刘行｜中国科学技术大学｜学者主页

2026

染色体着丝粒的动态组装与调控

胡诚诚，王志凯，刘行，姚雪彪

《中国科学:生命科学》

2026

染色体碎裂的模拟与建模：ecDNA起源的新见解（英文）

杨峻霄，刘行

《中国科学技术大学学报》

2026

WTAP tetramer ensures m6A writer assembly and faithful mitosis

Shan Zhang, J P Ye, Manjuan Zhang, Jie Cao, YJ Li, Ranran Hu, Da Chen, Ting Li, Jiasheng Chen, Wen Zhu, Wenli Jiang, Jianchao Li, Wei Hu, Jianzhao Liu, Xing Liu, Chao Wang

EMBO Reports

DOI

2026

Condensation of MATCAP promotes CENP-E-dependent chromosome congression in mitosis

Tongtong Yang, Wenping Hu, Panpan Xu, Huanyu Li, Yaqian Zhang, Fangyuan Xiong, Yunze Li, Chao Xu, Ke Ruan, Zhonghuai Hou, Zhikai Wang, Liangyu Zhang, Xuebiao Yao, ShengQi Xiang, Kai Jiang, Xing Liu

Nature Communications

DOI

2026

Epigenetic compartmentalization of mitotic chromosomes by phase-separation-driven repulsion between WDR5 and the chromosomal passenger complex

Yun Wang, Xianyun Jiang, Xing Liu, Xin Jiang, Xiyu Wang, Xiaoyu Song, Feng Chen, Yuanyuan Liu, Xu‐Zhuo Gou, Ai‐Hui Tang, Sibei Sheng, Xuebiao Yao, Zhonghuai Hou, Dan Liu

Nature Communications

DOI

2026

The endoplasmic reticulum protein Erg28 restrains Mto1-Mto2-γ-TuSC-mediated microtubule assembly

Shengnan Zheng, Zhikai Chen, Lingyun Nie, Wenyue Liu, Yaqian Zhang, Kai Jiang, Xing Liu, Chao Xu, Xuebiao Yao, Chuanhai Fu

Cell Reports

DOI

2026

Methylation of MATCAP by PRMT5 regulates microtubule detyrosination to ensure mitotic fidelity

Tongtong Yang, Wenping Hu, Yaqian Zhang, Fangyuan Xiong, Zhikai Wang, Xing Liu, Kai Jiang, Xuebiao Yao, Liangyu Zhang

Journal of Molecular Cell Biology

DOI

2026

The AAA-ATPase Yta4 inhibits the interaction between Ppa2 and Atg43 to promote Atg43 phosphorylation and mitophagy

Ke Liu, Jiajia He, Yifan Wu, Chenhui Zhao, Shuaijie Yan, Fangyuan Xiong, Xing Liu, Xuebiao Yao, Chuanhai Fu

Journal of Biological Chemistry

DOI

2026

Mitotic assembly of respiratory supercomplexes ensures accurate cell division and fuels tumor growth

Ting Wang, Aoxing Cheng, Lingyu Kong, Weiyi You, Jihua Liu, Xing Liu, Xuebiao Yao, Yi Yang, Yuzheng Zhao, Weiwei Yang, Kaiguang Zhang, Zhenye Yang, Jing Guo

EMBO Reports

DOI

2026

Probing Centromere Plasticity and Chromatin Remodeling Using Single‐Molecule Techniques

R X Liu, Jin Zhao, Hongfei Ma, Wenping Hu, Zhen Dou, Xing Liu

Cell Biology International

DOI

2026

Targeting the TBK1-p62 condensate axis restores sensitivity to EGFR-TKIs in resistant lung cancer

Yuexiao Song, Changchun Shao, Yiruo Zhang, Min Yang, Yaqian Liu, S M Chen, Jia Gao, Zihuan Li, Bin Li, Xuebiao Yao, Xing Liu, Ke Ruan, Yingying Du

Protein & Cell

DOI

2025

Crossover patterning through condensation and coarsening of pro-crossover factors

Liangyu Zhang, Weston T. Stauffer, Chenshu Liu, Hengyi Shao, Noor Abuzahriyeh, Rui Jiang, David Zwicker, Xing Liu, Xuebiao Yao, Abby F. Dernburg

Nature Cell Biology

DOI

2025

Modelling TIP60–YAP signalling in epithelial cell renewal using 3D gastric organoids

Hazrat Ismail, Zhen Dou, Dongmei Wang, Hengyi Shao, Xinjiao Gao, Chao Xu, Xing Liu, Chuanhai Fu, Xuebiao Yao, Xiaoyu Song

Journal of Molecular Cell Biology

DOI

2025

Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis

Chengcheng Hu, Qing Sheng Hu, Tongtong Yang, Panpan Xu, Fangyuan Xiong, Xinyang Wang, Chao Wang, Kai Jiang, Donald L. Hill, Lin Xue, Chang-Lu Tao, Chuanhai Fu, Liang N. Zhang, Dan Liu, ShengQi Xiang, Jianye Zang, Zhikai Wang, Xuebiao Yao, Xing Liu

Cell Reports

DOI

2025

Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin

Chenxi Hou, Fazhi Yu, Cheng Cao, Tianchen Wang, Zihang Pan, Mingru Zhong, Xing Liu, Xuebiao Yao, Kaiguang Zhang, Zhenye Yang, Jing Guo

Journal of Molecular Cell Biology

DOI

2025

Dimerization of ACAP4 is essential for its function in cell migration

Hongfei Ma, Jingjing He, Zhiyou Fang, Fangyuan Xiong, Xuannv Zhao, Dongmei Wang, Xiaoyu Song, Chuanhai Fu, Tetsuro Urushidani, Xuebiao Yao, Hongwu Qian, Xing Liu

Journal of Molecular Cell Biology

DOI

2025

Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity

Weihong Fu, Xueying Wang, Mussarat Rafiq, Hengyi Shao, Cun‐Yu Wang, Dongmei Wang, Chang-Lu Tao, Chuanhai Fu, Barbara Zieger, Xing Liu, Xuebiao Yao, Liangyu Zhang

Journal of Molecular Cell Biology

DOI

2025

Phase separation drives cortical enrichment of the F-BAR proteins Rga7 and Rga8 to maintain cell integrity

Biyu Zheng, Wenfan Wei, Xin Zhang, Lijin Wang, Xing Liu, Xiaoyu Song, ShengQi Xiang, Chao Xu, Chao Wang, Yuan Lin, Shengnan Zheng, Chuanhai Fu

Cellular and Molecular Life Sciences

DOI

2025

Fragment-Based Discovery of a Small-Molecule RhoGDI2 Ligand, HR3119, that Inhibits Cancer Cell Migration

Mingqing Liu, Shizhang Wan, Shuangxi Guo, Jiuyang Liu, Wenqian Li, Lei Wang, Fudong Li, Jiahai Zhang, Xing Liu, Dan Liu, Xuebiao Yao, Jia Gao, Ke Ruan, Wei He

ACS Chemical Biology

DOI

2025

Modeling Lipopolysaccharide‐Elicited Inflammation Using 3D Mouse Gastric Organoids

Aoqing Xu, Xiyu Wang, Zhifan Ye, Tao Li, Fengrui Yang, McKay Mullen, Xia Ding, Xing Liu, Zhikai Wang

Cell Biology International

DOI

2025

Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast

Yueyue Jiang, Yanze Jian, Lingyun Nie, Xin Gu, Ziyi Lu, Yongkang Chu, Xing Liu, Xuebiao Yao, Jin‐Qiu Zhou, Shengnan Zheng, Chuanhai Fu

Genome biology

DOI

2025

Corrigendum to “STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy” [Cell Insight 3 (2024) 100147]

Xiaoyu Song, Yufeng Xi, Ming Dai, Tao Li, Shihao Du, Yuxin Zhu, Mengjie Li, Yunze Li, Siqi Liu, Xia Ding, Xuebiao Yao, Ying Lai, Xing Liu

Cell Insight

DOI

2025

Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast

Lingyun Nie, Wenyue Liu, Zhuobi Liang, Fan Zheng, Xing Liu, Xuebiao Yao, ShengQi Xiang, Kai Jiang, Shengnan Zheng, Chuanhai Fu

Science Advances

DOI

2024

Aurora-A condensation mediated by BuGZ aids its mitotic centrosome functions

Hui Zheng, Qiaoqiao Zhang, Xing Liu, Fan Shi, Fengrui Yang, ShengQi Xiang, Hao Jiang

iScience

DOI

2024

Microtubule plus-end tracking protein EB1 orchestrates mitotic progression via liquid–liquid phase separation

Mengjie Li, Ming Dai, Xing Hong, Yunze Li, Xiyu Wang, Yini Lin, Tahir Ullah, Yuxin Zhu, Kai Jiang, Zhikai Wang, Zhonghuai Hou, Kai Zhang, Xuebiao Yao, Xiaoyu Song, Xing Liu

Journal of Molecular Cell Biology

DOI

2024

Probing centromere–kinetochore core complex CENP-L/M assembly using cenpemlin

Olanrewaju Ayodeji Durojaye, Fengrui Yang, Xinjiao Gao, Felix O. Aikhionbare, Liangyu Zhang, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2024

Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

Ting Zhang, Shuaiyu Liu, Olanrewaju Ayodeji Durojaye, Fangyuan Xiong, Zhiyou Fang, Tahir Ullah, Chuanhai Fu, Bo Sun, Hao Jiang, Peng Xia, Zhikai Wang, Xuebiao Yao, Xing Liu

Cell Reports

DOI

2024

ZW10: an emerging orchestrator of organelle dynamics during the cell division cycle

Sm Faysal Bellah, Fengrui Yang, Fangyuan Xiong, Zhen Dou, Xuebiao Yao, Xing Liu

Journal of Molecular Cell Biology

DOI

2024

Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities

Umer Ejaz, Zhen Dou, Phil Y. Yao, Zhikai Wang, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2024

A KDELR-mediated ER-retrieval system modulates mitochondrial functions via the unfolded protein response in fission yeast

Mengdan Zhu, Fang Zheng, Yifan Wu, Fenfen Dong, Yuzhou Wang, Fan Zheng, Xiaopeng Ma, Shisong Ma, Jiajia He, Xing Liu, Xuebiao Yao, Chuanhai Fu

Journal of Biological Chemistry

DOI

2024

Organization of microtubule plus-end dynamics by phase separation in mitosis

Fengrui Yang, Mingrui Ding, Xiaoyu Song, Fang Chen, Tongtong Yang, Chunyue Wang, Chengcheng Hu, Qing Sheng Hu, Yihan Yao, Shihao Du, Phil Y. Yao, Peng Xia, Gregory Adams, Chuanhai Fu, ShengQi Xiang, Dan Liu, Zhikai Wang, Kai Yuan, Xing Liu

Journal of Molecular Cell Biology

DOI

2024

PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis

Sm Faysal Bellah, Fangyuan Xiong, Zhen Dou, Fengrui Yang, Xing Liu, Xuebiao Yao, Xinjiao Gao, Liangyu Zhang

Journal of Molecular Cell Biology

DOI

2024

CSPP1 stabilizes microtubules by capping both plus and minus ends

Zhikai Wang, Wenwen Wang, Shuaiyu Liu, Fengrui Yang, Xu Liu, Xu Liu, Shasha Hua, Lijuan Zhu, Aoqing Xu, Donald L. Hill, Dongmei Wang, Kai Jiang, Jennifer Lippincott‐Schwartz, Xing Liu, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2024

Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis

Wei Liu, Zhen Dou, Chunyue Wang, Gangyin Zhao, Fengge Wu, Chunli Wang, Felix O. Aikhionbare, Mingliang Ye, Divine Mensah Sedzro, Zhenye Yang, Chuanhai Fu, Zhikai Wang, Xinjiao Gao, Xuebiao Yao, Xiaoyu Song, Xing Liu

Journal of Molecular Cell Biology

DOI

2024

Decoding dynamic molecular interactions in cells

Mussarat Rafiq, Chengcheng Hu, Xinjiao Gao, Zhikai Wang, Sérgio Schenkman, Andreas Merdes, Xing Liu

Cell Biology International

DOI

2024

Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway

Tao Li, Xiaoyu Song, Jiena Chen, Yuan Li, Jie Lin, Ping Li, Simiao Yu, Olanrewaju Ayodeji Durojaye, Fengrui Yang, Xing Liu, Jian Li, Shi‐Yuan Cheng, Xuebiao Yao, Xia Ding

International Journal of Biological Sciences

DOI

2024

LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination

Xiaolin Liang, Meng Gong, Zhikai Wang, Jie Wang, Weiwei Guo, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong, Chuanhai Fu, Xiangting Wang

Cell Discovery

DOI

2024

The absence of the ribosomal protein Rpl2702 elicits the MAPK-mTOR signaling to modulate mitochondrial morphology and functions

Ling Liu, Yifan Wu, Peng Liu, Mengdan Zhu, Shouhong Guang, Fengsong Wang, Xing Liu, Xuebiao Yao, Jiajia He, Chuanhai Fu

Redox Biology

DOI

2024

Fluorescence complementation-based FRET imaging reveals centromere assembly dynamics

Zhen Dou, Ran Liu, Ping Gui, Chuanhai Fu, Jennifer Lippincott‐Schwartz, Xuebiao Yao, Xing Liu

Molecular Biology of the Cell

DOI

2024

STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy

Xiaoyu Song, Yufeng Xi, Ming Dai, Tao Li, Shihao Du, Yuxin Zhu, Mengjie Li, Yunze Li, Siqi Liu, Xia Ding, Xuebiao Yao, Ying Lai, Xing Liu

Cell Insight

DOI

2023

Phosphorylation of Bub1 by Mph1 promotes Bub1 signaling at the kinetochore to ensure accurate chromosome segregation

Yanze Jian, Yueyue Jiang, Lingyun Nie, Zhen Dou, Xing Liu, Chuanhai Fu

Journal of Biological Chemistry

DOI

2023

Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics

Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li, Panpan Xu, Shuaiyu Liu, Ming Dai, Changbiao Chi, ShengQi Xiang, Chao Xu, Dong Li, Zhikai Wang, Lin Li, Donald L. Hill, Chuanhai Fu, Kai Yuan, Pilong Li, Jianye Zang, Zhonghuai Hou, Kai Jiang, Yunyu Shi, Xing Liu, Xuebiao Yao

Nature Cell Biology

DOI

2023

Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis

Fengge Wu, Hameed Akbar, Chunyue Wang, Xiao Ni Yuan, Zhen Dou, McKay Mullen, Liwen Niu, Liang Zhang, Jianye Zang, Zhikai Wang, Xuebiao Yao, Xiaoyu Song, Xing Liu

Journal of Molecular Cell Biology

DOI

2023

Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis

Ran Liu, Zhen Dou, Tian Tian, Xinjiao Gao, Lili Chen, Xiao Ni Yuan, Chunyue Wang, Jiahe Hao, Ping Gui, McKay Mullen, Felix O. Aikhionbare, Liwen Niu, Guo‐Qiang Bi, Peng Zou, Xuan Zhang, Chuanhai Fu, Xuebiao Yao, Jianye Zang, Xing Liu

Journal of Molecular Cell Biology

DOI

2023

PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres

Junying Li, Xiao Ni Yuan, Fengrui Yang, Jun Cao, Chunyue Wang, Saima Akram, Peng Zou, Felix O. Aikhionbare, Xuejun Li, Yong Chen, Liangyu Zhang, Chuanhai Fu, Zhikai Wang, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2023

The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission

Jiajia He, Ke Liu, Yifan Wu, Chenhui Zhao, Shuaijie Yan, Jiahui Chen, Lizhu Hu, Dongmei Wang, Fan Zheng, Wenfan Wei, Chao Xu, Chengdong Huang, Xing Liu, Xuebiao Yao, Lijun Ding, Zhiyou Fang, Ai‐Hui Tang, Chuanhai Fu

PLoS Biology

DOI

2022

The fission yeast kinetochore complex Mhf1–Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation

Yanze Jian, Lingyun Nie, Sikai Liu, Yueyue Jiang, Zhen Dou, Xing Liu, Xuebiao Yao, Chuanhai Fu

Journal of Cell Science

DOI

2022

Structural insights into human CCAN complex assembled onto DNA

Tian Tian, Lili Chen, Zhen Dou, Zhisen Yang, Xinjiao Gao, Xiao Ni Yuan, Chengliang Wang, Ran Liu, Zuojun Shen, Ping Gui, Maikun Teng, Xianlei Meng, Donald L. Hill, Lin Li, Xuan Zhang, Xing Liu, Linfeng Sun, Jianye Zang, Xuebiao Yao

Cell Discovery

DOI

2022

Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint

Sikai Liu, Xiao Ni Yuan, Ping Gui, Ran Liu, Olanrewaju Ayodeji Durojaye, Donald L. Hill, Chuanhai Fu, Xuebiao Yao, Zhen Dou, Xing Liu

EMBO Reports

DOI

2022

Fragment-Based Discovery of AF9 YEATS Domain Inhibitors

Yaqian Liu, Ruo‐Xing Jin, Hui Lu, Kang‐Jie Bian, Rui Wang, Lei Wang, Rui Gao, Jiahai Zhang, Jihui Wu, Xuebiao Yao, Xing Liu, Dan Liu, Xi‐Sheng Wang, Zhiyong Zhang, Ke Ruan

International Journal of Molecular Sciences

DOI

2022

The Cdc42 GTPase-activating protein Rga6 promotes the cortical localization of septin

Shengnan Zheng, Biyu Zheng, Zhenbang Liu, Xiaopeng Ma, Xing Liu, Xuebiao Yao, Wenfan Wei, Chuanhai Fu

Journal of Cell Science

DOI

2022

Phase separation of EB1 guides microtubule plus-end dynamics

Nature Cell Biology

DOI

2022

Correction: Aurora A–mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression

Ya Jiang, Ting Wang, Dandan Sheng, Chaoqiang Han, Tian Xu, Peng Zhang, Weiyi You, Weiwei Fan, Zhiyong Zhang, Tengchuan Jin, Xiaotao Duan, Xiao Yuan, Xing Liu, Kaiguang Zhang, Ke Ruan, Jue Shi, Jing Guo, Aoxing Cheng, Zhenye Yang

Journal of Biological Chemistry

DOI

2022

The Cdc42 GAP Rga6 promotes monopolar outgrowth of spores

Wenfan Wei, Biyu Zheng, Shengnan Zheng, Daqiang Wu, Yongkang Chu, Shenghao Zhang, Dongmei Wang, Xiaopeng Ma, Xing Liu, Xuebiao Yao, Chuanhai Fu

The Journal of Cell Biology

DOI

2022

Aurora A–mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression

Ya Ping Jiang, Ting Wang, Dandan Sheng, Chaoqiang Han, Xu Tian, Peng Zhang, Weiyi You, Weiwei Fan, Zhiyong Zhang, Tengchuan Jin, Xiaotao Duan, Xiao Ni Yuan, Xing Liu, Kaiguang Zhang, Ke Ruan, Jue Shi, Jing Guo, Aoxing Cheng, Zhenye Yang

Journal of Biological Chemistry

DOI

2022

Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis

Hameed Akbar, Jun Cao, Dongmei Wang, Xiao Ni Yuan, Manjuan Zhang, Saravanakumar Muthusamy, Xiaoyu Song, Xu Liu, Xu Liu, Felix O. Aikhionbare, Xuebiao Yao, Xinjiao Gao, Xing Liu, Xing Liu

Journal of Molecular Cell Biology

DOI

2022

Phosphorylation of CENP-R by Aurora B regulates kinetochore–microtubule attachment for accurate chromosome segregation

Divine Mensah Sedzro, Xiao Ni Yuan, McKay Mullen, Umer Ejaz, Tongtong Yang, Xu Liu, Xu Liu, Xiaoyu Song, Yun‐Chi Tang, Weijun Pan, Peng Zou, Xinjiao Gao, Dongmei Wang, Zhikai Wang, Zhen Dou, Xing Liu, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2022

Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity

Wenwen Wang, Fengrui Yang, Jie Lin, Saravanakumar Muthusamy, Shihao Du, McKay Mullen, Fatima Garba, Wanjuan Wang, Xu Liu, Xu Liu, Tao Li, Zhihong Yang, Xia Ding, Felix O. Aikhionbare, Xinjiao Gao, Zhikai Wang, Xing Liu, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2021

Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

Xiaoyu Song, Fengrui Yang, Xu Liu, Xu Liu, Peng Xia, Wu Yin, Yong Wang, Yong Wang, Xiao Yuan, Zhen Dou, Kai Jiang, Mingming Ma, Bing Hu, Rui Zhang, Chao Xu, Zhiyong Zhang, Ke Ruan, Ruijun Tian, Lin Li, Tao Liu, Donald L. Hill, Jianye Zang, Jinsong Li, Xing Liu, Jinsong Li, Jinke Cheng, Xuebiao Yao

Nature Chemical Biology

DOI

2021

Potent antitumor activity of a glutamyltransferase-derived peptide via an activation of oncosis pathway

Cheng Fang, Wenhui Li, Ruozhe Yin, Dinghuang Zhu, Xing Liu, Huihui Wu, Qingqiang Wang, Wenwen Wang, Quan Bai, Biliang Chen, Xuebiao Yao, Yong Chen

Scientific Reports

DOI

2021

AMPKα2 activation by an energy-independent signal ensures chromosomal stability during mitosis

Jianlin Lu, Yuanyuan Huang, Li Zhan, Ming Wang, Leilei Xu, McKay Mullen, Jianye Zang, G. Fang, Zhen Dou, Xing Liu, Wei Liu, Minerva T. Garcia-Barrio, Xuebiao Yao

iScience

DOI

2021

Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis

McKay Mullen, Fengrui Yang, Jun Cao, Yang Cao, Xu Liu, Xu Liu, Gee Young Lee, Tao Li, William Yao, Zhihong Yang, Jiahai Zhang, Kela Johnson, Felix O. Aikhionbare, Yong Chen, Xinjiao Gao, Dongmei Wang, Xia Ding, Hadiyah-Nicole Green, Xing Liu, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2021

Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism

Yuanyuan Huang, Jianlin Lu, Zhan Li, Ming Wang, Ronghua Shi, Xiao Ni Yuan, Xinjiao Gao, Xing Liu, Jianye Zang, Wei Liu, Xuebiao Yao

Journal of Biological Chemistry

DOI

2021

Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation

Leilei Xu, Mahboob Ali, Wenxiu Duan, Xiao Ni Yuan, Fatima Garba, McKay Mullen, Binwen Sun, Ina Poser, Hequan Duan, Jianlin Lu, Ruijun Tian, Yushu Ge, Lingluo Chu, Weijun Pan, Dongmei Wang, Anthony A. Hyman, Hadiyah Green, Lin Li, Zhen Dou, Dan Liu, Xing Liu, Xuebiao Yao

Cell Reports

DOI

2021

The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity

Xueying Wang, Wenwen Wang, Xiwei Wang, Ming Wang, Lijuan Zhu, Fatima Garba, Chuanhai Fu, Barbara Zieger, Xu Liu, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2021

Mechanisms and regulation underlying membraneless organelle plasticity control

Hazrat Ismail, Xu Liu, Fengrui Yang, Junying Li, Ayesha Zahid, Zhen Dou, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2020

Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells

Shihao Du, Xiaoyu Song, Yuan Li, Yalei Cao, Fuhao Chu, Olanrewaju Ayodeji Durojaye, Zeqi Su, Xiaoguang Shi, Jing Wang, Juan Cheng, Tangshun Wang, Xiang Gao, Yan Chen, Wuzhekai Zeng, Fengsong Wang, Dongmei Wang, Xing Liu, Xia Ding

Scientific Reports

DOI

2020

The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance

Ruijun Tang, Zhenghui Jiang, Fang Chen, Weiyu Yu, Kaijing Fan, Jieqiong Tan, Zhuohua Zhang, Xing Liu, Pishun Li, Kai Yuan

Cell Reports

DOI

2019

Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics

Ruoying Yu, Huihui Wu, Hazrat Ismail, Shihao Du, Jun Cao, Jianyu Wang, Tarsha L. Ward, Fengrui Yang, Ping Gui, Mahboob Ali, Lingluo Chu, Fei Mo, Qi Wang, Youjun Chu, Jianye Zang, Yun Zhao, Mingliang Ye, G. Fang, Peng R. Chen, Zhen Dou, Xinjiao Gao, Wenwen Wang, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2019

NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation

Huijuan Yu, Fengrui Yang, Peng Dong, Shanhui Liao, Wei R. Liu, Gangyin Zhao, Bo Qin, Zhen Dou, Zhe J. Liu, Wei Liu, Jianye Zang, Jennifer Lippincott‐Schwartz, Xing Liu, Xuebiao Yao

Cell Research

DOI

2019

Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly

Xu Liu, Xu Liu, Leilei Xu, Junying Li, Phil Y. Yao, Wanjuan Wang, Wanjuan Wang, Hazrat Ismail, Haowei Wang, Bryce Liao, Zhihong Yang, Tarsha L. Ward, Ke Ruan, Jianchun Zhang, Quan Wu, Ping He, Xia Ding, Dongmei Wang, Chuanhai Fu, Zhen Dou, Feng Yan, Wenwen Wang, Wenwen Wang, Xing Liu, Xing Liu, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2019

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores

Zhen Dou, Diogjena Katerina Prifti, Ping Gui, Xing Liu, Sabine Elowe, Xuebiao Yao

Cells

DOI

2018

Holliday junction recognition protein interacts with and specifies the centromeric assembly of CENP-T

Mingrui Ding, Jiying Jiang, Fengrui Yang, Fan Zheng, Jingwen Fang, Qian Wang, Jianyu Wang, William W. Yao, Xu Liu, Xu Liu, Xinjiao Gao, McKay Mullen, Ping He, Catherine Rono, Xia Ding, Jingjun Hong, Chuanhai Fu, Xing Liu, Xing Liu, Xuebiao Yao

Journal of Biological Chemistry

DOI

2018

Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion

Xiaoyu Song, Wei Liu, Xiao Ni Yuan, Jiying Jiang, Wanjuan Wang, McKay Mullen, Xuannv Zhao, Yin Zhang, Fusheng Liu, Shihao Du, Adeel ur Rehman, Ruijun Tian, Jian Li, Andra Frost, Zhenwei Song, Hadiyah-Nicole Green, Calmour Henry, Xing Liu, Xia Ding, Dongmei Wang, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2018

LRIF1 interacts with HP1 α to coordinate accurate chromosome segregation during mitosis

Saima Akram, Fengrui Yang, Junying Li, Gregory Adams, Yingying Liu, Xiaoxuan Zhuang, Lingluo Chu, Xu Liu, Xu Liu, Nerimah Emmett, Winston Thompson, McKay Mullen, Saravana Muthusamy, Wenwen Wang, Fei Mo, Xing Liu, Xing Liu

Journal of Molecular Cell Biology

DOI

2018

Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore

Tian Tian, Xiaorun Li, Yingying Liu, Chengliang Wang, Xing Liu, Guo‐Qiang Bi, Xuan Zhang, Xuebiao Yao, Z. Hong Zhou, Jianye Zang

Cell Research

DOI

2017

MST4 kinase phosphorylates ACAP4 protein to orchestrate apical membrane remodeling during gastric acid secretion

Xiao Ni Yuan, Phil Y. Yao, Jiying Jiang, Yin Zhang, Zeqi Su, Wendy Yao, Xueying Wang, Ping Gui, McKay Mullen, Calmour Henry, Tarsha L. Ward, Wenwen Wang, Larry Brako, Ruijun Tian, Xuannv Zhao, Fengsong Wang, Xinwang Cao, Dongmei Wang, Xing Liu, Xia Ding, Xuebiao Yao

Journal of Biological Chemistry

DOI

2016

Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity

Bo Qin, Dan Cao, Huihui Wu, Fei Mo, Hengyi Shao, Jane Chu, Michael L. Powell, Felix O. Aikhionbare, Dongmei Wang, Chuanhai Fu, Ping He, Weijun Pan, Wenwen Wang, Xing Liu, Xuebiao Yao

Scientific Reports

DOI

2016

Adaptor protein APPL1 interacts with EGFR to orchestrate EGF-stimulated signaling

Jiajia Zhou, Hongsheng Liu, Shu Fan Zhou, Ping He, Xing Liu

《中国科学通报：英文版》

DOI

2016

Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation

Hequan Duan, Chunli Wang, Ming Wang, Xinjiao Gao, Maomao Yan, Saima Akram, Wei Peng, Hanfa Zou, Dong Wang, Jiajia Zhou, Youjun Chu, Zhen Dou, Gregory Barrett, Hadiyah Green, Fangjun Wang, Ruijun Tian, Ping He, Wenwen Wang, Xing Liu, Xuebiao Yao

Journal of Biological Chemistry

DOI

2016

The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration

Gregory Adams, Jiajia Zhou, Wenwen Wang, Huihui Wu, Jie Quan, Yingying Liu, Peng Xia, Zhikai Wang, Shu Fan Zhou, Jiying Jiang, Fei Mo, Xiaoxuan Zhuang, Kelwyn Thomas, Donald L. Hill, Felix O. Aikhionbare, Ping He, Xing Liu, Xia Ding, Xuebiao Yao

Journal of Biological Chemistry

DOI

2016

Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation

Fei Mo, Xiaoxuan Zhuang, Xing Liu, Phil Y. Yao, Bo Qin, Zeqi Su, Jianye Zang, Zhiyong Wang, Jiancun Zhang, Zhen Dou, Changlin Tian, Maikun Teng, Liwen Niu, Donald L. Hill, Guowei Fang, Xia Ding, Chuanhai Fu, Xuebiao Yao

Nature Chemical Biology

DOI

2015

Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment

Zhen Dou, Xing Liu, Wenwen Wang, Tongge Zhu, Xinghui Wang, Leilei Xu, Ariane Abrieu, Chuanhai Fu, Donald L. Hill, Xuebiao Yao

Proceedings of the National Academy of Sciences

DOI

2015

Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis

Maomao Yan, Lingluo Chu, Bo Qin, Zhikai Wang, Xing Liu, Changjiang Jin, Guanglan Zhang, Marta Gómez-Ferrer, Alexander Hergovich, Zhengjun Chen, Ping He, Xinjiao Gao, Xuebiao Yao

Scientific Reports

DOI

2015

Cell Polarity Kinase MST4 Cooperates with cAMP-dependent Kinase to Orchestrate Histamine-stimulated Acid Secretion in Gastric Parietal Cells

Hao Jiang, Wenwen Wang, Yin Zhang, William W. Yao, Jiying Jiang, Bo Qin, Wendy Yao, Fusheng Liu, Huihui Wu, Tarsha L. Ward, Chun-Wei David Chen, Lifang Liu, Xia Ding, Xing Liu, Xuebiao Yao

Journal of Biological Chemistry

DOI

2015

Mitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in Mitosis

Lijuan Zhu, Zhikai Wang, Wenwen Wang, Chunli Wang, Shasha Hua, Zeqi Su, Larry Brako, Minerva T. Garcia-Barrio, Mingliang Ye, Xuan Wei, Hanfa Zou, Xia Ding, Lifang Liu, Xing Liu, Xuebiao Yao

Journal of Biological Chemistry

DOI

2015

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration

Dan Cao, Zeqi Su, Wenwen Wang, Huihui Wu, Xing Liu, Saima Akram, Bo Qin, Jiajia Zhou, Xiaoxuan Zhuang, Gregory Adams, Changjiang Jin, Xiwei Wang, Lifang Liu, Donald L. Hill, Dongmei Wang, Xia Ding, Xuebiao Yao

Journal of Biological Chemistry

DOI

2015

Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation

Hengyi Shao, Yuejia Huang, Liangyu Zhang, Kai Yuan, Youjun Chu, Zhen Dou, Changjiang Jin, Minerva T. Garcia-Barrio, Xing Liu, Xuebiao Yao

Scientific Reports

DOI

2014

Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking

Peng Xia, Xing Liu, Bing Wu, Shuyuan Zhang, Xiaoyu Song, Phil Y. Yao, Jennifer Lippincott‐Schwartz, Xuebiao Yao

Molecular Biology of the Cell

DOI

2014

Mitotic kinesin CENP‐E cooperates with microtubule‐bundling protein PRC1 in temporal control of central spindle assembly (801.2)

Xing Liu, Phil Y. Yao, Wenwen Wang, Bo Qin, Zhen Dou, Xia Ding, Xuebiao Yao

The FASEB Journal

DOI

2014

Chromatin Protein HP1α Interacts with the Mitotic Regulator Borealin Protein and Specifies the Centromere Localization of the Chromosomal Passenger Complex

Xing Liu, Zhenwei Song, Yuda Huo, Jiahai Zhang, Tongge Zhu, Jianyu Wang, Xuannv Zhao, Felix O. Aikhionbare, Jiancun Zhang, Hequan Duan, Jihui Wu, Zhen Dou, Yunyu Shi, Xuebiao Yao

Journal of Biological Chemistry

DOI

2014

Aurora A orchestrates entosis by regulating a dynamic MCAK–TIP150 interaction

Peng Xia, Jinhua Zhou, Xiaoyu Song, Bing Wu, Xing Liu, Di Li, Shuyuan Zhang, Zhikai Wang, Huijuan Yu, Tarsha L. Ward, Jiancun Zhang, Yinmei Li, Xiaoning Wang, Yong Chen, Zhen Gang Guo, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2014

The 68-kDa Telomeric Repeat Binding Factor 1 (TRF1)-associated Protein (TAP68) Interacts with and Recruits TRF1 to the Spindle Pole during Mitosis

Jianping Lan, Yuanyuan Zhu, Leilei Xu, Huijuan Yu, Jian Yu, Xing Liu, Chuanhai Fu, Xiaogang Wang, Yuwen Ke, He Huang, Zhen Dou

Journal of Biological Chemistry

DOI

2014

Mitotic Regulator Mis18β Interacts with and Specifies the Centromeric Assembly of Molecular Chaperone Holliday Junction Recognition Protein (HJURP)

Jianyu Wang, Xing Liu, Zhen Dou, Liang Chen, Hao Jiang, Chuanhai Fu, Guosheng Fu, Dan Liu, Jiancun Zhang, Tongge Zhu, Jingwen Fang, Jianye Zang, Jinke Cheng, Maikun Teng, Xia Ding, Xuebiao Yao

Journal of Biological Chemistry

DOI

2013

Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation

Xuannv Zhao, Dongmei Wang, Xing Liu, Lifang Liu, Zhenwei Song, Tongge Zhu, Gregory Adams, Xinjiao Gao, Ruijun Tian, Yuejia Huang, Runhua Chen, Fengsong Wang, Dong Liu, Xue Yu, Yong Chen, Zhengjun Chen, Maikun Teng, Xia Ding, Xuebiao Yao

Proceedings of the National Academy of Sciences

DOI

2013

Regulation of a Dynamic Interaction between Two Microtubule-binding Proteins, EB1 and TIP150, by the Mitotic p300/CBP-associated Factor (PCAF) Orchestrates Kinetochore Microtubule Plasticity and Chromosome Stability during Mitosis

Tarsha L. Ward, Ming Wang, Xing Liu, Zhikai Wang, Peng Xia, Youjun Chu, Xiwei Wang, Lifang Liu, Kai Jiang, Huijuan Yu, Maomao Yan, Jianyu Wang, Donald L. Hill, Yuejia Huang, Tongge Zhu, Xuebiao Yao

Journal of Biological Chemistry

DOI

2012

EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore–microtubule interactions in mitosis

Peng Xia, Zhikai Wang, Xing Liu, Bing Wu, Juncheng Wang, Tarsha L. Ward, Liangyu Zhang, Xia Ding, Gary H. Gibbons, Yunyu Shi, Xuebiao Yao

Proceedings of the National Academy of Sciences

DOI

2012

SUV39H1 orchestrates temporal dynamics of centromeric methylation essential for faithful chromosome segregation in mitosis

Lingluo Chu, Tongge Zhu, Xing Liu, Ruoying Yu, Méthode Bacanamwo, Zhen Dou, Youjun Chu, Hanfa Zou, Gary H. Gibbons, Dongmei Wang, Xia Ding, Xuebiao Yao

Journal of Molecular Cell Biology

DOI

2011

CENP-E Kinesin Interacts with SKAP Protein to Orchestrate Accurate Chromosome Segregation in Mitosis

Yuejia Huang, Wenwen Wang, Phil Y. Yao, Xiwei Wang, Xing Liu, Xiaoxuan Zhuang, Feng Yan, Jinhua Zhou, Jian Du, Tarsha L. Ward, Hanfa Zou, Jiancun Zhang, G. Fang, Xia Ding, Zhen Dou, Xuebiao Yao

Journal of Biological Chemistry

DOI

精选作品

期刊论文

染色体着丝粒的动态组装与调控

染色体碎裂的模拟与建模：ecDNA起源的新见解（英文）

WTAP tetramer ensures m6A writer assembly and faithful mitosis

Condensation of MATCAP promotes CENP-E-dependent chromosome congression in mitosis

Epigenetic compartmentalization of mitotic chromosomes by phase-separation-driven repulsion between WDR5 and the chromosomal passenger complex

The endoplasmic reticulum protein Erg28 restrains Mto1-Mto2-γ-TuSC-mediated microtubule assembly

Methylation of MATCAP by PRMT5 regulates microtubule detyrosination to ensure mitotic fidelity

The AAA-ATPase Yta4 inhibits the interaction between Ppa2 and Atg43 to promote Atg43 phosphorylation and mitophagy

Mitotic assembly of respiratory supercomplexes ensures accurate cell division and fuels tumor growth

Probing Centromere Plasticity and Chromatin Remodeling Using Single‐Molecule Techniques

Targeting the TBK1-p62 condensate axis restores sensitivity to EGFR-TKIs in resistant lung cancer

Crossover patterning through condensation and coarsening of pro-crossover factors

Modelling TIP60–YAP signalling in epithelial cell renewal using 3D gastric organoids

Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis

Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin

Dimerization of ACAP4 is essential for its function in cell migration

Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity

Phase separation drives cortical enrichment of the F-BAR proteins Rga7 and Rga8 to maintain cell integrity

Fragment-Based Discovery of a Small-Molecule RhoGDI2 Ligand, HR3119, that Inhibits Cancer Cell Migration

Modeling Lipopolysaccharide‐Elicited Inflammation Using 3D Mouse Gastric Organoids

Effects of chromosome number reduction on mitotic and meiotic stability in fission yeast

Corrigendum to “STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy” [Cell Insight 3 (2024) 100147]

Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast

Aurora-A condensation mediated by BuGZ aids its mitotic centrosome functions

Microtubule plus-end tracking protein EB1 orchestrates mitotic progression via liquid–liquid phase separation

Probing centromere–kinetochore core complex CENP-L/M assembly using cenpemlin

Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

ZW10: an emerging orchestrator of organelle dynamics during the cell division cycle

Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities

A KDELR-mediated ER-retrieval system modulates mitochondrial functions via the unfolded protein response in fission yeast

Organization of microtubule plus-end dynamics by phase separation in mitosis

PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis

CSPP1 stabilizes microtubules by capping both plus and minus ends

Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis

Decoding dynamic molecular interactions in cells

Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway

LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination

The absence of the ribosomal protein Rpl2702 elicits the MAPK-mTOR signaling to modulate mitochondrial morphology and functions

Fluorescence complementation-based FRET imaging reveals centromere assembly dynamics

STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy

Phosphorylation of Bub1 by Mph1 promotes Bub1 signaling at the kinetochore to ensure accurate chromosome segregation

Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics

Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis

Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis

PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres

The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission

The fission yeast kinetochore complex Mhf1–Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation

Structural insights into human CCAN complex assembled onto DNA

Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint

Fragment-Based Discovery of AF9 YEATS Domain Inhibitors

The Cdc42 GTPase-activating protein Rga6 promotes the cortical localization of septin

Phase separation of EB1 guides microtubule plus-end dynamics

Correction: Aurora A–mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression

The Cdc42 GAP Rga6 promotes monopolar outgrowth of spores

Aurora A–mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression

Acetylation of Nup62 by TIP60 ensures accurate chromosome segregation in mitosis

Phosphorylation of CENP-R by Aurora B regulates kinetochore–microtubule attachment for accurate chromosome segregation

Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity

Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

Potent antitumor activity of a glutamyltransferase-derived peptide via an activation of oncosis pathway

AMPKα2 activation by an energy-independent signal ensures chromosomal stability during mitosis

Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis

Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism

Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation

The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity

Mechanisms and regulation underlying membraneless organelle plasticity control

Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells

The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance

Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics

NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation

Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores

Holliday junction recognition protein interacts with and specifies the centromeric assembly of CENP-T

Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion

LRIF1 interacts with HP1 α to coordinate accurate chromosome segregation during mitosis

Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore

MST4 kinase phosphorylates ACAP4 protein to orchestrate apical membrane remodeling during gastric acid secretion

Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity