贺桂琼｜重庆医科大学｜学者主页

2026

Multi-omics analysis identifies the miR-28a-5p/SerpinA3N/PI3K/AKT axis as a regulator of microglial neuroinflammation and cognitive decline in Alzheimer's disease.

Yue Liu, Ruo-Ting Fu, Chuanhua Ge, Zhi-Min Long, Huai Wang, Guiqiong He

Brain Research Bulletin

2026

Intestinal ERβ loss: a missing link between estrogen deficiency and cognitive impairment

Yueyang Zhao, Huai Wang, Yu Qiu, Qing-Hua Geng, Qianxi Yang, Zhi-Min Long, Yun-Fang Jia, Qing Tang, Dong-Mei Wu, Huarong Yu, Guiqiong He

Genes & Diseases

DOI

2026

HDAC3 in Alzheimer’s Disease: established evidence, unresolved questions, and translational priorities

Jie-Ren Luo, Xueyi Wu, Donglin Jiang, Guiqiong He, Ye-Hong Du

Molecular Biology Reports

DOI

2026

NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer’s disease

Chuanhua Ge, Kun Wang, Hui-dong Tang, Yiling Ke, Huai Wang, Qiang Fu, Yun Xiu, Yong-Zheng Guo, Yun-Fang Jia, Zhi-Min Long, Guiqiong He, Qing Tang

Translational Neurodegeneration

DOI

2025

Integrated transcriptomic and proteomic analysis identifies FBXW7 as a key regulator of tau homeostasis in Alzheimer's disease

Huai Wang, Qianxi Yang, Chuanhua Ge, Jia-Qi Liu, Hemant Mistry, Yun-Fang Jia, Guiqiong He

Journal of Alzheimer's Disease

DOI

2025

The expression profile of type 1 equilibrative nucleoside transporter in aged C57BL/6J mouse brain

Xiaoyi Zhang, Zi-Teng Ma, Ya-Han Jin, Zhi-Min Long, Qing Tang, Guiqiong He, Yun-Fang Jia

Acta Biochimica et Biophysica Sinica

DOI

2025

ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer’s disease

Lilin Yi, Junjie Li, Yan He, Jiaojiao Wang, Maoju Wang, Song Guo, Man Luo, Bin Wu, Mingliang Xu, Qiuyun Tian, Yepeng Fan, Mulan Chen, Boqing Xu, Lei Xia, Weihong Song, Guiqiong He, Yehong Du, Zhifang Dong

Experimental & Molecular Medicine

DOI

2025

Porphyromonas gingivalis and Its Outer Membrane Vesicles Induce Neuroinflammation in Mice Through Distinct Mechanisms

Yu Lan Qiu, Yueyang Zhao, Guiqiong He, Deqin Yang

Immunity Inflammation and Disease

DOI

2024

靶向敲低腺苷转运体1通过降低炎症反应对阿尔茨海默病的保护作用研究

张效源，马子腾，贾云芳，贺桂琼

《陆军军医大学学报》

2024

Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer’s disease in vitro and in vivo

Zhimin Long, Chuanhua Ge, Yueyang Zhao, Yuanjie Liu, Qinghua Zeng, Qing Tang, Zhifang Dong, Guiqiong He

Neural Regeneration Research

DOI

2023

甘草素对去卵巢APP/PS1转基因小鼠肠道菌群的影响

耿清华，赵月阳，贺桂琼，余华荣

《中山大学学报(医学科学版)》

2023

miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mouse model of Alzheimer's disease

Man Luo, Yayan Pang, Junjie Li, Lilin Yi, Bin Wu, Qiuyun Tian, Yan He, Maoju Wang, Lei Xia, Guiqiong He, Weihong Song, Yehong Du, Zhifang Dong

Acta Pharmaceutica Sinica B

DOI

2023

Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer's disease

Jing He, Yuanjie Liu, Junhua Li, Yueyang Zhao, Hanxiao Jiang, Shifang Luo, Guiqiong He

International Journal of Molecular Medicine

DOI

2023

Alterations in expression and localization of POMGNT1 in the APP/PS1 mouse model of Alzheimer's disease

Hanxiao Jiang, Yuxue Feng, Xia Hao, Guiqiong He, Xiaofeng Li

Genes & Diseases

DOI

2023

MKP ‐1 regulates the inflammatory activation of microglia against Alzheimer's disease

Junhua Li, Lin Wang, Qinhua Zeng, Jing He, Qing Tang, Kejian Wang, Guiqiong He

CNS Neuroscience & Therapeutics

DOI

2023

Analysis of the expression and distribution of protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 in the normal adult mouse brain

Hanxiao Jiang, Yuxue Feng, Guiqiong He, Yuanjie Liu, Xiaofeng Li

Frontiers in Neuroanatomy

DOI

2022

中心体相关蛋白激酶7在小鼠中枢神经系统的分布

王琳，曾庆桦，龙志敏，葛传华，贺桂琼

《神经解剖学杂志》

2022

Editorial: The role of astrocyte in vascular aging

Sen Lin, Feng‐Quan Zhou, Jinbo Cheng, Xiang-Dong Sun, Guiqiong He

Frontiers in Aging Neuroscience

DOI

2022

Structure, function, and pathology of Neurexin-3

Rui Zhang, Hanxiao Jiang, Yuanjie Liu, Guiqiong He

Genes & Diseases

DOI

2021

Aβ对阿尔茨海默病模型小鼠脑神经元及小胶质细胞内溶酶体的影响

蒋玲芳，贺桂琼，汪克建，龙志敏

《重庆医科大学学报》

DOI

2021

慢性脑缺血小鼠海马CA1区和视网膜小胶质细胞的动态变化

付珏秀，赵月阳，贺桂琼，骆世芳

《神经解剖学杂志》

2021

β淀粉样蛋白25-35对大鼠星形胶质细胞自噬的影响

肖韵巧，龙志敏，贺桂琼，汪克建

《神经解剖学杂志》

DOI

2021

包含主要协同转运蛋白超家族结构域蛋白2a的研究进展

曾茹，贺桂琼

《生命科学》

DOI

2021

Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone

Mengli Ren, Min Hua Feng, Zhimin Long, Jing Ma, Xuehua Peng, Guiqiong He

Frontiers in Pharmacology

DOI

2021

Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

Yanzhen Li, Yuan-Jie Liu, Wei Zhang, Shi-Fang Luo, Xin Zhou, Guiqiong He

Neural Regeneration Research

DOI

2021

Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice

Min Luo, Qinghua Zeng, Kai Jiang, Yueyang Zhao, Zhimin Long, Yexiang Du, Kejian Wang, Guiqiong He

Genes & Diseases

DOI

2020

二氢杨梅素对APP/PS1转基因小鼠学习记忆和脑内自噬的影响

丁亚，赵月阳，贺桂琼

《神经解剖学杂志》

DOI

2020

Liquiritigenin Decreases Aβ Levels and Ameliorates Cognitive Decline by Regulating Microglia M1/M2 Transformation in AD Mice

Yexiang Du, Min Luo, Yehong Du, Mingliang Xu, Qiuhui Yao, Kejian Wang, Guiqiong He

Neurotoxicity Research

DOI

2020

Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer’s Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance

Yueyang Zhao, Zhimin Long, Ya Lan Ding, Tingting Jiang, Jiajun Liu, Yimin Li, Yuanjie Liu, Xuehua Peng, Kejian Wang, Min Hua Feng, Guiqiong He

Frontiers in Aging Neuroscience

DOI

2019

丙戊酸钠联合雌二醇对去卵巢APP/PS1双转基因小鼠精神行为及神经元的影响

李彦臻，张威，姜婷婷，罗敏，杜烨湘，贺桂琼，骆世芳

《中国细胞生物学学报》

2019

甘草素通过抗炎发挥对阿尔茨海默病的保护作用

杜烨湘，罗敏，冯敏，汪克建，贺桂琼

《免疫学杂志》

DOI

2019

自噬与NLRP3炎症小体激活间的相互作用

曹真睿，贺桂琼，龙志敏

《中国生物化学与分子生物学报》

2019

雌激素缺乏对痴呆小鼠学习记忆及海马区细胞增殖和成熟的影响

罗敏，赵月阳，杜烨湘，李彦臻，贺桂琼，汪克建

《中国细胞生物学学报》

2019

雌激素缺乏加重痴呆小鼠脑内炎症反应的机制初探

罗敏，姜婷婷，杜烨湘，汪克建，贺桂琼

《免疫学杂志》

DOI

2019

MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

Yehong Du, Yexiang Du, Yun Zhang, Zhilin Huang, Min Fu, Junjie Li, Yayan Pang, Peng Lei, Yu Tian Wang, Weihong Song, Guiqiong He, Zhifang Dong

Signal Transduction and Targeted Therapy

DOI

2019

Interaction between autophagy and the NLRP3 inflammasome

Zhenrui Cao, Yanhao Wang, Zhimin Long, Guiqiong He

Acta Biochimica et Biophysica Sinica

DOI

2019

Protein O-linked mannose β1, 2-N-acetylglucosaminyltransferase 1 gene is involved in the pathogenic process of Alzheimer′s disease model mice

Yuxue Feng, Jing Yang, Yang Liu, Guiqiong He, Xiaofeng Li

Chin J Neurol

DOI

2019

Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease

Qinghua Zeng, Zhimin Long, Min Hua Feng, Yueyang Zhao, Shifang Luo, Kejian Wang, Yingxiong Wang, Guang Yang, Guiqiong He

Frontiers in Aging Neuroscience

DOI

2018

甘草素对去卵巢APP/PS1双转基因小鼠的保护作用初探

姚秋会，贺桂琼，骆世芳，徐明亮，徐晓阳

《基因组学与应用生物学》

2018

APP/PS1/LC3三转基因小鼠的构建及其自噬流水平研究

陈婧菲，贺桂琼，龙志敏

《重庆医科大学学报》

2018

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP 3 inflammasome activation in APP / PS 1 transgenic mice

Jie Feng, Jing‐Xue Wang, Yehong Du, Ying Liu, Wei Zhang, Jing‐Fei Chen, Yuanjie Liu, Min Zheng, Kejian Wang, Guiqiong He

CNS Neuroscience & Therapeutics

DOI

2018

Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice

Qiuhui Yao, Min Hua Feng, Bo Yang, Zhimin Long, Shifang Luo, Min Luo, Guiqiong He, Kejian Wang

Acta Biochimica et Biophysica Sinica

DOI

2017

雌激素缺乏通过ERβ/GSK-3β通路加重痴呆小鼠认知损害的机制初探

张威，冯敏，骆世芳，贺桂琼

《重庆医科大学学报》

2017

β淀粉样蛋白及代谢酶类在阿尔茨海默病和糖尿病模型小鼠脑内的表达

刘滢，贺桂琼，覃万翔，罗敏，汪克建

《基础医学与临床》

2017

维持自噬稳态:阿尔茨海默病的防治新策略

龙志敏，贺桂琼

《现代医药卫生》

2017

双氢青蒿素抑制LPS诱导的小胶质细胞炎症反应

覃万翔，罗敏，石英，崔剑，聂发传，骆世芳，贺桂琼，汪克建

《陆军军医大学学报》

2017

二氢杨梅素对APP/PS1转基因小鼠抗炎的作用及其机制初探

丰洁，贺桂琼

《免疫学杂志》

2016

胰淀素在痴呆小鼠和正常小鼠脑内的分布和表达变化

张婷，曾庆桦，刘滢，贺桂琼，汪克建

《陆军军医大学学报》

2016

Gender difference in valproic acid-induced neuroprotective effects on APP/PS1 double transgenic mice modeling Alzheimer's disease

Zhimin Long, Qinghua Zeng, Kejian Wang, Akhilesh Sharma, Guiqiong He

Acta Biochimica et Biophysica Sinica

DOI

2015

丙戊酸钠对APP/PS1双转基因小鼠脑内星形胶质细胞和神经营养因子的影响

龙志敏，赵蕾，贺桂琼

《重庆医科大学学报》

2015

大麻素HU-210对APP/PS转基因小鼠学习记忆及脑内老年斑的影响

骆世芳，汪克建，龙志敏，杜烨鸿，贺桂琼，姜蓉

《重庆医科大学学报》

2015

慢性脑缺血对APP/PS1双转基因小鼠行为学及脑组织形态学的影响

杜烨鸿，王凌晞，姚秋会，贺桂琼，骆世芳，徐明亮

《重庆医科大学学报》

2015

卵巢切除对APP/PS1双转基因小鼠脑内老年斑及自噬的影响

徐明亮，龙志敏，廖娥，钟国超，杜烨鸿，骆世芳，贺桂琼

《解放军医学杂志》

2015

不同年龄段雌性APP/PS1双转基因小鼠脑内病理特征的动态变化

刘刚，廖娥，钟国超，王凌晞，周泽芬，贺桂琼

《重庆医科大学学报》

2015

Hippocampal neurogenesis in the APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer’s disease

Q. Zeng, Min Zheng, T. Zhang, Guiqiong He

Neuroscience

DOI

2015

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase‐3β Signaling Pathway in an Alzheimer's Disease Model

Zhimin Long, Lei Zhao, Rong Jiang, Kejian Wang, Shifang Luo, Min Zheng, Xiao‐Feng Li, Guiqiong He

CNS Neuroscience & Therapeutics

DOI

2014

MKP-1在APP/PS1双转基因小鼠脑内的分布及表达

杜烨鸿，徐明亮，贺桂琼，王凌晞，刘刚，周泽芬，龙志敏

《解放军医学杂志》

2014

慢性脑缺血对小鼠脑内星形胶质细胞的影响

王凌晞，刘刚，贺桂琼，楚亚楠，宋冲，周泽芬，姚秋会

《重庆医科大学学报》

2014

慢性脑缺血模型小鼠视网膜内血管内皮生长因子和胶质纤维酸性蛋白的表达变化

周泽芬，王凌唏，刘刚，龙志敏，骆世芳，贺桂琼，汪克建

《重庆医科大学学报》

2013

梓醇对APP/PS1双转基因小鼠焦虑行为和脑内神经元的影响

宋冲，楚亚楠，贺桂琼，刘刚，王凌晞，周泽芬，姚秋会

《重庆医科大学学报》

2013

反相高效液相色谱法测定小鼠脑中的梓醇

唐直婕，张梦，贺桂琼，宋冲，尚京川

《光谱实验室》

2012

丙戊酸钠对APP/PS1转基因小鼠自主活动及脑形态结构的影响

陈通，龙志敏，汪克建，赵蕾，贺桂琼

《陆军军医大学学报》

2012

丙戊酸钠对APP/PS1双重转基因小鼠脑组织Tau蛋白的影响

赵蕾，龙志敏，贺桂琼，宋冲，楚亚楠

《陆军军医大学学报》

2012

早老素增强子-2在APP/PS1双转基因小鼠脑内的分布及表达

楚亚楠，宋冲，贺桂琼，刘刚，王凌晞，周泽芬

《陆军军医大学学报》

2012

Localization of gamma‐secretase subunit Aph‐1 in the central nervous system of Alzheimer's disease mouse model

Guiqiong He, Shanquan Sun

The FASEB Journal

DOI

2012

Distribution of Nicastrin in the central nervous system of APP/PS1 double transgenic mice

Shifang Luo, Guiqiong He

The FASEB Journal

DOI

2012

Valproic acid attenuates neuronal apoptosis in APP/PS1 transgenic Alzheimer′s disease mice model

Guiqiong He, Lei Zhao

The FASEB Journal

DOI

2011

蛋白酶体抑制剂处理神经细胞系后Nicastrin的表达变化及其与Aβ的关系

龙志敏，赵蕾，骆世芳，汪克建，贺桂琼

《基础医学与临床》

2011

丙戊酸钠对APP/PS1双重转基因AD模型小鼠脑内老年斑和神经元的影响

龙志敏，赵蕾，高宝兵，汪克建，贺桂琼

《中国神经精神疾病杂志》

2010

蛋白酶体抑制剂对神经细胞nicastrin表达的影响

骆世芳，龙志敏，高宝兵，汪克建，贺桂琼

《中国病理生理杂志》

2010

γ-分泌酶组件蛋白Nicastrin的研究进展

龙志敏，贺桂琼

《生命科学》

2007

1. γ-分泌酶中Aph-1和Nicastrin蛋白降解途径的研究 2. 丙戊酸钠对Alzheimer's病的作用研究

贺桂琼

《重庆医科大学》

2006

Control of APP processing and Aβ generation level by BACE1 enzymatic activity and transcription

Yu Li, Weihui Zhou, Yigang Tong, Guiqiong He, Weihong Song

The FASEB Journal

DOI

2006

P3–234: Ubiquitin–proteasome pathway mediates degradation of Aph–1

Hong Qing, Guiqiong He, Weihong Song

Alzheimer s & Dementia

DOI

2006

BACE2, as a novel APP θ‐secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

Xiulian Sun, Guiqiong He, Weihong Song

The FASEB Journal

DOI

精选作品

期刊论文

Multi-omics analysis identifies the miR-28a-5p/SerpinA3N/PI3K/AKT axis as a regulator of microglial neuroinflammation and cognitive decline in Alzheimer's disease.

Intestinal ERβ loss: a missing link between estrogen deficiency and cognitive impairment

HDAC3 in Alzheimer’s Disease: established evidence, unresolved questions, and translational priorities

NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer’s disease

Integrated transcriptomic and proteomic analysis identifies FBXW7 as a key regulator of tau homeostasis in Alzheimer's disease

The expression profile of type 1 equilibrative nucleoside transporter in aged C57BL/6J mouse brain

ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer’s disease

Porphyromonas gingivalis and Its Outer Membrane Vesicles Induce Neuroinflammation in Mice Through Distinct Mechanisms

靶向敲低腺苷转运体1通过降低炎症反应对阿尔茨海默病的保护作用研究

Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer’s disease in vitro and in vivo

甘草素对去卵巢APP/PS1转基因小鼠肠道菌群的影响

miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mouse model of Alzheimer's disease

Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer's disease

Alterations in expression and localization of POMGNT1 in the APP/PS1 mouse model of Alzheimer's disease

MKP ‐1 regulates the inflammatory activation of microglia against Alzheimer's disease

Analysis of the expression and distribution of protein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 in the normal adult mouse brain

中心体相关蛋白激酶7在小鼠中枢神经系统的分布

Editorial: The role of astrocyte in vascular aging

Structure, function, and pathology of Neurexin-3

Aβ对阿尔茨海默病模型小鼠脑神经元及小胶质细胞内溶酶体的影响

慢性脑缺血小鼠海马CA1区和视网膜小胶质细胞的动态变化

β淀粉样蛋白25-35对大鼠星形胶质细胞自噬的影响

包含主要协同转运蛋白超家族结构域蛋白2a的研究进展

Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone

Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

Estrogen deficiency exacerbates learning and memory deficits associated with glucose metabolism disorder in APP/PS1 double transgenic female mice

二氢杨梅素对APP/PS1转基因小鼠学习记忆和脑内自噬的影响

Liquiritigenin Decreases Aβ Levels and Ameliorates Cognitive Decline by Regulating Microglia M1/M2 Transformation in AD Mice

Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer’s Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance

丙戊酸钠联合雌二醇对去卵巢APP/PS1双转基因小鼠精神行为及神经元的影响

甘草素通过抗炎发挥对阿尔茨海默病的保护作用

自噬与NLRP3炎症小体激活间的相互作用

雌激素缺乏对痴呆小鼠学习记忆及海马区细胞增殖和成熟的影响

雌激素缺乏加重痴呆小鼠脑内炎症反应的机制初探

MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

Interaction between autophagy and the NLRP3 inflammasome

Protein O-linked mannose β1, 2-N-acetylglucosaminyltransferase 1 gene is involved in the pathogenic process of Alzheimer′s disease model mice

Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease

甘草素对去卵巢APP/PS1双转基因小鼠的保护作用初探

APP/PS1/LC3三转基因小鼠的构建及其自噬流水平研究

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP 3 inflammasome activation in APP / PS 1 transgenic mice

Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice

雌激素缺乏通过ERβ/GSK-3β通路加重痴呆小鼠认知损害的机制初探

β淀粉样蛋白及代谢酶类在阿尔茨海默病和糖尿病模型小鼠脑内的表达

维持自噬稳态:阿尔茨海默病的防治新策略

双氢青蒿素抑制LPS诱导的小胶质细胞炎症反应

二氢杨梅素对APP/PS1转基因小鼠抗炎的作用及其机制初探

胰淀素在痴呆小鼠和正常小鼠脑内的分布和表达变化

Gender difference in valproic acid-induced neuroprotective effects on APP/PS1 double transgenic mice modeling Alzheimer's disease

丙戊酸钠对APP/PS1双转基因小鼠脑内星形胶质细胞和神经营养因子的影响

大麻素HU-210对APP/PS转基因小鼠学习记忆及脑内老年斑的影响

慢性脑缺血对APP/PS1双转基因小鼠行为学及脑组织形态学的影响

卵巢切除对APP/PS1双转基因小鼠脑内老年斑及自噬的影响

不同年龄段雌性APP/PS1双转基因小鼠脑内病理特征的动态变化

Hippocampal neurogenesis in the APP/PS1/nestin-GFP triple transgenic mouse model of Alzheimer’s disease

Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase‐3β Signaling Pathway in an Alzheimer's Disease Model

MKP-1在APP/PS1双转基因小鼠脑内的分布及表达

慢性脑缺血对小鼠脑内星形胶质细胞的影响

慢性脑缺血模型小鼠视网膜内血管内皮生长因子和胶质纤维酸性蛋白的表达变化

梓醇对APP/PS1双转基因小鼠焦虑行为和脑内神经元的影响

反相高效液相色谱法测定小鼠脑中的梓醇

丙戊酸钠对APP/PS1转基因小鼠自主活动及脑形态结构的影响

丙戊酸钠对APP/PS1双重转基因小鼠脑组织Tau蛋白的影响

早老素增强子-2在APP/PS1双转基因小鼠脑内的分布及表达

Localization of gamma‐secretase subunit Aph‐1 in the central nervous system of Alzheimer's disease mouse model

Distribution of Nicastrin in the central nervous system of APP/PS1 double transgenic mice

Valproic acid attenuates neuronal apoptosis in APP/PS1 transgenic Alzheimer′s disease mice model

蛋白酶体抑制剂处理神经细胞系后Nicastrin的表达变化及其与Aβ的关系

丙戊酸钠对APP/PS1双重转基因AD模型小鼠脑内老年斑和神经元的影响

蛋白酶体抑制剂对神经细胞nicastrin表达的影响

γ-分泌酶组件蛋白Nicastrin的研究进展

1. γ-分泌酶中Aph-1和Nicastrin蛋白降解途径的研究 2. 丙戊酸钠对Alzheimer's病的作用研究

Control of APP processing and Aβ generation level by BACE1 enzymatic activity and transcription

P3–234: Ubiquitin–proteasome pathway mediates degradation of Aph–1

BACE2, as a novel APP θ‐secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

会议论文

NEK7 mediates neuroinflammation and cognitive impairment in Alzheimer's disease via NLRP3/Caspase-1/IL-1β signaling pathway

雌激素缺乏对痴呆小鼠脑内葡萄糖代谢及学习记忆影响的机制研究