赵昌明｜武汉大学｜学者主页

期刊论文

2026

麦角硫因的“三重奏”抗氧化作用机制

崔雨婷，赵昌明

《中国抗生素杂志》

2024

Substrate-Dependent Mechanism Switch in the Desaturation Reactions of the Mononuclear Nonheme Iron Enzyme PtlD

Linyue Chen, Linyue Chen, Qian Deng, Tingting Ma, Jiayue Gu, Juan Yang, Xuan Zhang, You‐Quan Zou, Zixin Deng, Li Chen, Li Chen, Changming Zhao

ACS Catalysis

DOI

2023

Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis

Li Chen, Liping Zhang, Xujun Ye, Zixin Deng, Changming Zhao

Protein & Cell

DOI

2021

磺胺类和氨基磺酸类活性天然产物氮硫键生物合成研究进展

张莉萍，赵昌明

《中国抗生素杂志》

DOI

2021

Nitrogen–Nitrogen Bond Formation Reactions Involved in Natural Product Biosynthesis

Linyue Chen, Zixin Deng, Changming Zhao

ACS Chemical Biology

DOI

2020

Single-Step Replacement of an Unreactive C–H Bond by a C–S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis

Ronghai Cheng, Lian Wu, Rui Lai, Chao Peng, Nathchar Naowarojna, Weiyao Hu, Xin‐Hao Li, Stephen A. Whelan, Norman Lee, Juan Lopez, Changming Zhao, Youhua Yong, Jiahui Xue, Xuefeng Jiang, Mark W. Grinstaff, Zixin Deng, Jie‐Sheng Chen, Qiang Cui, Jiahai Zhou, Pinghua Liu

ACS Catalysis

DOI

2019

Biochemical Characterization of a Multifunctional Mononuclear Nonheme Iron Enzyme (PtlD) in Neopentalenoketolactone Biosynthesis

Qian Deng, Liu Yang, Linyue Chen, Meiling Xu, Nathchar Naowarojna, Norman Lee, Li Chen, Dongqing Zhu, Xuechuan Hong, Zixin Deng, Pinghua Liu, Changming Zhao

Organic Letters

DOI

2018

Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C–S Bond Formation

Li Chen, Nathchar Naowarojna, Heng Song, Shu Wang, Jiangyun Wang, Zixin Deng, Changming Zhao, Pinghua Liu

Journal of the American Chemical Society

DOI

2018

Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production

Qian Deng, Liqiongzi Xiao, Yang Liu, Lixin Zhang, Zixin Deng, Changming Zhao

Synthetic and Systems Biotechnology

DOI

2018

Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr)

Li Chen, Nathchar Naowarojna, Bin Chen, Meiling Xu, Melissa Quill, Jiangyun Wang, Zixin Deng, Changming Zhao, Pinghua Liu

ACS Catalysis

DOI

2018

Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis

Nathchar Naowarojna, Ronghai Cheng, Li Chen, Melissa Quill, Meiling Xu, Changming Zhao, Pinghua Liu

Biochemistry

DOI

2017

Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers

Qian Deng, Li Zhou, Meizhong Luo, Zixin Deng, Changming Zhao

Synthetic and Systems Biotechnology

DOI

2016

米贝链霉菌DSM41911的米尔贝霉素生物合成的初步研究

吕振斌，曾小东，田孝东，赵昌明，虞沂，段建利，邓子新

《微生物学杂志》

2016

Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins

Mi Li, Li Chen, Zixin Deng, Changming Zhao

FEBS Open Bio

DOI

2015

Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola

Li chen, Pin li, Zixin Deng, Changming Zhao

Scientific Reports

DOI

2014

膦酸天然产物中碳磷键生物合成机制的研究进展

王茜，赵昌明

《生物资源》

2014

Mining of the Pyrrolamide Antibiotics Analogs in Streptomyces netropsis Reveals the Amidohydrolase-Dependent “Iterative Strategy” Underlying the Pyrrole Polymerization

Chunlin Hao, Sheng Huang, Zixin Deng, Changming Zhao, Yi Yu

PLoS ONE

DOI

2013

Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection

Bradley S. Evans, Changming Zhao, Jiangtao Gao, Courtney M. Evans, Kou‐San Ju, James R. Doroghazi, Wilfred A. van der Donk, Neil L. Kelleher, William W. Metcalf

ACS Chemical Biology

DOI

2008

Zwittermicin A合成基因簇中腺苷酰化功能域的预测、表达与活性验证

宋春旭，赵昌明，喻子牛，孙明

《微生物学报》

会议论文

2008

苏云金芽胞杆菌中两种非蛋白质杀虫物质的生物合成途径

赵昌明，刘晓艳，罗毅，宋春旭，阮丽芳，喻子牛，孙明

《中国微生物学会《第二届全国农业微生物研究及产业化研讨会》和《第十一届全国杀虫微生物学术研讨会》暨《湖北省暨武汉市微生物学会和内蒙古微生物学会2008年会》》

2007

2，3-二氨基丙酸是Zwittermicin A生物合成的直接前体物之一

赵昌明，宋春旭，阮丽芳，喻子牛，孙明

《“环境与健康”学术研讨会论文摘要集》

2006

三个Zwittermicin A生物合成相关基因的克隆与分析

赵昌明，罗毅，宋春旭，曾慧，喻子牛，孙明

《第十届全国杀虫微生物学术研讨会暨全国生物农药与化学生物学研究与产业化会议》

2006

Zwittermicin A生物合成相关基因的克隆与功能分析

赵昌明，罗毅，宋春旭，曾慧，喻子牛，孙明

《2006中国微生物学会第九次全国会员代表大会暨学术年会》

2006

蜡状芽胞杆菌群中Zwittermicin A生物合成相关基因的克隆与分析

赵昌明，罗毅，宋春旭，曾慧，喻子牛，孙明

《第二届中国青年学者微生物遗传学学术研讨会论文集》

赵昌明

精选作品

期刊论文

麦角硫因的“三重奏”抗氧化作用机制

Substrate-Dependent Mechanism Switch in the Desaturation Reactions of the Mononuclear Nonheme Iron Enzyme PtlD

Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis

磺胺类和氨基磺酸类活性天然产物氮硫键生物合成研究进展

Nitrogen–Nitrogen Bond Formation Reactions Involved in Natural Product Biosynthesis

Single-Step Replacement of an Unreactive C–H Bond by a C–S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis

Biochemical Characterization of a Multifunctional Mononuclear Nonheme Iron Enzyme (PtlD) in Neopentalenoketolactone Biosynthesis

Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C–S Bond Formation

Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production

Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr)

Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis

Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers

米贝链霉菌DSM41911的米尔贝霉素生物合成的初步研究

Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins

Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola

膦酸天然产物中碳磷键生物合成机制的研究进展

Mining of the Pyrrolamide Antibiotics Analogs in Streptomyces netropsis Reveals the Amidohydrolase-Dependent “Iterative Strategy” Underlying the Pyrrole Polymerization

Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection

Zwittermicin A合成基因簇中腺苷酰化功能域的预测、表达与活性验证

会议论文

苏云金芽胞杆菌中两种非蛋白质杀虫物质的生物合成途径

2，3-二氨基丙酸是Zwittermicin A生物合成的直接前体物之一

三个Zwittermicin A生物合成相关基因的克隆与分析

Zwittermicin A生物合成相关基因的克隆与功能分析

蜡状芽胞杆菌群中Zwittermicin A生物合成相关基因的克隆与分析

研究方向