吴照球｜中国药科大学｜学者主页

2026

ZEB1翻译后修饰及相关药物研究进展

罗婧宇，吴照球

《生物化工》

2026

Targeting of MARK2, but not other MARKs, suppresses TNBC progression by inhibition of the mutant p53-driven signaling pathway.

Min Zhang, Xi-Long Zhu, Mengqian Cui, Yinan Guan, Yong Zhang, Stephen J. Weiss, Jun Chen, Yong-Zhong Yao, Rong Fu, Zhaoqiu Wu

Chinese Journal of Natural Medicines

DOI

2026

Transcription factor targeting strategies in cancer: mechanisms, challenges and cutting-edge progress

Hui Chen, Rong Fu, Zhao‐Qiu Wu

Acta Pharmacologica Sinica

DOI

2026

Discovery of Novel Snail Inhibitors Derived from Omeprazole for Antiatherosclerotic Therapy: A Structure-Based Approach.

Zhaolan Zeng, Yang Lu, Mengsha Fang, Xiao-Peng Guo, Wenyi Zhong, Geting Xiong, Yu Wang, Feng-Ze Sun, Jin-Yi Xu, Zhaoqiu Wu, Rong Fu, Jie Liu

Journal of Medicinal Chemistry

DOI

2025

PAPSS2在疾病中的作用研究进展

张佳艺，吴照球

《生物化工》

DOI

2025

CD47翻译后修饰在肿瘤发病机制中的研究进展

王俊豪，吴照球

《生物化工》

DOI

2025

USP37在肿瘤发病机制中的作用研究进展

崔孟茜，吴照球

《生物化工》

DOI

2025

Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing

Yujiao Xu, Xin Gu, Wenshu Li, Boyang Lin, Yiting Xu, Qingcheng Wei, Qingyuan Liu, Yamin Zhao, Rongzhuo Long, Hu‐Lin Jiang, Zhao‐Qiu Wu, Yunyao Liu, Lei Qiang

Autophagy

DOI

2025

Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation

Bo‐Xue Ren, Zhao-Lan Zeng, Li Deng, Jia-meng Hu, Mingzhen Chen, Hao-wei Jiang, Chen-Zi Zang, Shentong Fang, Stephen J. Weiss, Jie Liu, Rong Fu, Zhao‐Qiu Wu

Acta Pharmacologica Sinica

DOI

2024

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

Bo‐Xue Ren, Yang LI, Lei Di, Ranran CHENG, Li‐Juan Liu, Hongmei Li, Yi Li, Zhang‐Rui Tang, Yong‐Ming Yan, Tao Lu, Rong FU, Yong‐Xian Cheng, Zhao‐Qiu Wu

Chinese Journal of Natural Medicines

DOI

2023

E3泛素连接酶的结构功能及其在肿瘤中的最新研究进展

朱玲媛，吴照球

《生物化工》

2023

Pharmacological targeting of Axin2 suppresses cell growth and metastasis in colorectal cancer

Cheng Li-zhi, Danling Huang, Zhang‐Rui Tang, Jiahao Zhang, Ting Xiong, Chen Zhou, Naixia Zhang, Rong Fu, Yong‐Xian Cheng, Zhao‐Qiu Wu

British Journal of Pharmacology

DOI

2022

NLRP3炎性小体在动脉粥样硬化中的病理作用研究和临床试验进展

姜昊玮，吴照球

《生物化工》

2022

Structural Optimization and Improving Antitumor Potential of Moreollic Acid from Gamboge

Cheng Li-zhi, Danling Huang, Min Liao, Keming Li, Zhao‐Qiu Wu, Yong‐Xian Cheng

Molecules

DOI

2021

The antibiotic drug trimethoprim suppresses tumour growth and metastasis via targeting Snail

Bo‐Xue Ren, Yang Li, Hongmei Li, Tao Lu, Zhao‐Qiu Wu, Rong Fu

British Journal of Pharmacology

DOI

2021

Omeprazole suppresses aggressive cancer growth and metastasis in mice through promoting Snail degradation

Yang Li, Bo‐Xue Ren, Hongmei Li, Tao Lu, Rong Fu, Zhao‐Qiu Wu

Acta Pharmacologica Sinica

DOI

2020

A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer

Hongmei Li, Yan-Ran Bi, Li Yang, Rong Fu, Wen-Cong Lv, Nan Jiang, Ying Xu, Bo‐Xue Ren, Yadong Chen, Hui Xie, Shui Wang, Tao Lu, Zhao‐Qiu Wu

Science Advances

DOI

2020

Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies

Rong Fu, Yi Li, Nan Jiang, Bo‐Xue Ren, Chen-Zi Zang, Lijuan Liu, Wencong Lv, Hongmei Li, Stephen J. Weiss, Zhengyu Li, Tao Lu, Zhao‐Qiu Wu

Journal of Clinical Investigation

DOI

2020

Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

Rong Fu, Wencong Lv, Ying Xu, Mu-Yun Gong, Xiao-Jie Chen, Nan Jiang, Yan Xu, Qingqiang Yao, Lei Di, Tao Lu, Liming Wang, Ran Mo, Zhao‐Qiu Wu

Nature Communications

DOI

2019

滋养血管新生与动脉粥样硬化斑块稳定性的关系

陈明真，龚慕云，傅蓉，吴照球

《世界最新医学信息文摘》

DOI

2019

锌指转录因子SNAIL调控和功能

毕嫣然，吴照球，傅蓉

《世界最新医学信息文摘》

DOI

2019

A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

Rong Fu, Chenfeng Han, Ting Ni, Lei Di, Li‐Juan Liu, Wencong Lv, Yan-Ran Bi, Nan Jiang, Yin He, Hongmei Li, Shui Wang, Hui Xie, Baoan Chen, Xiaosheng Wang, Stephen J. Weiss, Tao Lu, Qinglong Guo, Zhao‐Qiu Wu

Nature Communications

DOI

2019

Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer

Lei Di, Li‐Juan Liu, Yong‐Ming Yan, Rong Fu, Yi Li, Ying Xu, Yong‐Xian Cheng, Zhao‐Qiu Wu

Journal of Experimental & Clinical Cancer Research

DOI

2018

LW106, a novel indoleamine 2,3‐dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma‐immune crosstalk and cancer stem cell enrichment in tumour micro‐environment

Rong Fu, Yi‐Wei Zhang, Hongmei Li, Wencong Lv, Li Zhao, Qinglong Guo, Tao Lu, Stephen J. Weiss, Zhiyu Li, Zhao‐Qiu Wu

British Journal of Pharmacology

DOI

2015

Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis

Rong Fu, Yan Chen, Xiaoping Wang, Teng An, Lei Tao, Yuxin Zhou, Yujie Huang, Baoan Chen, Zhiyu Li, Qidong You, Qinglong Guo, Zhao‐Qiu Wu

Oncotarget

DOI

2015

Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation

Yang Sun, Yue Zhao, Jing Yao, Li Zhao, Zhao‐Qiu Wu, Yu Wang, Di Pan, Hanchi Miao, Qinglong Guo, Na Lu

Biochemical Pharmacology

DOI

2006

慢性吗啡引起的抑制海马神经元Na+,K+-ATPase活性和降低能量代谢酶的表达可能参与小鼠吗啡依赖的形成

吴照球，陈晓岚，卢刚，陈洁，池志强，刘景根

《中国药物依赖性杂志》

2004

藤黄酸诱导人胃腺癌SGC-7901细胞的凋亡作用(英文)

郭青龙，赵丽，尤启冬，吴照球，顾红燕

Chinese Journal of Natural Medicines

2003

藤黄总酸对实验性肿瘤及肿瘤细胞体外生长的抑制作用(英文)

吴照球，郭青龙，尤启冬，赵丽

Chinese Journal of Natural Medicines

2003

藤黄酸对实验性动物造血功能及免疫功能的影响

郭青龙，赵丽，吴照球，尤启冬，俞刚，张晴

Chinese Journal of Natural Medicines

吴照球

精选作品

期刊论文

ZEB1翻译后修饰及相关药物研究进展

Targeting of MARK2, but not other MARKs, suppresses TNBC progression by inhibition of the mutant p53-driven signaling pathway.

Transcription factor targeting strategies in cancer: mechanisms, challenges and cutting-edge progress

Discovery of Novel Snail Inhibitors Derived from Omeprazole for Antiatherosclerotic Therapy: A Structure-Based Approach.

PAPSS2在疾病中的作用研究进展

CD47翻译后修饰在肿瘤发病机制中的研究进展

USP37在肿瘤发病机制中的作用研究进展

Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing

Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

E3泛素连接酶的结构功能及其在肿瘤中的最新研究进展

Pharmacological targeting of Axin2 suppresses cell growth and metastasis in colorectal cancer

NLRP3炎性小体在动脉粥样硬化中的病理作用研究和临床试验进展

Structural Optimization and Improving Antitumor Potential of Moreollic Acid from Gamboge

The antibiotic drug trimethoprim suppresses tumour growth and metastasis via targeting Snail

Omeprazole suppresses aggressive cancer growth and metastasis in mice through promoting Snail degradation

A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer

Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies

Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis

滋养血管新生与动脉粥样硬化斑块稳定性的关系

锌指转录因子SNAIL调控和功能

A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours

Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer

LW106, a novel indoleamine 2,3‐dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma‐immune crosstalk and cancer stem cell enrichment in tumour micro‐environment

Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis

Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation

慢性吗啡引起的抑制海马神经元Na+,K+-ATPase活性和降低能量代谢酶的表达可能参与小鼠吗啡依赖的形成

藤黄酸诱导人胃腺癌SGC-7901细胞的凋亡作用(英文)

藤黄总酸对实验性肿瘤及肿瘤细胞体外生长的抑制作用(英文)

藤黄酸对实验性动物造血功能及免疫功能的影响

会议论文

Snail1/p53信号轴在乳腺肿瘤干细胞的扩增及活性调节中的关键作用

预印本

A non-canonical top-down pathway regulating relapse to opioid