方美娟｜厦门大学｜学者主页

2025

Structure-Based Design and Optimization of Bi-Aryl Amide Derivatives as Nur77 Ligands for Nur77-Bcl-2-Dependent Apoptotic Cancer Therapy.

Taige Zhao, Jun Chen, Wen-Bin Hong, Yijing Zhong, Hongsheng Li, Xiaodan Li, Ying-Kun Qiu, Lijuan Wang, Zhen Wu, Xiumin Wang, Xue-Qin Chen, Meijuan Fang

Journal of Medicinal Chemistry

DOI

2025

Corrigendum to "Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl-pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment" [Bioorg. Chem. 162 (2025) 108577].

Xiaohui Chen, Rongna Li, Ying-Kun Qiu, Fanhong Lin, Shu-Tong Chen, Xiaodan Li, Hui Sun, Guan-Min Jiang, Hua Fang, Jingbo Qin, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2025

Design, synthesis, and evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as anti-HCC agents targeting Nur77.

Shengwei Hu, Xiaodan Li, Mingyue Yu, Haofan Zhang, Xiang Wang, Chen Qi, Shiyan Huang, Ziyi Xu, Hongyu Hu, Si-Ming Chen, Meijuan Fang, Jin-Zhang Zeng

Bioorganic chemistry (Print)

DOI

2025

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.

Yin Cao, Sen Huang, Yao-Hui He, Yuxiang Zhang, Si-Mian Chen, Meng-xian Huang, Fengming He, Shu-Tong Chen, Di Wang, Ziyi Yang, Xinwei Zhao, Xiumin Wang, Zhen Wu, Mingtao Ao, Ying-Kun Qiu, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2024

基于激酶的蛋白水解靶向嵌合体研究进展

张宇翔，敖名涛，方美娟，吴振

《黑龙江大学自然科学学报》

2024

Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy

Jun Chen, Taige Zhao, Wen-Bin Hong, Hongsheng Li, Mingtao Ao, Yijing Zhong, Xiao-Y. Chen, Ying-Kun Qiu, Xiumin Wang, Zhen Wu, Tian-Wei Lin, Baicun Li, Xue-Qin Chen, Meijuan Fang

Acta Pharmaceutica Sinica B

DOI

2023

Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy.

Jun Chen, Taige Zhao, Fengming He, Yijing Zhong, Susu Wang, Zi-Qing Tang, Ying-Kun Qiu, Zhanghua Wu, Meijuan Fang

European journal of medicinal chemistry

DOI

2023

Inhibition of Nur77 expression and translocation by compound B6 reduces ER stress and alleviates cigarette smoke-induced inflammation and injury in bronchial epithelial cells

Chenli Chang, Fengming He, Mingtao Ao, Jun Chen, Tao Yu, Wei-Yu Li, Baicun Li, Meijuan Fang, Ting-Lin B. Yang

Frontiers in Pharmacology

DOI

2023

Discovery of new DHA ethanolamine derivatives as potential anti-inflammatory agents targeting Nur77.

H. Fang, Meng-yu Li, Xiu-min Wang, Wei-Zhu Chen, Fengming He, Yi-Ping Zhang, Kaiqiang Guo, Wen-Hui Jin, Baicun Li, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2023

Discovery of 5-(Pyrimidin-2-ylamino)-1H-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer.

Jingbo Qin, Bo-Ning Niu, Xiaohui Chen, Cheng Hu, Sheng Lu, Hongsheng Li, Weihao Liu, Jiayi Li, Zihao Teng, Ying-Huang Yang, Hong-Yu Hu, Yang Xu, Shuaidong Huo, Zhen Wu, Ying-Kun Qiu, Hu Zhou, Meijuan Fang

Journal of Medicinal Chemistry

DOI

2023

The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma

Zhijian Kuang, Kaiqiang Guo, Yin Cao, Meng-Xue Jiang, Chaojie Wang, Qiaoqiong Wu, Guosheng Hu, Mingtao Ao, Mingfeng Huang, Jingbo Qin, Taige Zhao, Sheng Lu, Cui-Ling Sun, Mingyu Li, Tong Wu, Wen Liu, Meijuan Fang

British Journal of Cancer

DOI

2023

Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

Fengming He, Jun Chen, Taige Zhao, Qiaoqiong Wu, Na Yin, Xiu-min Wang, Yijing Zhong, Xiaodan Guo, Ying-Kun Qiu, Baicun Li, Meijuan Fang, Zhanghua Wu

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2023

Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors.

Yuqing Qian, Si-Yu Zhou, Jiayi Li, Mingyuan Ma, H. Chen, Yin Cao, Yuxiang Zhang, Chao Sun, Kang Li, Yi-Zhao Liu, Shutong Dai, Mingtao Ao, Meijuan Fang, Zhen Wu, Ming-Dong Li

European Journal of Pharmacology

DOI

2023

Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling

Haofan Zhang, Fengming He, Guiping Gao, Sheng Lu, Qiaochu Wei, Hong-Yu Hu, Zhanghua Wu, Meijuan Fang, Xiumin Wang

Molecules

DOI

2023

Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the in vivo anti-obesity effect of the DPA-EA and DHA-EA mixture prepared from algae oil

H. Fang, Yin Cao, Jianyu Zhang, Xiu-min Wang, Mengyu Li, Zhuan Hong, Zhanghua Wu, Meijuan Fang

Frontiers in Pharmacology

DOI

2023

Identification and characterization of 7-azaindole derivatives as inhibitors of the SARS-CoV-2 spike-hACE2 protein interaction

Chaojie Wang, Fengming He, Ke Sun, Kaiqiang Guo, Sheng Lu, Tong Wu, Xiang Gao, Meijuan Fang

International Journal of Biological Macromolecules

DOI

2023

Identification of potential ATP-competitive cyclin-dependent kinase 1 inhibitors: De novo drug generation, molecular docking, and molecular dynamics simulation

Fengming He, Xiu-min Wang, Qiaoqiong Wu, Shunzhi Liu, Yin Cao, Xiaodan Guo, S. Yin, Na Yin, Baicun Li, Meijuan Fang

Comput. Biol. Medicine

DOI

2022

The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9

Mingtao Ao, Jun Wu, Yin Cao, Yao-hui He, Yuxiang Zhang, Xiang Gao, Yuhua Xue, Meijuan Fang, Zhanghua Wu

Chinese Chemical Letters

DOI

2022

Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo.

Mingtao Ao, Jianyu Zhang, Yuqing Qian, Boqun Li, Xiumei Wang, Jun Chen, Yuxiang Zhang, Yin Cao, Ying-Kun Qiu, Yang Xu, Zhanghua Wu, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2022

Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77.

Jing-Bo Qin, Xiaohui Chen, Weihao Liu, Jun Chen, Weirong Liu, Yong-Zhen Xia, Zhehui Li, Mingyu Li, Shao-Juan Wang, Quan Yuan, Ying-Kun Qiu, Zhanghua Wu, Meijuan Fang

European journal of medicinal chemistry

DOI

2022

Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma.

Baicun Li, Jian-gang Huang, Jie Liu, Fengming He, Fang-Fang Wen, Changming Yang, Wang Wang, Tong Wu, Taige Zhao, Jie Yao, Shunzhi Liu, Ying-Kun Qiu, Meijuan Fang, Jinzhang Zeng, Zhanghua Wu

Bioorganic chemistry (Print)

DOI

2022

Design, synthesis, and biological evaluation of (E)-N'-substitute-4-((4-pyridylpyrimidin-2-yl)amino)benzohydrazide derivatives as novel potential CDK9 inhibitors

Fengming He, Wang Cong, C. Yin, Chenfan Li, Sheng-Xian Zhao, Zhanghua Wu, Hong-Yu Hu, Meijuan Fang

Arabian Journal of Chemistry

DOI

2022

AI-Aided Design of Novel Targeted Covalent Inhibitors against SARS-CoV-2

Bo-Wen Tang, Fengming He, Dongpeng Liu, Fei He, Tong Wu, Meijuan Fang, Zhangming Niu, Zhanghua Wu, Dong Xu

Biomolecules

DOI

2022

Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors.

Yuqing Qian, Mingtao Ao, Boqun Li, Zhijian Kuang, Xiu-min Wang, Yin Cao, Jiayi Li, Ying-Kun Qiu, Kaiqiang Guo, Meijuan Fang, Zhanghua Wu

Bioorganic chemistry (Print)

DOI

2021

Synthesis, SAR study, and bioactivity evaluation of a series of Quinoline-Indole-Schiff base derivatives: Compound 10E as a new Nur77 exporter and autophagic death inducer.

Baicun Li, Jie Yao, Fengming He, Jie Liu, Zong-Xin Lin, Shunzhi Liu, Wang Wang, Tong Wu, Jian-gang Huang, Kun Chen, Meijuan Fang, Jingwei Chen, Jin-Zhang Zeng

Bioorganic chemistry (Print)

DOI

2021

Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities.

Mingtao Ao, Xian-Wen Hu, Yuqing Qian, Boqun Li, Jianyu Zhang, Yin Cao, Yuxiang Zhang, Kaiqiang Guo, Ying-Kun Qiu, Fuquan Jiang, Zhen Wu, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2021

Synthesis and Antiproliferative Activity of New Thiosemicarboxamide Derivatives

Jun Wu, Ya-Fei Guo, Jun Chen, Sangsang Hu, K. Sun, Hong-Yu Hu, Meijuan Fang, Yuhua Xue

Chemistry and Biodiversity

DOI

2021

Anti-inflammatory sesquiterpenoids from the heartwood of Juniperus formosana Hayata.

Shunzhi Liu, Jianyu Zhang, Fengming He, Wen-Hao Fu, Bowen Tang, Yang Bin, Meijuan Fang, Zhen Wu, Ying-Kun Qiu

Fitoterapia

DOI

2021

Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent

Jun Wu, Hong-Yu Hu, Mingtao Ao, Zhenzhen Cui, Xiaoping Zhou, Jing-Bo Qin, Ya-Fei Guo, Jingwei Chen, Yuhua Xue, Meijuan Fang

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2021

Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1/AMPK/ PPARα pathway via targeting nicotinamide N-methyltransferase.

En-Hui Yao, Xiazhen Yang, Xue-Feng Huang, Yu-Chen Mi, Xiaoqian Wu, Meijuan Fang, Jin-Hua Huang, Yan Qiu, Xiao-Ting Hong, Lu Peng, Jie Ren, Rui Huang, Cai-Xia Chen, Li-Chao Yang, Yu Zhou, Rengong Zhuo, Xin Jin, Yun Zhao

Phytomedicine

DOI

2020

Synthesis and biological evaluation of (3/4-(pyrimidin-2-ylamino)benzoyl)-based hydrazine-1-carboxamide/carbothioamide derivatives as novel RXRα antagonists

Jing-Bo Qin, Jie Liu, Chun-Xiao Wu, Jianwenn Xu, Bowen Tang, Kaiqiang Guo, Xiaohui Chen, Weihao Liu, Tong Wu, Hu Zhou, Meijuan Fang, Zhen Wu

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2020

Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77.

H. Fang, Jianyu Zhang, Mingtao Ao, Fengming He, Wei-Zhu Chen, Yuqing Qian, Yuxiang Zhang, Yang Xu, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2020

Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.

Baicun Li, Jie Yao, Kaiqiang Guo, Fengming He, Kun Chen, Zong-Xin Lin, Shunzhi Liu, Jian-gang Huang, Qiaoqiong Wu, Meijuan Fang, Jinzhang Zeng, Zhen Wu

European journal of medicinal chemistry

DOI

2020

Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors.

Hong-Yu Hu, Jun Wu, Mingtao Ao, Xiaoping Zhou, Boqun Li, Zhenzhen Cui, Tong Wu, L. Wang, Yuhua Xue, Zhen Wu, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2020

Glycine metabolomic changes induced by anticancer agents in A549 cells

Kaiqiang Guo, Yin Cao, Zan Li, Xiaoxiao Zhou, Rong Ding, Kejing Chen, Yan Liu, Ying-Kun Qiu, Zhanghua Wu, Meijuan Fang

Amino Acids

DOI

2020

Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents.

Baicun Li, Fei-Feng Zhu, Fengming He, Qingqing Huang, X. Liu, Tong Wu, Taige Zhao, Ying-Kun Qiu, Zhen Wu, Yuhua Xue, Meijuan Fang

Bioorganic chemistry (Print)

DOI

2020

New cyclopentenoneacrylic acid derivatives from a marine-derived fungus Trichoderma atroviride H548

Xi-Xiang Tang, Shun-Zhi Liu, Yu-Ying Sun, Fengming He, Guangquan Xu, Meijuan Fang, Wu Zhen, Ying-Kun Qiu

Natural Product Research

DOI

2020

A self-attention based message passing neural network for predicting molecular lipophilicity and aqueous solubility

Bowen Tang, Skyler T. Kramer, Meijuan Fang, Ying-Kun Qiu, Zhen Wu, Dong Xu

Journal of Cheminformatics

DOI

2019

4-取代-1-(2-甲基-6-(吡啶-3-基)-烟酰)氨基脲类衍生物合成与生物活性研究（英文）

胡鸿雨，吴俊，袁建锋，王珍妮，李晨帆，严晓阳，方美娟，赵胜贤

《有机化学》

2019

Insights into the stereoselectivity of human SETD7 methyltransferase

Bowen Tang, Baicun Li, Boqun Li, Jing-Bo Qin, Junming Zhao, Jianwenn Xu, Ying-Kun Qiu, Zhanghua Wu, Meijuan Fang

RSC Advances

DOI

2019

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

Xi-Xiang Tang, Shun-Zhi Liu, Xiang-Bo Yan, Bowen Tang, Meijuan Fang, Xiu-min Wang, Zhen Wu, Ying-Kun Qiu

Marine Drugs

DOI

2019

New β-Lactone with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus MCCC3A00957.

Xi-Xiang Tang, Xiang-Bo Yan, Wen-Hao Fu, L. Yi, Bowen Tang, Li-Bo Yu, Meijuan Fang, Zhen Wu, Ying-Kun Qiu

Journal of Agricultural and Food Chemistry

DOI

2019

Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors.

H. Fang, Jian-Lin He, Tan Ran, Hui Chen, Wen-Hui Jin, Bowen Tang, Zhuan Hong, Meijuan Fang

Bioorganic & Medicinal Chemistry

DOI

2018

苯胺基喹唑啉类酪氨酸激酶抑制剂的电喷雾质谱裂解规律

王立强，王凤玲，周玥莹，李赞，高源，吴振，方美娟

《华侨大学学报(自然科学版)》

2018

重组人组织激肽释放酶结合蛋白抗氧化活性及抗凝活性分析

周玥莹，龙莎，方美娟，王立强

《华侨大学学报(自然科学版)》

2018

采用原研制剂制备米诺膦酸片及体外溶出度的一致性考察

宋伟杰，曾皓月，龙莎，王立强，乔凤敏，方美娟

《华侨大学学报(自然科学版)》

2018

Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

Longhe Yang, Han Ouyang, Xiang-Bo Yan, Bowen Tang, Meijuan Fang, Zhen Wu, Jing-wei Chen, Ying-Kun Qiu

Marine Drugs

DOI

2018

Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1

Mingtao Ao, Zhenrui Pan, Yuqing Qian, Bowen Tang, Zeming Feng, H. Fang, Zhen Wu, Jingwei Chen, Yuhua Xue, Meijuan Fang

RSC Advances

DOI

2018

Moringa oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPARα.

Yu Zhou, Wu-Shuang Yang, Zhiqun Li, Doudou Luo, Wei-Jie Li, Ya-Li Zhang, Xuan Wang, Meijuan Fang, Qing Chen, Xin Jin

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2017

pDNA-巯基壳聚糖纳米粒的制备及Box-Behnken效应面法工艺优化

曾皓月，王之，方美娟，王立强

《华侨大学学报(自然科学版)》

2017

吲哚-3-乙醛酰胺类化合物的合成及生物活性研究进展

胡鸿雨，王飞，赵胜贤，方美娟

《合成化学》

2017

Synthesis and biological evaluation of 1-(2-(adamantane-1-yl)-1H-indol-5-yl)-3-substituted urea/thiourea derivatives as anticancer agents

Hong-Yu Hu, Chunrong Lin, Mingtao Ao, Yu-hua Ji, Bowen Tang, Xiaoxiao Zhou, Meijuan Fang, Jin-Zhang Zeng, Zhen Wu

DOI

2017

Development of an on-line mixed-mode gel liquid chromatography×reversed phase liquid chromatography method for separation of water extract from Flos Carthami.

Yu-Qing Wang, Xueyan Tang, Jia-Fu Li, Yun-Long Wu, Yu-Ying Sun, Meijuan Fang, Zhen Wu, Xiu-min Wang, Ying-Kun Qiu

Journal of Chromatography A

DOI

2017

The molecular mechanism of hPPARα activation

Bowen Tang, Boqun Li, Yuqing Qian, Mingtao Ao, Kaiqiang Guo, Meijuan Fang, