang, Justin Jang Hann Chu, Linqi Zhang

Frontiers in Immunology

DOI

2021

A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus

Qian‐Ying Zhu, Sisi Shan, Jinfang Yu, Siying Peng, Cong Sun, Yanan Zuo, Lan‐Yi Zhong, Shumei Yan, Xiao Zhang, Ziqing Yang, Yong‐Jian Peng, Xuanling Shi, Su‐Mei Cao, Xinquan Wang, Mu‐Sheng Zeng, Linqi Zhang

Nature Communications

DOI

2021

A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Chang Ming Guo, Yanan Peng, Lin Lin, Xiaoyan Pan, Mengqi Fang, Yun Zhao, Keyan Bao, Runhan Li, Jian-Bao Han, Jiaorong Chen, Tian‐Zhang Song, Xiaoli Feng, Yahong Zhou, Gan Zhao, Leike Zhang, Yong‐Tang Zheng, Ping Zhu, Haiying Hang, Linqi Zhang, Zhaolin Hua, Hongyu Deng, Baidong Hou

Cell Reports Medicine

DOI

2021

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Qi Zhang, Bin Ju, Jiwan Ge, Jasper Fuk‐Woo Chan, Lin Cheng, Ruoke Wang, Weijin Huang, Mengqi Fang, Peng Chen, Bing Zhou, Shuo Song, Sisi Shan, Baohua Yan, Senyan Zhang, Xiangyang Ge, Jiazhen Yu, Juanjuan Zhao, Haiyan Wang, Li Liu, Qining Lv, Lili Fu, Xuanling Shi, Kwok‐Yung Yuen, Lei Liu, Youchun Wang, Zhiwei Chen, Linqi Zhang, Xinquan Wang, Zheng Zhang

Nature Communications

DOI

2021

Role of efficient testing and contact tracing in mitigating the COVID-19 pandemic: a network modelling study

Yiying Hu, Jianying Guo, Guanqiao Li, Xi Lu, Xiang Li, Yuan Zhang, Lin Cong, Yanni Kang, Xiaoyu Jia, Xuanling Shi, Guotong Xie, Linqi Zhang

BMJ Open

DOI

2021

Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection

Mingxi Li, Jingao Guo, Shuaiyao Lu, Runhong Zhou, Hongyang Shi, Xuanling Shi, Lin Cheng, Qingtai Liang, Hongqi Liu, Pui Wang, Nan Wang, Yifeng Wang, Lili Fu, Man Xing, Ruoke Wang, Bin Ju, Li Liu, Siu-Ying Lau, Wenxu Jia, Xin Tong, Yuan Lin, Yong Sheng Guo, Hai Qi, Qi Zhang, Zhen Jian Huang, Honglin Chen, Zheng Zhang, Zhiwei Chen, Xiaozhong Peng, Dongming Zhou, Linqi Zhang

Frontiers in Immunology

DOI

2021

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

Ruoke Wang, Qi Zhang, Jiwan Ge, Wenlin Ren, Rui Zhang, Jun Lan, Bin Ju, Bin Su, Fengting Yu, Peng Chen, Huiyu Liao, Yingmei Feng, Xuemei Li, Xuanling Shi, Zheng Zhang, Fujie Zhang, Qiang Ding, Tong Zhang, Xinquan Wang, Linqi Zhang

Immunity

DOI

2021

Differential impact of non-pharmaceutical public health interventions on COVID-19 epidemics in the United States

Xiaoshuang Liu, Xiao Xu, Guanqiao Li, Xian Lei Xu, Yuyao Sun, Fei Wang, Xuanling Shi, Xiang Li, Guotong Xie, Linqi Zhang

BMC Public Health

DOI

2021

HLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients

Ruonan Xu, Jiyuan Zhang, Bo Tu, Zhe Xu, Hui-Huang Huang, Lei Huang, Yan‐Mei Jiao, Tao Yang, Chao Zhang, Enqiang Qin, Tianjun Jiang, Yunbo Xie, Yuanyuan Li, Lei Jin, Chun‐Bao Zhou, Ming Shi, Mei Guo, Hui‐Sheng Ai, Linqi Zhang, Fu‐Sheng Wang

Signal Transduction and Targeted Therapy

DOI

2021

An integrated framework for modelling quantitative effects of entry restrictions and travel quarantine on importation risk of COVID-19

Tiange Chen, Siwan Huang, Guanqiao Li, Yuan Zhang, Ye Li, Jinyi Zhu, Xuanling Shi, Xiang Li, Guotong Xie, Linqi Zhang

Journal of Biomedical Informatics

DOI

2021

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

Renhong Yan, Ruoke Wang, Bin Ju, Jinfang Yu, Yuanyuan Zhang, Nan Liu, Jia Wang, Qi Zhang, Peng Chen, Bing Zhou, Yaning Li, Yaping Shen, Shuyuan Zhang, Long Tian, Yingying Guo, Lu Xia, Xinyue Zhong, Lin Cheng, Xiangyang Ge, Juanjuan Zhao, Hongwei Wang, Xinquan Wang, Zheng Zhang, Linqi Zhang, Qiang Zhou

Cell Research

DOI

2021

A novel cell culture system modeling the SARS-CoV-2 life cycle

Xiaohui Ju, Yunkai Zhu, Yuyan Wang, Jingrui Li, Jiaxing Zhang, Mingli Gong, Wenlin Ren, Sai Li, Jin Zhong, Linqi Zhang, Qiangfeng Cliff Zhang, Rong Zhang, Qiang Ding

PLoS Pathogens

DOI

2020

新型冠状病毒肺炎疫情对抗病毒药研发和监管的启示

许淑红，赵建中，王雪，张绮，张林琦，王涛

《中国临床药理学杂志》

DOI

2020

从血浆疗法到单克隆抗体，再到新冠疫苗

高菲，李杨阳，张林琦

《大众健康》

2020

A safety consideration of mesenchymal stem cell therapy on COVID-19

Yajun Cao, Hongyan Wu, Wanli Zhai, Ying Wang, Mengdi Li, Meng Li, Liu Yang, Ye Tian, Yunhao Song, Jun Li, Yinyin Wang, Qiang Ding, Linqi Zhang, Ming Cai, Zhijie Chang

Stem Cell Research

DOI

2020

Surging publications on the COVID-19 pandemic

Guanqiao Li, Yangzhong Zhou, Junyi Ji, Xiaozhen Liu, Qiao Jin, Linqi Zhang

Clinical Microbiology and Infection

DOI

2020

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Qianqian Li, Jiajing Wu, Jianhui Nie, Li Zhang, Huan Hao, Shuo Liu, Chenyan Zhao, Qi Zhang, Huan Liu, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Qiyu Sun, Junkai Liu, Linqi Zhang, Xuguang Li, Weijin Huang, Youchun Wang

Cell

DOI

2020

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

Ling Li, Wei jin Zhang, Yu Hu, Xunliang Tong, Shangen Zheng, Juntao Yang, Yujie Kong, Lili Ren, Qing Wei, Heng Mei, Caiying Hu, Cuihua Tao, Ru Yang, Jue Wang, Yongpei Yu, Yong Sheng Guo, Xiaoxiong Wu, Zhihua Xu, Li Zeng, Nian Xiong, Lifeng Chen, Juan Wang, Ning Man, Yu Liu, Haixia Xu, E. Deng, Xuejun Zhang, Chenyue Li, Conghui Wang, Shisheng Su, Linqi Zhang, Jianwei Wang, Yanyun Wu, Zhong Liu

JAMA

DOI

2020

Human neutralizing antibodies elicited by SARS-CoV-2 infection

Bin Ju, Qi Zhang, Jiwan Ge, Ruoke Wang, Jing Sun, Xiangyang Ge, Jiazhen Yu, Sisi Shan, Bing Zhou, Shuo Song, Xian Tang, Jinfang Yu, Jun Lan, Jing Yuan, Haiyan Wang, Juanjuan Zhao, Shuye Zhang, Youchun Wang, Xuanling Shi, Lei Liu, Jincun Zhao, Xinquan Wang, Zheng Zhang, Linqi Zhang

Nature

DOI

2020

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan, Jiwan Ge, Jinfang Yu, Sisi Shan, Huan Zhou, Shilong Fan, Qi Zhang, Xuanling Shi, Qisheng Wang, Linqi Zhang, Xinquan Wang

Nature

DOI

2020

Establishment of replication-competent vesicular stomatitis virus-based recombinant viruses suitable for SARS-CoV-2 entry and neutralization assays

Hongyue Li, Chaoyue Zhao, Yuhang Zhang, Fei Yuan, Qi Zhang, Xuanling Shi, Linqi Zhang, Cheng‐Feng Qin, Aihua Zheng

Emerging Microbes & Infections

DOI

2020

Anonymous Linkage Between College Students and Human Immunodeficiency Virus (HIV) Facilities: Systematic Evaluation of Urine Self-Collection for HIV Testing Initiative in China

Yi Lv, Guanqiao Li, Maogui Hu, Chengdong Xu, Hongyan Lu, Lu Chen, Yan Xing, Shu Liang, Yanling Ma, Shujia Liang, Minghua Zhuang, Yi Li, Chun Hong Huang, Yaqing Bai, Yan Jiang, Linqi Zhang

Clinical Infectious Diseases

DOI

2020

Structural basis of severe acute respiratory syndrome coronavirus 2 infection

Jiwan Ge, Senyan Zhang, Linqi Zhang, Xinquan Wang

Current Opinion in HIV and AIDS

DOI

2020

Stabilized diverse HIV-1 envelope trimers for vaccine design

Qian Wang, Bingting Ma, Qingtai Liang, Angqi Zhu, Hua Wang, Lili Fu, Xiaoxu Han, Xuanling Shi, Ye Xiang, Hong Shang, Linqi Zhang

Emerging Microbes & Infections

DOI

2019

HIV-1广谱中和抗体的研究进展

汪桦，张林琦

《中国艾滋病性病》

DOI

2019

在华非洲黑种人艾滋病传播风险分析

徐俊芳，王培成，齐腾飞，张林琦，程峰

《中国艾滋病性病》

DOI

2019

“免疫艾滋病基因编辑婴儿”的问题与危害

史宣玲，张林琦

《医学与哲学》

2019

Development of a Potent and Protective Germline-Like Antibody Lineage Against Zika Virus in a Convalescent Human

Fei Gao, Xiaohe Lin, Linling He, Ruoke Wang, Han Wang, Xuanling Shi, Fuchun Zhang, Chibiao Yin, Linqi Zhang, Jiang Zhu, Lei Yu

Frontiers in Immunology

DOI

2019

Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

Haixia Zhou, Yingzhu Chen, Shuyuan Zhang, Peihua Niu, Kun Qin, Wenxu Jia, Baoying Huang, Senyan Zhang, Jun Lan, Linqi Zhang, Wenjie Tan, Xinquan Wang

Nature Communications

DOI

2019

Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody

Lin Wang, Ruoke Wang, Lei Wang, Haijing Ben, Lei Yu, Fei Gao, Xuanling Shi, Chibiao Yin, Fuchun Zhang, Ye Xiang, Linqi Zhang

Cell Reports

DOI

2019

Discovery of New Hepatitis B Virus Capsid Assembly Modulators by an Optimal High-Throughput Cell-Based Assay

Yameng Pei, Chunting Wang, Haijing Ben, Lei Wang, Yao Ma, Qingyan Ma, Ye Xiang, Linqi Zhang, Gang Liu

ACS Infectious Diseases

DOI

2019

Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1

Pengfei Wang, Yanan Zuo, Jianfeng Sun, Teng Zuo, Senyan Zhang, Shichun Guo, Xuanling Shi, Mifang Liang, Paul Zhou, Linqi Zhang, Xinquan Wang

Journal of Biological Chemistry

DOI

2019

Antibodies and vaccines against Middle East respiratory syndrome coronavirus

Jiuyang Xu, Wenxu Jia, Pengfei Wang, Senyan Zhang, Xuanling Shi, Xinquan Wang, Linqi Zhang

Emerging Microbes & Infections

DOI

2019

Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection

Wenxu Jia, Rudragouda Channappanavar, Chao Zhang, Mingxi Li, Haixia Zhou, Shuyuan Zhang, Pan-Pan Zhou, Jiuyang Xu, Sisi Shan, Xuanling Shi, Xinquan Wang, Jincun Zhao, Dongming Zhou, Stanley M. Perlman, Linqi Zhang

Emerging Microbes & Infections

DOI

2019

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine

DOI

2019

Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies

Pan-Pan Zhou, Han Wang, Mengqi Fang, Yangyang Li, Hua Wang, Shasha Shi, Zihao Li, Jiapeng Wu, Xiaoxu Han, Xuanling Shi, Hong Shang, Tongqing Zhou, Linqi Zhang

PLoS Pathogens

DOI

2019

HIV upsurge in China's students

Guanqiao Li, Yan Jiang, Linqi Zhang

Science

DOI

2019

A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation

Qian Wang, Lihong Liu, Wuze Ren, Agegnehu Gettie, Hua Wang, Qingtai Liang, Xuanling Shi, David C. Montefiori, Tongqing Zhou, Linqi Zhang

Cell Reports

DOI

2018

Kinetics of antigen‐specific IgM/IgG/IgA antibody responses during Zika virus natural infection in two patients

Lingzhai Zhao, Wenxin Hong, Jian Wang, Lei Yu, Fengyu Hu, Shuang Qiu, Chi‐Biao Yin, Xiaoping Tang, Linqi Zhang, Xia Jin, Fuchun Zhang

Journal of Medical Virology

DOI

2018

Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies

Yanan Zuo, Pengfei Wang, Jianfeng Sun, Shichun Guo, Guiqin Wang, Teng Zuo, Shilong Fan, Paul Zhou, Mifang Liang, Xuanling Shi, Xinquan Wang, Linqi Zhang

Journal of Biological Chemistry

DOI

2018

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Senyan Zhang, Pan-Pan Zhou, Pengfei Wang, Yangyang Li, Liwei Jiang, Wenxu Jia, Han Wang, Angela Fan, Dongli Wang, Xuanling Shi, Xianyang Fang, Michal Hammel, Shuying Wang, Xinquan Wang, Linqi Zhang

Cell Reports

DOI

2018

GP205, a new hepatitis C virus NS3/4A protease inhibitor, displays higher metabolic stability in vitro and drug exposure in vivo

Pei-Bin Zhai, Jie Qing, Ben Li, Linqi Zhang, Lan Ma, Li Chen

Acta Pharmacologica Sinica

DOI

2018

Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient

Peihua Niu, Senyan Zhang, Pan-Pan Zhou, Baoying Huang, Yao Liang Deng, Kun Qin, Pengfei Wang, Wenling Wang, Xinquan Wang, Jianfang Zhou, Linqi Zhang, Wenjie Tan

The Journal of Infectious Diseases

DOI

2018

A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos

Cui Li, Fei Gao, Lei Yu, Ruoke Wang, Yisheng Jiang, Xuanling Shi, Chibiao Yin, Xiaoping Tang, Fuchun Zhang, Zhiheng Xu, Linqi Zhang

Cell Reports

DOI

2018

Open letter from Chinese HIV professionals on human genome editing

Linqi Zhang, Ping Zhong, Xiaomei Zhai, Yiming Shao, Shan Lu

The Lancet

DOI

2018

V4 region of the HIV-1 envelope gene mediates immune escape and may not promote the development of broadly neutralizing antibodies

Yangtao Ji, Xiaoxu Han, Wen Tian, Yang Gao, Jin Su, Linqi Zhang, Hong Shang

Vaccine

DOI

2018

Strategies for an HIV cure: progress and challenges

Fu Sheng Wang, Linqi Zhang, Daniel C. Douek, Andrew James McMichael, Xiao‐Ning Xu, Sharon R. Lewin

Nature Immunology

DOI

2018

DeepHINT: understanding HIV-1 integration via deep learning with attention

Hailin Hu, An Xiao, Sai Mei Zhang, Yangyang Li, Xuanling Shi, Tao Jiang, Linqi Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Jianyang Zeng

Bioinformatics

DOI

2018

Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice

Xilin Wu, Jia Guo, Mengyue Niu, Minghui An, Li Liu, Hui Wang, Xia Jin, Qi Zhang, Ka Shing Lam, Tongjin Wu, Hua Wang, Qian Wang, Yanhua Du, Jingjing Li, Lin Cheng, Hang Ying Tang, Hong Shang, Linqi Zhang, Paul Zhou, Zhiwei Chen

Journal of Clinical Investigation

DOI

2017

A vaccine crisis in the era of social media

Zhongyi Gu, Patrick A Badger, Jing Yu Su, Edward Zhang, Xiguang Li, Linqi Zhang

National Science Review

DOI

2017

Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro

Min Li, Xin Wang, Qihui Wang, Lei Yu, Lanfeng Wang, Jinghua Yan, Fuchun Zhang, Linqi Zhang, George F. Gao, Xia Jin

Science China Life Sciences

DOI

2017

Delineating antibody recognition against Zika virus during natural infection

Lei Yu, Ruoke Wang, Fei Gao, Min Li, Jianying Liu, Jian Wang, Wenxin Hong, Lingzhai Zhao, Yingfen Wen, Chibiao Yin, Hua Wang, Qi Zhang, Yangyang Li, Pan-Pan Zhou, Rudian Zhang, Yang Liu, Xiaoping Tang, Yongjun Guan, Cheng‐Feng Qin, Ling Chen, Xuanling Shi, Xia Jin, Gong Cheng, Fuchun Zhang, Linqi Zhang

JCI Insight

DOI

2017

Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses

Xian Tang, Jia Guo, Lin Cheng, Caijun Sun, Li Liu, Teng Zuo, Hui Wang, Ling Chen, Linqi Zhang, Zhiwei Chen

Vaccine

DOI

2017

Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses

Hua Wang, Xiangjun Chen, Dianhong Wang, Chen Yao, Qian Wang, Jiayu Xie, Xuanling Shi, Ye Xiang, Wanli Liu, Linqi Zhang

Journal of Biological Chemistry

DOI

2016

TALEN-Mediated Knockout of CCR5 Confers Protection Against Infection of Human Immunodeficiency Virus

Bingjie Shi, Juan Li, Xuanling Shi, Wenxu Jia, Yi Wen, Xiongbing Hu, Fengfeng Zhuang, Jianzhong Xi, Linqi Zhang

JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI

2016

Potent neutralizing monoclonal antibodies against Ebola virus infection

Qi Zhang, Miao Gui, Xuefeng Niu, Shihua He, Ruoke Wang, Yupeng Feng, Andrea Kroeker, Yanan Zuo, Hua Wang, Ying Wang, Jiade Li, Chufang Li, Yi Shi, Xuanling Shi, George F. Gao, Ye Xiang, Xiangguo Qiu, Ling Chen, Linqi Zhang

Scientific Reports

DOI

2016

Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Xiaohua Ye, Chen Fan, Zhiqiang Ku, Teng Zuo, Liangliang Kong, Chao Zhang, Jinping Shi, Qingwei Liu, Tan Chen, Yingyi Zhang, Wen Jiang, Linqi Zhang, Zhong Wei Huang, Yao Cong

PLoS Pathogens

DOI

2016

Spatiotemporal hierarchy in antibody recognition against transmitted HIV-1 envelope glycoprotein during natural infection

Jin Su, Yangtao Ji, Qian Wang, Hua Wang, Xuanling Shi, Xiaoxu Han, Tongqing Zhou, Hong Shang, Linqi Zhang

Retrovirology

DOI

2015

MSM and HIV-1 infection in China

Hong Shang, Linqi Zhang

National Science Review

DOI

2015

Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection

Teng Zuo, Jianfeng Sun, Guiqin Wang, Liwei Jiang, Yanan Zuo, Danyang Li, Xuanling Shi, Xi Liu, Shilong Fan, Huanhuan Ren, Hongxing Hu, Lina Sun, Boping Zhou, Mifang Liang, Paul Zhou, Xinquan Wang, Linqi Zhang

Nature Communications

DOI

2015

Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition

Wenzhong Yan, Jie Qing, Hanbing Mei, Junxiu Nong, Jin Yan Huang, Jin Zhu, Hualiang Jiang, Lei Liu, Linqi Zhang, Jian Li

Bioorganic & Medicinal Chemistry Letters

DOI

2015

No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses

Dimiter Stanchev Dimitrov, Shibo Jiang, Tianlei Ying, Chien-Te Kent Tseng, Linqi Zhang, Kwok‐Yung Yuen

Proceedings of the National Academy of Sciences

DOI

2015

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27

Xiaojuan Yu, Senyan Zhang, Liwei Jiang, Ye Cui, Dongxia Li, Dongli Wang, Nianshuang Wang, Lili Fu, Xuanlin Shi, Ziqiang Li, Linqi Zhang, Xinquan Wang

Scientific Reports

DOI

2015

Discovery of Imidazo[1,2-α][1,8]naphthyridine Derivatives as Potential HCV Entry Inhibitor

Huan Wang, Shuo Wang, Lili Cheng, Ligong Chen, Yongguang Wang, Jie Qing, Shengdian Huang, Yuanhao Wang, Xiaoqiang Lei, Yunfei Wu, Zhilong Ma, Linqi Zhang, Yefeng Tang

ACS Medicinal Chemistry Letters

DOI

2015

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization

Wenzhong Yan, Jie Qing, Hanbing Mei, Fei Mao, Jin Yan Huang, Jin Zhu, Hualiang Jiang, Lei Liu, Linqi Zhang, Jian Li

Molecules

DOI

2015

A Dual-Reporter System for Real-Time Monitoring and High-throughput CRISPR/Cas9 Library Screening of the Hepatitis C Virus

Qingpeng Ren, Chan Li, Pengfei Yuan, Changzu Cai, Linqi Zhang, Guangxiang George Luo, Wensheng Wei

Scientific Reports

DOI

2015

Simian Immunodeficiency Virus Infection Evades Vaccine-Elicited Antibody Responses to V2 Region

Jia Guo, Teng Zuo, Lin Cheng, Xilin Wu, Jiansong Tang, Caijun Sun, Liqiang Feng, Ling Chen, Linqi Zhang, Zhiwei Chen

JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI

2014

Combinatorial library-based profiling of the antibody response against hepatitis C virus in humans

Kan Luo, Shu Li, Liwei Jiang, Teng Zuo, Jie Qing, Xuanling Shi, Yali Liu, Hao Wu, Xinyue Chen, Linqi Zhang

Journal of General Virology

DOI

2014

Complex structure of MERS-CoV spike glycoprotein with human receptor DPP4

Nianshuang Wang, Liwei Jiang, Xuanling Shi, Kwok-Man Vincent Poon, Kwok‐Yung Yuen, Bo‐Jian Zheng, Linqi Zhang, Xinquan Wang

Acta Crystallographica Section A Foundations and Advances

DOI

2014

Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein

Liwei Jiang, Nianshuang Wang, Teng Zuo, Xuanling Shi, Vincent Kwok‐Man Poon, Yongkang Wu, Fei Gao, Danyang Li, Ruoke Wang, Jianying Guo, Lili Fu, Kwok‐Yung Yuen, Bo‐Jian Zheng, Xinquan Wang, Linqi Zhang

Science Translational Medicine

DOI

2014

Migration Patterns of Hepatitis C Virus in China Characterized for Five Major Subtypes Based on Samples from 411 Volunteer Blood Donors from 17 Provinces and Municipalities

Ling Lü, Min Wang, Wenjie Xia, Linwei Tian, Ru Xu, Chunhua Li, Jingxing Wang, Rong Xia, Huaping Xiong, Ke Huang, Jieting Huang, Tatsunori Nakano, Phil Bennett, Yong Zhang, Linqi Zhang, Yongshui Fu

Journal of Virology

DOI

2014

Design and synthesis of imidazo[1,2-α][1,8]naphthyridine derivatives as anti-HCV agents via direct C–H arylation

Shengdian Huang, Jie Qing, Shuo Wang, Huan Wang, Linqi Zhang, Yefeng Tang

Organic & Biomolecular Chemistry

DOI

2013

抗人类免疫缺陷病毒广谱中和抗体与疫苗设计

王若珂，郭建影，张林琦

《微生物与感染》

2013

DNA Prime and Virus-like Particle Boost From a Single H5N1 Strain Elicits Broadly Neutralizing Antibody Responses Against Head Region of H5 Hemagglutinin

Guiqin Wang, Fan Zhou, Philippe Buchy, Teng Zuo, Hongxing Hu, Jingjing Liu, Yufeng Song, Heng Ding, Cheguo Tsai, Ze Chen, Linqi Zhang, Vincent Deubel, Paul Zhou

The Journal of Infectious Diseases

DOI

2013

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

Nianshuang Wang, Xuanling Shi, Liwei Jiang, Senyan Zhang, Dongli Wang, Pei Tong, Dongxing Guo, Lili Fu, Ye Cui, Xi Liu, Kelly C. Arledge, Ying-Hua Chen, Linqi Zhang, Xinquan Wang

Cell Research

DOI

2013

Comprehensive mapping of SIVmac239 envelope antigenic determinants recognized by specific polyclonal antibodies in vaccinated and/or infected macaques (P4503)

Jia Guo, Teng Zuo, Lin Cheng, Caijun Sun, Ling Chen, Linqi Zhang, Zhiwei Chen

The Journal of Immunology

DOI

2013

Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys

Caijun Sun, Zhiwei Chen, Xian Tang, Yinfeng Zhang, Liqiang Feng, Yanhua Du, Lijun Xiao, Li Liu, Weijun Zhu, Ling Chen, Linqi Zhang

Journal of Virology

DOI

2013

Stapled peptide-based membrane fusion inhibitors of hepatitis C virus

Hong‐Kui Cui, Jie Qing, Ye Guo, Yujia Wang, Lijia Cui, Tianhua He, Linqi Zhang, Lei Liu

Bioorganic & Medicinal Chemistry

DOI

2013

Persistence of VRC01-resistant HIV-1 during antiretroviral therapy

Dongxing Guo, Xuanling Shi, Dingka Song, Linqi Zhang

Science China Life Sciences

DOI

2012

Unraveling of a Neutralization Mechanism by Two Human Antibodies against Conserved Epitopes in the Globular Head of H5 Hemagglutinin

Mengran Qian, Hongxing Hu, Teng Zuo, Guiqin Wang, Linqi Zhang, Paul Zhou

Journal of Virology

DOI

2012

A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

Hongxing Hu, Jarrod Voss, Guoliang Zhang, Philippe Buchy, Teng Zuo, Lulan Wang, Feng Wang, Fan Zhou, Guiqing Wang, Cheguo Tsai, Lesley J. Calder, Steve J. Gamblin, Linqi Zhang, Vincent Deubel, Boping Zhou, John James Skehel, Paul Zhou

Journal of Virology

DOI

2012

A Single Residue within the V5 Region of HIV-1 Envelope Facilitates Viral Escape from the Broadly Neutralizing Monoclonal Antibody VRC01

Dongxing Guo, Xuanling Shi, Kelly C. Arledge, Dingka Song, Liwei Jiang, Lili Fu, Xinqi Gong, Senyan Zhang, Xinquan Wang, Linqi Zhang

Journal of Biological Chemistry

DOI

2011

HIV-1广谱中和抗体的研究进展和启示

汪桦，刘懿锋，张林琦

《中国病毒病杂志》

2011

Comprehensive Analysis of Pathogen-specific Antibody Response in Vivo Based on an Antigen Library Displayed on Surface of Yeast

Teng Zuo, Xuanling Shi, Zhonghua Liu, Linlin Guo, Qing Sheng Zhao, Tianxia Guan, Xian‐Ming Pan, Na Jia, Wu‐Chun Cao, Boping Zhou, Mark Goldin, Linqi Zhang

Journal of Biological Chemistry

DOI

2011

Intranasal Immunization with Recombinant HA and Mast Cell Activator C48/80 Elicits Protective Immunity against 2009 Pandemic H1N1 Influenza in Mice

Shu Meng, Zhonghua Liu, Lili Xu, Li Li, Shan Mei, Linlin Bao, Wei Deng, Lina Li, Rongyue Lei, Liangzhi Xie, Chuan Qin, Linqi Zhang

PLoS ONE

DOI

2011

Potent and Broad Anti-HIV-1 Activity Exhibited by a Glycosyl-Phosphatidylinositol-Anchored Peptide Derived from the CDR H3 of Broadly Neutralizing Antibody PG16

Lihong Liu, Michael Wen, Weiming Wang, Shumei Wang, Lifei Yang, Yong Liu, Mengran Qian, Linqi Zhang, Yiming Shao, Jason T. Kimata, Paul Zhou

Journal of Virology

DOI

2011

Rapid Turnover of 2-LTR HIV-1 DNA during Early Stage of Highly Active Antiretroviral Therapy

Weijun Zhu, Yanmei Jiao, Rongyue Lei, Wei Hua, Rui Wang, Yunxia Ji, Zhiying Liu, Feili Wei, Tong Zhang, Xuanlin Shi, Hao Wu, Linqi Zhang

PLoS ONE

DOI

2010

黏膜免疫系统和黏膜疫苗

孟姝，李莉，梅珊，张林琦

《传染病信息》

2010

In Vitro Selection and Characterization of HIV-1 Variants with Increased Resistance to Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

Zhonghua Liu, Shan Mei, Li Li, Lu Lu, Shu Meng, Cheng Chen, Yuxian He, Shibo Jiang, Linqi Zhang

Journal of Biological Chemistry

DOI

2010

AIDS Vaccine for Asia Network (AVAN): Expanding the Regional Role in Developing HIV Vaccines

Stephen John Kent, David A. Cooper, Mean Chhi Vun, Yiming Shao, Linqi Zhang, Nirmal Kumar Ganguly, Budiman Bela, Hiko Tamashiro, Rossana A. Ditangco, Supachai Rerks‐Ngarm, Punnee Pitisuttithum, Nguyễn Văn Kính, Alan Bernstein, Saladin Osmanov, for the AIDS Vaccine for Asia Network investigators and supporters

PLoS Medicine

DOI

2010

Defining the objectives of the AIDS vaccine for Asia network: report of the WHO-UNAIDS/Global HIV vaccine enterprise regional consultation on expanding AIDS vaccine research and development capacity in Asia

Supachai Rerks‐Ngarm, Punnee Pitisuttithum, Nirmal Kumar Ganguly, Linqi Zhang, Hiko Tamashiro, David A. Cooper, Mean Chhi Vun, Budiman Bela, Rossana A. Ditangco, Nguyễn Văn Kính, Alan Bernstein, Saladin Osmanov, Bonnie J. Mathieson, Stephen John Kent, Yiming Shao

Current Opinion in HIV and AIDS

DOI

2010

Acute Infection of Chinese Macaques by a CCR5-Tropic SHIV Carrying a Primary HIV-1 Subtype B' Envelope

Haibo Wang, Ke Zhuang, Li Liu, Zhijiao Tang, Juanjie Tang, Po Tien, Linqi Zhang, Zhiwei Chen

JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI

2009

One time intranasal vaccination with a modified vaccinia Tiantan strain MVTTZCI protects animals against pathogenic viral challenge

Wenbo Yu, Qing Fang, Weijun Zhu, Haibo Wang, Po Tien, Linqi Zhang, Zhiwei Chen

Vaccine

DOI

2009

A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal Vaccination

Xiaoxing Huang, Bin Lu, Wenbo Yu, Qing Fang, Li Liu, Ke Zhuang, Tingting Shen, Haibo Wang, Tian Po, Linqi Zhang, Zhiwei Chen

PLoS ONE

DOI

2008

Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B

Gavin Bart, Paola Piccolo, Linqi Zhang, Ira Jacobson, Robert A. Schaefer, Mary Jeanne Kreek

Addiction，Vol. 1030, No. 40

DOI

2008

Design and Evaluation of Sifuvirtide, a Novel HIV-1 Fusion Inhibitor

Yuxian He, Yonghong Xiao, Haifeng Song, Qing Liang, Dan Ju, Xin Chen, Hong Lü, Weiguo Jing, Shibo Jiang, Linqi Zhang

Journal of Biological Chemistry

DOI

2007

Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques

Hannah Yuan Chen, Michele Di Mascio, Alan S. Perelson, David D. Ho, Linqi Zhang

Proceedings of the National Academy of Sciences

DOI

2005

人类免疫缺陷病毒-1感染者外周血单个核细胞体外培养的免疫学及病毒学特点

张政，赵敏，聂为民，金磊，姜天俊，汤紫荣，王建，张林琦，王福生

《中华医学杂志》

2004

中国部分地区HIV-1流行株基因型分布与母婴传播

李关汉，陈志伟，陈铮，魏飞力，梅珊，黄耀新，张林琦，曹韵贞

《中华流行病学杂志》

2003

中国经血传播人群中艾滋病病毒-1与丙型肝炎病毒亚型分布研究

阴宁，梅珊，李莉，魏飞力，张林琦，曹韵贞

《中华流行病学杂志》

2002

HIV-1感染者中HCV混合感染情况分析

阴宁，梅珊，张林琦，周曾全，卢维全，何云，张福杰，曹韵贞

《中国感染与化疗杂志》

1995

HIV-1急性感染期的病毒学研究

张林琦

《传染病信息》

1994

丙型肝炎病毒的分子生物学

张林琦

《国际病毒学杂志》

1992

两株海南省恶性疟原虫gp195的脱氧核糖核酸序列分析

管惟滨，D.Walliker，L.Ranford-Cartwright，张林琦，徐荻

《中国寄生虫学与寄生虫病杂志》

精选作品

期刊论文

创新型治疗用生物制品CMC加速开发与注册的国内外法规现状与分析

A potent human neutralizing antibody targeting the receptor-binding site in the glycoprotein gp350 of Epstein-Barr virus

Decoding antibody response to MERS-CoV in wild dromedary camels

Rational Design and Identification of Highly Selective TLR8 Agonists as Potent HIV-1 Latency Reversal Agents

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection

Broad and durable protection against SARS-CoV-2 and SARS-CoV by an intranasal chimpanzee adenovirus vaccine expressing tandem RBDs and nucleocapsid

Bruton's tyrosine kinase inhibitor BTKi-2 inhibits mpox virus and vaccinia virus infection

Identification and characterization of bone marrow plasma cells producing IFN-γ-neutralizing autoantibodies in adult-onset immunodeficiency

Decoding antibody response to MERS-CoV in wild dromedary camels

Grand Challenges on HIV/AIDS in China – The 5th Symposium, Yunnan 2024

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Organoid-based neutralization assays reveal a distinctive profile of SARS-CoV-2 antibodies and recapitulate the real-world efficacy

Enantiomer-dependent and modification-free DNA matrix as an adjuvant for subunit vaccines against SARS-CoV-2 or pneumococcal infections

FlowDesign: Improved design of antibody CDRs through flow matching and better prior distributions

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration

The Fourth Symposium of Grand Challenges on HIV (2023.12.28)

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

Pandemic research: the need for a paradigm shift

Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells

Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria

Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1

Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody

Editorial: AIDS 40th Year

Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

安巴韦单抗注射液（BRII-196）及罗米司韦单抗注射液（BRII-198）——中国首个自主知识产权新冠病毒中和抗体联合治疗药物

美国FDA紧急使用授权（EUA）批准的新冠病毒抗体药物研发进展

Broadly neutralizing antibodies against SARS-CoV-2 variants

A commentary of “‘Shock and Kill’ of Latent HIV” : 10 remarkable discoveries from 2020 in Nature

The Rational Combination Strategy of Immunomodulatory Latency Reversing Agents and Novel Immunotherapy to Achieve HIV-1 Cure

Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses

Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein

Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

Identification and semisynthesis of (−)-anisomelic acid as oral agent against SARS-CoV-2 in mice

Case report: Drug rash with eosinophilia and systemic symptoms syndrome in a patient with anti–interferon-γ autoantibody–associated immunodeficiency

Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2

The humoral response and antibodies against SARS-CoV-2 infection

SARS-CoV-2 Omicron Variants Reduce Antibody Neutralization and Acquire Usage of Mouse ACE2

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

潜伏的HIV病毒被“激杀”

美国食品药品监督管理局接受不确定性:治疗多重耐药的人类免疫缺陷病毒感染的单克隆抗体加速获批

新冠病毒变异，可怕吗

疫苗接种可以阻断新冠传播吗

Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

Tandem bispecific antibody prevents pathogenic SHIVSF162P3CN infection and disease progression

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants

A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus

A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Role of efficient testing and contact tracing in mitigating the COVID-19 pandemic: a network modelling study

Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

Differential impact of non-pharmaceutical public health interventions on COVID-19 epidemics in the United States

HLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients

An integrated framework for modelling quantitative effects of entry restrictions and travel quarantine on importation risk of COVID-19

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

A novel cell culture system modeling the SARS-CoV-2 life cycle

新型冠状病毒肺炎疫情对抗病毒药研发和监管的启示

从血浆疗法到单克隆抗体，再到新冠疫苗

A safety consideration of mesenchymal stem cell therapy on COVID-19

Surging publications on the COVID-19 pandemic

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

Human neutralizing antibodies elicited by SARS-CoV-2 infection