王玉强｜暨南大学｜学者主页

2025

Multi-functional Memantine Nitrate Attenuated Cognitive Impairment in Models of Vascular Dementia and Alzheimer's Disease through Neuroprotection and Increased Cerebral Blood Flow.

Guangying Chen, Kexin Zhang, Minghua Sun, Ningqing Xie, Liangmiao Wu, Gui-Liang Zhang, Bao-Jian Guo, Chunhui Huang, Maggie Pui Man Hoi, Gao-Xiao Zhang, Changzheng Shi, Ye-Wei Sun, Zai-Jun Zhang, Yuqiang Wang

Neuropharmacology

DOI

2025

Neuroprotective and intraocular pressure lowering effects of dual-functional memantine nitrate MN-08 on the experimental models of glaucoma

Huihui Hu, Liangmiao Wu, Xiaodi Hu, Ming-Hua Wang, Ye-Wei Sun, Gao-Xiao Zhang, Yuqiang Wang, Peng Yi, Zai-Jun Zhang

Scientific Reports

DOI

2024

Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer’s Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways

Xin-Hua Zhou, Zeyu Zhu, Shaoming Kuang, Kaipeng Huang, Yueping Li, Yuqiang Wang, Haiyun Chen, Maggie Pui Man Hoi, Ben-Hong Xu, Xi-Fei Yang, Zai-Jun Zhang

Pharmaceuticals

DOI

2024

iTRAQ-Based Proteomic Analysis Unveils NCAM1 as a Novel Regulator in Doxorubicin-Induced Cardiotoxicity and DT-010-Exerted Cardioprotection

Sijie Wang, Caipeng Xie, Huihui Hu, Pei Yu, Haijing Zhong, Yuqiang Wang, L. Shan

Current Pharmaceutical Analysis

DOI

2024

Tetramethylpyrazine nitrone delays the aging process of C. elegans by improving mitochondrial function through the AMPK/mTORC1 signaling pathway.

Tingting Zhang, Mei Jing, Lili Fei, Zai-Jun Zhang, Peng Yi, Ye-Wei Sun, Yuqiang Wang

Biochemical and Biophysical Research Communications - BBRC

DOI

2024

Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling

Gui-Liang Zhang, Zirong Liang, Yuqiang Wang, Zai-Jun Zhang, P. Hoi

Antioxidants

DOI

2024

Tetramethylpyrazine Nitrone alleviates D-galactose-induced murine skeletal muscle aging and motor deficits by activating the AMPK signaling pathway

Lulin Nie, Kaiwu He, Chaoming Qiu, Qing Li, Bocheng Xiong, Chuanyue Gao, Xiufen Zhang, Mei Jing, Wei Wu, Jianjun Liu, Gaoxiao Zhang, Zaijun Zhang, Xifei Yang, Yewei Sun, Yuqiang Wang

Biomedicine & Pharmacotherapy

DOI

2024

Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation

Baojian Guo, Chengyou Zheng, Jie Cao, Xiaoling Qiu, Fangcheng Luo, Haitao Li, Simon Ming‐Yuen Lee, Xifei Yang, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Yuqiang Wang

NeuroMolecular Medicine

DOI

2023

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis

Xinhua Zhou, Kaipeng Huang, Yuqiang Wang, Zaijun Zhang, Yingying Liu, Qinghua Hou, Xifei Yang, Maggie Pui Man Hoi

Frontiers in Pharmacology

DOI

2023

Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson’s disease models

Baojian Guo, Chengyou Zheng, Jie Cao, Fangcheng Luo, Haitao Li, Shengquan Hu, Simon Ming‐Yuen Lee, Xifei Yang, Gaoxiao Zhang, Zaijun Zhang, Yewei Sun, Yuqiang Wang

Journal of Advanced Research

DOI

2023

Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β

Shao‐Ru Chen, Zheng-qing Li, Jun Xu, Mo‐Yu Ding, Yaming Shan, Yung‐Chi Cheng, Gao-xiao Zhang, Ye-wei Sun, Yuqiang Wang, Ying Wang, Ying Wang, Ying Wang

Acta Pharmacologica Sinica

DOI

2022

Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice

Huihui Hu, Houde Jiang, Kexin Zhang, Zaijun Zhang, Yuqiang Wang, Yi Peng, Gaoxiao Zhang, Yewei Sun

Biomedicine & Pharmacotherapy

DOI

2022

Tetramethylpyrazine nitrone activates hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia

Yun Cen, Peile Wang, Fangfang Gao, Mei Jing, Zaijun Zhang, Yi Peng, Gaoxiao Zhang, Yewei Sun, Yuqiang Wang

Frontiers in Pharmacology

DOI

2022

iTRAQ-based Proteomics Analysis of ADTM for Preventing the Development of Nitroglycerin-induced Tolerance

Luchen Shan, Huihui Hu, Jia Wu, Baojian Guo, Yuqiang Wang

Current Pharmaceutical Analysis

DOI

2022

Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway

Jie Xu, Yun‐Lin Ao, Chunhui Huang, Xiubao Song, Guiliang Zhang, Wei Cui, Yuqiang Wang, Xiao‐Qi Zhang, Zaijun Zhang

npj Parkinson s Disease

DOI

2022

Andrographolide Derivative AL-1 Ameliorates LPS-induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome and Lung Permeability

Tangjia Li, Chu Zhang, Yuke Wei, Haijing Zhong, Luchen Shan, Pei Yu, Yuqiang Wang, Lipeng Xu

Current Pharmaceutical Design

DOI

2022

Tetramethylpyrazine nitrone TBN extends the lifespan of C. elegans by activating the Nrf2/SKN-1 signaling pathway

Ting Wang, Mei Jing, Ting Zhang, Zaijun Zhang, Yewei Sun, Yuqiang Wang

Biochemical and Biophysical Research Communications

DOI

2022

A novel neuroprotective cholinesterase-monoamine oxidase inhibitor for treatment of dementia and depression in Parkinson’s disease

Wei Liu, Yuqiang Wang, Moussa B. H. Youdim

Ageing and Neurodegenerative Diseases

DOI

2021

Danshensu derivative ADTM ameliorates CCl4‑induced acute liver injury in mice through inhibiting oxidative stress and apoptosis

Shu Jia, Qi Chen, Jingyi Wu, Xiaokun Yao, Xiaokun Yao, Jingping Shao, Xiaoyan Cheng, Congcong Zhang, Danwei Cen, Yuqiang Wang, Zhihong Shen, Luchen Shan, Xiaomin Yao, Xiaomin Yao

