纪志梁｜厦门大学｜学者主页

2026

Star-Shaped Multivalent Molecular Scavengers for Neutrophil Extracellular Trap-Associated Chromatin Neutralization and Sepsis Treatment

Chuanxu Cheng, Quanxin Ning, Juan Du, Jianati Dawulieti, Chenyang Guo, Madi Sun, Kunbao Zhang, Haijun Li, Qunjie Bi, Jian Li, Zhen Wu, Ziping Wu, Lili Li, Hanyao Huang, Zhi‐Liang Ji, Jin‐Zhi Du, Chao YANG, Kam W. Leong, Dan Shao

Journal of the American Chemical Society

DOI

2026

Quantitative and interface-aware prediction of peptide–protein interactions by VITAL

Wei-Hao Chen, Qi-Wen Wang, Zhiyi Li, Song-Yang Li, Chen Lin, Zhi‐Liang Ji

Nature Machine Intelligence

DOI

2026

GenART: Reading the genome’s language with adaptive “words”

Kehan Chen, Ping Han, Zhe Lin, Shang Gao, X L Yang, Xiangxiang Zeng, Yeyun Gong, Zhi‐Liang Ji, Chen Lin

Cell Reports Methods

DOI

2026

TiSMeD: A tissue-specific methylation and expression database for biomarker and translational applications

Jiao Cheng, Zhe Lin, Lvying Wu, Qianying Li, Huajun Yin, Hao Wang, Hao Chen, Xiaoyan Chen, Zhi‐Liang Ji

Molecular Therapy — Nucleic Acids

DOI

2025

From parents to offspring: a comprehensive review of antidepressant-linked reproductive risks

Sixian Wu, Fei Yan, Yazhen Wei, Qingming Liu, Qixuan Yue, Gelin Huang, Xiaoliang Li, Zhi‐Liang Ji, Jiaqi Ni, Wenming Xu

Biology of Reproduction

DOI

2025

Resiquimod‐Induced Nanovaccine (RINV) for Personalized Cancer Immunotherapy

Wei Xu, Jiaqi Luo, Shiyu Wang, Zhenlin Gao, Feng‐Qin Luo, Xin Zhang, Kai‐Shuo Wang, Juan Du, Zhi‐Liang Ji, Jin‐Zhi Du, Jun Wang

Angewandte Chemie

DOI

2024

CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice

Xueguang Zhang, Gelin Huang, Ting Jiang, Lanlan Meng, Tongtong Li, Guohui Zhang, Nan Wu, Xinyi Chen, Bingwang Zhao, Nana Li, Sixian Wu, Junceng Guo, Rui Zheng, Zhi‐Liang Ji, Zhigang Xu, Zhen‐Bo Wang, Dong Deng, Yue‐Qiu Tan, Wenming Xu

Nature Communications

DOI

2024

Nphos: Database and Predictor of Protein N -phosphorylation

Mingxiao Zhao, Ruofan Ding, Qiang Chen, Junhua Meng, Fulai Li, Songsen Fu, Biling Huang, Yan Liu, Zhi‐Liang Ji, Yufen Zhao

Genomics Proteomics & Bioinformatics

DOI

2024

Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI

Qing Li, Juncen Guo, Gelin Huang, Nan Wu, Su Chen, Jing Dai, Xueguang Zhang, Guohui Zhang, Weiwei Zhi, Jierui Yan, Rui Zheng, Fei Yan, Zheng Yan, Ling Wu, Sixian Wu, Zhi‐Liang Ji, Jiuzhi Zeng, Ge Lin, Bin Li, Wenming Xu

Reproduction

DOI

2024

Mining Real-World Big Data to Characterize Adverse Drug Reaction Quantitatively: Mixed Methods Study

Qi-Xuan Yue, Ruofan Ding, Wei-Hao Chen, Lvying Wu, Ke Liu, Zhi‐Liang Ji

Journal of Medical Internet Research

DOI

2024

PhosMap: An ensemble bioinformatic platform to empower interactive analysis of quantitative phosphoproteomics

