董忠军｜安徽医科大学｜学者主页

2026

METTL14-mediated m6A methylation orchestrates early NK cell development by maintaining metabolic fitness

Huan Ma, Zhenzhen Tu, Su-Rong Deng, Yi-Rong Sun, Shuxin Wang, Hong-Xia Wang, Chen Cheng, Xiang Li, Zhongjun Dong, Sha-Sha Chen

Cell Death & Disease

DOI

2026

Liver kinase B1 maintains natural killer cell survival by regulating redox homeostasis

Wanqing Meng, Liang Luo, Zhiqiang Xiao, Jiayuan Huang, Yong Huang, Ming-Yue Zhao, Wenkai Lv, B. Xin, Peiran Feng, Jun He, Han-Lin Shuai, Zhongjun Dong, Meixiang Yang

Cell Death and Disease

DOI

2025

AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity.

Haoran Wei, Caixia Suo, Xuemei Gu, Sheng-Qi Shen, Ka-Shuai Lin, Chuxu Zhu, Kai Yan, Zhenhua Bian, Liang Chen, Tong Zhang, Ronghui Yan, Zhiyi Yang, Ying-Xuan Yu, Zhikun Li, Rui Liu, Jun-Ming He, Qi-Wei He, Xiu-Ying Zhong, W. Jia, Chun-Ming Wong, Zhongjun Dong, Jie Cao, Linchong Sun, Hua-Feng Zhang, Ping Gao

Cell Metabolism

DOI

2025

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Jun-Ming He, Xinlei Hou, Xiaomei Feng, Ya-Yun Dong, M. Ren, S. Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Sha-Sha Chen, Meixiang Yang, Zhongjun Dong

Advancement of science

DOI

2025

Reduced immune response to SARS-CoV-2 infection in the elderly after 6 months

Q. Luo, Qin-Qin Song, Yan Li, Kexin Zong, Ti Liu, Jun-Ming He, Guo-Yong Mei, Hai-Jun Du, Zhiqiang Xia, Mi Liu, Juan Song, Chen Gao, Dong Xia, Guangyu Xue, Wenyan Tian, Yi Qu, Zeng-Qiang Kou, Zhongjun Dong, Jun Han

Frontiers in Immunology

DOI

2025

Calpain-2 facilitates infection of the intracellular bacteria Listeria monocytogenes and invasion intestinal immune barrier by impairing nitric oxide homeostasis

Bo Yao, Jing-Ru Wang, Ding-Yu Hou, Weiming Liu, Chen Xie, Kaiyuan Shi, Wenyi Han, Xiaofeng Miao, Jun Chen, Zhi-Hui Cai, Hui Yang, Qinjie Ling, Kai Yin, Zhongjun Dong, Zhi Huang

Journal of Advanced Research

DOI

2025

Adaptive immune cells antagonize ILC2 homeostasis via SLAMF3 and SLAMF5

Yuande Wang, Dan Li, Yehai Liu, Sha-Sha Chen, Zhongjun Dong

Science Advances

DOI

2024

STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking

Jun-Ming He, Yue-Xi He, Ruo-Jia Biao, Yuqing Wei, Zhongjun Dong, Juan Du

Journal of Translational Medicine

DOI

2024

A single-cell analysis of the NK-cell landscape reveals that dietary restriction boosts NK cell antitumor immunity via Eomesdermin.

Jun-Ming He, Donglin Chen, Wei Xiong, Yuande Wang, Sha-Sha Chen, Meixiang Yang, Zhongjun Dong

Cancer immunology research

DOI

2024

SLAM-family receptors promote resolution of ILC2-mediated inflammation

Yuande Wang, Yuhe Quan, Jun-Ming He, Sha-Sha Chen, Zhongjun Dong

Nature Communications

DOI

2024

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan, Zhi-Zhong Li, Guo-Dong Sun, Zhongjun Dong, Meixiang Yang

Cell Death and Disease

DOI

2024

Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively

Jun-Ming He, Donglin Chen, Wei Xiong, Xinlei Hou, Yuhe Quan, Meixiang Yang, Zhongjun Dong

Cellular & Molecular Immunology

DOI

2024

cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation

Ruibo Zhao, Jinghe Zhang, Jialu Ma, Yali Qu, Zhenrong Yang, Zhi-Nan Yin, Fengyin Li, Zhongjun Dong, Qin-Miao Sun, Shu Zhu, Zhijian J. Chen, Daxing Gao

Science immunology

DOI

2024

Unleashing a safe and potent pro-senescence anti-tumor strategy.

