任思强｜南方医科大学｜学者主页

2026

Newborn neurons compete with neuronal ensembles to moderate behavioral responses to stress

Can-Yuan Zhang, Su-Fen Wei, Yaping Wang, Jia-Qi Nie, Qi Wang, Fuling Wu, Ming-Feng Huang, Wei-Zhong Cai, Liang-Yü Chen, Jin-Ming Liu, Fang Guo, Xiao-Shan Lin, Shu-Ji Li, Xiangna Guo, Siqiang Ren, Xiong Cao

Cell Reports

DOI

2026

The axon initial segment-associated microglia regulate neuronal activity and visual perception

Yaping Wang, Qiushi Wang, Chen Gao, Shu He, Cheng Wei, Jia Song, Xinli Liu, Xiaoli Liu, Shi Feng, Wen Yao, Wen Wu, Tian-Ming Gao, Siqiang Ren

Cell Research

DOI

2025

Microglial TREM2 deficiency causes E/I imbalance and triggers ASD-like behaviors by altering potassium channel Kv1.3 activation

Yaping Wang, Qiushi Wang, Rongfang Li, Youxin Yu, Feng Shi, Wen Wu, Siqiang Ren

Neurobiology of Disease

DOI

2025

Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading

Xiaoli Liu, Huijun Wang, Xi Tian, Yingqi Luo, Minmin Ma, Zilong Zheng, Yaping Wang, Feng Shi, Qiushi Wang, Zhuo Fei Xu, Wen Yao, Siqiang Ren

Journal of Neuroinflammation

DOI

2024

Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours

Hu‐Jiang Shi, Yi-Ren Xue, Hua Shao, Wei Cheng, Ting Liu, Jie He, Yuhao Yang, Hongmei Wang, Na Li, Siqiang Ren, Lei Chang, Zhen Wang, Li‐Juan Zhu

Brain

DOI

2024

Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission

Shufen Li, Hongyu Ni, Yaping Wang, Xiaohui Wu, Jianqiang Bi, Haiyan Ou, Zhongwei Li, Junjiao Ping, Zhongju Wang, Renhao Chen, Qiong Yang, Meijun Jiang, Liping Cao, Tingyun Jiang, Siqiang Ren, Cunyou Zhao

BMC Medicine

DOI

2023

Electroacupuncture alleviated depression‐like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress‐induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter

Xiaowen Cai, Mei Wu, Zhinan Zhang, Huacong Liu, Shengtao Huang, Jia Song, Siqiang Ren, Yong Huang

CNS Neuroscience & Therapeutics

DOI

2020

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan, Wen Wu

Journal of Neuroinflammation

DOI

2020

Author response: Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

Siqiang Ren, Wen Yao, M. Tambini, Tao Yin, Kelly A. Norris, L. D'Adamio

DOI

2020

Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

Siqiang Ren, Wen Yao, M. Tambini, Tao Yin, Kelly A. Norris, L. D'Adamio

eLife

DOI

2020

TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2R47H rats.

Siqiang Ren, L. Breuillaud, Wen Yao, Tao Yin, Kelly A. Norris, S. Zehntner, L. D'Adamio

Journal of Biological Chemistry

DOI

2020

TNFα reduces inhibitory transmission in young Trem2R47H Sporadic Alzheimer rats before observable Aβ and brain pathology

Siqiang Ren, L. Breuillaud, Wen Yao, Tao Yin, Kelly A. Norris, S. Zehntner, L. D'Adamio

bioRxiv

DOI

2018

Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

Siqiang Ren, W. Yao, Jing‐Zhi Yan, Chunhui Jin, Jiasheng Yin, Jianmin Yuan, Shui Yu, Zao-Huo Cheng

Scientific Reports

DOI

2013

Aβ induces acute depression of excitatory glutamatergic synaptic transmission through distinct phosphatase-dependent mechanisms in rat CA1 pyramidal neurons.

Wen Yao, Hao-Jun Zou, Dang Sun, Siqiang Ren

Brain Research

DOI

2013

PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP

Siqiang Ren, Jing‐Zhi Yan, Xiao-Yan Zhang, Yunfei Bu, Weiwei Pan, W. Yao, T. Tian, Wei Lu

EMBO Journal

DOI

2012

Regulation of Spike Timing-Dependent Plasticity of Olfactory Inputs in Mitral Cells in the Rat Olfactory Bulb

Teng Ma, Xiao-Lei Zhao, Lei Cai, Nan Zhang, Siqiang Ren, Fang Ji, T. Tian, Wei Lu

PLoS ONE

DOI

2012

Glycine Exerts Dual Roles in Ischemic Injury Through Distinct Mechanisms

W. Yao, Fang Ji, Zheng-chun Chen, Nan Zhang, Siqiang Ren, Xiao-Yan Zhang, Su-Yi Liu, Wei Lu

Stroke

DOI

2011

Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons

Rong-qing Chen, Shan-Hui Wang, W. Yao, Jing-Jing Wang, Fang Ji, Jing‐Zhi Yan, Siqiang Ren, Zheng Chen, Su-Yi Liu, Wei Lu

Neuropsychopharmacology

DOI

2011

Protein Kinase C Promotes N-Methyl-d-aspartate (NMDA) Receptor Trafficking by Indirectly Triggering Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Autophosphorylation*

Jing‐Zhi Yan, Zhuo Xu, Siqiang Ren, Bin Hu, W. Yao, Shan-Hui Wang, Su-Yi Liu, Wei Lu

Journal of Biological Chemistry

DOI

任思强

精选作品

期刊论文

Newborn neurons compete with neuronal ensembles to moderate behavioral responses to stress

The axon initial segment-associated microglia regulate neuronal activity and visual perception

Microglial TREM2 deficiency causes E/I imbalance and triggers ASD-like behaviors by altering potassium channel Kv1.3 activation

Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading

Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours

Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission

Electroacupuncture alleviated depression‐like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress‐induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

Author response: Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2R47H rats.

TNFα reduces inhibitory transmission in young Trem2R47H Sporadic Alzheimer rats before observable Aβ and brain pathology

Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

Aβ induces acute depression of excitatory glutamatergic synaptic transmission through distinct phosphatase-dependent mechanisms in rat CA1 pyramidal neurons.

PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP

Regulation of Spike Timing-Dependent Plasticity of Olfactory Inputs in Mitral Cells in the Rat Olfactory Bulb

Glycine Exerts Dual Roles in Ischemic Injury Through Distinct Mechanisms

Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons

Protein Kinase C Promotes N-Methyl-d-aspartate (NMDA) Receptor Trafficking by Indirectly Triggering Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Autophosphorylation*

研究方向