Mengsha Tong, Zan Liu, Jiaao Li, Xin Lan Wei, Wenhao Shi, Chenyu Liang, Chunyu Yu, Rongting Huang, Yuxiang Lin, Xinkang Wang, Shun Wang, Yi Wang, Jialiang Huang, Yini Wang, Tingting Li, Jun Qin, Dongdong Zhan, Zhi‐Liang Ji

Computers in Biology and Medicine

DOI

2024

SperMD: the expression atlas of sperm maturation

Yifan Li, Qianying Li, Lvying Wu, Haiyan Wang, Hui Min Shi, Chenhui Yang, Yiqun Gu, Jianyuan Li, Zhi‐Liang Ji

BMC Bioinformatics

DOI

2023

An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

Zeshuai Wang, Zhisheng Wu, Hao Wang, Ruoqing Feng, Guanlin Wang, Muxi Li, Shuang-Yin Wang, Xiaoyan Chen, Yiyi Su, Jun Wang, Weiwen Zhang, Yuzhou Bao, Zhenwei Lan, Zhuo Song, Yiheng Wang, Xianyang Luo, Lingyu Zhao, Anli Hou, Shuye Tian, Hongliang Gao, Wenbin Miao, Yingyu Liu, Huilin Wang, Yin Cui, Zhi‐Liang Ji, Mingqian Feng, Hongkun Liu, Lianghui Diao, Ido Amit, Yun Chen, Yong Zeng, Florent Ginhoux, Xueqing Wu, Yuanfang Zhu, Hanjie Li

Cell

DOI

2023

ROS-induced oxidative stress is a major contributor to sperm cryoinjury

Hui Shi, Qian-Ying Li, Hui Li, Hai-Yan Wang, Chuan-Xi Fan, Qiaoyan Dong, Bochen Pan, Zhi‐Liang Ji, Jianyuan Li

Human Reproduction

DOI

2023

TransIntegrator: capture nearly full protein-coding transcript variants via integrating Illumina and PacBio transcriptomes

Zhe Lin, Yangmei Qin, Hao Chen, Dan Shi, Mindong Zhong, Te An, Linshan Chen, Yiquan Wang, Fan Lin, Guang Li, Zhi‐Liang Ji

Briefings in Bioinformatics

DOI

2022

The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice

Sixian Wu, Xiaoliang Li, Lijun Shang, Lvying Wu, Tongtong Li, Peiyv Li, Zhi‐Liang Ji, Jian-Wen Hou, Mingzhu Yin, Wenming Xu

Acta Biochimica et Biophysica Sinica

DOI

2022

Discovering Innate Driver Variants for Risk Assessment of Early Colorectal Cancer Metastasis

Ruofan Ding, Yun Zhang, Lvying Wu, Pan You, Zanxi Fang, Zhiyuan Li, Zhongying Zhang, Zhi‐Liang Ji

Frontiers in Oncology

DOI

2022

Acid‐Responsive Dual‐Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder

Xueqin He, Jiang Xie, Jing Zhang, Xiaorong Wang, Xufeng Jia, Heng Yin, Zhongqing Qiu, Zhihang Yang, Jiao Chen, Zhi‐Liang Ji, Wenqi Yu, Meiwan Chen, Wenming Xu, Huile Gao

Advanced Science

DOI

2022

Filamin A Is a Potential Driver of Breast Cancer Metastasis via Regulation of MMP-1

Jie Zhou, Lvying Wu, Pengyan Xu, Yue Li, Zhi‐Liang Ji, Xinmei Kang

Frontiers in Oncology

DOI

2022

Determination of the Amino Acid Recruitment Order in Early Life by Genome-Wide Analysis of Amino Acid Usage Bias

Mingxiao Zhao, Ruofan Ding, Yan Liu, Zhi‐Liang Ji, Yufen Zhao

Biomolecules

DOI

2022

Construction of integrative transcriptome to boost systematic exploration of Bougainvillea

Qi Luo, Ziliang Chen, Tingting Xu, Dangzheng Huang, Haitao Hou, Chenjie Hong, Fulin Zhan, Hangqi Guo, Zhe Lin, Xiao-Ling Guo, Liang Chen, Zhi‐Liang Ji

Scientific Reports

DOI

2021

Untangling ITS2 genotypes of algal symbionts in zooxanthellate corals

Tuo Shi, Gaofeng Niu, Hagit Kvitt, Xinqing Zheng, Qiaoyun Qin, Danye Sun, Zhiliang Ji, Dan Tchernov

Molecular Ecology Resources，Vol. 210, No. 10

DOI

2021

Loss-of-function missense variant ofAKAP4induced male infertility through reduced interaction with QRICH2 during sperm flagella development

Guohui Zhang, Dongyan Li, Chaofeng Tu, Lanlan Meng, Yue‐Qiu Tan, Zhi‐Liang Ji, Jiao Cheng, Guangxiu Lu, Ge Lin, Huan Zhang, Jin‐Peng Sun, Ming‐Wei Wang, Juan Du, Wenming Xu

Human Molecular Genetics

DOI

2021

Segmental duplication as potential biomarkers for non-invasive prenatal testing of aneuploidies

Xinwen Chen, Yifan Li, Qiuying Huang, Xingming Lin, Xudong Wang, Wang Yf, Ying Liu, Qiushun He, Yinghua Liu, Ting Wang, Zhi‐Liang Ji, Qingge Li

EBioMedicine

DOI

2021

Gene network analyses unveil possible molecular basis underlying drug-induced glaucoma

Ruofan Ding, Qian Yu, Ke Liu, Juan Du, Hua-Jun Yin, Zhi‐Liang Ji

BMC Medical Genomics

DOI

2021

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates

Yunfei Xu, Xu Chen, Zhao Yang, Peng Xiao, Chunhua Liu, Kangshuai Li, Xiaozhen Yang, Yijing Wang, Zhongliang Zhu, Zhigang Xu, Sheng Zhang, Chuan Wang, Youchen Song, Wei‐Dong Zhao, Changhe Wang, Zhi‐Liang Ji, Zhong‐Yin Zhang, Min Cui, Jin‐Peng Sun, Xiao Yu

EMBO Reports

DOI

2021

Exploring the mechanism of PingTang No.5 capsule on nonalcoholic fatty liver disease through network pharmacology and experimental validation

Tzu-Chieh Hung, Nengjiang Zhao, Caoxin Huang, Suhuan Liu, Tao Liu, Wenfang Huang, Xiangbin Xu, Zhi‐Liang Ji, Shuyu Yang

Biomedicine & Pharmacotherapy

DOI

2020

Paradoxical Mitophagy Regulation by PINK1 and TUFm

Jingjing Lin, Kai Chen, Wenfeng Chen, Yizhou Yao, Shiwei Ni, Meina Ye, Gui‐Feng Zhuang, Minhuang Hu, Jun Gao, Caixi Gao, Yan Liu, Mingjuan Yang, Zhenkun Zhang, Xiaohui Zhang, Jiexiang Huang, Fei Chen, Ling V. Sun, Xi Zhang, Suhong Yu, Yuling Chen, Yating Jiang, Shujuan Wang, Xiaozhen Yang, Ke Liu, Hai‐Meng ZHOU, Zhi‐Liang Ji, Haiteng Deng, M. Emdadul Haque, Jun‐Xiang Li, Li-Zhi Mi, Yuexi Li, Yufeng Yang

Molecular Cell

DOI

2019

Broad‐Spectrum Profiling of Drug Safety via Learning Complex Network

Ke Liu, Ruofan Ding, Han Xu, Yangmei Qin, Qiushun He, Fei Du, Yun Zhang, Lixia Yao, Pan You, Yanping Xiang, Zhi‐Liang Ji

Clinical Pharmacology & Therapeutics

DOI

2019

Large-Scale Target Identification of Herbal Medicine Using a Reverse Docking Approach

Haiping Zhang, Jianbo Pan, Xuli Wu, Zuo Ai-ren, Yanjie Wei, Zhi‐Liang Ji

ACS Omega

DOI

2019

Deep sequencing reveals microRNA signature is altered in the rat epididymis following bilateral castration

Yan Li, Haiyan Wang, Yangmei Qin, Juan Liu, Ning Li, Zhi‐Liang Ji, Jianyuan Li

Genes & Genomics

DOI

2018

Biophysical characterization and ligand-binding properties of the elongation factor Tu from

Juanjuan Yang, Jing Hong, Luo Ling, Ke Liu, Chun Meng, Zhi‐Liang Ji, Donghai Lin

Acta Biochimica et Biophysica Sinica

DOI

2018

In-silico Antigenicity Determination and Clustering of Dengue Virus Serotypes

Jingxuan Qiu, Yuxuan Shang, Zhi‐Liang Ji, Tianyi Qiu

Frontiers in Genetics

DOI

2018

Detecting Pharmacovigilance Signals Combining Electronic Medical Records With Spontaneous Reports: A Case Study of Conventional Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis

Liwei Wang, Majid Rastegar-Mojarad, Zhi‐Liang Ji, Sijia Liu, Ke Liu, Sungrim Moon, Feichen Shen, Yanshan Wang, Lixia Yao, John M. Davis, Hongfang Liu

Frontiers in Pharmacology

DOI

2017

ADMETNet: The knowledge base of pharmacokinetics and toxicology network

Quan Xu, Ke Liu, Xingming Lin, Yangmei Qin, Linshan Chen, Jiao Cheng, Mindong Zhong, Qiushun He, Yinbo Li, Tingwu Wang, Jianbo Pan, Menglu Peng, Lixia Yao, Zhi‐Liang Ji

Journal of genetics and genomics/Journal of Genetics and Genomics

DOI

2017

ADReCS-Target: target profiles for aiding drug safety research and application

Li-Hong Huang, Qiushun He, Ke Liu, Jiao Cheng, Min-Dong Zhong, Lin-Shan Chen, Li-Xia Yao, Zhi‐Liang Ji

Nucleic Acids Research

DOI

2017

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

Jia Zhang, Suili Wang, Bin Jiang, Lihong Huang, Zhi‐Liang Ji, Xiaotong Li, Huamin Zhou, Aidong Han, Ai Chen, Yanan Wu, Huanhuan Ma, Wentao Zhao, Qingwen Zhao, Changchuan Xie, Xiaoyan Sun, Yanming Zhou, Huiying Huang, Muhammad Suleman, Furong Lin, Lin Zhou, Fang Tian, Meijun Jin, Yana Cai, Nan Zhang, Qinxi Li

Nature Communications

DOI

2017

Evolutionary relationships between seryl-histidine dipeptide and modern serine proteases from the analysis based on mass spectrometry and bioinformatics

Yan Liu, Yinbo Li, Xiang Gao, Yong‐Fei Yu, Xiao-xia Liu, Zhi‐Liang Ji, Yuan Ma, Yanmei Li, Yufen Zhao

Amino Acids

DOI

2017

Meet Our Editorial Board Member

Zhi‐Liang Ji

Protein and Peptide Letters

DOI

2016

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Fuqin Fan, Zhixiang He, Lulu Kong, Qinghua Chen, Quan Yuan, Shihao Zhang, Jinjin Ye, Hao Liu, Xiufeng Sun, Jing Geng, Lunzhi Yuan, Lixin Hong, Xiao Chen, Weiji Zhang, Xihuan Sun, Yunzhan Li, Ping Wang, Lihong Huang, Xinrui Wu, Zhi‐Liang Ji, Qiao Wu, Ningshao Xia, Nathanael S. Gray, Lanfen Chen, Cai‐Hong Yun, Xianming Deng, Dawang Zhou

Science Translational Medicine

DOI

2016

Pattern Genes Suggest Functional Connectivity of Organs

Yangmei Qin, Jianbo Pan, Mei‐Chun Cai, Lixia Yao, Zhi‐Liang Ji

Scientific Reports

DOI

2016

Analysis of the chemical toxicity effects using the enrichment of Gene Ontology terms and KEGG pathways

Lei Chen, Yuhang Zhang, Quan Zou, Chen Chu, Zhi‐Liang Ji

Biochimica et Biophysica Acta (BBA) - General Subjects

DOI

2016

Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A

Shasha Shi, Ke Liu, Yanheng Chen, Shijun Zhang, Juanyu Lin, Chenfang Gong, Quan‐wen Jin, Xiang‐Jiao Yang, Ruichuan Chen, Zhi‐Liang Ji, Aidong Han

Journal of Biological Chemistry

DOI

2016

Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity

Chengyong He, Shengwei Jiang, Haijing Jin, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhi‐Liang Ji, Yu‐Chun Lin, Zhong‐Ning Lin, Gang Liu

Biomaterials

DOI

2015

The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis

Senjie Lin, Shifeng Cheng, Bo Song, Xiao Zhong, Xin Lin, Wujiao Li, Ling Li, Yaqun Zhang, Huan Zhang, Zhi‐Liang Ji, Meichun Cai, Yunyun Zhuang, Xinguo Shi, Lingxiao Lin, Lu Wang, Zhaobao Wang, Xin Liu, Yu Sheng, Peng Zeng, Han Hao, Quan Zou, Chengxuan Chen, Yanjun Li, Ying Wang, Chunyan Xu, Shanshan Meng, Xun Xu, Jun Wang, Huanming Yang, David A. Campbell, Nancy R. Sturm, Steve Dagenais-Bellefeuille, David Morse

Science

DOI

2015

BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1

Zhenfeng Zhang, Pengfei Ma, Ying Jing, Yan Yan, Mei‐Chun Cai, Meiying Zhang, Shengzhe Zhang, Huixin Peng, Zhi‐Liang Ji, Wen J. Di, Zhenyu Gu, Wei‐Qiang Gao, Guanglei Zhuang

Theranostics

DOI

2015

MVsCarta: A protein database of matrix vesicles to aid understanding of biomineralization

Yazhou Cui, Quan Xu, Jing Yuan Luan, Shichang Hu, Jianbo Pan, Jinxiang Han, Zhi‐Liang Ji

BioScience Trends

DOI

2014

ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms

Mei‐Chun Cai, Quan Xu, Yan-Jing Pan, Wen Pan, Nan Ji, Yin-Bo Li, Hai-Jing Jin, Ke Liu, Zhi‐Liang Ji

Nucleic Acids Research

DOI

2014

Rapid Assessment of Adverse Drug Reactions by Statistical Solution of Gene Association Network

Yanping Xiang, Ke Liu, Xianying Cheng, Cheng Cheng, Fang Gong, Jianbo Pan, Zhi‐Liang Ji

IEEE Transactions on Computational Biology and Bioinformatics

DOI

2014

Network Understanding of Herb Medicine via Rapid Identification of Ingredient-Target Interactions

Haiping Zhang, Jianbo Pan, Chi Zhang, Nan Ji, Hao Wang, Zhi‐Liang Ji

Scientific Reports

DOI

2013

miRClassify: An advanced web server for miRNA family classification and annotation

Quan Zou, Yaozong Mao, Lingling Hu, Yunfeng Wu, Zhi‐Liang Ji

Computers in Biology and Medicine

DOI

2013

PaGenBase: A Pattern Gene Database for the Global and Dynamic Understanding of Gene Function

Jianbo Pan, Shichang Hu, Dan Shi, Mei‐Chun Cai, Yin-Bo Li, Quan Zou, Zhi‐Liang Ji

PLoS ONE

DOI

2013

High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

Jianbo Pan, Nan Ji, Wen Pan, Hong Ru, Hao Wang, Zhi‐Liang Ji

Toxicology and Applied Pharmacology

DOI

2013

Briefing in family characteristics of microRNAs and their applications in cancer research

Qicong Wang, Leyi Wei, Xinjun Guan, Yunfeng Wu, Quan Zou, Zhi‐Liang Ji

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI

2012

PaGeFinder: quantitative identification of spatiotemporal pattern genes

Jianbo Pan, Shichang Hu, Hao Wang, Quan Zou, Zhi‐Liang Ji

Bioinformatics

DOI

2012

A Global Characterization and Identification of Multifunctional Enzymes

Xian-Ying Cheng, Wei-Juan Huang, Shi-Chang Hu, Hailei Zhang, Hao Wang, Jing-Xian Zhang, Honghuang Lin, Yu Chen, Quan Zou, Zhi‐Liang Ji

PLoS ONE

DOI

2011

The GH18 family of chitinases: Their domain architectures, functions and evolutions

Qian‐Sheng Huang, Xiaolan Xie, Ge Liang, Fang Gong, Ye Wang, Xiaoqian Wei, Qin Wang, Zhi‐Liang Ji, Qing‐Xi Chen

Glycobiology

DOI

2010

TiSGeD: a database for tissue-specific genes

Sheng-Jian Xiao, Chi Zhang, Quan Zou, Zhi‐Liang Ji

Bioinformatics

DOI

2010

Genome wide exploration of the origin and evolution of amino acids

Xiaoxia Liu, Jingxian Zhang, Feng Ni, Dong Xu, Bucong Han, Daxiong Han, Zhi‐Liang Ji, Yufen Zhao

BMC Evolutionary Biology

DOI

2008

Evolutionary and Transcriptional Analysis of Karyopherin β Superfamily Proteins

Yu Quan, Zhi‐Liang Ji, Xiao Wang, Alan Michael Tartakoff, Tao Tao

Molecular & Cellular Proteomics

DOI

2007

生物信息学在药物不良反应研究中的应用

王怡，曾雅明，杨淑佳，纪志梁

《中国药学杂志》

2007

DITOP: drug-induced toxicity related protein database

Jingxian Zhang, Weijuan Huang, Jinghua Zeng, Wen-Hui Huang, Yi Wang, Rui Zhao, Bucong Han, Qingfeng Liu, Yu Chen, Zhi‐Liang Ji

Bioinformatics

DOI

2006

细胞核质转运受体Importin β家族与转运调控

王潇，王玉鹏，全宇，纪志梁，陶涛

《中国细胞生物学学报》

2006

生物信息学在免疫学上的应用

黄文晖，纪志梁

《细胞与分子免疫学杂志》

2005

Traditional Chinese medicine information database

Zhi‐Liang Ji, Hufeng Zhou, J.F. Wang, Lianyi Han, C.J. Zheng, Yu Chen

Journal of Ethnopharmacology

DOI

2005

Computer prediction of drug resistance mutations in proteins

Zhiwei Cao, Lianyi Han, Chuxin Zheng, Zhi‐Liang Ji, Xi Chen, Honghuang Lin, Yu Chen

Drug Discovery Today

DOI

2004

Prediction of functional class of novel viral proteins by a statistical learning method irrespective of sequence similarity

Lianyi Han, C.Z. Cai, Zhi‐Liang Ji, Yu Chen

Virology

DOI

精选作品

期刊论文

Star-Shaped Multivalent Molecular Scavengers for Neutrophil Extracellular Trap-Associated Chromatin Neutralization and Sepsis Treatment

Quantitative and interface-aware prediction of peptide–protein interactions by VITAL

GenART: Reading the genome’s language with adaptive “words”

TiSMeD: A tissue-specific methylation and expression database for biomarker and translational applications

From parents to offspring: a comprehensive review of antidepressant-linked reproductive risks

Resiquimod‐Induced Nanovaccine (RINV) for Personalized Cancer Immunotherapy

CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice

Nphos: Database and Predictor of Protein N -phosphorylation

Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI

Mining Real-World Big Data to Characterize Adverse Drug Reaction Quantitatively: Mixed Methods Study

PhosMap: An ensemble bioinformatic platform to empower interactive analysis of quantitative phosphoproteomics

SperMD: the expression atlas of sperm maturation

An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

ROS-induced oxidative stress is a major contributor to sperm cryoinjury

TransIntegrator: capture nearly full protein-coding transcript variants via integrating Illumina and PacBio transcriptomes

The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice

Discovering Innate Driver Variants for Risk Assessment of Early Colorectal Cancer Metastasis

Acid‐Responsive Dual‐Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder

Filamin A Is a Potential Driver of Breast Cancer Metastasis via Regulation of MMP-1

Determination of the Amino Acid Recruitment Order in Early Life by Genome-Wide Analysis of Amino Acid Usage Bias

Construction of integrative transcriptome to boost systematic exploration of Bougainvillea

Untangling ITS2 genotypes of algal symbionts in zooxanthellate corals

Loss-of-function missense variant ofAKAP4induced male infertility through reduced interaction with QRICH2 during sperm flagella development

Segmental duplication as potential biomarkers for non-invasive prenatal testing of aneuploidies

Gene network analyses unveil possible molecular basis underlying drug-induced glaucoma

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates

Exploring the mechanism of PingTang No.5 capsule on nonalcoholic fatty liver disease through network pharmacology and experimental validation

Paradoxical Mitophagy Regulation by PINK1 and TUFm

Broad‐Spectrum Profiling of Drug Safety via Learning Complex Network

Large-Scale Target Identification of Herbal Medicine Using a Reverse Docking Approach

Deep sequencing reveals microRNA signature is altered in the rat epididymis following bilateral castration

Biophysical characterization and ligand-binding properties of the elongation factor Tu from

In-silico Antigenicity Determination and Clustering of Dengue Virus Serotypes

Detecting Pharmacovigilance Signals Combining Electronic Medical Records With Spontaneous Reports: A Case Study of Conventional Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis

ADMETNet: The knowledge base of pharmacokinetics and toxicology network

ADReCS-Target: target profiles for aiding drug safety research and application

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

Evolutionary relationships between seryl-histidine dipeptide and modern serine proteases from the analysis based on mass spectrometry and bioinformatics

Meet Our Editorial Board Member

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Pattern Genes Suggest Functional Connectivity of Organs

Analysis of the chemical toxicity effects using the enrichment of Gene Ontology terms and KEGG pathways

Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A

Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity

The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis

BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1

MVsCarta: A protein database of matrix vesicles to aid understanding of biomineralization

ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms

Rapid Assessment of Adverse Drug Reactions by Statistical Solution of Gene Association Network

Network Understanding of Herb Medicine via Rapid Identification of Ingredient-Target Interactions

miRClassify: An advanced web server for miRNA family classification and annotation

PaGenBase: A Pattern Gene Database for the Global and Dynamic Understanding of Gene Function

High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

Briefing in family characteristics of microRNAs and their applications in cancer research

PaGeFinder: quantitative identification of spatiotemporal pattern genes

A Global Characterization and Identification of Multifunctional Enzymes

The GH18 family of chitinases: Their domain architectures, functions and evolutions

TiSGeD: a database for tissue-specific genes

Genome wide exploration of the origin and evolution of amino acids

Evolutionary and Transcriptional Analysis of Karyopherin β Superfamily Proteins

生物信息学在药物不良反应研究中的应用

DITOP: drug-induced toxicity related protein database

细胞核质转运受体Importin β家族与转运调控

生物信息学在免疫学上的应用

Traditional Chinese medicine information database

Computer prediction of drug resistance mutations in proteins

Prediction of functional class of novel viral proteins by a statistical learning method irrespective of sequence similarity

会议论文

重度抑郁症家族致病基因的发现与功能研究

基于全基因组的临床药物不良反应评估

Rapid Drug Safety Assessment in the Big Data Era

The interaction of RKIP and its inhibitors

RKIP抑制剂的筛选与相互作用的研究

Mining Serial Transcriptomes for Modularly Expressed Genes to Aid Dynamic Understanding of Gene Functions

RKIP抑制剂的筛选与相互作用研究

鸦胆子抗癌活性分子机制的网络化分析

利用机器学习方法预测严重药物不良反应-呼吸困难

Prediction of Adverse Drug Reactions via Gene Regulation Network.