杨恒文｜暨南大学｜学者主页

2025

Complement factor D is a drug target for metabolic-associated fatty liver disease

Rong Guo, Ziyun Li, Ziyun Li, Jie Wu, Zilin Zhang, Junxiang Shu, Xiaoxi Zhou, Wenfang Zhou, Yiming Chen, Dongxia Guan, Qian Wang, Qiping Shi, Hengwen Yang, Guangqiang Li

Molecular Immunology

DOI

2025

The many faces of Interleukin-27 in liver diseases: from immune regulator to metabolic player

Xiaoxi Zhou, Hengdong Qu, Yiming Cui, Wenjing Zhou, Qian Wang, Hengwen Yang, Jian Hong, Ye Li, Zhinan Yin

Life Sciences

DOI

2025

Gut microbiota-derived histamine exacerbates psoriasis by promoting γδT17 cell differentiation via the Hrh1/Wnt Axis

Waiming Cheng, Meihong He, Elfira Jurat, Luoyi Jin, Shunchang Luo, Zerong Guan, Yingying Zeng, Xianghong Wang, Jianlei Hao, Xin Tang, Haiyan Zhu, Zhinan Yin, Hengwen Yang

International Immunopharmacology

DOI

2025

NF-κB inactivation in myeloid cell leads to reprogramming of whole-body energy metabolism in response to high-fat diet

Xianghong Wang, Zhe Yang, Xin Ye, Owen P. McGuinness, Hengwen Yang, Hongyun Lu, Jianping Ye

Cell Death Discovery

DOI

2025

SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance

Dehai Li, Jing Zhu, Mingyue Zhang, Qiping Shi, Rong Guo, Daming Zhang, Pei Zheng, Hua Zhang, Guangqiang Li, Jie Wu, Guodong Sun, Qiong Wen, Jingyi Tan, Zonghua Liu, Xindong Liu, Hengwen Yang, Hongyun Lu, Guangchao Cao, Zhinan Yin, Qian Wang

Cell Reports

DOI

2025

Modulation of γδ T cells by USF3: Implications for liver fibrosis and immune regulation

Xianghong Wang, Rong Lin, Dehai Li, Weiyuan Ye, Zhe Yang, Niujian Wu, Qiong Wen, Jingyi Tan, Chuanchuan Sun, Zhinan Yin, Hongyun Lu, Hengwen Yang

International Immunopharmacology

DOI

2024

Disruption of the gut microbiota-inflammation-brain axis in unmedicated bipolar disorder II depression

Zixuan Guo, Shu Xiao, Guanmao Chen, Shuming Zhong, Hui Zhong, Shilin Sun, Pan Chen, Xinyue Tang, Hengwen Yang, Yanbin Jia, Zhinan Yin, Li Huang, Ying Wang

Translational Psychiatry，Vol. 14, No. 10

DOI

2024

Gut proinflammatory bacteria is associated with abnormal functional connectivity of hippocampus in unmedicated patients with major depressive disorder

Shu Xiao, Zibin Yang, Hong Yan, Guanmao Chen, Shuming Zhong, Pan Chen, Hui Zhong, Hengwen Yang, Yanbin Jia, Zhinan Yin, Jiaying Gong, Li Huang, Ying Wang

Translational Psychiatry，Vol. 14, No. 10

DOI

2024

IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation

Mingyue Zhang, Dehai Li, Jing Zhu, Xue Xia, Hua Zhang, Jie Jayne Wu, Shengli Wang, Anyi Deng, Qiong Wen, Jingyi Tan, Jianlei Hao, Jun Jiang, Xiucong Bao, Guodong Sun, Jiajing Lu, Quanli Yang, Hengwen Yang, Guangchao Cao, Zhinan Yin, Qian Wang

Cell Death and Disease

DOI

2024

Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus

Zhongzhen Li, Zhiwei Lei, Wanying Yang, Chunxia Jing, Xiaolin Sun, Guang Yang, Xiaozhen Zhao, Mingjiao Zhang, Miaomiao Xu, Yuanjia Tang, Qingwen Wang, Jing Zhao, Zixing Zhou, Zihao Wen, Xiaojing Chen, Qinglin Peng, Guochun Wang, Pingjing Zhang, Erwei Sun, Nan Shen, Weiguo Xu, Zhanguo Li, Hengwen Yang, Zhinan Yin

Parasites & Vectors

DOI

2023

Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

Xin Tang, Chuanxi Wang, Chuanxi Wang, Lei Wang, Feifei Ren, Runqiao Kuang, Zhenhua Li, Xue Han, Yiming Chen, Guo‐Dong Chen, Xiuqing Wu, Jie Liu, Hengwen Yang, Xingzhong Liu, Chen Wang, Chen Wang, Hao Gao, Zhinan Yin

Acta Pharmaceutica Sinica B

DOI

2021

DPSN：扩增子测序引物标准化命名数据库（英文）

谭宇翔，田义霞，陈俊宇，尹芝南，杨恒文

《微生物学报》

2021

IL-27 signalling promotes adipocyte thermogenesis and energy expenditure

Qian Wang, Dehai Li, Guangchao Cao, Qiping Shi, Jing Zhu, Mingyue Zhang, Hao Cheng, Qiong Wen, Hao Ying Xu, Leqing Zhu, Hua Zhang, Rachel J. Perry, Olga Spadaro, Yunfan Yang, Shengqi He, Yong Chen, Baocheng Wang, Guangqiang Li, Zonghua Liu, Caixian Yang, Xiaoli Wu, Libing Zhou, Qinghua Zhou, Zhenyu Ju, Hongyun Lu, Yongjie Xin, Xiaoyong Yang, Cunchuan Wang, Yong Liu, Gerald I. Shulman, Vishwa Deep Dixit, Ligong Lu, Hengwen Yang, Richard Anthony Flavell, Zhinan Yin

Nature

DOI

2021

Pregnancy Induces an Immunological Memory Characterized by Maternal Immune Alterations Through Specific Genes Methylation

Xiaobo Huang, Liling Wang, Sijia Zhao, Hong Liu, Si Chen, Li Wu, Liping Liu, Jiahui Ding, Hengwen Yang, Anthony J. Maxwell, Zhinan Yin, Gil Mor, Aihua Liao

Frontiers in Immunology

DOI

2021

Metabolic Control of γδ T Cell Function

Ziyu Meng, Guangchao Cao, Quanli Yang, Hengwen Yang, Jianlei Hao, Zhinan Yin

Infectious Microbes & Diseases

DOI

2021

Roux‐en‐Y Gastric Bypass Improved Insulin Resistance via Alteration of the Human Gut Microbiome and Alleviation of Endotoxemia

Qiping Shi, Qian Wang, Hui Zhong, Dehai Li, Shuxing Yu, Hengwen Yang, Cunchuan Wang, Zhinan Yin

BioMed Research International

DOI

2020

Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD

Qian Wang, Dehai Li, Jing Zhu, Mingyue Zhang, Hua Zhang, Guangchao Cao, Leqing Zhu, Qiping Shi, Jianlei Hao, Qiong Wen, Zonghua Liu, Hengwen Yang, Zhinan Yin

Frontiers in Immunology

DOI

2020

Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2

Qin-Li Wan, Xiaodie Fu, Wenyu Dai, Jing Yang, Zhenhuan Luo, Xiao Meng, Xiao Liu, Ruowei Zhong, Hengwen Yang, Qinghua Zhou

Aging

DOI

2020

Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function

Quanli Yang, Xia Liu, Qihui Liu, Zerong Guan, Jing Luo, Guangchao Cao, Ruitian Cai, Zhenhua Li, Yan Xu, Zengfeng Wu, Miaomiao Xu, Song Zhang, Fan Zhang, Hengwen Yang, Xue-Jia Lin, Meixiang Yang, Yangzhe Wu, Yunfei Gao, Richard Anthony Flavell, Jianlei Hao, Zhinan Yin

Cell Death and Differentiation

DOI

2019

Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity

Jing Zhu, Ruitian Cai, Yuxiang Tan, Xiuqing Wu, Qiong Wen, Zonghua Liu, Shu‐Hua Ouyang, Zhinan Yin, Hengwen Yang

Journal of Functional Foods

DOI

2019

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang, Qinghua Zhou

Aging

DOI

2018

Gut microbiota have blood types as human

Qizheng Wu, Hui Zhong, Yafei Zhai, Yanjiong Jia, Zhinan Yin, Min Chen, Hengwen Yang, Peng George Wang

《中国科学通报：英文版》

DOI

2018

Transmembrane domain dependent inhibitory function of FcγRIIB

Junyi Wang, Zongyu Li, Liling Xu, Hengwen Yang, Wanli Liu

Protein & Cell

DOI

2017

γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury

Guodong Sun, Shuxian Yang, Guangchao Cao, Qianghua Wang, Jianlei Hao, Qiong Wen, Zhizhong Li, Kwok‐Fai So, Zonghua Liu, Sufang Zhou, Yongxiang Zhao, Hengwen Yang, Libing Zhou, Zhinan Yin

The Journal of Experimental Medicine

DOI

2017

Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice

Guangchao Cao, Qian Wang, Wanjun Huang, Jiyu Tong, Dewei Ye, Yan He, Zonghua Liu, Xin Tang, Hao Cheng, Qiong Wen, Dehai Li, Hau-Tak Chau, Yiming Wen, Hui Zhong, Ziyu Meng, Hui Liu, Zhenzhou Wu, Liqing Zhao, Richard Anthony Flavell, Hongwei Zhou, Aimin Xu, Hengwen Yang, Zhinan Yin

Cell Discovery

DOI

2016

Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China

Jiaojiao Liu, Hengwen Yang, Zongsheng Yin, Xingpeng Jiang, Haohui Zhong, D. Qiu, F. Zhu, R. Li

European Journal of Clinical Microbiology & Infectious Diseases

DOI

2016

mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α

Guangchao Cao, Qian Wang, Guangqiang Li, Ziyu Meng, Hui Liu, Jiyu Tong, Wanjun Huang, Zonghua Liu, Yanqiong Jia, Jun Wei, Hongbo Chi, Hengwen Yang, Liqing Zhao, Zhenzhou Wu, Jianlei Hao, Zhinan Yin

Journal of Leukocyte Biology

DOI

杨恒文

精选作品

期刊论文

Complement factor D is a drug target for metabolic-associated fatty liver disease

The many faces of Interleukin-27 in liver diseases: from immune regulator to metabolic player

Gut microbiota-derived histamine exacerbates psoriasis by promoting γδT17 cell differentiation via the Hrh1/Wnt Axis

NF-κB inactivation in myeloid cell leads to reprogramming of whole-body energy metabolism in response to high-fat diet

SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance

Modulation of γδ T cells by USF3: Implications for liver fibrosis and immune regulation

Disruption of the gut microbiota-inflammation-brain axis in unmedicated bipolar disorder II depression

Gut proinflammatory bacteria is associated with abnormal functional connectivity of hippocampus in unmedicated patients with major depressive disorder

IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation

Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus

Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

DPSN：扩增子测序引物标准化命名数据库（英文）

IL-27 signalling promotes adipocyte thermogenesis and energy expenditure

Pregnancy Induces an Immunological Memory Characterized by Maternal Immune Alterations Through Specific Genes Methylation

Metabolic Control of γδ T Cell Function

Roux‐en‐Y Gastric Bypass Improved Insulin Resistance via Alteration of the Human Gut Microbiome and Alleviation of Endotoxemia

Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD

Uric acid induces stress resistance and extends the life span through activating the stress response factor DAF-16/FOXO and SKN-1/NRF2

Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function

Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Gut microbiota have blood types as human

Transmembrane domain dependent inhibitory function of FcγRIIB

γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury

Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice

Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China

mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α

研究方向