张延东｜厦门大学｜学者主页

2026

A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting

Wen-bin Pei, Zi-yu Lei, Fu-quan Xie, Peng Chen, Yong-cheng Su, Yu-shan Qin, Jiang-quan Li, Qian-wen Shen, Miaomiao Ma, Chun-yi Gao, Jia-chen Zhu, Yajie Xu, Kai-yue Zhang, Wei Zhang, Yandong Zhang, Tianhui Hu, Beibei Xu

Acta Pharmacologica Sinica

DOI

2025

Deciphering the Thiolactonization Mechanism in Thiolactomycin Biosynthesis

Jiawei Guo, Qiaoyu Zhang, Yang Shen, Fangyuan Cheng, Moli Sang, Xuan Wang, Yunjun Pan, Mingyu Liu, Hao‐Bing Yu, Bo Hu, Sheng Wang, Liangzhen Zheng, Ce Geng, Chaofan Yang, Lianzhong Luo, Gang Zhang, Lei Du, Yuanning Li, Wei Zhang, Yandong Zhang, Binju Wang, Shengying Li, Xingwang Zhang

Journal of the American Chemical Society

DOI

2025

Developing Dual-State Emission Berberine Derivatives as Theranostic Agents by Reducing Nonradiative Transition Pathways

Fuquan Xie, Beibei Xu, Peng Chen, Yushan Qin, Wenbin Pei, Jiangquan Li, Tianhui Hu, Qi Gao, Siying Chen, Yandong Zhang, Defa Li, Zhongjian Xie

Journal of Medicinal Chemistry

DOI

2024

Synthetic Studies toward Pseudolaric Acids: Radical Cyclization to Form Bridged Scaffold

Yujie Niu, Minggui Lin, Hao Cui, Yanji Huang, Yang Shen, Yandong Zhang

Chinese Journal of Chemistry

DOI

2024

Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB

Chun‐Lan Xie, Hongxiu Xiao, Pei‐Fang Song, Qingmei Liu, Haoxiang Wei, Liang Wu, Guanghao Zhu, Guang‐Ming Liu, Yandong Zhang, Ping Wang, Xian‐Wen Yang

Journal of Medicinal Chemistry

DOI

2023

Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization

Pengfei Fu, Tao Liu, Yang Shen, Xin Lei, Tianjie Xiao, Peng Chen, Dongsheng Qiu, Zhen Wang, Yandong Zhang

Journal of the American Chemical Society

DOI

2022

Unexpected Pyridinyl Group Mediated Metal-Free Wacker-Type Oxidation en Route to Pyrido[2,1-a]isoindol-5-ium Salts

Yandong Zhang, Dong Shi, Tao Zeng, Xin Lei, Xiaotong Wu, Mansirun Li

Synthesis

DOI

2022

Synthesis of Clionastatins A and B through Enhancement of Chlorination and Oxidation Levels of Testosterone

Hao Cui, Yang Shen, Ruifeng Wang, Haoxiang Wei, Xin Lei, Yanyu Chen, Pengfei Fu, Haoxiang Wang, Ruihao Bi, Yandong Zhang

Chinese Journal of Chemistry

DOI

2022

Two-Stage Syntheses of Clionastatins A and B

Hao Cui, Yang Shen, Yanyu Chen, Ruifeng Wang, Haoxiang Wei, Pengfei Fu, Xin Lei, Haoxiang Wang, Ruihao Bi, Yandong Zhang

Journal of the American Chemical Society

DOI

2021

科教融合建设一流本科专业——厦门大学创建国家级一流化学专业的探索与实践

黎朝，温庭斌，吴伟泰，张延东，曹晓宇，朱亚先，吕鑫

《大学化学》

2021

Total Synthesis and Assignment of the Absolute Configuration of (+)-Omphalic Acid

Renzhi Chen, Dongsheng Qiu, Xin Lei, Yujie Niu, Yuhui Hua, Huayu Peng, Tao Zeng, Yandong Zhang

Organic Letters

DOI

2021

Divergent total syntheses of pseudoberberine and nitidine through C H vinylation and switchable 6π electrocyclizations

Xunjin Jiang, Zhixiong Zeng, Dong Shi, Chenguang Liu, Yandong Zhang

Tetrahedron Letters

DOI

2021

Total Synthesis of Stemarene and Betaerene Diterpenoids: Divergent Ring-Formation Strategy and Late-Stage C–H Functionalization

Renzhi Chen, Feng Zhang, Yuhui Hua, Dong Shi, Xin Lei, Hongxiu Xiao, Yinong Wang, Shihao Ding, Yang Shen, Yandong Zhang

CCS Chemistry

DOI

2021

Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes

Yang Shen, Linbin Li, Xiaoxia Xiao, Sihan Yang, Yuhui Hua, Yinglu Wang, Yun‐wu Zhang, Yandong Zhang

Journal of the American Chemical Society

DOI

2020

Conformational Design Principles in Total Synthesis

Renzhi Chen, Yang Shen, Sihan Yang, Yandong Zhang

Angewandte Chemie

DOI

2020

Merging C–H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis

Xunjin Jiang, Zhixiong Zeng, Yuhui Hua, Beibei Xu, Yang Shen, Jing Xiong, Huijuan Qiu, Yifan Wu, Tianhui Hu, Yandong Zhang

Journal of the American Chemical Society

DOI

2020

Structure–Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer

Beibei Xu, Xunjin Jiang, Jing Xiong, Jun Lan, Yuan Tian, Linhai Zhong, Xinquan Wang, Ning Xu, Hanwei Cao, Wenqing Zhang, Hao Zhang, Xiaoting Hong, Yan-yan Zhan, Yandong Zhang, Tianhui Hu

Journal of Medicinal Chemistry

DOI

2020

Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone

Renzhi Chen, Sihan Yang, Yandong Zhang

Organic & Biomolecular Chemistry

DOI

2019

Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia

Chun‐Lan Xie, Renzhi Chen, Sihan Yang, Jin‐Mei Xia, Gaiyun Zhang, Chao-Hong Chen, Yandong Zhang, Xian‐Wen Yang

Organic Letters

DOI

2019

Divergent total syntheses of five illudalane sesquiterpenes and assignment of the absolute configuration

Zhixiong Zeng, Yifan Zhao, Yandong Zhang

Chemical Communications

DOI

2019

Domino enyne metathesis en route to skeletally diverse, privileged scaffolds: synthesis of the tricyclic core of pseudolaric acid F

Minggui Lin, Hao Cui, Yuhui Hua, Yandong Zhang

Organic Chemistry Frontiers

DOI

2018

Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization–Dedimerization Strategy and Absolute Configuration Assignment

Renzhi Chen, Linbin Li, Na Lin, Rong Zhou, Yuhui Hua, Hejun Deng, Yandong Zhang

Organic Letters

DOI

2018

Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis

Jundong Li, Yilin Ye, Yandong Zhang

Organic Chemistry Frontiers

DOI

2017

Innentitelbild: Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization (Angew. Chem. 28/2017)

Chenguang Liu, Renzhi Chen, Yang Shen, Zhanhao Liang, Yuhui Hua, Yandong Zhang

Angewandte Chemie

DOI

2017

Inside Cover: Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization (Angew. Chem. Int. Ed. 28/2017)

Chenguang Liu, Renzhi Chen, Yang Shen, Zhanhao Liang, Yuhui Hua, Yandong Zhang

Angewandte Chemie International Edition

DOI

2017

Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization

Chenguang Liu, Renzhi Chen, Yang Shen, Zhanhao Liang, Yuhui Hua, Yandong Zhang

Angewandte Chemie

DOI

2017

Cover Feature: Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis (Chem. Eur. J. 10/2018)

Minggui Lin, Peijun Cai, Zhixiong Zeng, Na Lin, Yang Shen, Bin Tang, Fan Li, Chen Chen, Zhi‐Xiang Yu, Yandong Zhang

Chemistry - A European Journal

DOI

2017

Enantioselective total synthesis of periconiasin A

Zhixiong Zeng, Cheng Chen, Yandong Zhang

Organic Chemistry Frontiers

DOI

2017

Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis

Minggui Lin, Peijun Cai, Zhixiong Zeng, Na Lin, Yang Shen, Bin Tang, Fan Li, Chen Chen, Zhi‐Xiang Yu, Yandong Zhang

Chemistry - A European Journal

DOI

2016

Jiadifenolide的合成研究进展

李林斌，沈洋，张延东

《有机化学》

2016

Synthesis of β -prolinols via [3+2] cycloaddition and one-pot programmed reduction: Valuable building blocks for polyheterocycles

Jundong Li, Na Lin, Lei Yu, Yandong Zhang

Tetrahedron Letters

DOI

2016

Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process

Chen‐Guang Liu, Zhixiong Zeng, Renzhi Chen, Xunjin Jiang, Yinglu Wang, Yandong Zhang

Organic Letters

DOI

2016

ChemInform Abstract: Recent Progress in the Synthesis of 5‐Unsubstituted Pyrrolidines via [3 + 2] Cycloadditions

Jundong Li, Huaibo Zhao, Yandong Zhang

ChemInform

DOI

2015

Protecting-Group-Free Total Synthesis of (−)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans

Yang Shen, Linbin Li, Zhi-Sheng Pan, Yinglu Wang, Jundong Li, Kuangyu Wang, Xiance Wang, Youyu Zhang, Youyu Zhang, Tianhui Hu, Yandong Zhang, Yandong Zhang

Organic Letters

DOI

2015

Recent Progress in the Synthesis of 5-Unsubstituted Pyrrolidines via [3+2] Cycloadditions

Yandong Zhang, Jundong Li, Huaibo Zhao

Synlett

DOI

2015

The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five‐Step Synthesis of (±)‐Isoretronecanol

Jundong Li, Huaibo Zhao, Xunjin Jiang, Xiance Wang, Haiming Hu, Lei Yu, Yandong Zhang

Angewandte Chemie

DOI

2015

ChemInform Abstract: The Cyano Group as a Traceless Activation Group for the Intermolecular [3 + 2] Cycloaddition of Azomethine Ylides: A Five‐Step Synthesis of (.+‐.)‐Isoretronecanol.

Jundong Li, Huaibo Zhao, Xunjin Jiang, Xiance Wang, Haiming Hu, Lei Yu, Yandong Zhang

ChemInform

DOI

精选作品

期刊论文

A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting

Deciphering the Thiolactonization Mechanism in Thiolactomycin Biosynthesis

Developing Dual-State Emission Berberine Derivatives as Theranostic Agents by Reducing Nonradiative Transition Pathways

Synthetic Studies toward Pseudolaric Acids: Radical Cyclization to Form Bridged Scaffold

Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB

Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization

Unexpected Pyridinyl Group Mediated Metal-Free Wacker-Type Oxidation en Route to Pyrido[2,1-a]isoindol-5-ium Salts

Synthesis of Clionastatins A and B through Enhancement of Chlorination and Oxidation Levels of Testosterone

Two-Stage Syntheses of Clionastatins A and B

科教融合建设一流本科专业——厦门大学创建国家级一流化学专业的探索与实践

Total Synthesis and Assignment of the Absolute Configuration of (+)-Omphalic Acid

Divergent total syntheses of pseudoberberine and nitidine through C H vinylation and switchable 6π electrocyclizations

Total Synthesis of Stemarene and Betaerene Diterpenoids: Divergent Ring-Formation Strategy and Late-Stage C–H Functionalization

Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes

Conformational Design Principles in Total Synthesis

Merging C–H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis

Structure–Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer

Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone

Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia

Divergent total syntheses of five illudalane sesquiterpenes and assignment of the absolute configuration

Domino enyne metathesis en route to skeletally diverse, privileged scaffolds: synthesis of the tricyclic core of pseudolaric acid F

Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization–Dedimerization Strategy and Absolute Configuration Assignment

Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis

Innentitelbild: Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization (Angew. Chem. 28/2017)

Inside Cover: Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization (Angew. Chem. Int. Ed. 28/2017)

Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization

Cover Feature: Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis (Chem. Eur. J. 10/2018)

Enantioselective total synthesis of periconiasin A

Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis

Jiadifenolide的合成研究进展

Synthesis of β -prolinols via [3+2] cycloaddition and one-pot programmed reduction: Valuable building blocks for polyheterocycles

Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process

ChemInform Abstract: Recent Progress in the Synthesis of 5‐Unsubstituted Pyrrolidines via [3 + 2] Cycloadditions

Protecting-Group-Free Total Synthesis of (−)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans

Recent Progress in the Synthesis of 5-Unsubstituted Pyrrolidines via [3+2] Cycloadditions

The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five‐Step Synthesis of (±)‐Isoretronecanol

ChemInform Abstract: The Cyano Group as a Traceless Activation Group for the Intermolecular [3 + 2] Cycloaddition of Azomethine Ylides: A Five‐Step Synthesis of (.+‐.)‐Isoretronecanol.

会议论文

萜类全合成与碳氢活化

序言

New Reaction Development Driven by Natural Product Synthesis: a Case Study in the Total Synthesis of Illicium Sesquiterpenes

研究方向