Sha-Sha Chen, Bei-Cheng Sun, Zhongjun Dong

Cancer Cell

DOI

2024

Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence

Sha-Sha Chen, Ze-Hua Li, Jin Feng, Yuhe Quan, Jun-Ming He, Ji-Qing Hao, Zhongjun Dong

Advancement of science

DOI

2024

Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis

Peiran Feng, Quanli Yang, Liang Luo, Zerong Guan, Jiamin Fu, Mingyu Zhao, Wanqing Meng, Shuo Wan, Jun He, Zhi-Zhong Li, Guang Wang, Guo-Dong Sun, Zhongjun Dong, Meixiang Yang

Cell Death and Differentiation

DOI

2023

NK细胞生物特性及抗肿瘤治疗研究进展

陈莎莎，权雨荷，董忠军

《中国细胞生物学学报》

2023

Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development

L. Luo, Peiran Feng, Quanli Yang, Wenkai Lv, Wanqing Meng, Z. Yin, Zhi-Zhong Li, Guodong Sun, Zhongjun Dong, Meixiang Yang

Theranostics

DOI

2022

TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis

Qifeng He, Yijun Lu, W. Tian, R. Jiang, Weiwei Yu, Yong Liu, Meiling Sun, Fei Wang, Haitian Zhang, Ning Wu, Zhongjun Dong, Beicheng Sun

Cellular & Molecular Immunology

DOI

2022

SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors

Dan Li, Wei Xiong, Yuande Wang, Jin Feng, Yue-Xi He, Juan Du, Jing Wang, Mei-Xiang Yang, H. Zeng, Yong-Guang Yang, Ning Wu, Sha-Sha Chen, Zhongjun Dong

Science immunology

DOI

2021

The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis

Peiran Feng, Quanli Yang, L. Luo, Yadong Sun, Wenkai Lv, Shuo Wan, Zerong Guan, Zhiqiang Xiao, Feng Liu, Ze-Hua Li, Zhongjun Dong, Mei-Xiang Yang

Theranostics

DOI

2021

mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet

Dan Li, Yuande Wang, Mei-Xiang Yang, Zhongjun Dong

Cell Death and Differentiation

DOI

2021

Detection of CD8+ T cell-mediated immune responses to bacterial infection in mice

Jun Wu, Gen Li, Dan Li, Jia-Wen Zhou, Zhongjun Dong, Peng Jiang

STAR Protocols

DOI

2021

Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses

Jun Wu, Gen Li, Le Li, Dan Li, Zhongjun Dong, P. Jiang

Nature Cell Biology

DOI

2021

Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival

Junming He, Jun Zhao, Yuhe Quan, Xinlei Hou, Mei-Xiang Yang, Zhongjun Dong

Frontiers in Immunology

DOI

2021

Declined miR‐181a‐5p expression is associated with impaired natural killer cell development and function with aging

Jiao Lu, Shan Li, Xiaopeng Li, Wen-Ming Zhao, X. Duan, Xiu-Ling Gu, Jian-Qiao Xu, Bolan Yu, L. Sigal, Zhongjun Dong, Li-Xin Xie, Min Fang

Aging Cell

DOI

2020

Regulation of MHC class I-independent NK cell education by SLAM family receptors.

Sha-Sha Chen, Dan Li, Yuande Wang, Qiaozhen Li, Zhongjun Dong

Advances in Immunology

DOI

2020

PBX1 expression in uterine natural killer cells drives fetal growth

Yong-Gang Zhou, Bin-Qing Fu, Xiuxiu Xu, Jinghe Zhang, X. Tong, Yanshi Wang, Zhongjun Dong, Xiaoren Zhang, N. Shen, Yiwen Zhai, X. Kong, R. Sun, Z. Tian, Hai-Ming Wei

Science Translational Medicine

DOI

2020

Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization

Yue-Xi He, Juan Du, Zhongjun Dong

Oncoimmunology

DOI

2020

PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter

Xiuxiu Xu, Yong-Gang Zhou, Bin-Qing Fu, Jinghe Zhang, Zhongjun Dong, Xiaoren Zhang, N. Shen, R. Sun, Z. Tian, Hai-Ming Wei

The FASEB Journal

DOI

2019

Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells

Chunxiao Liu, Yifan Zhou, Meng-Di Li, Ying Wang, Liu Yang, Shigao Yang, Yarui Feng, Yin-Yin Wang, Yang-Meng Wang, F. Ren, Jun Li, Zhongjun Dong, Y. Chin, Xin-Yuan Fu, Li Wu, Zhi-Jie Chang

Theranostics

DOI

2019

Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

Xiaoqian Zhang, Jin Feng, Sha-Sha Chen, Haoyan Yang, Zhongjun Dong

Nature Communications

DOI

2019

Concomitant deletion of SLAM‐family receptors, NKG2D and DNAM‐1 reveals gene redundancy of NK cell activating receptors in NK cell development and education

Sha-Sha Chen, Zhongjun Dong

Journal of Leukocyte Biology

DOI

2019

Stage-specific requirement of kinase PDK1 for NK cells development and activation

Junming He, Yuande Wang, Tian Liu, Guangao Liu, Sha-Sha Chen, Qiaozhen Li, Yuhe Quan, Haoyan Yang, Jin Feng, Song Wang, Mei-Xiang Yang, Zhongjun Dong

Cell Death and Differentiation

DOI

2019

Liver‐Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD‐1‐PD‐L1 Axis

Jing Zhou, Hui Peng, Kun Li, K. Qu, Baohui Wang, Yu-Zhang Wu, L. Ye, Zhongjun Dong, Hai-Ming Wei, R. Sun, Z. Tian

Immunity

DOI

2019

NK cell recognition of hematopoietic cells by SLAM-SAP families

Sha-Sha Chen, Zhongjun Dong

Cellular & Molecular Immunology

DOI

2018

自然杀伤细胞通过分泌生长促进因子协助胚胎早期发育

傅斌清，周永刚，倪想，Xianhong Tong，Xiuxiu Xu，Zhongjun Dong，Rui Sun，田志刚，魏海明

《科学新闻》

2018

BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis

Jin-Feng Zhou, Weiming Lai, Wanjie Yang, Juping Pan, Hu Shen, Ying-Ying Cai, Cui-Xia Yang, N. Ma, Yue Zhang, Ru Zhang, Xin Xie, Zhongjun Dong, Yuan Gao, Chang-Sheng Du

Cellular & Molecular Immunology

DOI

2018

PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses

Jing Wang, Sichen Liu, B. Hou, Mei-Xiang Yang, Zhongjun Dong, Hai Qi, Wanli Liu

Frontiers in Immunology

DOI

2018

Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages

Xiaokang Zeng, Guangao Liu, Wanwen Peng, Junming He, Chen-Xu Cai, W. Xiong, Sha-Sha Chen, Mei-Xiang Yang, Zhongjun Dong

Cellular & Molecular Immunology

DOI

2017

自身特异的活化性受体SLAM家族受体对NK细胞教育至关重要

Shasha Chen, Meixiang Yang, Juan Du, Dan Li, Zehua Li, Chenxu Cai, Yuanwu Ma, Lianfeng Zhang, 田志刚, 董忠军

《科学新闻》

2017

IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis

Jin-Ling Huang, Q. Yuan, Hui Zhu, L. Yin, Shan-Juan Hong, Zhongjun Dong, W. Jin, C. Dong

Journal of Immunology

DOI

2017

Natural Killer Cells Promote Fetal Development through the Secretion of Growth‐Promoting Factors

Bin-Qing Fu, Yong-Gang Zhou, Xiang Ni, X. Tong, Xiuxiu Xu, Zhongjun Dong, R. Sun, Z. Tian, Hai-Ming Wei

Immunity

DOI

2017

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity

Sha-Sha Chen, Chen-Xu Cai, Ze-Hua Li, Guangao Liu, Yuande Wang, M. Blonska, Dan Li, Juan Du, Xin Lin, Mei-Xiang Yang, Zhongjun Dong

Journal of Experimental Medicine

DOI

2017

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

Young-hee Lee, N. Martín-Orozco, Pei-Lin Zheng, Jing Li, Peng Zhang, H. Tan, H. Park, M. Jeong, S. Chang, Byung-Seok Kim, Wei Xiong, Wenjuan Zang, Li Guo, Yang Liu, Zhongjun Dong, W. Overwijk, P. Hwu, Q. Yi, L. Kwak, Zhi-Ying Yang, T. Mak, Wei Li, L. Radvanyi, L. Ni, Dongfang Liu, C. Dong

Cell Research

DOI

2016

The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education.

Sha-Sha Chen, Mei-Xiang Yang, Juan Du, Dan Li, Ze-Hua Li, Chen-Xu Cai, Yuanwu Ma, Lian-Feng Zhang, Z. Tian, Zhongjun Dong

Immunity

DOI

2016

A hematopoietic cell–driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education

Ning Wu, Ming-Chao Zhong, Romain Roncagalli, Luis-Alberto Pérez-Quintero, Huai-Jian Guo, Zhanguang Zhang, C. Lenoir, Zhongjun Dong, S. Latour, A. Veillette

Nature Immunology

DOI

2016

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

Mei-Xiang Yang, Sha-Sha Chen, Juan Du, Junming He, Yuande Wang, Ze-Hua Li, Guangao Liu, Wanwen Peng, Xiaokang Zeng, Dan Li, Pang-Lian Xu, Wei Guo, Z. Chang, Song Wang, Z. Tian, Zhongjun Dong

Nature Communications

DOI

2016

This information is current as in Autoimmune Hepatitis IL-17 C / IL-17 RE Augments T Cell Function

Qing Yuan, Hui Zhu, Lan-Lan Yin, Shan-Juan Hong, Zhongjun Dong, W. Jin

2016

PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model

J. Du, Mei-Xiang Yang, Sheila N. Chen, Dan Li, Z. Chang, Zhongjun Dong

Oncogene

DOI

2015

PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness

Mei-Xiang Yang, Dan Li, Z. Chang, Zhongzhou Yang, Z. Tian, Zhongjun Dong

Journal of Experimental Medicine

DOI

2014

SAP-Regulated T Cell–APC Adhesion and Ligation-Dependent and -Independent Ly108–CD3ζ Interactions

Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Jun-Xia Cao, W. Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lian-Feng Zhang, Long-Yan Wu, Hai Qi

Journal of Immunology

DOI

2013

From the guest editors: Cancer-associated inflammation and tumor microenvironment.

Zhongjun Dong, C. Dong

Cancer Journal

DOI

2012

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.

Zhongjun Dong, D. Davidson, Luis-Alberto Pérez-Quintero, T. Kurosaki, W. Swat, A. Veillette

Immunity

DOI

2012

Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation.

F. Guimont-Desrochers, G. Boucher, Zhongjun Dong, M. Dupuis, A. Veillette, S. Lesage

Blood

DOI

2010

How do SAP family deficiencies compromise immunity?

Zhongjun Dong, A. Veillette

Trends in immunology

DOI

2009

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

M. Cruz-Munoz, Zhongjun Dong, Xiaochu Shi, Shao-Hua Zhang, A. Veillette

Nature Immunology

DOI

2009

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

Zhongjun Dong, M. Cruz-Munoz, Ming-Chao Zhong, Riyan Chen, S. Latour, A. Veillette

Nature Immunology

DOI

2009

Importance and mechanism of ‘switch’ function of SAP family adapters

A. Veillette, Zhongjun Dong, Luis-Alberto Pérez-Quintero, Ming-Chao Zhong, M. Cruz-Munoz

Immunological Reviews

DOI

2008

SAP expression in T cells, not in B cells, is required for humoral immunity

A. Veillette, Shao-Hua Zhang, Xiaochu Shi, Zhongjun Dong, D. Davidson, Ming-Chao Zhong

Proceedings of the National Academy of Sciences of the United States of America

DOI

2007

Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes.

A. Veillette, Zhongjun Dong, S. Latour

Immunity

DOI

2007

Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice

Zhongjun Dong, Jian-Hong Zhang, R. Sun, Hai-Ming Wei, Z. Tian

Hepatology

DOI

2007

The involvement of heat shock proteins in murine liver regeneration.

Qing-Hua Shi, Zhongjun Dong, Hai-Ming Wei

Cellular & Molecular Immunology

2007

Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D‐ligand interaction and natural killer cells

Yong-Yan Chen, Hai-Ming Wei, R. Sun, Zhongjun Dong, Jian Zhang, Z. Tian

Hepatology

DOI

2007

The roles of innate immune cells in liver injury and regeneration.

Zhongjun Dong, Hai-Ming Wei, R. Sun, Z. Tian

Cellular & Molecular Immunology

2006

固有免疫细胞在肝脏损伤和再生中的效应机制

董忠军

《中国科学技术大学》

2006

Selective elimination of hepatic natural killer T cells with Concanavalin A improves liver regeneration in mice

Wen Huang, Zhongjun Dong, Hai-Ming Wei, Chen Ding, R. Sun, Z. Tian

Liver international (Print)

DOI

2006

Pre-activation of T lymphocytes by low dose of concanavalin A aggravates toll-like receptor-3 ligand-induced NK cell-mediated liver injury.

Jing Wang, R. Sun, Hai-Ming Wei, Zhongjun Dong, Z. Tian

International Immunopharmacology

DOI

2006

Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism.

Jing Wang, R. Sun, Hai-Ming Wei, Zhongjun Dong, B. Gao, Z. Tian

Journal of Hepatology

DOI

2005

Impaired NK cell cytotoxicity by high level of interferon-γ in concanavalin A-induced hepatitis

Zhongjun Dong, Cai Zhang, Hai-Ming Wei, R. Sun, Z. Tian

DOI

2005

APC-Independent NK Cell Activation

Zhongjun Dong, Z. Tian

Journal of Immunology

DOI

2005

Isolation of lymphocytes and their innate immune characterizations from liver, intestine, lung and uterus.

Jian-Hong Zhang, Zhongjun Dong, R. Zhou, Deming Luo, Hai-Ming Wei, Z. Tian

Cellular & Molecular Immunology

2004

Involvement of natural killer cells in PolyI:C-induced liver injury.

Zhongjun Dong, Hai-Ming Wei, R. Sun, Zhi-Qing Hu, B. Gao, Z. Tian

Journal of Hepatology

DOI

2004

Isolation of murine hepatic lymphocytes using mechanical dissection for phenotypic and functional analysis of NK1.1+ cells.

Zhongjun Dong, Hai-Ming Wei, R. Sun, Z. Tian, B. Gao

World Journal of Gastroenterology

DOI

2003

小鼠趋化因子SLC的基因克隆及真核表达

董忠军，赵跃然，游力，高春义，田志刚

《中国免疫学杂志》

2002

淋巴细胞归巢趋化因子SLC的研究进展

董忠军

《现代免疫学》

2002

小鼠肝脏天然免疫淋巴细胞分离及其特性研究

董忠军，魏海明，王静，罗德明，张亮，陈清烽，田志刚

《海军军医大学学报》

2002

人次级淋巴组织趋化因子的基因克隆及原核表达

董忠军，赵跃然，游力，高春义，魏海明，田志刚

《海军军医大学学报》

2002

Isolation and characteristics of murine hepatic innate lymphocytes

Zhongjun Dong, Hai-Ming Wei, Jing Wang, Deming Luo, Liang Zhang, Qingfeng Chen, Z. Tian

精选作品

期刊论文

METTL14-mediated m6A methylation orchestrates early NK cell development by maintaining metabolic fitness

Liver kinase B1 maintains natural killer cell survival by regulating redox homeostasis

AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity.

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Reduced immune response to SARS-CoV-2 infection in the elderly after 6 months

Calpain-2 facilitates infection of the intracellular bacteria Listeria monocytogenes and invasion intestinal immune barrier by impairing nitric oxide homeostasis

Adaptive immune cells antagonize ILC2 homeostasis via SLAMF3 and SLAMF5

STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking

A single-cell analysis of the NK-cell landscape reveals that dietary restriction boosts NK cell antitumor immunity via Eomesdermin.

SLAM-family receptors promote resolution of ILC2-mediated inflammation

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively

cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation

Unleashing a safe and potent pro-senescence anti-tumor strategy.

Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence

Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis

NK细胞生物特性及抗肿瘤治疗研究进展

Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development

TOX deficiency facilitates the differentiation of IL-17A-producing γδ T cells to drive autoimmune hepatitis

SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors

The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis

mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet

Detection of CD8+ T cell-mediated immune responses to bacterial infection in mice

Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses

Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival

Declined miR‐181a‐5p expression is associated with impaired natural killer cell development and function with aging

Regulation of MHC class I-independent NK cell education by SLAM family receptors.

PBX1 expression in uterine natural killer cells drives fetal growth

Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization

PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter

Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells

Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

Concomitant deletion of SLAM‐family receptors, NKG2D and DNAM‐1 reveals gene redundancy of NK cell activating receptors in NK cell development and education

Stage-specific requirement of kinase PDK1 for NK cells development and activation

Liver‐Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD‐1‐PD‐L1 Axis

NK cell recognition of hematopoietic cells by SLAM-SAP families

自然杀伤细胞通过分泌生长促进因子协助胚胎早期发育

BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis

PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses

Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages

自身特异的活化性受体SLAM家族受体对NK细胞教育至关重要

IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis

Natural Killer Cells Promote Fetal Development through the Secretion of Growth‐Promoting Factors

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education.

A hematopoietic cell–driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

This information is current as in Autoimmune Hepatitis IL-17 C / IL-17 RE Augments T Cell Function

PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model

PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness

SAP-Regulated T Cell–APC Adhesion and Ligation-Dependent and -Independent Ly108–CD3ζ Interactions

From the guest editors: Cancer-associated inflammation and tumor microenvironment.

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.

Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation.

How do SAP family deficiencies compromise immunity?

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

Importance and mechanism of ‘switch’ function of SAP family adapters

SAP expression in T cells, not in B cells, is required for humoral immunity

Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes.

Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice

The involvement of heat shock proteins in murine liver regeneration.

Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D‐ligand interaction and natural killer cells

The roles of innate immune cells in liver injury and regeneration.

固有免疫细胞在肝脏损伤和再生中的效应机制

Selective elimination of hepatic natural killer T cells with Concanavalin A improves liver regeneration in mice

Pre-activation of T lymphocytes by low dose of concanavalin A aggravates toll-like receptor-3 ligand-induced NK cell-mediated liver injury.

Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism.

Impaired NK cell cytotoxicity by high level of interferon-γ in concanavalin A-induced hepatitis

APC-Independent NK Cell Activation

Isolation of lymphocytes and their innate immune characterizations from liver, intestine, lung and uterus.

Involvement of natural killer cells in PolyI:C-induced liver injury.

Isolation of murine hepatic lymphocytes using mechanical dissection for phenotypic and functional analysis of NK1.1+ cells.

小鼠趋化因子SLC的基因克隆及真核表达

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