张绮｜清华大学｜学者主页

2026

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection

Qi Zhang, Peng Chen, Fenglin Guo, Runhong Zhou, Ruihan Guo, Xiaofei Ge, Qianqian Yang, Xin Xie, Wei Xia, Junping Fan, Ziqing Yang, Yan Xu, Huiyu Huang, Jinqian Li, Han Wang, Huiyu Liao, Xuanling Shi, Na Liu, Yuting Chen, Zhiwei Chen, Jianzhu Ma, Xinquan Wang, Tong Zhang, Linqi Zhang

Immunity

精选作品

期刊论文

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection

Broad and durable protection against SARS-CoV-2 and SARS-CoV by an intranasal chimpanzee adenovirus vaccine expressing tandem RBDs and nucleocapsid

Identification and characterization of bone marrow plasma cells producing IFN-γ-neutralizing autoantibodies in adult-onset immunodeficiency

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Exploring distinct modes of inter-spike cross-linking for enhanced neutralization by SARS-CoV-2 antibodies

Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1

DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection

Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1

Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

安巴韦单抗注射液（BRII-196）及罗米司韦单抗注射液（BRII-198）——中国首个自主知识产权新冠病毒中和抗体联合治疗药物

Identification and semisynthesis of (−)-anisomelic acid as oral agent against SARS-CoV-2 in mice

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332

Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses

Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2

Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2

SARS-CoV-2 Omicron Variants Reduce Antibody Neutralization and Acquire Usage of Mouse ACE2

RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Deep learning guided optimization of human antibody against SARS-CoV-2 variants with broad neutralization

美国食品药品监督管理局接受不确定性:治疗多重耐药的人类免疫缺陷病毒感染的单克隆抗体加速获批

A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

Tandem bispecific antibody prevents pathogenic SHIVSF162P3CN infection and disease progression

新型冠状病毒肺炎疫情对抗病毒药研发和监管的启示

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Human neutralizing antibodies elicited by SARS-CoV-2 infection

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Establishment of replication-competent vesicular stomatitis virus-based recombinant viruses suitable for SARS-CoV-2 entry and neutralization assays

Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice

Delineating antibody recognition against Zika virus during natural infection

Potent neutralizing monoclonal antibodies against Ebola virus infection

预印本

Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization

Breakthrough infection with Omicron subvariant BF.7 induces broadly neutralizing antibodies to SARS-CoV-2 variants including XBB lineage

SARS-CoV-2 variants resist antibody neutralization and broaden host ACE2 usage

研究方向