李先伟｜皖南医学院｜学者主页

2024

埃克替尼对肺动脉高压大鼠右心室重构的保护作用

胡霞，顾文强，严静静，黄维琳，李先伟

《中国临床药理学杂志》

2024

依帕司他对放射性肺炎小鼠线粒体氧化应激损伤的保护作用

李泽朋，顾文强，陈晓，王银华，李先伟

《中国临床药理学与治疗学》

2024

埃克替尼抑制肺泡上皮细胞上皮间充质转化进程改善博来霉素诱导的肺纤维化

许文奇，肖雷，徐炜，严静静，顾文强，李先伟

《中国药学杂志》

2023

IL-33调控NF-κB/Twist信号通路促进肺泡上皮细胞上皮-间质转分化的机制研究

高云星，付裕，陈晓，李泽朋，何晓伟，李先伟

《中国免疫学杂志》

2023

IL-33通过激活NF-κB信号通路上调eIF3a的表达介导小鼠肺肌纤维母细胞增殖分化促进肺纤维化

高云星，付裕，陈晓，李泽朋，何晓伟，李先伟

《细胞与分子免疫学杂志》

2023

[IL-33 up-regulates eIF3a expression by activating NF-κB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].

Yunxing Gao, Yu Fu, Xiao Chen, Zepeng Li, Xiaowei He, Xian-Wei Li

PubMed

2023

Effect of AR gene-specific knockout on the process of radiation-induced pulmonary fibrosis and its mechanism

Ziyu Zhang, Zepeng Li, Xiao Chen, Yinhua Wang, Xian-Wei Li

Cellular and Molecular Biology

DOI

2022

含羞草碱调控Notch1/Twist1信号通路改善博莱霉素诱导的大鼠肺纤维化

何晓伟，汤娟，陈晓，李先伟

《齐齐哈尔医学院学报》

2022

异钩藤碱调控ERK/p27Kip1信号通路改善博莱霉素诱导的小鼠肺纤维化

陈晓，李泽朋，何晓伟，李先伟

《天然产物研究与开发》

2021

Ⅱ型肺泡上皮细胞间质转分化中的Notch-1/Twist-1信号通路机制

汤娟，柯洁，付裕，何晓伟，李先伟

《中国应用生理学杂志》

2021

[Effects of Notch-1/Twist-1 axis in the process of epithelial-mesenchymal transition of type II alveolar epithelial cell and its mechanism].

Juan Tang, Jie Ke, Yu Fu, Xiaowei He, Xian-Wei Li

PubMed

DOI

2020

小剂量辣椒素抗小鼠肺纤维化的作用及其机制

卢林明，俞婷婷，何晓伟，汤娟，李先伟

《中国应用生理学杂志》

2020

白杨素调控NF-κB/Twist 1信号通路抑制Ⅱ型肺泡上皮细胞间质转分化的机制研究

卢林明，付裕，李秋阳，何晓伟，汤娟，李先伟

《中国中药杂志》

DOI

2019

二甲双胍对肺纤维化大鼠肺组织肺泡上皮-间充质转化的抑制作用及机制

郝伟，左东泽，张俊秀，蒋莉莉，熊莺，李先伟，杨解人

《中国病理生理杂志》

2018

依帕司他通过抑制醛糖还原酶表达抑制血小板衍生生长因子诱导的大鼠肺动脉平滑肌细胞增殖（英文）

张倩，俞婷婷，蒋莉莉，左东泽，李先伟，洪宗元

《中国药理学与毒理学杂志》

2018

依帕司他对肺动脉高压大鼠肺血管重构的影响

俞婷婷，张倩，蒋莉莉，左东泽，李先伟

《中国现代应用药学》

2018

[Rutaecarpine protects against bleomycin-induced pulmonary fibrosis through inhibiting Notch1/eIF3a signaling pathway in rats].

Yunxing Gao, Lili Jiang, Qian Zhang, Dong-Ze Zuo, Xian-Wei Li

PubMed

DOI

2017

依帕司他对肺动脉高压大鼠右心室重构的作用及机制

李先伟，蒋莉莉，左东泽，俞婷婷

《中国药学杂志》

2017

降钙素基因相关肽对肺纤维化大鼠肺组织eIF3a、p27表达的影响

李先伟，左东泽，沈媛媛，郝伟

《中国应用生理学杂志》

2017

[Effects of calcitonin gene-related peptide on eIF3a and p27 expression in bleomycin-induced pulmonary fibrosis of rats].

Xian-Wei Li, Dong-Ze Zuo, Yuanyuan Shen, Wei Hao

PubMed

DOI

2016

Calcitonin gene-related peptide down-regulates bleomycin-induced pulmonary fibrosis

Xian-Wei Li, Xiaohui Li, Jie Du, Dai Li, Yuan‐Jian Li, Chang-Ping Hu

Canadian Journal of Physiology and Pharmacology

DOI

2016

Fluorofenidone attenuates bleomycin-induced pulmonary fibrosis by inhibiting eukaryotic translation initiation factor 3a (eIF3a) in rats

Yuehan Wu, Xian-Wei Li, Wen‐Qun Li, Xiaohui Li, Yuan‐Jian Li, Gaoyun Hu, Zhaoqian Liu, Dai Li

European Journal of Pharmacology

DOI

2015

Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat

Xian-Wei Li, Yuanyuan Shen, Yining Lu, Yang Jie-ren

Korean Journal of Physiology and Pharmacology

DOI

2015

白杨素对野百合碱诱导的肺动脉高压大鼠右心室NOX4及NF-κB表达的影响

李先伟，过波，沈媛媛，杨解人

《药学学报》

DOI

2015

Inhibitory effect of l-mimosine on bleomycin-induced pulmonary fibrosis in rats: Role of eIF3a and p27

Xian-Wei Li, Chang-Ping Hu, Yuan‐Jian Li, Yuan-Xing Gao, Xiangming Wang, Yang Jie-ren

International Immunopharmacology

DOI

2015

Role of eukaryotic translation initiation factor 3a in bleomycin-induced pulmonary fibrosis

Xian-Wei Li, Yuehan Wu, Xiaohui Li, Dai Li, Jie Du, Chang-Ping Hu, Yuan‐Jian Li

European Journal of Pharmacology

DOI

2015

Effects of chrysin (5,7-dihydroxyflavone) on vascular remodeling in hypoxia-induced pulmonary hypertension in rats

Xian-Wei Li, Xiangming Wang, Shu Li, Yang Jie-ren

Chinese Medicine

DOI

2014

吴茱萸次碱对肺动脉高压大鼠右心室重构的影响

李先伟，汪向明，李曙，杨解人

《中国应用生理学杂志》

2013

降钙素基因相关肽对低氧性肺动脉高压肺动脉胶原沉积的影响

李先伟，杜洁，李元建

《中国应用生理学杂志》

2013

Fluorofenidone attenuates vascular remodeling in hypoxia-induced pulmonary hypertension of rats

Xian-Wei Li, Jie Du, Gaoyun Hu, Chang-Ping Hu, Dai Li, Yuan‐Jian Li, Xiaohui Li

Canadian Journal of Physiology and Pharmacology

DOI

2013

[The effect of calcitonin gene-related peptide on collagen accumulation in pulmonary arteries of rats with hypoxic pulmonary arterial hypertension].

Xian-Wei Li, Jie Du, Yuan‐Jian Li

PubMed

2012

CGRP在大鼠肺动脉高压血管重构和博莱霉素诱导肺纤维化中的作用及机制

李先伟

《中南大学》

李先伟

精选作品

期刊论文

埃克替尼对肺动脉高压大鼠右心室重构的保护作用

依帕司他对放射性肺炎小鼠线粒体氧化应激损伤的保护作用

埃克替尼抑制肺泡上皮细胞上皮间充质转化进程改善博来霉素诱导的肺纤维化

IL-33调控NF-κB/Twist信号通路促进肺泡上皮细胞上皮-间质转分化的机制研究

IL-33通过激活NF-κB信号通路上调eIF3a的表达介导小鼠肺肌纤维母细胞增殖分化促进肺纤维化

[IL-33 up-regulates eIF3a expression by activating NF-κB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].

Effect of AR gene-specific knockout on the process of radiation-induced pulmonary fibrosis and its mechanism

含羞草碱调控Notch1/Twist1信号通路改善博莱霉素诱导的大鼠肺纤维化

异钩藤碱调控ERK/p27Kip1信号通路改善博莱霉素诱导的小鼠肺纤维化

Ⅱ型肺泡上皮细胞间质转分化中的Notch-1/Twist-1信号通路机制

[Effects of Notch-1/Twist-1 axis in the process of epithelial-mesenchymal transition of type II alveolar epithelial cell and its mechanism].

小剂量辣椒素抗小鼠肺纤维化的作用及其机制

白杨素调控NF-κB/Twist 1信号通路抑制Ⅱ型肺泡上皮细胞间质转分化的机制研究

二甲双胍对肺纤维化大鼠肺组织肺泡上皮-间充质转化的抑制作用及机制

依帕司他通过抑制醛糖还原酶表达抑制血小板衍生生长因子诱导的大鼠肺动脉平滑肌细胞增殖（英文）

依帕司他对肺动脉高压大鼠肺血管重构的影响

[Rutaecarpine protects against bleomycin-induced pulmonary fibrosis through inhibiting Notch1/eIF3a signaling pathway in rats].

依帕司他对肺动脉高压大鼠右心室重构的作用及机制

降钙素基因相关肽对肺纤维化大鼠肺组织eIF3a、p27表达的影响

[Effects of calcitonin gene-related peptide on eIF3a and p27 expression in bleomycin-induced pulmonary fibrosis of rats].

Calcitonin gene-related peptide down-regulates bleomycin-induced pulmonary fibrosis

Fluorofenidone attenuates bleomycin-induced pulmonary fibrosis by inhibiting eukaryotic translation initiation factor 3a (eIF3a) in rats

Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat

白杨素对野百合碱诱导的肺动脉高压大鼠右心室NOX4及NF-κB表达的影响

Inhibitory effect of l-mimosine on bleomycin-induced pulmonary fibrosis in rats: Role of eIF3a and p27

Role of eukaryotic translation initiation factor 3a in bleomycin-induced pulmonary fibrosis

Effects of chrysin (5,7-dihydroxyflavone) on vascular remodeling in hypoxia-induced pulmonary hypertension in rats

吴茱萸次碱对肺动脉高压大鼠右心室重构的影响

降钙素基因相关肽对低氧性肺动脉高压肺动脉胶原沉积的影响

Fluorofenidone attenuates vascular remodeling in hypoxia-induced pulmonary hypertension of rats

[The effect of calcitonin gene-related peptide on collagen accumulation in pulmonary arteries of rats with hypoxic pulmonary arterial hypertension].

CGRP在大鼠肺动脉高压血管重构和博莱霉素诱导肺纤维化中的作用及机制

会议论文

EIF3a/NDRG1通路在博来霉素诱导的肺纤维化中的作用

eIF3a在博来霉素诱导肺纤维化中的作用及机制

降钙素基因相关肽抑制肺纤维化及机制

研究方向