Pathology - Research and Practice

DOI

2021

Therapeutic efficacy of novel memantine nitrate MN‐08 in animal models of Alzheimer’s disease

Liangmiao Wu, Xinhua Zhou, Yiwan Cao, Shinghung Mak, Ling Zha, Ning Li, Zhiyang Su, Yifan Han, Yuqiang Wang, Maggie Pui Man Hoi, Yewei Sun, Gaoxiao Zhang, Zaijun Zhang, Xifei Yang

Aging Cell

DOI

2021

TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS

Chunhui Huang, Jun Li, Guiliang Zhang, Yingqi Lin, Caijuan Li, Xiao-Feng Zheng, Xichen Song, Bofeng Han, Baojian Guo, Zhuchi Tu, Jun Zhang, Yewei Sun, Yuqiang Wang, Zaijun Zhang, Sen Yan

Human Molecular Genetics

DOI

2021

Dual-Functional MN-08 Attenuated Pulmonary Arterial Hypertension Through Vasodilation and Inhibition of Pulmonary Arterial Remodeling

Fangcheng Luo, Liangmiao Wu, Guoqing Xie, Fangfang Gao, Zhixiang Zhang, Guang‐Ying Chen, Zheng Liu, Ling Zha, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Yuqiang Wang

Hypertension

DOI

2021

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

Guiliang Zhang, Jiahui Wu, Chunhui Huang, Jiehong Cheng, Zhiyang Su, Zeyu Zhu, Xifei Yang, Baojian Guo, Liangmiao Wu, Zaijun Zhang, Gaoxiao Zhang, Haiyun Chen, Yewei Sun, Yuqiang Wang

Journal of Molecular Neuroscience

DOI

2021

Neuroprotection against 1-Methyl-4-phenylpyridinium-induced cytotoxicity by naturally occurring polydatin through activation of transcription factor MEF2D

Jie Cao, Baojian Guo, Sai Li, Xaojing Zhang, Xiao‐Qi Zhang, Gaoxiao Zhang, Yewei Sun, Yuqiang Wang, Xiubao Song, Zaijun Zhang

Neuroreport

DOI

2020

Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice

Jing Wen, Shangming Li, Chengyou Zheng, Fengjiao Wang, Yangwen Luo, Liangmiao Wu, Jie Cao, Baojian Guo, Pei Yu, Gaoxiao Zhang, Shupeng Li, Yewei Sun, Xifei Yang, Zaijun Zhang, Yuqiang Wang

Neuropharmacology

DOI

2020

A novel danshensu/tetramethypyrazine derivative attenuates oxidative stress‑induced autophagy injury via the AMPK‑mTOR‑Ulk1 signaling pathway in cardiomyocytes

Caipeng Xie, Jingxiong Luo, Huihui Hu, Liang Wang, Pei Yu, Lipeng Xu, Yewei Sun, Yuqiang Wang, Luchen Shan

Experimental and Therapeutic Medicine

DOI

2020

Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine- nitrone Derivatives as Antioxidants

Haiyun Chen, Chunyan Yan, Jie Cao, Zheng Liu, Yewei Sun, Yuqiang Wang

Letters in Drug Design & Discovery

DOI

2020

Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo

Shinghung Mak, Zheng Liu, Liangmiao Wu, Baojian Guo, Fangcheng Luo, Ziyan Liu, Shengquan Hu, Jiajun Wang, Guozhen Cui, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Yifan Han, Yifan Han

ACS Chemical Neuroscience

DOI

2019

Neuroprotective and Neurogenic Effects of Novel Tetramethylpyrazine Derivative T-006 in Parkinson's Disease Models Through Activating the MEF2-PGC1α and BDNF/CREB Pathways

Haiyun Chen, Jie Cao, Ling Zha, Peile Wang, Zheng Liu, Baojian Guo, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Yuqiang Wang

Aging

DOI

2019

Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease

Xinhua Zhou, Liang You Wang, Wei Xiao, Zhiyang Su, Chengyou Zheng, Zaijun Zhang, Yuqiang Wang, Benhong Xu, Xifei Yang, Maggie Pui Man Hoi

Experimental Neurobiology

DOI

2019

A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer

Xinhua Zhou, Anqi Wang, Liang Wang, Jianhua Yin, Li Wang, Lijun Di, Maggie Pui Man Hoi, Luchen Shan, Xu Wu, Yuqiang Wang

Frontiers in Pharmacology

DOI

2019

Andrographolide derivative AL-1 reduces intestinal permeability in dextran sulfate sodium (DSS)-induced mice colitis model

Nan Jiang, Yuke Wei, Yun Cen, Luchen Shan, Zaijun Zhang, Pei Yu, Yuqiang Wang, Lipeng Xu

Life Sciences

DOI

2019

Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson’s Disease In Vitro and In Vivo

Hefeng Zhou, Min Shao, Xuanjun Yang, Chuwen Li, Guozhen Cui, Gao Cheng, Lijun Di, Hanbing Zhong, Yuqiang Wang, Zaijun Zhang, Simon Ming‐Yuen Lee

Oxidative Medicine and Cellular Longevity

DOI

2019

Andrographolide Derivative AL-1 Ameliorates Dextran Sodium Sulfate-Induced Murine Colitis by Inhibiting NF-κB and MAPK Signaling Pathways

Mei Jing, Yuqiang Wang, Lipeng Xu

Oxidative Medicine and Cellular Longevity

DOI

2019

Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models

Hefeng Zhou, Min Shao, Baojian Guo, Chuwen Li, Yucong Lu, Xuanjun Yang, Li Shengnan, Haitao Li, Qi Zhu, Hanbing Zhong, Yuqiang Wang, Zaijun Zhang, Jiahong Lu, Simon Ming‐Yuen Lee

Neurotherapeutics

DOI

2019

Enantioselective Syntheses of α‐exo‐Methylene‐Lactones via Organocatalytic Halolactonization

Wei Wang, Haoquan He, Min Gan, Haitao Wang, Yuqiang Wang, Xiaojian Jiang

Advanced Synthesis & Catalysis

DOI

2019

Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models

Liangmiao Wu, Zhiyang Su, Ling Zha, Zeyu Zhu, Wei Yong Liu, Yewei Sun, Pei Yu, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhang

NeuroMolecular Medicine

DOI

2019

Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke

Liangmiao Wu, Jie Cao, Ning Li, Haiyun Chen, Wei Da Liu, Gaoxiao Zhang, Yu Liu, Yuqiang Wang, Yewei Sun, Zaijun Zhang

Neuroreport

DOI

2019

Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice

Baojian Guo, Zhuyun Liu, Mo‐Yu Ding, Feng Li, Mei Jing, Lipeng Xu, Yuqiang Wang, Yuqiang Wang, Zaijun Zhang, Yitao Wang, Yitao Wang, Decai Wang, Guo‐Chun Zhou, Ying Wang, Ying Wang

Biochemical Pharmacology

DOI

2019

Enantioselective Halolactonizations Using Amino-Acid-Derived Phthalazine Catalysts

Min Gan, Wei Wang, Haitao Wang, Yuqiang Wang, Xiaojian Jiang

Organic Letters

DOI

2019

The dual‐functional memantine nitrate MN‐08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models

Fangcheng Luo, Liangmiao Wu, Zhixiang Zhang, Zhixiang Zhang, Zeyu Zhu, Zheng Liu, Baojian Guo, Ning Li, Jun Ju, Qiang Zhou, Shupeng Li, Xifei Yang, Shinghung Mak, Yifan Han, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhang, Zaijun Zhang

British Journal of Pharmacology

DOI

2018

Enantioseletive Fluorination of 3‐Functionalized Oxindoles Using Electron‐rich Amino Urea Catalyst

Xiaojian Jiang, Haitao Wang, Haoquan He, Wei Wang, Yuqiang Wang, Zhihai Ke, Ying‐Yeung Yeung

Advanced Synthesis & Catalysis

DOI

2018

Tetramethylpyrazine nitrone modulates mitochondria, alpha-synuclein, and neuroinflammation to prevent neurodegeneration in experimental models of Parkinson's disease

Zaijun Zhang, Baojian Guo, Chengyou Zheng, Yuqiang Wang

Proceedings for Annual Meeting of The Japanese Pharmacological Society

DOI

2018

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

Shengquan Hu, Huihui Hu, Shinghung Mak, Guozhen Cui, Mingyuen Lee, Luchen Shan, Yuqiang Wang, Huangquan Lin, Yifan Han, Yifan Han

Frontiers in Pharmacology

DOI

2018

Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla

Shengquan Hu, Shinghung Mak, Xialin Zuo, Haitao Li, Yuqiang Wang, Yifan Han

Frontiers in Pharmacology

DOI

2018

Hippocampal Proteomic Alteration in Triple Transgenic Mouse Model of Alzheimer’s Disease and Implication of PINK 1 Regulation in Donepezil Treatment

Xinhua Zhou, Wei Xiao, Zhiyang Su, Jiehong Cheng, Chengyou Zheng, Zaijun Zhang, Yuqiang Wang, Liang Wang, Benhong Xu, Shupen Li, Xifei Yang, Maggie Pui Man Hoi

Journal of Proteome Research

DOI

2018

The novel N-methyl-d-aspartate receptor antagonist MN-08 ameliorates lipopolysaccharide-induced acute lung injury in mice

Jinxin Jiang, Qianqian Jian, Mei Jing, Zaijun Zhang, Gaoxiao Zhang, Luchen Shan, Pei Yu, Yuqiang Wang, Lipeng Xu

International Immunopharmacology

DOI

2018

Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats

Ning Li, Xiubao Song, Liangmiao Wu, Tao Zhang, Chen Zhao, Xifei Yang, Luchen Shan, Pei Yu, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhang

Neuroscience Letters

DOI

2018

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

Haiyun Chen, Jie Cao, Zeyu Zhu, Gaoxiao Zhang, Luchen Shan, Pei Yu, Yuqiang Wang, Yewei Sun, Zaijun Zhang

Frontiers in Neuroscience

DOI

2018

A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice

Guozhen Cui, Qiqi Xin, Hisa Hui Ling Tseng, Maggie Pui Man Hoi, Yan Wang, Binrui Yang, Inleng Choi, Yuqiang Wang, Rong Yuan, Keji Chen, Weihong Cong, Simon Ming‐Yuen Lee

Pharmacological Research

DOI

2018

Enantioselective Bromolactonization of Deactivated Olefinic Acids

Xiaojian Jiang, Shenghui Liu, Si Yang, Mei Jing, Lipeng Xu, Pei Yu, Yuqiang Wang, Ying‐Yeung Yeung

Organic Letters

DOI

2018

A Novel Danshensu-Tetramethylpyrazine Conjugate DT-018 Provides Cardioprotection by Preserving Mitochondrial Function Through the MEF2D/PGC-1α Pathway

Xiao‐Jing Zhang, Jingxiong Luo, Ya-Li Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun, Luchen Shan, Yuqiang Wang

Current Pharmaceutical Design

DOI

2018

Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy

Gaoxiao Zhang, Tao Zhang, Liangmiao Wu, Xinhua Zhou, Jianbo Gu, Cuimei Li, Wei Liu, Cheng Long, Xifei Yang, Luchen Shan, Lipeng Xu, Yuqiang Wang, Yewei Sun, Zaijun Zhang

NeuroMolecular Medicine

DOI

2018

Memantine Nitrate Ester Derivatives MN-08 Improves Cognitive and Attenuates Alzheimer's Disease-Like Neuropathology in Transgenic mice

Xinhua Zhou, Xifei Yang, Zaijun Zhang, Yuqiang Wang, Maggie Pui Man Hoi

Proceedings for Annual Meeting of The Japanese Pharmacological Society

DOI

2017

Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson’s Disease Model

Zheng Liu, Wei Cai, Ming Lang, Ruizuo Yan, Zhenshen Li, Gaoxiao Zhang, Pei Yu, Yuqiang Wang, Yewei Sun, Zaijun Zhang

Journal of Molecular Neuroscience

DOI

2017

Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia

Henry C.-H. Law, Samuel S.W. Szeto, Quan Quan, Yun Zhao, Zaijun Zhang, Olga Krakovska, Leong Ting Lui, Chengyou Zheng, Simon Ming‐Yuen Lee, K. W. Michael Siu, Yuqiang Wang, Ivan Keung Chu

Journal of Proteome Research

DOI

2017

A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs

Benhong Xu, Huixing Deng, Xiaojing Zhang, Jingxiong Luo, Gaoxiao Zhang, Zaijun Zhang, Yuqiang Wang, Luchen Shan

European Journal of Pharmacology

DOI

2017

Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia

Tao Zhang, Jianbo Gu, Liangmiao Wu, Ning Li, Yewei Sun, Pei Yu, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhang

Neuropharmacology

DOI

2017

Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B

Baojian Guo, Shengquan Hu, Chengyou Zheng, Hongyu Wang, Fangcheng Luo, Haitao Li, Wei Cui, Xifei Yang, Guozhen Cui, Shinghung Mak, Tony Chunglit Choi, Edmond Dik-Lung, Yuqiang Wang, Simon Ming‐Yuen Lee, Yifan Han, Yifan Han

Neuropharmacology

DOI

2017

Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post‐ischaemic neuroregeneration and recovery of neurological functions in rats

Gaoxiao Zhang, Tao Zhang, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Luchen Shan, Pei Yu, Xifei Yang, Yaohui Tang, Guo‐Yuan Yang, Yuqiang Wang, Yewei Sun, Zaijun Zhang

British Journal of Pharmacology

DOI

2017

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador‐Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin M. Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi

Nature Communications

DOI

2017

Pharmacokinetics of Memantine-derivative MN-08 in Rats: A Preclinical Study

Chaoqiang Luo, Fangcheng Luo, Yewei Sun, Lipeng Xu, Pei Yu, Yuqiang Wang, Zaijun Zhang

Journal of Pharmaceutical and Biomedical Sciences

2017

Cardioprotection of a Novel Danshensu Derivate Against Oxidative Injury and Mitochondrial Dysfunction in Vitro and Myocardial Ischemia/Reperfusion Injury in Rat

Huixing Deng, Ya-Li Huang, Xiao‐Jing Zhang, Jingxiong Luo, Huihui Hu, Yuqiang Wang, Luchen Shan

Journal of Pharmaceutical and Biomedical Sciences

2017

Synthesis and Biological Evaluation of Andrographolide Derivatives as Potential Anti-Inflammatory Agents

Haibing Duan, Mei Jing, Zhenshen Li, Zaijun Zhang, Yuqiang Wang, Lipeng Xu, Pei Yu

Journal of Pharmaceutical and Biomedical Sciences

2017

Tetramethylpyrazine nitrone protects retinal ganglion cells against N‐methyl‐ d ‐aspartate‐induced excitotoxicity

Xiaopeng Luo, Yankun Yu, Zongqin Xiang, Huisu Wu, Seeram Ramakrishna, Yuqiang Wang, Kwok‐Fai So, Zaijun Zhang, Ying Xu

Journal of Neurochemistry

DOI

2017

A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway

Xiaojing Zhang, Huihui Hu, Jingxiong Luo, Huixing Deng, Pei Yu, Zaijun Zhang, Gaoxiao Zhang, Luchen Shan, Yuqiang Wang

Biological and Pharmaceutical Bulletin

DOI

2017

Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents

Yingfei Wang, Xiao‐Jing Zhang, Changjiang Xu, Gaoxiao Zhang, Zaijun Zhang, Pei Yu, Luchen Shan, Yewei Sun, Yuqiang Wang

Chemical and Pharmaceutical Bulletin

DOI

2016

丹参素衍生物对斑马鱼促血管新生作用的研究

崔国祯，徐燕玲，孙安露，单璐琛，王玉强，李铭源

《中国药理学通报》

2016

新药T-006对东莨菪碱所致记忆障碍模型动物学习记忆的改善作用

宋奇，王琴，吴韦黎，邵敏，张宇，张在军，王玉强，陶亮

《中国药理学通报》

2016

神经细胞氧化应激在血管痴呆大鼠模型中病理学变化及其意义

古建波，张涛，吴良淼，张高小，王玉强

《中国临床药理学杂志》

2016

Synthesis of 3,3‐Dihalo‐2‐oxindoles from 2‐Substituted Indoles via Halogenation–Decarboxylation/Desulfonamidation–Oxidation Process

Xiaojian Jiang, Feng Zhang, Junjie Yang, Pei Yu, Yi Peng, Yewei Sun, Yuqiang Wang

Advanced Synthesis & Catalysis

DOI

2016

ChemInform Abstract: Synthesis of Quaternary 3,3‐Disubstituted 2‐Oxindoles from 2‐Substituted Indole Using Selectfluor.

Xiaojian Jiang, Junjie Yang, Feng Zhang, Pei Yu, Yi Peng, Yewei Sun, Yuqiang Wang

ChemInform

DOI

2016

Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models

Daping Xu, Haiyun Chen, Shinghung Mak, Shengquan Hu, Karl Wah Keung Tsim, Hu Yuanjia, Yewei Sun, Gaoxiao Zhang, Yuqiang Wang, Yifan Han, Yifan Han

Neurochemistry International

DOI

2016

Facile Synthesis of 3‐Halobenzo‐heterocyclic‐2‐carbonyl Compounds via in situ Halogenation‐Oxidation

Xiaojian Jiang, Junjie Yang, Feng Zhang, Pei Yu, Yi Peng, Yewei Sun, Yuqiang Wang

Advanced Synthesis & Catalysis

DOI

2016

Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine

Shengquan Hu, Liang Wang, Shinghung Mak, Yifan Han, Daping Xu, Haitao Li, Yide Li, Hu Yuanjia, Simon Ming‐Yuen Lee, Yuqiang Wang, Yifan Han

NeuroMolecular Medicine

DOI

2016

Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B

Baojian Guo, Chengyou Zheng, Wei Cai, Jiehong Cheng, Hongyu Wang, Haitao Li, Yewei Sun, Wei Cui, Yuqiang Wang, Yifan Han, Simon Ming‐Yuen Lee, Yifan Han

Journal of Agricultural and Food Chemistry

DOI

2016

No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice

Yifan Han, Yifan Han, Chengyou Zheng, Bao-jian Guo, Wei Cai, Wei Cui, Shinghung Mak, Yuqiang Wang, Simon Ming‐Yuen Lee

Neural Regeneration Research

DOI

2016

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

Hai‐Jing Zhong, Wanhe Wang, Tian‐Shu Kang, Hui Min Yan, Yali Yang, Lipeng Xu, Yuqiang Wang, Dik‐Lung Ma, Chung‐Hang Leung

Journal of Medicinal Chemistry

DOI

2016

A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells

Liang Wang, Judy Yuet‐Wa Chan, Xinhua Zhou, Guozhen Cui, Zhixiang Yan, Li Wang, Ru Yan, Lijun Di, Yuqiang Wang, Maggie Pui Man Hoi, Luchen Shan, Simon Ming‐Yuen Lee

Frontiers in Pharmacology

DOI

2016

Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells

Wei Liu, Alon Rabinovich, Yuval Nash, Dan Frenkel, Yuqiang Wang, Moussa B. H. Youdim, Orly Weinreb

Neuropharmacology

DOI

2016

Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer’s disease

Wei Liu, Ming Lang, Moussa B. H. Youdim, Tamar Amit, Yewei Sun, Zaijun Zhang, Yuqiang Wang, Orly Weinreb

Neuropharmacology

DOI

2016

Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy

Zaijun Zhang, Gaoxiao Zhang, Yewei Sun, Samuel S.W. Szeto, Henry C.-H. Law, Quan Quan, Guohui Li, Pei Yu, Eiketsu Sho, Michael K. W. Siu, Simon Ming‐Yuen Lee, Ivan Keung Chu, Yuqiang Wang

Scientific Reports

DOI

2016

Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases

Zheng Liu, Si Yang, Xiaoyong Jin, Gaoxiao Zhang, Baojian Guo, Haiyun Chen, Pei Yu, Yewei Sun, Zaijun Zhang, Yuqiang Wang

MedChemComm

DOI

2016

Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine Derivatives as Potential Neuroprotective Agents

Haiyun Chen, Guolian Tan, Jie Cao, Gaoxiao Zhang, Peng Yi, Pei Yu, Yewei Sun, Zaijun Zhang, Yuqiang Wang

Chemical and Pharmaceutical Bulletin

DOI

2016

Development of the novel antiplatelet agent ADTM, originating from traditional Chinese medicine: a chemical proteomic analysis and in-vivo assessment of efficacy in an animal model

Guozhen Cui, Angela Wa Ho, Simon Ming‐Yuen Lee, Yuqiang Wang, Maggie Pui Man Hoi

The Lancet

DOI

2016

Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury

Gaoxiao Zhang, Fen Zhang, Tao Zhang, Jianbo Gu, Cuimei Li, Yewei Sun, Pei Yu, Zaijun Zhang, Yuqiang Wang

Neurochemical Research

DOI

2016

Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways

Yali Yang, Hui Min Yan, Mei Jing, Zaijun Zhang, Gaoxiao Zhang, Yewei Sun, Luchen Shan, Pei Yu, Yuqiang Wang, Lipeng Xu

Scientific Reports

DOI

2016

Synthesis of Quaternary 3,3-Disubstituted 2-Oxindoles from 2-Substituted Indole Using Selectfluor

Xiaojian Jiang, Junjie Yang, Feng Zhang, Pei Yu, Yi Peng, Yewei Sun, Yuqiang Wang

Organic Letters

DOI

2016

A Promising Dual-functional Neuroprotective Derivative of Memantine

Xiaoyong Jin, Zheng Liu, Baojian Guo, Gaoxiao Zhang, Zaijun Zhang, Lipeng Xu, Yuqiang Wang, Yewei Sun

Journal of Pharmaceutical and Biomedical Sciences

2016

A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced NeurotoxicityIn VitroandIn Vivo

Guozhen Cui, Luchen Shan, Yang Chen, Hefeng Zhou, Yuqiang Wang, Simon Ming‐Yuen Lee

The American Journal of Chinese Medicine

DOI

2015

Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β

Shengquan Hu, Wei Cui, Yifan Han, Shinghung Mak, Daping Xu, Gang Li, Hu Yuanjia, Yuqiang Wang, Mingyuen Lee, Karl Wah Keung Tsim, Yifan Han

Journal of Molecular Neuroscience

DOI

2015

A Potent Multi-functional Neuroprotective Derivative of Tetramethylpyrazine

Hai-Yun Chen, Da-Ping Xu, Guo-Lian Tan, Wei Cai, Gao-Xiao Zhang, Wei Cui, Jinzhao Wang, Cheng Long, Ye-Wei Sun, Pei Yu, Karl Wah Keung Tsim, Yifan Han, Yifan Han, Yuqiang Wang

Journal of Molecular Neuroscience

DOI

2015

Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries

Rachel Wai-Sum Li, Cui Yang, Luchen Shan, Zaijun Zhang, Yuqiang Wang, Yiu Wa Kwan, Simon Ming‐Yuen Lee, Maggie Pui Man Hoi, Shun‐Wan Chan, Alex Chun Cheung, Kwok-Kin Cheung, Gph Leung

European Journal of Pharmacology

DOI

2015

Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

Zaijun Zhang, Guohui Li, Samuel S.W. Szeto, Cheong Meng Chong, Quan Quan, Chen Huang, Wei Cui, Baojian Guo, Yuqiang Wang, Yifan Han, K. W. Michael Siu, Simon Ming‐Yuen Lee, Ivan Keung Chu

Free Radical Biology and Medicine

DOI

2015

Radical-scavenging And Anti-oxidative Activities Of TBN In Cell-free System And Murine H9c2 Cardiomyoblast Cells

Longjun Zhu, Yewei Sun, Gaoxiao Zhang, Pei Yu, Yuqiang Wang, Zaijun Zhang

Journal of Antioxidant Activity

DOI

2015

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease

Hiroto Takahashi, Peng Xia, Jiankun Cui, Maria V. Talantova, Karthik Bodhinathan, Wenjun Li, Sofiyan Saleem, Emily A. Holland, Gary Tong, Juan Piña-Crespo, Dongxian Zhang, Nobuki Nakanishi, James W. Larrick, Scott R. McKercher, Tomohiro Nakamura, Yuqiang Wang, Stuart A. Lipton

Scientific Reports

DOI

2015

A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells

Liang Wang, Xiaojing Zhang, Judy Yuet‐Wa Chan, Luchen Shan, Guozhen Cui, Qingbin Cui, Yingfei Wang, Jingjing Li, Huanxian Chen, Qingwen Zhang, Pei Yu, Yifan Han, Yuqiang Wang, Simon Ming‐Yuen Lee

Journal of Cellular Biochemistry

DOI

2015

Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy

Guozhen Cui, Luchen Shan, Lin Guo, Ivan Keung Chu, Guohui Li, Quan Quan, Yun Zhao, Cheong Meng Chong, Zaijun Zhang, Pei Yu, Maggie Pui Man Hoi, Yewei Sun, Yuqiang Wang, Simon Ming‐Yuen Lee

Scientific Reports

DOI

2015

Andrographolide derivative AL ‐1 improves insulin resistance through down‐regulation of NF ‐ κB signalling pathway

Yongmei Li, Hui Min Yan, Zaijun Zhang, Gaoxiao Zhang, Yewei Sun, Pei Yu, Yuqiang Wang, Lipeng Xu

British Journal of Pharmacology

DOI

2015

Identification of disulfide isomerase ERp57 as a target for small molecule cardioprotective agents

Guozhen Cui, Luchen Shan, Ivan Keung Chu, Guohui Li, Gph Leung, Yuqiang Wang, Yiu Wa Kwan, Shun‐Wan Chan, Maggie Pui Man Hoi, Simon Ming‐Yuen Lee

RSC Advances

DOI

2015

Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury

Xinhua Zhou, Longjun Zhu, Liang Wang, Baojian Guo, Gaoxiao Zhang, Yewei Sun, Zaijun Zhang, Simon Ming‐Yuen Lee, Pei Yu, Yuqiang Wang

Oxidative Medicine and Cellular Longevity

DOI

2014

Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice

Zaijun Zhang, Daoxu Lai, Liang Wang, Pei Yu, Longjun Zhu, Baojian Guo, Lipeng Xu, Libing Zhou, Yewei Sun, Simon Ming Yuen Lee, Yuqiang Wang

Pharmacology Biochemistry And Behavior，Vol. 122

DOI

2014

氯肟衍生物对记忆障碍模型动物空间学习记忆障碍改善作用及其机制研究

于潇冰，王琴，杨克凡，范丽霞，张在军，王玉强，陶亮

《中国药理学通报》

2014

Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction

Wei Cui, Yifan Han, Shengquan Hu, Shinghung Mak, Daping Xu, Chung‐Lit Choi, Yuqiang Wang, Karl Wah Keung Tsim, Ming‐Yuen Lee, Jianhui Rong, Yifan Han

CNS Neuroscience & Therapeutics

DOI

2014

A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways

Da-Ping Xu, Kun Zhang, Yifan Han, Ye-Wei Sun, Bao-Jian Guo, Yuqiang Wang, Maggie Pui Man Hoi, Yifan Han, Simon Ming‐Yuen Lee

Neurochemistry International

DOI

2014

Synthesis and relationship of stability and biological activity of new DSS and TMP conjugates

Yewei Sun, Zicheng Tan, Zhibin Liang, Liang Wang, Luchen Shan, Pei Yu, Simon Ming‐Yuen Lee, Yuqiang Wang

MedChemComm

DOI

2014

Pharmacokinetic Analysis of Tetramethylpyrazine Bis-Nitrone TN-2 in Rats and its Protein Binding In Vitro

Yewei Sun, Kaiyi Liao, Sai Li, Zaijun Zhang, Pei Yu, Yuqiang Wang

Letters in Drug Design & Discovery

DOI

2014

An unexpected replacement of a methyl with an amino in the tetramethylpyrazine system

Ming Lang, Hui Qin Yao, Pengfei Fu, Wei Cai, Yuqiang Wang, Pei Yu

Research on Chemical Intermediates

DOI

2014

Protective effects of apocynin nitrone on acute lung injury induced by lipopolysaccharide in rats

Lipeng Xu, Yongmei Li, Sainan Wan, Yuqiang Wang, Pei Yu

International Immunopharmacology

DOI

2014

Design, Synthesis, and Preliminary Cardioprotective Effect Evaluation of Danshensu Derivatives

Qingbin Cui, Yonghong Chen, Mingjuan Zhang, Luchen Shan, Yewei Sun, Pei Yu, Gaoxiao Zhang, Dingyuan Wang, Zengchao Zhao, Qian Xu, Benhong Xu, Yuqiang Wang

Chemical Biology & Drug Design

DOI

2014

Synthesis and Preliminary Biologic Activity Evaluation of Nitric Oxide-Releasing Andrographolide Derivatives in RIN-m Cells

Zhibin Liang, Enming Du, Lipeng Xu, Yewei Sun, Gaoxiao Zhang, Pei Yu, Yuqiang Wang

Chemical and Pharmaceutical Bulletin

DOI

2014

A Selective O - and N -Acylation Protocol for Carbamyl Chloride

Ming Lang, Ruizuo Yan, Yuqiang Wang, Pei Yu

Chinese Journal of Organic Chemistry

DOI

2013

丹参素结构中醇羟基的修饰与初步活性评价

崔庆彬，单璐琛，朱华，于沛，王玉强

《国际药学研究杂志》

2013

Therapeutic Effects of Multifunctional Tetramethylpyrazine Nitrone on Models of Parkinson’s Disease in Vitro and in Vivo

Baojian Guo, Daping Xu, Hongwei Duan, Jing Du, Zaijun Zhang, Simon Ming‐Yuen Lee, Yuqiang Wang

Biological and Pharmaceutical Bulletin

DOI

2013

The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-Induced Neurotoxicity via Inhibition of Mitochondrial-Dependent Apoptosis

Daping Xu, Hongwei Duan, Yifan Han, Wei Cui, Liang Wang, Yewei Sun, Ming Lang, Maggie Pui Man Hoi, Yifan Han, Yuqiang Wang, Simon Ming‐Yuen Lee

Journal of Neuroimmune Pharmacology

DOI

2013

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Maria V. Talantova, Sara Sanz‐Blasco, Xiaofei Zhang, Peng Xia, Mohd Waseem Akhtar, Shu‐ichi Okamoto, Gustavo Dziewczapolski, Tomohiro Nakamura, Gang Cao, Alexander E. Pratt, Yeon‐Joo Kang, Shichun Tu, Elena Molokanova, Scott R. McKercher, Samuel Andrew Hires, Hagit Sason, David G. Stouffer, Matthew W. Buczynski, James P. Solomon, Sarah A. Michael, Evan T. Powers, Jeffery W. Kelly, Amanda J. Roberts, Gary Tong, Traci Fang Newmeyer, James Parker, Emily A. Holland, Dongxian Zhang, Nobuki Nakanishi, Huei-Sheng Vincent Chen, Herman Wolosker, Yuqiang Wang, Loren H. Parsons, Rajesh Ambasudhan, Eliezer Masliah, Stephen F. Heinemann, Juan Piña-Crespo, Stuart A. Lipton

Proceedings of the National Academy of Sciences

DOI

2013

Protective Effects of Andrographolide Analogue AL-1 on ROS-Induced RIN-mβ Cell Death by Inducing ROS Generation

Guang‐Rong Yan, Hui-Hua Zhou, Yang Wang, Yin Zhong, Zi-Lu Tan, Yuqiang Wang, Qing‐Yu He

PLoS ONE

DOI

2013

A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways

Guozhen Cui, Luchen Shan, Ming-Wai Hung, Siwai Lei, Inleng Choi, Zaijun Zhang, Pei Yu, Maggie Pui Man Hoi, Yuqiang Wang, Simon Ming‐Yuen Lee

International Journal of Cardiology

DOI

2012

Novel multi-functional nitrones for treatment of ischemic stroke

Yewei Sun, Gaoxiao Zhang, Zaijun Zhang, Pei Yu, Haijing Zhong, Jing Du, Yuqiang Wang

Bioorganic & Medicinal Chemistry

DOI

2012

Reaction Characteristics of Andrographolide and its Analogue AL-1 with GSH, as a Simple Chemical Simulation of NF-κB Inhibition

Hui Qin Yao, Sha Li, Pei Yu, Xiaodan Tang, Jie Jiang, Yuqiang Wang

Molecules

DOI

2012

A novel andrographolide derivative AL ‐1 exerts its cytotoxicity on K 562 cells through a ROS ‐dependent mechanism

Yong‐Yang Zhu, Guangchuang Yu, Ye Zhang, Xu Zheng, Yuqiang Wang, Guang‐Rong Yan, Qing‐Yu He

PROTEOMICS

DOI

2012

Effects of 14-Alpha-Lipoyl Andrographolide on Quorum Sensing in Pseudomonas aeruginosa

Li Ma, Xiangyang Liu, Haihua Liang, Yi‐Zhou Che, Caixia Chen, Huanqin Dai, Ke Yu, Mei Liu, Z. Luyan, Ching‐Hong Yang, Fuhang Song, Yuqiang Wang, Lixin Zhang

Antimicrobial Agents and Chemotherapy

DOI

2012

Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models

Yewei Sun, Pei Yu, Gaoxiao Zhang, Liang Wang, Haijing Zhong, Ziyuan Zhai, Linda Wang, Yuqiang Wang

Journal of Neuroscience Research

DOI

2012

Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs

Pei Yu, Longfei Xia, Jing Zhao, Gaoxiao Zhang, Zaijun Zhang, Ming Lang, Yuqiang Wang

Biological and Pharmaceutical Bulletin

DOI

2011

川芎嗪硝酮衍生物在大鼠体内的组织分布研究

李沙，王磊，陈海南，李晓飞，马志国，赵文，蒋杰，王玉强

《中国临床药理学杂志》

2011

川芎嗪硝酮衍生物在脑缺血模型大鼠脑中浓度

黎赛，李沙，陈海南，孙业伟，张高小，王兴立，蒋杰，赵文，王玉强

《中国临床药理学杂志》

2011

Synthesis and biological evaluations of novel apocynin analogues

Xiaoyu Lu, Sainan Wan, Jie Jiang, Xiaojian Jiang, Wenjing Yang, Pei Yu, Lipeng Xu, Zaijun Zhang, Gaoxiao Zhang, Luchen Shan, Yuqiang Wang

European Journal of Medicinal Chemistry

DOI

2011

Synergistic Effect of 14-Alpha-Lipoyl Andrographolide and Various Antibiotics on the Formation of Biofilms and Production of Exopolysaccharide and Pyocyanin by Pseudomonas aeruginosa

Xiangping Zeng, Xiangyang Liu, Jiang Bian, Gang Pei, Huanqin Dai, Steven W. Polyak, Fuhang Song, Li Ma, Yuqiang Wang, Lixin Zhang

Antimicrobial Agents and Chemotherapy

DOI

2011

Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC–UV method in rats

Sha Li, Hainan Chen, Xingli Wang, Jianfeng Wu, Jie Jiang, Yuqiang Wang

European Journal of Drug Metabolism and Pharmacokinetics

DOI

2011

Effect of TMP on Dopaminergic Neuron Injury Induced by MPTP in vivo and vitro

Yuqiang Wang

Lishizhen Medicine and Materia Medica Research

2010

白藜芦醇衍生物的药理活性研究进展

刘伟，于沛，王玉强

《医药导报》

2010

Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells

Hongli Sun, Lipeng Xu, Pei Yu, Jie Jiang, Gaoxiao Zhang, Yuqiang Wang

Bioorganic & Medicinal Chemistry Letters

DOI

2010

Design, synthesis and antibacterial activity of novel andrographolide derivatives

Zhongli Wang, Zhongli Wang, Pei Yu, Gaoxiao Zhang, Lipeng Xu, Liang Wang, Dingyuan Wang, Liang Wang, Liang Wang, Xiangping Zeng, Yuqiang Wang

Bioorganic & Medicinal Chemistry

DOI

2010

Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models

Zaijun Zhang, Sha Li, Jie Jiang, Pei Yu, Jing Liang, Yuqiang Wang

Chinese Medicine

DOI

2010

QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors

Jun Xu, Sichao Huang, Haibin Luo, LI Guo-ji, Jiaolin Bao, Shaohui Cai, Yuqiang Wang

International Journal of Molecular Sciences

DOI

2009

Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment

Zaijun Zhang, Jie Jiang, Pei Yu, Xiangping Zeng, James W. Larrick, Yuqiang Wang

Journal of Translational Medicine

DOI

2009

Activity of Andrographolide and Its Derivatives against Influenza Virus in Vivo and in Vitro

Jianxin Chen, Hui-Jun Xue, Wen‐Cai Ye, Binghu Fang, Yahong Liu, Shaohua Yuan, Pei Yu, Yuqiang Wang

Biological and Pharmaceutical Bulletin

DOI

2008

Synthesis and evaluation of antibacterial activities of andrographolide analogues

Xiaojian Jiang, Pei Yu, Jie Jiang, Zaijun Zhang, Zhongli Wang, Zhaoqi Yang, Zhiming Tian, Susan C. Wright, James W. Larrick, Yuqiang Wang

European Journal of Medicinal Chemistry

DOI

2008

Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke

Yewei Sun, Jie Jiang, Zaijun Zhang, Pei Yu, Linda Wang, Chang-Lin Xu, Wei Liu, Yuqiang Wang

Bioorganic & Medicinal Chemistry

DOI

2008

Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog

Yuqiang Wang, Jie Jiang, Xiaojian Jiang, Shaohui Cai, Hai Han, Lianfa Li, Zhiming Tian, Wei Jiang, Zaijun Zhang, Ying Xiao, Susan C. Wright, James W. Larrick

Bioorganic & Medicinal Chemistry

DOI

2008

Pyridine‐4‐thiol and Amphoteric Analogs: Novel Protection of Aryl Bromides in Strong Alkali

Wei‐Min Chen, Chao Cheng, Bing‐Zhou Li, Tse‐Lok Ho, Zhao‐Shuo Cai, Yuqiang Wang, Pinghua Sun

Helvetica Chimica Acta

DOI

2007

HPLC determination of andrographolide in rat whole blood: study on the pharmacokinetics of andrographolide incorporated in liposomes and tablets

Xu‐Bin Suo, Han Zhang, Yuqiang Wang

Biomedical Chromatography

DOI

2006

槲皮素抗氧化作用研究进展

王玉强，刘慧，马玉坤，翟光喜

《药学研究》

2006

Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue

Yuqiang Wang, Lianfa Li, Zhiming Tian, Wei Jiang, James W. Larrick

Bioorganic & Medicinal Chemistry

DOI

2006

Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate

Yuqiang Wang, Lianfa Li, Wei Jiang, Zhaoqi Yang, Zaijun Zhang

Bioorganic & Medicinal Chemistry Letters

DOI

2005

Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate

Yuqiang Wang, Lianfa Li, Wei Jiang, James W. Larrick

Bioorganic & Medicinal Chemistry

DOI

精选作品

期刊论文

Multi-functional Memantine Nitrate Attenuated Cognitive Impairment in Models of Vascular Dementia and Alzheimer's Disease through Neuroprotection and Increased Cerebral Blood Flow.

Neuroprotective and intraocular pressure lowering effects of dual-functional memantine nitrate MN-08 on the experimental models of glaucoma

Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer’s Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways

iTRAQ-Based Proteomic Analysis Unveils NCAM1 as a Novel Regulator in Doxorubicin-Induced Cardiotoxicity and DT-010-Exerted Cardioprotection

Tetramethylpyrazine nitrone delays the aging process of C. elegans by improving mitochondrial function through the AMPK/mTORC1 signaling pathway.

Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling

Tetramethylpyrazine Nitrone alleviates D-galactose-induced murine skeletal muscle aging and motor deficits by activating the AMPK signaling pathway

Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis

Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson’s disease models

Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β

Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice

Tetramethylpyrazine nitrone activates hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia

iTRAQ-based Proteomics Analysis of ADTM for Preventing the Development of Nitroglycerin-induced Tolerance

Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway

Andrographolide Derivative AL-1 Ameliorates LPS-induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome and Lung Permeability

Tetramethylpyrazine nitrone TBN extends the lifespan of C. elegans by activating the Nrf2/SKN-1 signaling pathway

A novel neuroprotective cholinesterase-monoamine oxidase inhibitor for treatment of dementia and depression in Parkinson’s disease

Danshensu derivative ADTM ameliorates CCl4‑induced acute liver injury in mice through inhibiting oxidative stress and apoptosis

Therapeutic efficacy of novel memantine nitrate MN‐08 in animal models of Alzheimer’s disease

TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS

Dual-Functional MN-08 Attenuated Pulmonary Arterial Hypertension Through Vasodilation and Inhibition of Pulmonary Arterial Remodeling

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

Neuroprotection against 1-Methyl-4-phenylpyridinium-induced cytotoxicity by naturally occurring polydatin through activation of transcription factor MEF2D

Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice

A novel danshensu/tetramethypyrazine derivative attenuates oxidative stress‑induced autophagy injury via the AMPK‑mTOR‑Ulk1 signaling pathway in cardiomyocytes

Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine- nitrone Derivatives as Antioxidants

Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo

Neuroprotective and Neurogenic Effects of Novel Tetramethylpyrazine Derivative T-006 in Parkinson's Disease Models Through Activating the MEF2-PGC1α and BDNF/CREB Pathways

Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease

A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer

Andrographolide derivative AL-1 reduces intestinal permeability in dextran sulfate sodium (DSS)-induced mice colitis model

Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson’s Disease In Vitro and In Vivo

Andrographolide Derivative AL-1 Ameliorates Dextran Sodium Sulfate-Induced Murine Colitis by Inhibiting NF-κB and MAPK Signaling Pathways

Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models

Enantioselective Syntheses of α‐exo‐Methylene‐Lactones via Organocatalytic Halolactonization

Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models

Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke

Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice

Enantioselective Halolactonizations Using Amino-Acid-Derived Phthalazine Catalysts

The dual‐functional memantine nitrate MN‐08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models

Enantioseletive Fluorination of 3‐Functionalized Oxindoles Using Electron‐rich Amino Urea Catalyst

Tetramethylpyrazine nitrone modulates mitochondria, alpha-synuclein, and neuroinflammation to prevent neurodegeneration in experimental models of Parkinson's disease

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

Neuroprotection Against MPP+-Induced Cytotoxicity Through the Activation of PI3-K/Akt/GSK3β/MEF2D Signaling Pathway by Rhynchophylline, the Major Tetracyclic Oxindole Alkaloid Isolated From Uncaria rhynchophylla

Hippocampal Proteomic Alteration in Triple Transgenic Mouse Model of Alzheimer’s Disease and Implication of PINK 1 Regulation in Donepezil Treatment

The novel N-methyl-d-aspartate receptor antagonist MN-08 ameliorates lipopolysaccharide-induced acute lung injury in mice

Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice

Enantioselective Bromolactonization of Deactivated Olefinic Acids

A Novel Danshensu-Tetramethylpyrazine Conjugate DT-018 Provides Cardioprotection by Preserving Mitochondrial Function Through the MEF2D/PGC-1α Pathway

Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy

Memantine Nitrate Ester Derivatives MN-08 Improves Cognitive and Attenuates Alzheimer's Disease-Like Neuropathology in Transgenic mice

Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson’s Disease Model

Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia

A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs

Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia

Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B

Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post‐ischaemic neuroregeneration and recovery of neurological functions in rats

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

Pharmacokinetics of Memantine-derivative MN-08 in Rats: A Preclinical Study

Cardioprotection of a Novel Danshensu Derivate Against Oxidative Injury and Mitochondrial Dysfunction in Vitro and Myocardial Ischemia/Reperfusion Injury in Rat

Synthesis and Biological Evaluation of Andrographolide Derivatives as Potential Anti-Inflammatory Agents

Tetramethylpyrazine nitrone protects retinal ganglion cells against N‐methyl‐ d ‐aspartate‐induced excitotoxicity

A Novel Danshensu-Tetramethylpyrazine Conjugate DT-010 Provides Cardioprotection through the PGC-1α/Nrf2/HO-1 Pathway

Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents

丹参素衍生物对斑马鱼促血管新生作用的研究

新药T-006对东莨菪碱所致记忆障碍模型动物学习记忆的改善作用

神经细胞氧化应激在血管痴呆大鼠模型中病理学变化及其意义

Synthesis of 3,3‐Dihalo‐2‐oxindoles from 2‐Substituted Indoles via Halogenation–Decarboxylation/Desulfonamidation–Oxidation Process

ChemInform Abstract: Synthesis of Quaternary 3,3‐Disubstituted 2‐Oxindoles from 2‐Substituted Indole Using Selectfluor.

Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models

Facile Synthesis of 3‐Halobenzo‐heterocyclic‐2‐carbonyl Compounds via in situ Halogenation‐Oxidation

Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine

Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B

No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease