百晓学者学者目录

刘相国

博导、教授、研究员，山东大学

精选作品

期刊论文

2026

Engrailed-1 in eccrine sweat gland development and regeneration: from evolutionary innovation to therapeutic perspectives

Lei Zhang, Zi-Zhen Zhang, Jia-Qi Cheng, Jun-Hong Zhao, Yan-Yi Xing, Xiangguo Liu, Li-Hong Peng, Si-Xun Wu, Hai-Hong Li

Frontiers in Cell and Developmental Biology

DOI

2026

A scalable gelatin sponge-based 3D culture platform for human umbilical cord mesenchymal stem cell-derived conditioned medium promotes hair follicle regeneration

Yong-Jing Yan, Xiangguo Liu, Jun-Hong Zhao, Cang-Yu Wang, Lei Zhang, Hai-Hong Li

European Journal of Medical Research

DOI

2025

BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells

Yu Wang, Ning Mu, Xinke Wang, Jianhao Liu, Yi-Qing Qu, Xiangguo Liu, Ling Su

Cell Communication and Signaling

DOI

2023

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells

Limei Xu, Feifei Shi, Yingdi Wu, S. Yao, Yingying Wang, Xukai Jiang, L. Su, Xiangguo Liu

Cell Communication and Signaling

DOI

2023

Epithelial polarity-driven membrane separation but not cavitation regulates lumen formation of rat eccrine sweat glands.

Zixiu Chen, Jun-Hong Zhao, Cang-Yu Wang, Xiangguo Liu, Zihua Chen, Jianda Zhou, Lei Zhang, Cuiping Zhang, Hai-Hong Li

Acta Histochemica

DOI

2023

Sharing Weal and Woe: A Commentary on “Gasdermin E Regulates the Stability and Activation of EGFR in Human Non-Small Cell Lung Cancer Cells”

Limei Xu, Xiangguo Liu

Journal of cellular immunology

DOI

2023

NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway

Qi Wu, Huijiang Zhang, Shengjie You, Zhaoyu Xu, Xiangguo Liu, Xue-Dong Chen, Wei-Li Zhang, Junjie Ye, Peng Li, Xiaoqing Zhou

Environmental Toxicology

DOI

2023

DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells

Yingying Wang, Minli Wei, Min Su, Zhiyuan Du, Jia-Xi Dong, Yu Zhang, Yingdi Wu, Xiaopeng Li, L. Su, Xiangguo Liu

iScience

DOI

2023

Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells

Ning Mu, Yu Wang, Xiaopeng Li, Zhiyuan Du, Yingdi Wu, Min Su, Yingying Wang, Xiaoyang Sun, Ling Su, Xiangguo Liu

Cell Death and Disease

DOI

2022

lncRNA CYTOR promotes aberrant glycolysis and mitochondrial respiration via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma

Wei-Wen Zhu, Jie Wang, Xiangguo Liu, Yan-Bin Xu, Run Zhai, Jiayi Zhang, Meng-Qi Wang, Meng-Yao Wang, Laikui Liu

Cell Death and Disease

DOI

2022

Autophagy, not apoptosis, plays a role in lumen formation of eccrine gland organoids

Lijie Du, Lei Zhang, Jun-Hong Zhao, Zixiu Chen, Xiangguo Liu, Manxiu Cao, Lei You, Yonghong Zhang, Xiao-Bing Fu, Hai-Hong Li

Chinese Medical Journal

DOI

2022

Foxa1 mediates eccrine sweat gland development through transcriptional regulation of Na-K-ATPase expression

Jun-Hong Zhao, Lei Zhang, Lijie Du, Zixiu Chen, Yue Tang, Lijun Chen, Xiangguo Liu, Lei You, Yong-Hong Zhang, Xiao-Bo Fu, Hai-Hong Li

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

DOI

2022

Ferroptosis in osteosarcoma: A promising future

Xiangguo Liu, S. Du, Sheng-Dong Wang, Kai-Shan Ye

Frontiers in Oncology

DOI

2022

SENP1 inhibition suppresses the growth of lung cancer cells through activation of A20-mediated ferroptosis

Chuancheng Gao, F. Xiao, Lin Zhang, Yang Sun, Lei Wang, Xiangguo Liu, Huiyan Sun, Z. Xie, Yaqin Liang, Qinqin Xu, Lisheng Wang

Annals of Translational Medicine

DOI

2022

Differential antigen expression between human apocrine sweat glands and eccrine sweat glands

Manxiu Cao, Lei Zhang, Jia-Qi Cheng, Cang-Yu Wang, Jun-Hong Zhao, Xiangguo Liu, Yong-Jing Yan, Yue Tang, Zixiu Chen, Hai-Hong Li

European Journal of Histochemistry

DOI

2021

Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells

Xiaopeng Li, Guilin Ma, Wen-Wen Guo, N. Mu, Yingying Wang, Xiangguo Liu, L. Su

Cell Communication and Signaling

DOI

2020

YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells

Yingying Wang, Sen Guo, Dongmei Li, Yong-Kang Tang, Lei Li, L. Su, Xiangguo Liu

Cell Death and Disease

DOI

2020

The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells

Yu Wang, Qingguo Sun, N. Mu, Xiaoyang Sun, Yingying Wang, Song-Qing Fan, L. Su, Xiangguo Liu

Cell Communication and Signaling

DOI

2020

The dual functions of α-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells

Qilin Wang, Xiangguo Liu

Cancer Cell International

DOI

2020

Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells.

S. Yao, Feifei Shi, N. Mu, Xiaopeng Li, Guilin Ma, Yingying Wang, Xiaoyang Sun, Xiangguo Liu, L. Su

Cancer Letters

DOI

2020

[Corrigendum] VDAC upregulation and αTAT1-mediated α-tubulin acetylation contribute to tanespimycin-induced apoptosis in Calu-1 cells

Qilin Wang, Xiangguo Liu

Oncology Report

DOI

2019

Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells

N. Mu, Yuan-Jiu Lei, Yu Wang, Yingying Wang, Q. Duan, Guilin Ma, Xiangguo Liu, L. Su

Apoptosis

DOI

2019

Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells.

S. Yao, Feifei Shi, Yingying Wang, Xiaoyang Sun, W. Sun, Yifeng Zhang, Xian-Fang Liu, Xiangguo Liu, L. Su

Cellular Signalling

DOI

2019

Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells

Wentao An, Shun Yao, Xiaoyang Sun, Zhaoyuan Hou, Yidan Lin, Ling Su, Xiangguo Liu

Journal of Experimental & Clinical Cancer Research

DOI

2019

The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells

Mingyue Li, Wentao An, Linyan Xu, Yidan Lin, Ling Su, Xiangguo Liu

Journal of Experimental & Clinical Cancer Research

DOI

2018

MiR‐490‐5p inhibits the metastasis of hepatocellular carcinoma by down‐regulating E2F2 and ECT2

Zheng-Qing Fang, Mao-Chun Li, Yu-Qin Zhang, Xiangguo Liu

Journal of Cellular Biochemistry

DOI

2017

Suppression of LASP-1 attenuates the carcinogenesis of prostatic cancer cell lines: Key role of the NF-κB pathway.

Wen-Dong Sun, Li-Qiang Guo, Guangfeng Shao, Xiangguo Liu, Yong Guan, L. Su, Sheng-Tian Zhao

Oncology Report

DOI

2016

A novel derivative of tetrandrine (H1) induces endoplasmic reticulum stress-mediated apoptosis and prosurvival autophagy in human non-small cell lung cancer cells

Yi-Dan Lin, Yu Wang, Xian-Fang Liu, Jia-cheng Yan, L. Su, Xiangguo Liu

Tumor Biology

DOI

2016

CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells

Zhiyong Liu, Shu-Zhou Chu, S. Yao, Y. Li, Song-Qing Fan, Xiaoyang Sun, L. Su, Xiangguo Liu

OncoTarget

DOI

2016

Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells

Xinghui Yu, Jianya Ling, Xian-Fang Liu, Sen Guo, Yi-Dan Lin, Xiangguo Liu, L. Su

OncoTarget

DOI

2016

Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer.

Mutian Zhang, L. Su, Zhenna Xiao, Xian-Fang Liu, Xiangguo Liu

American Journal of Cancer Research

2016

Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer.

Mutian Zhang, Ling Su, Zhenna Xiao, Xianfang Liu, Xiangguo Liu

PubMed

2015

Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells

Xian-Fang Liu, Sen Guo, Xiangguo Liu, L. Su

Apoptosis

DOI

2015

DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells*

Tianliang Li, L. Su, Yuan-Jiu Lei, Xian-Fang Liu, Yajing Zhang, Xiangguo Liu

Journal of Biological Chemistry

DOI

2015

EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells

J. Cui, Wen-Dong Sun, Xuexi Hao, Min Wei, Xiaonan Su, Yajing Zhang, L. Su, Xiangguo Liu

Cancer Cell International

DOI

2014

Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells

J. Yan, N. Zhong, Guo-Hua Liu, K. Chen, Xiangguo Liu, L. Su, S. Singhal

Cell Death and Disease

DOI

2014

Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells

Xiao-Fei Zhao, Xiangguo Liu, L. Su

Journal of experimental & clinical cancer research : CR

DOI

2014

TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells

Zhenyu Zhang, Xiaohong Liang, Lifen Gao, Hongxin Ma, Xiangguo Liu, Yacheng Pan, Wenjiang Yan, Haixia Shan, Zhaojun Wang, Y H Chen, Chunhong Ma

Oncogene

DOI

2013

The chalcone 2′‐hydroxy‐4′,5′‐dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells

Lina Yang, L. Su, Cong-Mei Cao, Linyan Xu, D. Zhong, Li-Jia Xu, Xiangguo Liu

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology

DOI

2013

Loss of CDH1 up‐regulates epidermal growth factor receptor via phosphorylation of YBX1 in non‐small cell lung cancer cells

Xian-Fang Liu, L. Su, Xiangguo Liu

FEBS Letters

DOI

2013

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells

Tianliang Li, Ling Su, Ning Zhong, Xuexi Hao, Diansheng Zhong, Sunil Kumar Singhal, Xiangguo Liu

Autophagy

DOI

2012

Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells

Guangbo Liu, L. Su, Xuexi Hao, N. Zhong, D. Zhong, S. Singhal, Xiangguo Liu

Journal of Cellular and Molecular Medicine

DOI

2012

PKCδ Regulates Death Receptor 5 Expression Induced by PS-341 through ATF4–ATF3/CHOP Axis in Human Lung Cancer Cells

Linyan Xu, L. Su, Xiangguo Liu

Molecular Cancer Therapeutics

DOI

2012

Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells

Qilin Wang, Wen-Dong Sun, Xuexi Hao, Tian-Liang Li, L. Su, Xiangguo Liu

Cancer Cell International

DOI

2011

Hedgehog信号通路与肿瘤

王琪琳，苏玲，刘相国

《生命的化学》

2011

Death receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells.

L. Su, Guangbo Liu, Xuexi Hao, N. Zhong, D. Zhong, Xiangguo Liu, S. Singhal

European Journal of Cancer

DOI

2010

ERK/Ribosomal S6 Kinase (RSK) Signaling Positively Regulates Death Receptor 5 Expression through Co-activation of CHOP and Elk1*

You-Take Oh, Xiangguo Liu, P. Yue, Su-Min Kang, Jing Chen, J. Taunton, F. Khuri, Shi-Yong Sun

Journal of Biological Chemistry

DOI

2008

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

Yidan Lin, Xiangguo Liu, Ping Yue, Doris M. Benbrook, Kenneth Darrell Berlin, Fadlo Raja Khuri, Shi‐Yong Sun

Molecular Cancer Therapeutics

DOI

2007

Therapeutic potential of the Akt inhibitor perifosine in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for metastatic head and neck cancer.

Yi-Dan Lin, Xiangguo Liu, Z. Chen, P. Yue, S. Lonial, Dong M. Shin, F. Khuri, Shi-Yong Sun

2003

小鼠脾细胞凋亡释放RNA与自身免疫病的相关性

赵文璞，刘相国，王炜，张岩，吕平，张玲，高晓明

《中国生物化学与分子生物学报》

会议论文

2011

ATF4-ATF3-CHOP通路调控DR5诱导肿瘤细胞凋亡

刘广博，苏玲，刘相国

《“细胞活动 生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会论文摘要集》

2009

内质网应激ATF4-CHOP通路上调抗肿瘤药物诱导的DR5表达

苏玲，钟殿胜，刘相国

《第十一届中国细胞生物学学术大会暨2009西安细胞生物学国际会议》

2008

Dimethyl-celecoxib通过CHOP-依赖的DR5的升高和泛素/蛋白酶体介导的c-FLIP的降低来促进TRAIL诱导的非小细胞肺癌细胞凋亡

陈淑珍，刘相国，岳平，Axel H.Schnthal，Fadlo R.Khuri，孙士勇

《第五届中国肿瘤学术大会暨第七届海峡两岸肿瘤学术会议、国际肿瘤细胞与基因治疗学会会议、第二届中日肿瘤介入治疗学术会议论文集》

研究方向

细胞 焦亡、凋亡及自噬的调控 机制

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