胥文春｜重庆医科大学｜学者主页

2026

Protective role of lactate in allergic airway inflammation: mitigation of inflammatory injury, epithelial barrier integrity restoration, and gut-lung axis involvement

Meilian Lin, Jie Zhou, Yan Wang, Wenchun Xu, XD Sun

Respiratory Research

2025

CD5L Inhibits Allergic Airway Inflammation by Lysophosphatidylcholine-Induced ILC2 Apoptosis

Yan Wang, Yan Wang, Te Chen, Te Chen, Yaqi Qin, Meilian Lin, Shifei Yao, Xiaoyu Sun, Yanjun Jia, Xiaoliang Yang, Qingxiang Kong, Minghao Zhang, Xuemei Zhang, Yibing Yin, Wenchun Xu, Wenchun Xu

Antioxidants and Redox Signaling

DOI

2023

The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma

Shifei Yao, Danlin Weng, Yan Wang, Yanyu Zhang, Qi Huang, Kaifeng Wu, Honghui Li, Xuemei Zhang, Yibing Yin, Wenchun Xu

Journal of Translational Medicine

DOI

2023

IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells

Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu

iScience

DOI

2023

Progranulin deficiency suppresses allergic asthma and enhances efferocytosis via PPAR‐γ/MFG‐E8 regulation in macrophages

Qi Huang, Danlin Weng, Shifei Yao, Hailan Shen, Song Gao, Yanyu Zhang, Wenjie Huang, Yan Wang, Hong Wang, Wenchun Xu

Immunity Inflammation and Disease

DOI

2022

CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2

Danlin Weng, Song Gao, Hailan Shen, Shifei Yao, Qi Huang, Yanyu Zhang, Wenjie Huang, Yan Wang, Xuemei Zhang, Yibing Yin, Wenchun Xu

Immunology

DOI

2021

颗粒蛋白前体通过抑制IL-6表达减轻哮喘气道炎症

齐玉红，孙思，王玲，杨静，吴光英，黄琪，胥文春

《中国应用生理学杂志》

2021

Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K/Akt/NF-kB in Asthma

Xu Chen, Jing Yang, Hailan Shen, Xuemei Zhang, Hong Wang, Guangying Wu, Yuhong Qi, Ling Wang, Wenchun Xu

Journal of Asthma and Allergy

DOI

2020

Streptococcus pneumoniae aminopeptidase N regulates dendritic cells that attenuates type‐2 airway inflammation in murine allergic asthma

Guangying Wu, Xuemei Zhang, Xu Chen, Jian Wang, Jing Yang, Ling Wang, Si Sun, Yuhong Qi, Hong Wang, Yibing Yin, Wenchun Xu

British Journal of Pharmacology

DOI

2019

Type I IFN expression is stimulated by cytosolic Mt DNA released from pneumolysin‐damaged mitochondria via the STING signaling pathway in macrophages

Xuexue Hu, Xiaoqiong Peng, Chang Lu, Xuemei Zhang, Lingling Gan, Yue Gao, Shenghui Yang, Wenchun Xu, Jian Wang, Yibing Yin, Hong Wang

FEBS Journal

DOI

2019

Mast cell degranulation impairs pneumococcus clearance in mice via IL-6 dependent and TNF-α independent mechanisms

Jing Yang, Jichao Wang, Xuemei Zhang, Yulan Qiu, Jurong Yan, Si Sun, Yujuan He, Yibing Yin, Wenchun Xu

World Allergy Organization Journal

DOI

2018

Streptococcus pneumoniae Attenuated Strain SPY1 with an Artificial Mineral Shell Induces Humoral and Th17 Cellular Immunity and Protects Mice against Pneumococcal Infection

Xinyuan Zhang, Jingjing Cui, Yingying Wu, Hong Wang, Jian Wang, Yulan Qiu, Yunjun Mo, Yujuan He, Xuemei Zhang, Yibing Yin, Wenchun Xu

Frontiers in Immunology

DOI

2017

DnaJ (hsp40) of Streptococcus pneumoniae is involved in bacterial virulence and elicits a strong natural immune reaction via PI3K/JNK

Jin Cui, Chenyu Ma, Guo Ye, Yong Shi, Wenchun Xu, Liang Zhong, Jian Wang, Yibing Yin, Xuemei Zhang, Hong Wang

Molecular Immunology

DOI

2016

Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathway

Yingying Wu, Jingjing Cui, Xuemei Zhang, Song Gao, Feng Ma, Hua Chuan Yao, Xiaoyu Sun, Yujuan He, Yibing Yin, Wenchun Xu

Immunobiology

DOI

2015

[Pneumococcal HSP40 induces the immune response in mouse macrophages via p38MAPK and JNK signaling pathways].

Yingying Wu, Song Gao, Feng Ma, Jingjing Cui, Hua Chuan Yao, Xiaoyu Sun, Jichao Wang, Wenchun Xu

PubMed

2015

Pneumococcal wall teichoic acid is required for the pathogenesis of Streptococcus pneumoniae in murine models

Hongmei Xu, Libin Wang, Jian Huang, Yanqing Zhang, Feng Ma, Jianmin Wang, Wenchun Xu, Xuemei Zhang, Yibing Yin, Kaifeng Wu

The Journal of Microbiology

DOI

2014

c‐Jun N‐terminal kinase and Akt signalling pathways regulating tumour necrosis factor‐α‐induced interleukin‐32 expression in human lung fibroblasts: implications in airway inflammation

Dagen Li, Dapeng Chen, Xuemei Zhang, Hong Wang, Zixin Song, Wenchun Xu, Yujuan He, Yibing Yin, Ju Cao

Immunology

DOI

2014

GHIP in Streptococcus pneumoniae is involved in antibacterial resistance and elicits a strong innate immune response through TLR 2 and JNK /p38 MAPK

Jie Dong, Jian Wang, Yujuan He, Chenwei Li, Aie Zhou, Jin Cui, Wenchun Xu, Liang Zhong, Yibing Yin, Xuemei Zhang, Hong Wang

FEBS Journal

DOI

2013

Screening and identification of ClpE interaction proteins in Streptococcus pneumoniae by a bacterial two-hybrid system and co-immunoprecipitation

Wenjuan Yan, Yingying Cai, Qun Zhang, Yusi Liu, Wenchun Xu, Yibing Yin, Yujuan He, Hong Wang, Xuemei Zhang

The Journal of Microbiology

DOI

2013

Screening and Identification of DnaJ Interaction Proteins in Streptococcus pneumoniae

Yingying Cai, Wenjuan Yan, Wenchun Xu, Yibing Yin, Yujuan He, Hong Wang, Xuemei Zhang

Current Microbiology

DOI

2012

SP0454, a putative threonine dehydratase, is required for pneumococcal virulence in mice

Wenjuan Yan, Hong Wang, Wenchun Xu, Kaifeng Wu, Run Yao, Xiuyu Xu, Jie Dong, YanQing Zhang, Wen Zhong, Xuemei Zhang

The Journal of Microbiology

DOI

2007

Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP

Ju Cao, Dapeng Chen, Wenchun Xu, Tingmei Chen, Songxiao Xu, Jingyong Luo, Qing Zhao, Beizhong Liu, Dongsheng Wang, Xuemei Zhang, You-Lan Shan, Yibing Yin

Vaccine

DOI

胥文春

精选作品

期刊论文

Protective role of lactate in allergic airway inflammation: mitigation of inflammatory injury, epithelial barrier integrity restoration, and gut-lung axis involvement

CD5L Inhibits Allergic Airway Inflammation by Lysophosphatidylcholine-Induced ILC2 Apoptosis

The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma

IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells

Progranulin deficiency suppresses allergic asthma and enhances efferocytosis via PPAR‐γ/MFG‐E8 regulation in macrophages

CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2

颗粒蛋白前体通过抑制IL-6表达减轻哮喘气道炎症

Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K/Akt/NF-kB in Asthma

Streptococcus pneumoniae aminopeptidase N regulates dendritic cells that attenuates type‐2 airway inflammation in murine allergic asthma

Type I IFN expression is stimulated by cytosolic Mt DNA released from pneumolysin‐damaged mitochondria via the STING signaling pathway in macrophages

Mast cell degranulation impairs pneumococcus clearance in mice via IL-6 dependent and TNF-α independent mechanisms

Streptococcus pneumoniae Attenuated Strain SPY1 with an Artificial Mineral Shell Induces Humoral and Th17 Cellular Immunity and Protects Mice against Pneumococcal Infection

DnaJ (hsp40) of Streptococcus pneumoniae is involved in bacterial virulence and elicits a strong natural immune reaction via PI3K/JNK

Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathway

[Pneumococcal HSP40 induces the immune response in mouse macrophages via p38MAPK and JNK signaling pathways].

Pneumococcal wall teichoic acid is required for the pathogenesis of Streptococcus pneumoniae in murine models

c‐Jun N‐terminal kinase and Akt signalling pathways regulating tumour necrosis factor‐α‐induced interleukin‐32 expression in human lung fibroblasts: implications in airway inflammation

GHIP in Streptococcus pneumoniae is involved in antibacterial resistance and elicits a strong innate immune response through TLR 2 and JNK /p38 MAPK

Screening and identification of ClpE interaction proteins in Streptococcus pneumoniae by a bacterial two-hybrid system and co-immunoprecipitation

Screening and Identification of DnaJ Interaction Proteins in Streptococcus pneumoniae

SP0454, a putative threonine dehydratase, is required for pneumococcal virulence in mice

Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP

研究方向