陈泉｜中国科学技术大学｜学者主页

2026

Author Correction: NRF1-mediated innate immune response drives inflammaging

Hong Lei, Tian Zhao, Jiao-Jiao Zhang, Yijia Long, Yong-Ze Chen, Yi-Xuan Zhu, Yuan-Yuan Meng, Yinmei Tang, Xin Liu, Jia-Xin Sun, Zhuoya Li, Jing-Yi Su, Fengcongzhe Gong, Guo Chen, Baofa Sun, Yan-Fang Chen, Quan Chen, Yanjun Li, Yu-Shan Zhu

Nature Communications

DOI

2026

Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.

Qian Luo, Qiang-Qiang Liu, Hong-Cheng Cheng, Jia-Le Wang, Tian Zhao, Jiao-Jiao Zhang, Cheng-Long Mu, Yuan-Yuan Meng, Lin-Bo Chen, Chang-Qian Zhou, Hong Lei, Jian-Yu Yang, Guo Chen, Yan-Jun Li, Lei-Ting Pan, Quan Chen, Yu-Shan Zhu

Cell Reports

DOI

2026

Author Correction: Broadening the molecular glue landscape

Qianping Zhang, Tiantian Sun, Fan Yu, Wei Liu, Jin Gao, Jinyu Chen, Hao Zheng, Jinming Liu, Chenjian Miao, Huan-Yi Guo, Wu Tian, Meihui Su, Yingjie Guo, Xi Liu, Yandong Pei, Zhuo-Fei Wang, Shang Chen, Cheng-Long Mu, S. Lam, Guang-Hou Shui, Zong-Jin Li, Zhongbo Yu, Yan Zhang, Guo Chen, Congcong Lu, Adam C. Midgley, Changhua Li, Xin Bian, Xudong Liao, Yong Wang, Wei Xiong, Hongying Zhu, Yan-Jun Li, Quan Chen

Nature Chemical Biology

DOI

2026

Zero-shot deep learning with multi-objective optimization improves thermostability of zearalenone hydrolase and xylanase

Fan Wu, Rongjie Wu, Linghui Chen, Quan Chen, Haiyan Liu

New Biotechnology

DOI

2026

Trans-interface coupling in the tetrameric enzyme underlies allosteric control in Escherichia coli biosynthetic threonine deaminase

Samaneh Khodi, Abeeb Abiodun Yekeen, Haiyan Liu, Quan Chen

Journal of Structural Biology X

DOI

2025

Designing flexible protein structures and sampling protein conformations with a unified model using vector quantization and diffusion

Yufeng Liu, Linghui Chen, Quan Chen, Haiyan Liu

National Science Review

2025

NRF1-mediated innate immune response drives inflammaging

H. Lei, Tian Zhao, Jiao-Jiao Zhang, Yijia Long, Yong-Ze Chen, Yi-Xuan Zhu, Yuan-Yuan Meng, Yinmei Tang, Xin Liu, Jia-Xin Sun, Zhuo-Ya Li, Jing-Yi Su, Fengcongzhe Gong, Guo Chen, Baofa Sun, Yan-Fang Chen, Quan Chen, Yanjun Li, Yu-Shan Zhu

Nature Communications

DOI

2025

Sweetening ferroptosis spread

Tiantian Sun, Jin Gao, Quan Chen

Nature Chemical Biology

DOI

2025

Mitochondria transfer

N. Chandel, Marni J. Falk, Janine H. Santos, Jonathan R. Brestoff, A. V. Lechuga-Vieco, Yasemin Sancak, Quan Chen, Álvaro A. Elorza, Rubén Quintana-Cabrera

Nature Metabolism

DOI

2024

Stapled peptides: targeting protein-protein interactions in drug development

Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

Exploration of Drug Science

DOI

2024

RETRACTED ARTICLE: Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance

Hao Zheng, Jinming Liu, Qingyuan Cheng, Qianping Zhang, Yaoyao Zhang, Lingyu Jiang, Yan Huang, Wenlei Li, Yan-Ping Zhao, Guo Chen, Fan Yu, Lei Liu, Yan-Jun Li, Xudong Liao, Lai Xu, Yi Xiao, Zhibo Zheng, Ming Li, Hongyi Wang, Gang Hu, Lei Du, Quan Chen

Nature Cancer

DOI

2024

Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer

Quan Chen, Hao Zheng

Nature Cancer

DOI

2024

Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells

Jiao Yang, Jiameng Dan, Nannan Zhao, Lin-Lin Liu, Huasong Wang, Qiang-Qiang Liu, Lingling Wang, Jie Li, Yiwei Wu, Fei-Long Chen, Wei-Lun Fu, Fei Liu, Meiqi Lin, Wei-Yu Zhang, Fu-Quan Chen, Xin-Qi Liu, Xinyi Lu, Quan Chen, Xudong Wu, Yuyu Niu, Na Yang, Yu-Shan Zhu, J. Long, Lin Liu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2024

Author Correction: PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury

Nature Chemical Biology

DOI

2024

PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury

Nature Chemical Biology

DOI

2024

The Humanization and Maturation of an Anti-PrPc Antibody

Cheng Zhang, Fanlei Ran, L. Du, Xiaohui Wang, Lei Liu, Jinming Liu, Quan Chen, Yang Cao, Lijun Bi, H. Hang

Bioengineering

DOI

2024

Nature conference on mitochondria and immunity: Uncovering Mitochondria–Immunity crosstalk and fostering global scientific exchanges

Juan Liu, Yanjun Li, Yu-Shan Zhu, Quan Chen

Mitochondrial Communications

DOI

2023

Structure-destabilizing mutations unleash an intrinsic perforation activity of antiapoptotic Bcl-2 in the mitochondrial membrane enabling apoptotic cell death

Ping Gao, Zhi Zhang, Rui Wang, Li Huang, Hao Wu, Zhenzhen Qiao, Xiaohui Wang, Haijing Jin, Jun Peng, Lei Liu, Quan Chen, Jia-Ling Lin

Mitochondrial Communications

DOI

2023

NRF1‐mediated mitochondrial biogenesis antagonizes innate antiviral immunity

Tian Zhao, Jiao-Jiao Zhang, Hong-ling Lei, Yuan-Yuan Meng, Hong-Cheng Cheng, Yan-Ping Zhao, Guang-Feng Geng, Cheng-Long Mu, Lin-Bo Chen, Qiang-Qiang Liu, Qian Luo, Chuanmei Zhang, Yijia Long, Jing-Yi Su, Yin-Hao Wang, Zhuo-Ya Li, Jia-Xin Sun, Guo Chen, Yan-Jun Li, Xudong Liao, Ying-Li Shang, Gang Hu, Quan Chen, Yu-Shan Zhu

EMBO Journal

DOI

2023

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function

Lin-Bo Chen, Qianping Zhang, Yuan-Yuan Meng, Tian Zhao, Cheng-Long Mu, Chang-Ying Fu, Caijuan Deng, Jianyu Feng, Siling Du, Wei Liu, Guang-Feng Geng, K. Ma, Hong-Cheng Cheng, Qiang-Qiang Liu, Qian Luo, Jiao-Jiao Zhang, Zhanqiang Du, Lin Cao, Hui Wang, Yong Liu, Jianping Lin, Guo Chen, Lei Liu, S. Lam, Guang-Hou Shui, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2022

Hypoxia Dynamically Regulates DBC1 Ubiquitination and Stability by SIAH2 and OTUD5 in Breast Cancer Progression

Qiang-Qiang Liu, Qian Luo, Jianyu Feng, Yan-Ping Zhao, Lin-Lin Liu, Biao Ma, Hong-Cheng Cheng, Tian Zhao, Jiaojiao Zhang, Cheng-Long Mu, Lin-Bo Chen, Hong Lei, Y. Long, Jin Su, Guo Chen, Yan-Jun Li, Quan Chen, Yu-Shan Zhu

bioRxiv

DOI

2022

LGR4 cooperates with PrPc to endow the stemness of colorectal cancer stem cells contributing to tumorigenesis and liver metastasis.

Qi Cheng, Hao Zheng, Ming Li, Hongyi Wang, Xiao-Xia Guo, Zhibo Zheng, Chuyan Chen, Jinming Liu, Tian-Cheng Zhan, Zhaowei Li, Hao Wu, Jing-Dong Han, Lei Liu, T. Tang, Quan Chen, Lei Du

Cancer Letters

DOI

2022

Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms

Fei-Xiang Bao, Lingyan Zhou, Rui Zhou, Qiao-Ying Huang, Junguo Chen, Sheng Zeng, Yi Wu, Liang Yang, Shufang Qian, Mengfei Wang, Xueying He, Shang-You Liang, Juntao Qi, Ge Xiang, Qi Long, Jingyi Guo, Zhongfu Ying, Yan-Shuang Zhou, Qiuge Zhao, Jiwei Zhang, Di Zhang, Wei Sun, Mi Gao, Hao Wu, Yifan Zhao, Jinfu J. Nie, Min Li, Quan Chen, Jie-Kai Chen, Xiao Zhang, G. Pan, H. Zhang, Ming-Tao Li, M. Tian, Xing-Guo Liu

Science Advances

DOI

2022

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

Qiang-Qiang Liu, Qian Luo, Jianyu Feng, Yan-Ping Zhao, Biao Ma, Hong-Cheng Cheng, Tian Zhao, Hong Lei, Cheng-Long Mu, Lin-Bo Chen, Yuan-Yuan Meng, Jiaojiao Zhang, Yijia Long, Jing-Yi Su, Guo Chen, Yan-Jun Li, G. Hu, Xudong Liao, Quan Chen, Yu-Shan Zhu

eLife

DOI

2022

Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.

Cell Reports

DOI

2022

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy

Kun Liu, Qian Zhao, Hongyan Sun, Lei Liu, Chao-Qun Wang, Zheng Li, You-Qing Xu, Liang Wang, Lin Zhang, Hong-Hai Zhang, Quan Chen, Tong-Biao Zhao

Cell Death and Disease

DOI

2022

A noncanonical autophagy function of ATG9A for Golgi integrity and dynamics

Yuan-Yuan Meng, Qian Luo, Quan Chen, Yu-Shan Zhu

Autophagy

DOI

2021

Targeting stemness of cancer stem cells to fight colorectal cancers.

Lei Du, Qi Cheng, Hao Zheng, Jinming Liu, Lei Liu, Quan Chen

Seminars in Cancer Biology

DOI

2021

The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases

Lei Liu, Yimei Li, Quan Chen

Frontiers in Physiology

DOI

2021

Receptor-mediated mitophagy regulates EPO production and protects against renal anemia

Guang-Feng Geng, Jin-Hua Liu, Changlu Xu, Yandong Pei, Lin-Bo Chen, Cheng-Long Mu, Ding Wang, Jie Gao, Yue Li, Jing Liang, Tian Zhao, Chuanmei Zhang, Jia-Xi Zhou, Quan Chen, Yu-Shan Zhu, Lihong Shi

eLife

DOI

2021

Molecular regulation of mitochondrial autophagy and cellular fate

K. Ma, Hao Wu, Lei Liu, Yu-Shan Zhu, Quan Chen

DOI

2021

A zinc transporter, transmembrane protein 163 (TMEM163), is critical for the biogenesis of platelet dense granules.

Yefeng Yuan, Teng Liu, Xia-He Huang, Yuanying Chen, Wei-Lin Zhang, Ting Li, Lin Yang, Quan Chen, Ying-Chun Wang, A. Wei, Wei Li

Blood

DOI

2021

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis

Lei Liu, Yan-Jun Li, Jia-Ni Wang, Di Zhang, Hao Wu, Wenhui Li, Huifang Wei, Nan Ta, Yuyuan Fan, Yujiao Liu, Xiaohui Wang, Jun Wang, Xin Pan, Xudong Liao, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2021

PINK1‐mediated mitophagy maintains pluripotency through optineurin

Chao-Qun Wang, Kun Liu, Jia-Ni Cao, Liang Wang, Qian Zhao, Zheng Li, Hong-Hai Zhang, Quan Chen, Tongbiao Zhao

Cell Proliferation

DOI

2020

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Hao Wu, Huifang Wei, Di Zhang, Sheikh Arslan Sehgal, De-Jiu Zhang, Xiaohui Wang, Yan Qin, Lei Liu, Quan Chen

Redox Biology

DOI

2020

Atg1 kinase in fission yeast is activated by Atg11-mediated dimerization and cis-autophosphorylation

Zhao-Qian Pan, Guang-Can Shao, Xiao-Man Liu, Quan Chen, M. Dong, Li-Lin Du

eLife

DOI

2020

Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

Lei Liu, Xudong Liao, Hao Wu, Yan-Jun Li, Yu-Shan Zhu, Quan Chen

Antioxidants and Redox Signaling

DOI

2020

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

K. Ma, Guo Chen, Wenhui Li, O. Kepp, Yu-Shan Zhu, Quan Chen

Frontiers in Cell and Developmental Biology

DOI

2019

数据与计算驱动的蛋白质元件预测和设计

刘海燕，陈泉，龙朋朋，黄斌，许洋，陈耀晞

《生命科学》

DOI

2019

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

Biao Ma, Hong-Cheng Cheng, Cheng-Long Mu, Guang-Feng Geng, Tian Zhao, Qian Luo, K. Ma, Rui Chang, Qiang-Qiang Liu, Ruize Gao, J. Nie, Jiaying Xie, Jinxue Han, Lin-Bo Chen, Gui Ma, Yu-Shan Zhu, Quan Chen

Nature Communications

DOI

2019

Bcl-2家族蛋白的生理功能及结构基础

Jian-Yu Feng, Yu-Shan Zhu, Quan Chen, Jia-Lin Lin, Jianyu Feng, Yu-Shan Zhu, Quan Chen, Jia-Ling Lin

Zhongguo xi bao sheng wu xue xue bao

2019

Mechanism of mitophagy in cell homeostasis

Lin-Bo Chen, K. Ma, Quan Chen, Yu-Shan Zhu

Scientia Sinica Vitae

DOI

2019

Mitochondria organize the cellular proteostatic response and promote cellular senescence

Yan-Jun Li, Lei Liu, Yu-Shan Zhu, Quan Chen

Cell Stress

DOI

2019

FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Wenhui Li, Yan-Jun Li, Sami Siraj, Haojie Jin, Yuyuan Fan, Xin-Rong Yang, Xiao-Wu Huang, Xiaohui Wang, Jun Wang, Lei Liu, Lei Du, Quan Chen

Hepatology

DOI

2019

Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate

K. Ma, Zhi Zhang, Rui Chang, Hong-Cheng Cheng, Cheng-Long Mu, Tian Zhao, Lin-Bo Chen, Chuanmei Zhang, Qian Luo, Jia-Ling Lin, Yu-Shan Zhu, Quan Chen

Cell Death and Differentiation

DOI

2019

FUNDC2 regulates platelet activation through AKT/GSK-3β/cGMP axis.

Qi Ma, Wei-Lin Zhang, Chongzhuo Zhu, Jun-Ling Liu, Quan Chen

Cardiovascular Research

DOI

2019

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

Hao Wu, You Wang, Wenhui Li, Hui Chen, Lei Du, Dong Liu, Xiaohui Wang, Tao Xu, Lei Liu, Quan Chen

Autophagy

DOI

2019

Nix-mediated mitophagy regulates platelet activation and life span.

Wei-Lin Zhang, Qi Ma, Sami Siraj, P. Ney, Jun-Ling Liu, Xudong Liao, Yefeng Yuan, Wei Li, Lei Liu, Quan Chen

Blood Advances

DOI

2018

STING directly activates autophagy to tune the innate immune response

Dong Liu, Hao Wu, Chenguang Wang, Yan-Jun Li, Huabin Tian, Sami Siraj, Sheikh Arslan Sehgal, Xiao-Hui Wang, Jun Wang, Ying-Li Shang, Zheng-Fan Jiang, Lei Liu, Quan Chen

Cell Death and Differentiation

DOI

2018

Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury.

Wei-Lin Zhang, Chuyan Chen, Jun Wang, Lei Liu, Yubin He, Quan Chen

Physiology

DOI

2018

Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway

Qi Ma, Chongzhuo Zhu, Wei-Lin Zhang, Nan Ta, Rong Zhang, Lei Liu, D. Feng, He-Ping Cheng, Jun-Ling Liu, Quan Chen

Cell Death and Differentiation

DOI

2018

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

Cheng-Long Mu, Biao Ma, Chuanmei Zhang, Guang-Feng Geng, Xin-Ling Zhang, Lin-Bo Chen, Meng Wang, Jie Li, Tian Zhao, Hong-Cheng Cheng, Qianping Zhang, K. Ma, Qian Luo, Rui Chang, Qiang-Qiang Liu, Hao Wu, Lei Liu, Xiaohui Wang, Jun Wang, Yong Zhang, Yungang Zhao, L. Wen, Quan Chen, Yu-Shan Zhu

bioRxiv

DOI

2018

VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis.

V. Shoshan-Barmatz, Y. Krelin, Quan Chen

Current Medicinal Chemistry

DOI

2018

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

Yan-Jun Li, Yanhong Xue, Xiao-Jun Xu, Guopeng Wang, Yi-Qun Liu, Hao Wu, Wenhui Li, Yueying Wang, Zi-Heng Chen, Wei-Lin Zhang, Yu-Shan Zhu, Wei Ji, Tao Xu, Lei Liu, Quan Chen

EMBO Journal

DOI

2018

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Ting-Ting Fu, Zhi-Sheng Xu, Lin Liu, Qiqi Guo, Hao Wu, Xi-Jun Liang, Danxia Zhou, Liwei Xiao, Lei Liu, Yong Liu, Min-Sheng Zhu, Quan Chen, Z. Gan

Cell Reports

DOI

2017

MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy

Zi-Heng Chen, Sami Siraj, Lei Liu, Quan Chen

Autophagy

DOI

2017

Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin

Xiaofang Huang, Xin Zhou, Xiaoyu Hu, Amit S. Joshi, Xiangyang Guo, Yu-Shan Zhu, Quan Chen, W. Prinz, Jun-Jie Hu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2017

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy

Zi-Heng Chen, Lei Liu, Qi Cheng, Yan-Jun Li, Hao Wu, Wei-Lin Zhang, Yueying Wang, Sheikh Arslan Sehgal, Sami Siraj, Xiaohui Wang, Jun Wang, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2017

A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration

Hui-Liang Zhang, Pei Wang, Sara Bisetto, Y. Yoon, Quan Chen, S. Sheu, Wang Wang

Cardiovascular Research

DOI

2017

High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1

Pinglei Liu, Kun Liu, Haifeng Gu, Weixu Wang, Jiaqi Gong, Ying-Jie Zhu, Qian Zhao, Jia-Ni Cao, Chunseng Han, Fei Gao, Quan Chen, Wei Li, Jian-Wei Jiao, Baoyang Hu, Qi Zhou, Tongbiao Zhao

Cell Death and Differentiation

DOI

2016

蛋白A亲和层析法纯化单克隆抗体工艺的优化

陈泉，卓燕玲，许爱娜，咸漠，彭馨莹，杨元生，张海波，年锐，张巍

《生物工程学报》

2016

TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel.

Qiao-Chu Wang, Q. Zheng, Haiyan Tan, Bing Zhang, Xiaoling Li, Yuxiu Yang, Jie Yu, Yang Liu, Hao Chai, Xi Wang, Zhongshuai Sun, Jiu-Qiang Wang, Shu Zhu, Fengli Wang, Mao-Jun Yang, Cai-Xia Guo, Heng Wang, Qing-Yin Zheng, Yang Li, Quan Chen, Ai-Min Zhou, Tie-Shan Tang

Cell

DOI

2016

Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

Biao Ma, Hong-Cheng Cheng, Ruize Gao, Cheng-Long Mu, Ling Chen, Shian Wu, Quan Chen, Yu-Shan Zhu

Nature Communications

DOI

2016

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

Chang-Qian Zhou, K. Ma, Ruize Gao, Cheng-Long Mu, Lin-Bo Chen, Qiang-Qiang Liu, Qian Luo, D. Feng, Yu-Shan Zhu, Quan Chen

Cell Research

DOI

2016

Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy

Yi-Han Wang, Jiu-Qiang Wang, Qiao-Chu Wang, Yun Wang, Cai-Xia Guo, Quan Chen, Tuan-Yao Chai, Tie-Shan Tang

Scientific Reports

DOI

2016

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

Ming Chen, Zi-Heng Chen, Yueying Wang, Zheng Tan, Chongzhuo Zhu, Yan-Jun Li, Zhe Han, Lin-Bo Chen, Ruize Gao, Lei Liu, Quan Chen

Autophagy

DOI

2016

Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control.

Hao Wu, Huifang Wei, Sheikh Arslan Sehgal, Lei Liu, Quan Chen

Free Radical Biology & Medicine

DOI

2016

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling

Dan Liu, Lei Du, Dong Chen, Zhong-De Ye, Hong-Xia Duan, Tao Tu, Jing Feng, Yili Yang, Quan Chen, Xi-Yun Yan

OncoTarget

DOI

2016

Author response: Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

Wei-Lin Zhang, H. Ren, Chunling Xu, Chongzhuo Zhu, Hao Wu, Dong Liu, Jun Wang, Lei Liu, Wei Li, Qi Ma, Lei Du, Ming-Fei Zheng, Chuanmao Zhang, Jun-Ling Liu, Quan Chen

DOI

2016

パーキンはp62のプロテアソーム分解を促進する:Parkinson病の病因における神経細胞の選択的脆弱性の意味【Powered by NICT】

Ping-Ping Song, Shan-Shan Li, Hao Wu, Rui-Ze Gao, G. Rao, Dong-Mei Wang, Zi-Heng Chen, Biao Ma, Hong-Xia Wang, N. Sui, Hai-Teng Deng, Zhuo Zhang, T. Tang, Zheng Tan, Ze-Han Han, Tie-Yuan Lu, Yu-Shan Zhu, Quan Chen

2016

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

Yao Kuang, K. Ma, Chang-Qian Zhou, P. Ding, Yu-Shan Zhu, Quan Chen, B. Xia

Autophagy

DOI

2016

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

Wei-Lin Zhang, H. Ren, Chunling Xu, Chongzhuo Zhu, Hao Wu, Dong Liu, Jun Wang, Lei Liu, Wei Li, Qi Ma, Lei Du, Ming-Fei Zheng, Chuanmao Zhang, Jun-Ling Liu, Quan Chen

eLife

DOI

2016

ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance

Kun Liu, Qian Zhao, Pinglei Liu, Jia-Ni Cao, Jiaqi Gong, Chao-Qun Wang, Weixu Wang, Xiao-Yan Li, Hongyan Sun, Chao Zhang, Yufei Li, Minggui Jiang, Shaohua Zhu, Qingyuan Sun, Jian-Wei Jiao, Baoyang Hu, Xiao-Yang Zhao, Wei Li, Quan Chen, Qi Zhou, Tongbiao Zhao

Autophagy

DOI

2016

Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity.

Luwei He, Jun-Jie Han, Bao-wei Li, Li Huang, Ke-yin Ma, Quan Chen, Xinzhong Liu, Li Bao, Hong-Wei Liu

European journal of medicinal chemistry

DOI

2016

Proteins of well-defined structures can be designed without backbone readjustment by a statistical model

Xiaoqun Zhou, Peng Xiong, Meng Wang, Rongsheng Ma, Jiahai Zhang, Quan Chen, Haiyan Liu

Journal of Structural Biology

DOI

2015

3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cells.

Dan-Feng Xue, Quan-Xin Wang, Zi-Heng Chen, L. Cai, Li Bao, Qiu-Yue Qi, Lei Liu, Xiaohui Wang, Haijing Jin, Jun Wang, Hao Wu, Hong-Wei Liu, Quan Chen

Bioorganic & Medicinal Chemistry Letters

DOI

2015

A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells*

Li Huang, Jun-Jie Han, Danya Ben-Hail, Luwei He, Bao-wei Li, Zi-Heng Chen, Yueying Wang, Yan-lei Yang, Lei Liu, Yu-Shan Zhu, V. Shoshan-Barmatz, Hong-Wei Liu, Quan Chen

Journal of Biological Chemistry

DOI

2015

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.

Huifang Wei, Lei Liu, Quan Chen

Biochimica et Biophysica Acta

DOI

2015

Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis

Hao Wu, Quan Chen

Antioxidants and Redox Signaling

DOI

2015

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

Jie Li, W. Qi, Guo Chen, D. Feng, Jin-Hua Liu, Biao Ma, Chang-Qian Zhou, Cheng-Long Mu, Wei-Lin Zhang, Quan Chen, Yu-Shan Zhu

Autophagy

DOI

2014

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

W. Yue, Zi-Heng Chen, Hai-Yang Liu, Chen Yan, Ming Chen, D. Feng, Chao-Jun Yan, Hao Wu, Lei Du, Yueying Wang, Jin-Hua Liu, Xiaohu Huang, Laixin Xia, Lei Liu, Xiaohui Wang, Haijing Jin, Jun Wang, Zhiyin Song, X. Hao, Quan Chen

Cell Research

DOI

2014

Receptor-mediated mitophagy in yeast and mammalian systems

Lei Liu, Kaori Sakakibara, Quan Chen, K. Okamoto

Cell Research

DOI

2014

A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.

Guo Chen, Zhe Han, D. Feng, Yanfang Chen, Lin-Bo Chen, Hao Wu, Li Huang, Chang-Qian Zhou, Xiangyu Cai, Chang-Ying Fu, L. Duan, Xiaohui Wang, Lei Liu, Xin-Qi Liu, Yuequan Shen, Yu-Shan Zhu, Quan Chen

Molecules and Cells

DOI

2014

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

Biao Ma, Yan Chen, Ling Chen, Hong-Cheng Cheng, Cheng-Long Mu, J. Li, Ruize Gao, Chang-Qian Zhou, Lei Cao, Jin-Hua Liu, Yu-Shan Zhu, Quan Chen, Shian Wu

Nature Cell Biology

DOI

2014

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy

Hao Wu, Dan-Feng Xue, Guo Chen, Zhe Han, Li Huang, Chongzhuo Zhu, Xiaohui Wang, Haijing Jin, Jun Wang, Yu-Shan Zhu, Lei Liu, Quan Chen

Autophagy

DOI

2014

Drp1 Is Dispensable for Mitochondria Biogenesis in Induction to Pluripotency but Required for Differentiation of Embryonic Stem Cells

Lei Wang, Xiao-Ying Ye, Qiang Zhao, Zhong-Cheng Zhou, Jiameng Dan, Yu-Shan Zhu, Quan Chen, Lin Liu

Stem Cells and Development

DOI

2014

Monitoring mitophagy in mammalian cells.

Yu-Shan Zhu, Guo Chen, Lin-Bo Chen, Wei-Lin Zhang, D. Feng, Lei Liu, Quan Chen

Methods in Enzymology

DOI

2013

Molecular signaling toward mitophagy and its physiological significance.

D. Feng, Lei Liu, Yu-Shan Zhu, Quan Chen

Experimental Cell Research

DOI

2013

Osteopontin, a possible modulator of cancer stem cells and their malignant niche

G. Rao, Lei Du, Quan Chen

Oncoimmunology

DOI

2013

Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs

G. Rao, Hong-Min Liu, Bao-wei Li, J. Hao, Yan-lei Yang, Ming-Rong Wang, Xiaohui Wang, Jun Wang, Haijing Jin, Lei Du, Quan Chen

Acta Pharmacologica Sinica

DOI

2013

Remarkably reduced expression of FoxO3a in metaplastic colorectum, primary colorectal cancer and liver metastasis

Leya He, Xin Wei, Lei Du, Lu Liu, Feng Xu, Jiang Min, Chuan Li, D. Tao, Quan Chen, Jun-bo Hu, J. Gong

Journal of Huazhong University of Science and Technology. Medical Sciences

DOI

2013

A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.

Jin-Hua Liu, Cheng-Long Mu, W. Yue, Jie Li, Biao Ma, Lixia Zhao, Lei Liu, Quan Chen, Chen Yan, Hai-Yang Liu, Xiao-Jiang Hao, Yu-Shan Zhu

Free Radical Biology & Medicine

DOI

2013

CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer.

Lei Du, G. Rao, Hongyi Wang, Bao-wei Li, Weili Tian, Jian-Tao Cui, Leya He, Brian Laffin, Xiu-Yun Tian, C. Hao, Hong-Min Liu, Xin Sun, Yu-Shan Zhu, Dean G. Tang, M. Mehrpour, Youyong Lu, Quan Chen

Cancer Research

DOI

2013

Phosphorylation Events in Selective Mitophagy: Possible Biochemical Markers?

Wei-Lin Zhang, Hao Wu, Lei Liu, Yu-Shan Zhu, Quan Chen

Current Pathobiology Reports

DOI

2012

Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer

G. Rao, Hongyi Wang, Bao-wei Li, Li Huang, Dan-Feng Xue, Xiaohui Wang, Haijing Jin, Jun Wang, Yu-Shan Zhu, Youyong Lu, Lei Du, Quan Chen

Clinical Cancer Research

DOI

2012

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes*

Ting Zhao, Xiaohu Huang, Liang Han, Xian-Hua Wang, Hong-Qiang Cheng, Yungang Zhao, Quan Chen, Ju Chen, He-ping Cheng, Ruiping Xiao, Ming-Qi Zheng

Journal of Biological Chemistry

DOI

2012

Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease*

Jiu-Qiang Wang, Qian Chen, Xian-Hua Wang, Qiao-Chu Wang, Yun Wang, He-ping Cheng, Cai-Xia Guo, Qin-Miao Sun, Quan Chen, Tie-Shan Tang

Journal of Biological Chemistry

DOI

2012

Appoptosin is a Novel Proapoptotic Protein and Mediates Cell Death in Neurodegeneration

Han Zhang, Yun-Wu Zhang, Yao-Min Chen, Xiumei Huang, Fang-Fang Zhou, Weiwei Wang, Bo Xian, Xian Zhang, E. Masliah, Quan Chen, J. Han, Guo-Jun Bu, John Calvin Reed, F. Liao, Ye-Guang Chen, Hua-Xi Xu

Journal of Neuroscience

DOI

2012

Reactive Oxygen Species,Mitochondrial Permeability Transition and Apoptosis

Qi Ma, Lei Liu, Quan Chen

DOI

2012

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

Lei Liu, D. Feng, Guo Chen, Ming Chen, Q. Zheng, Pingping Song, Qi Ma, Chongzhuo Zhu, Rui Wang, Wan-Jun Qi, Lei Huang, P. Xue, Bao-wei Li, Xiaohui Wang, Haijing Jin, Jun Wang, Fuquan Yang, Ping-Sheng Liu, Yu-Shan Zhu, Sen-Fang Sui, Quan Chen

Nature Cell Biology

DOI

2011

Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release

Yu-Shan Zhu, Min Li, Xiaohui Wang, Haijing Jin, Shu-Sen Liu, Jian-Xing Xu, Quan Chen

Cell Research

DOI

2011

APOPTOSIS OXIDATIVE STRESS-INDUCED MITOCHONDRIAL SIGNALS FOR Superoxide Flashes : EARLY Cell Biology

Qi Ma, H. Fang, Wei Shang, Lei Liu, Zheng-Shuang Xu, T. Ye, Xian-Hua Wang, Ming-Qi Zheng, Quan Chen, He-Ping Cheng

2011

Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule*

Lixia Zhao, F. He, Hai-Yang Liu, Yu-Shan Zhu, Weili Tian, P. Gao, Hong-Ping He, W. Yue, Xiaobo Lei, Biyun Ni, Xiaohui Wang, Haijing Jin, X. Hao, Jia-Ling Lin, Quan Chen

Journal of Biological Chemistry

DOI

2011

Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells through Upregulation of Bim

Biyun Ni, Qi Ma, Bao-wei Li, Lixia Zhao, Yong Liu, Yu-Shan Zhu, Quan Chen

Clinical Cancer Research

DOI

2011

Application of anti-cellular-prion-protein monoclonal antibody in preparing antitumor drugs

Quan Chen, Lei Du, Jun Wang, Haijing Jin, Xiaohui Wang, Bao-wei Li

2011

Superoxide Flashes

Qi Ma, H. Fang, Wei Shang, Lei Liu, Zheng-Shuang Xu, T. Ye, Xian-Hua Wang, Ming-Qi Zheng, Quan Chen, He-Ping Cheng

Journal of Biological Chemistry

DOI

2010

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

Yu-Shan Zhu, Lixia Zhao, Lei Liu, P. Gao, Weili Tian, Xiaohui Wang, Haijing Jin, Hai-Dong Xu, Quan Chen

Protein & Cell

DOI

2010

The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells*

P. Gao, C. Bauvy, S. Souquere, G. Tonelli, Lei Liu, Yu-Shan Zhu, Zhenzhen Qiao, Daniela Bakula, T. Proikas-Cezanne, G. Pierron, P. Codogno, Quan Chen, M. Mehrpour

Journal of Biological Chemistry

DOI

2010

PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha.

Di Shao, Yang Liu, Xiaojun Liu, Liu-luan Zhu, Ying Cui, An-Fang Cui, Ai-Jun Qiao, Xingxing Kong, Yong Liu, Quan Chen, N. Gupta, Fu-De Fang, Yong-Sheng Chang

Mitochondrion (Amsterdam. Print)

DOI

2010

Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus

Lixia Zhao, Yu-Shan Zhu, Dong-Mei Wang, Ming Chen, P. Gao, Wei-Ming Xiao, G. Rao, Xiaohui Wang, Haijing Jin, Lin Xu, N. Sui, Quan Chen

Autophagy

DOI

2009

Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells.

Fang Huang, Chun-Lai Nie, Yang Yang, W. Yue, Yun Ren, Ying-Li Shang, Xiaohui Wang, Haijing Jin, Cai-Min Xu, Quan Chen

Free Radical Biology & Medicine

DOI

2009

Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells.

Xiang-Xuan Zhao, Yong Liu, Qi Ma, Xiaohui Wang, Haijing Jin, M. Mehrpour, Quan Chen

Biochemical and Biophysical Research Communications - BBRC

DOI

2009

Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine‐induced acute liver injury

Ying-Li Shang, Yong Liu, Lei Du, You-Liang Wang, Xuan Cheng, Wei-Ming Xiao, Xiaohui Wang, Haijing Jin, X. Yang, Shu-Sen Liu, Quan Chen

Hepatology

DOI

2008

Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death

Changhai Tian, P. Gao, Yanhua Zheng, W. Yue, Xiaohui Wang, Haijing Jin, Quan Chen

Cell Research

DOI

2008

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

Lei Du, Hongyi Wang, Leya He, Jingyu Zhang, Biyun Ni, Xiaohui Wang, Haijing Jin, N. Cahuzac, M. Mehrpour, Youyong Lu, Quan Chen

Clinical Cancer Research

DOI

2008

Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis*

Chun-Lai Nie, Changhai Tian, Lixia Zhao, P. Petit, M. Mehrpour, Quan Chen

Journal of Biological Chemistry

DOI

2008

15-氧代绣线菊内酯，其药物组合物和其制备方法及其应用

Xia Hao, Quan Chen, Hai-Yang Liu, Lixia Zhao, Ying-Tong Di, Haijing Jin, Hong-Ping He, Wen Le, Suo Gao, Xiao-Hui Wang, Lei Du

2006

Nitric oxide signaling in stretch‐induced apoptosis of neonatal rat cardiomyocytes

Xudong Liao, Jun-ming Liu, Lei Du, A. Tang, Ying-Li Shang, Shi-Qiang Wang, Lan-Ying Chen, Quan Chen

The FASEB Journal

DOI

2006

Gossypol induces Bax/Bak‐independent activation of apoptosis and cytochrome c release via a conformational change in Bcl‐2

Xiaobo Lei, Ying-Yu Chen, Guan-Hua Du, Wen-Yu Yu, Xiaohui Wang, H. Qu, Bin Xia, Hong-Ping He, Jian-Hua Mao, Wei-Xing Zong, Xudong Liao, M. Mehrpour, X. Hao, Quan Chen

The FASEB Journal

DOI

2006

Identification of genes regulated by Wnt/β-catenin pathway and involved in apoptosis via microarray analysis

Mo-Li Huang, Yi-Hua Wang, Daochun Sun, Hong-Xia Zhu, Yan-Bin Yin, Wei Zhang, Shangbin Yang, L. Quan, Jin-Feng Bai, Sheng-Qi Wang, Quan Chen, Song-Gang Li, Ning-Zhi Xu

BMC Cancer

DOI

2005

Involvement of death receptor signaling in mechanical stretch-induced cardiomyocyte apoptosis.

Xudong Liao, Xiaohui Wang, Ying Gu, Quan Chen, Lan-Ying Chen

Life Science

DOI

2004

小泛素相关修饰物SUMO研究进展

陈泉，施蕴渝

《生命科学》

2004

Mechanical stretch induces mitochondria-dependent apoptosis in neonatal rat cardiomyocytes and G2/M accumulation in cardiac fibroblasts

Xudong Liao, Xiao-Hui Wang, Haijing Jin, Lan-Ying Chen, Quan Chen

Cell Research

DOI

2003

Redox regulation of apoptosis before and after cytochrome C release

Quan Chen, Meredith E. Crosby, A. Almasan

Korean Journal of Biological Sciences

DOI

2003

Role of Ca2+ signaling in initiation of stretch-induced apoptosis in neonatal heart cells.

Xudong Liao, A. Tang, Quan Chen, Haijing Jin, Caihong Wu, Lan-Ying Chen, Shi-Qiang Wang

Biochemical and Biophysical Research Communications - BBRC

DOI

2002

Human endothelial senescence can be induced by TNF-α

Jian-Jun Zhou, Yunfei Gao, Hongfang Wang, Quan Chen, Caihong Wu, M. Feng

Science Bulletin

DOI

2002

Bid BH3 peptide, but not its mutant form G94E, induces permeability transition pore opening and cytochrome c release in vitro

T. Xia, Chun-Sun Jiang, Lin-Jiang Li, Yong Zhang, Haijing Jin, Shu-Sen Liu, Caihong Wu, Quan Chen

DOI

2002

Mechanism of mitochondrial respiratory control in caspase-3 induced positive feedback loop in apoptosis

T. Xia, Chun-Sun Jiang, Lin-Jiang Li, Quan Chen, Caihong Wu, Shu-Sen Liu

DOI

2002

A study on permeability transition pore opening and cytochrome c release from mitochondria, induced by caspase‐3 in vitro

T. Xia, Chun-Sun Jiang, Lin-Jiang Li, Caihong Wu, Quan Chen, Shu-Sen Liu

FEBS Letters

DOI

2001

The Late Increase of Free Radicals During Genotoxic-Stress Induced Apoptosis is Associated with Cytochrome C Release From Mitochondria Induced by Caspase-Mediated Feedback Loop Amplification

Quan Chen, Yucheng Chai, Suparna Mazuder, Judy Drazba, G. Chisolm, A. Almasan

TheScientificWorldJournal

DOI

精选作品

期刊论文

Author Correction: NRF1-mediated innate immune response drives inflammaging

Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.

Author Correction: Broadening the molecular glue landscape

Zero-shot deep learning with multi-objective optimization improves thermostability of zearalenone hydrolase and xylanase

Trans-interface coupling in the tetrameric enzyme underlies allosteric control in Escherichia coli biosynthetic threonine deaminase

Designing flexible protein structures and sampling protein conformations with a unified model using vector quantization and diffusion

NRF1-mediated innate immune response drives inflammaging

Sweetening ferroptosis spread

Mitochondria transfer

Stapled peptides: targeting protein-protein interactions in drug development

RETRACTED ARTICLE: Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance

Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer

Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells

Author Correction: PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury

PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury

The Humanization and Maturation of an Anti-PrPc Antibody

Nature conference on mitochondria and immunity: Uncovering Mitochondria–Immunity crosstalk and fostering global scientific exchanges

Structure-destabilizing mutations unleash an intrinsic perforation activity of antiapoptotic Bcl-2 in the mitochondrial membrane enabling apoptotic cell death

NRF1‐mediated mitochondrial biogenesis antagonizes innate antiviral immunity

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function

Hypoxia Dynamically Regulates DBC1 Ubiquitination and Stability by SIAH2 and OTUD5 in Breast Cancer Progression

LGR4 cooperates with PrPc to endow the stemness of colorectal cancer stem cells contributing to tumorigenesis and liver metastasis.

Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy

A noncanonical autophagy function of ATG9A for Golgi integrity and dynamics

Targeting stemness of cancer stem cells to fight colorectal cancers.

The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases

Receptor-mediated mitophagy regulates EPO production and protects against renal anemia

Molecular regulation of mitochondrial autophagy and cellular fate

A zinc transporter, transmembrane protein 163 (TMEM163), is critical for the biogenesis of platelet dense granules.

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis

PINK1‐mediated mitophagy maintains pluripotency through optineurin

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Atg1 kinase in fission yeast is activated by Atg11-mediated dimerization and cis-autophosphorylation

Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

数据与计算驱动的蛋白质元件预测和设计

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

Bcl-2家族蛋白的生理功能及结构基础

Mechanism of mitophagy in cell homeostasis

Mitochondria organize the cellular proteostatic response and promote cellular senescence

FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate

FUNDC2 regulates platelet activation through AKT/GSK-3β/cGMP axis.

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

Nix-mediated mitophagy regulates platelet activation and life span.

STING directly activates autophagy to tune the innate immune response

Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury.

Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis.

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy

Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy

A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration

High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1

蛋白A亲和层析法纯化单克隆抗体工艺的优化

TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel.

Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control.

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling

Author response: Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

パーキンはp62のプロテアソーム分解を促進する:Parkinson病の病因における神経細胞の選択的脆弱性の意味【Powered by NICT】

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance

Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity.

Proteins of well-defined structures can be designed without backbone readjustment by a statistical model

3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cells.

A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells*

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.