唐煌｜广西师范大学｜学者主页

2026

Design, synthesis and anti-Alzheimer's disease activity evaluation of dual 17β-HSD10 and CDK5/p25 inhibitors based on the naphtho[2,3-b]furan-4,9-dione scaffold

Shiyun Dao, Chao Cui, Wanqing He, Erfeng Liu, Lijun Zhang, Huang Tang

European Journal of Medicinal Chemistry

DOI

2026

Synthesis and biological evaluation of novel naphthoquinone [2,3-d] thiazole derivatives as potent 17β-HSD10 inhibitor

Erfeng Liu, Shiyun Dao, Chao Cui, Wanqing He, Lijun Zhang, Huang Tang

Bioorganic Chemistry

DOI

2021

Novel sampangine derivatives as potent inhibitors of Cu2+-mediated amyloid-β protein aggregation, oxidative stress and inflammation

Xiaoyan Zou, Ren-ren Xie, Wěi Li, Chun-ling Su, Yu-si Chen, Huang Tang

International Journal of Biological Macromolecules

DOI

2020

Inhibitory potency of 4- substituted sampangine derivatives toward Cu2+ mediated aggregation of amyloid β-peptide, oxidative stress, and inflammation in Alzheimer's disease

Chun-ling Su, Yusi Chen, Kelin Chen, Wěi Li, Huang Tang

Neurochemistry International

DOI

2019

Hybrids of oxoisoaporphine–tetrahydroisoquinoline: novel multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease

Yusi Chen, Chunlin Su, Li Wang, Jingfang Qin, Shenqi Wei, Huang Tang

Molecular Diversity

DOI

2018

Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease

Juan Wang, Wěi Li, Jingfang Qin, Li Wang, Shenqi Wei, Huang Tang

Bioorganic Chemistry

DOI

2017

Synthesis of derivatives of cleistopholine and their anti-acetylcholinesterase and anti-β-amyloid aggregation activity

Zhenhua Wu, Wen-Xia Liao, Kelin Chen, Jingfang Qin, Huang Tang

Bioorganic Chemistry

DOI

2017

4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors

Kelin Chen, Ling Gan, Zhen-Hua Wu, Jin-Fang Qin, Wen-Xia Liao, Huang Tang

International Journal of Biological Macromolecules

DOI

2017

Oxoisoaporphine alkaloid derivative 8-1 reduces Aβ 1-42 secretion and toxicity in human cell and Caenorhabditis elegans models of Alzheimer's disease

Liyingzi Huang, Yunfeng Luo, Zhijun Pu, Xianghui Kong, Xiang Fu, Huanhuan Xing, Shenqi Wei, Wei Chen, Huang Tang

Neurochemistry International

DOI

2016

Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer’s disease

Shenqi Wei, Wei Chen, Jingfang Qin, Yingzi Huangli, Li Wang, Yue Shen, Huang Tang

Bioorganic & Medicinal Chemistry

DOI

2014

6-(烷胺酰肼基)-1-氮杂苯并蒽酮衍生物的合成及生物活性研究

钟书明，卫沈旗，刘允，唐煌

《有机化学》

2014

Novel hybrids of oxoisoaporphine-tryptamine as acetylcholinesterase-induced β-amyloid aggregation inhibitors with improved antioxidant properties

Hai-Tao Zhao, Shu‐Ming Zhong, Jiang‐Ke Qin, Huang Tang

Journal of the Serbian Chemical Society

DOI

2014

Anti-neurotoxicity effects of oxoisoaporphine-lipoic acid hybrids

Wei Chen, Yuhuan Wu, Shu‐Ming Zhong, Ling Cheng, Qinghua Li, Huang Tang

Chemico-Biological Interactions

DOI

2013

Synthesis and biological evaluation of 1, 3-dihydroxyxanthone mannich base derivatives as anticholinesterase agents

Jiang‐Ke Qin, Wenli Lan, Zhong Liu, JUN C. HUANG, Huang Tang, Heng‐Shan Wang

Chemistry Central Journal

DOI

2012

氧化异阿朴菲-褪黑素杂合体的合成、抗β淀粉样蛋白聚集及抗氧化活性

唐煌，钟书明，赵丽珍，赵海涛

《应用化学》

2012

6-[(2-Hydroxyethyl)amino]-7H-dibenzo[de,h]quinolin-7-one

Huang Tang, Zhiyu Wang, Yan‐Cheng Liu

Acta Crystallographica Section E Structure Reports Online

DOI

2012

Oxoisoaporphine-Melatonin Hybrids: Synthesis, Inhibition of β-Amyloid Aggregation and Antioxidation

Huang Tang, Shu‐Ming Zhong, Li-Zhen Zhao, Hai-Tao Zhao

Chinese Journal of Applied Chemistry

DOI

2012

Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

Huang Tang, Hai-Tao Zhao, Shu‐Ming Zhong, Zhiyu Wang, Zhen‐Feng Chen, Hong Liang

Bioorganic & Medicinal Chemistry Letters

DOI

2011

氧化阿朴菲生物碱衍生物与DNA的相互作用及抗肿瘤活性研究

唐煌，魏永标，王晓冬，黄志纾，古练权

《西北药学杂志》

2011

ChemInform Abstract: Hybrids of Oxoisoaporphine‐Tacrine Congeners: Novel Acetylcholinesterase and Acetylcholinesterase‐Induced β‐Amyloid Aggregation Inhibitors.

Huang Tang, Lizhen Zhao, Hao‐Tao Zhao, Shi‐Liang Huang, Shu‐Ming Zhong, Jiang‐Ke Qin, Zhen‐Feng Chen, Zhi‐Shu Huang, Hong Liang

ChemInform

DOI

2011

Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors

Huang Tang, Li-Zhen Zhao, Hao‐Tao Zhao, Shi‐Liang Huang, Shu‐Ming Zhong, Jiang‐Ke Qin, Zhen‐Feng Chen, Zhi‐Shu Huang, Hong Liang

European Journal of Medicinal Chemistry

DOI

2010

呫吨酮并吡啶季铵盐的合成及其生物活性

覃江克，兰文丽，韩留玉，唐煌，苏桂发，戴支凯，徐庆

《应用化学》

2009

呋喃并呫吨酮衍生物的合成与生物活性研究

覃江克，韩留玉，兰文丽，唐煌，苏桂发，戴支凯，徐庆

《化学学报》

唐煌

精选作品

期刊论文

Design, synthesis and anti-Alzheimer's disease activity evaluation of dual 17β-HSD10 and CDK5/p25 inhibitors based on the naphtho[2,3-b]furan-4,9-dione scaffold

Synthesis and biological evaluation of novel naphthoquinone [2,3-d] thiazole derivatives as potent 17β-HSD10 inhibitor

Novel sampangine derivatives as potent inhibitors of Cu2+-mediated amyloid-β protein aggregation, oxidative stress and inflammation

Inhibitory potency of 4- substituted sampangine derivatives toward Cu2+ mediated aggregation of amyloid β-peptide, oxidative stress, and inflammation in Alzheimer's disease

Hybrids of oxoisoaporphine–tetrahydroisoquinoline: novel multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease

Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease

Synthesis of derivatives of cleistopholine and their anti-acetylcholinesterase and anti-β-amyloid aggregation activity

4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors

Oxoisoaporphine alkaloid derivative 8-1 reduces Aβ 1-42 secretion and toxicity in human cell and Caenorhabditis elegans models of Alzheimer's disease

Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer’s disease

6-(烷胺酰肼基)-1-氮杂苯并蒽酮衍生物的合成及生物活性研究

Novel hybrids of oxoisoaporphine-tryptamine as acetylcholinesterase-induced β-amyloid aggregation inhibitors with improved antioxidant properties

Anti-neurotoxicity effects of oxoisoaporphine-lipoic acid hybrids

Synthesis and biological evaluation of 1, 3-dihydroxyxanthone mannich base derivatives as anticholinesterase agents

氧化异阿朴菲-褪黑素杂合体的合成、抗β淀粉样蛋白聚集及抗氧化活性

6-[(2-Hydroxyethyl)amino]-7H-dibenzo[de,h]quinolin-7-one

Oxoisoaporphine-Melatonin Hybrids: Synthesis, Inhibition of β-Amyloid Aggregation and Antioxidation

Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

氧化阿朴菲生物碱衍生物与DNA的相互作用及抗肿瘤活性研究

ChemInform Abstract: Hybrids of Oxoisoaporphine‐Tacrine Congeners: Novel Acetylcholinesterase and Acetylcholinesterase‐Induced β‐Amyloid Aggregation Inhibitors.

Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors

呫吨酮并吡啶季铵盐的合成及其生物活性

呋喃并呫吨酮衍生物的合成与生物活性研究

研究方向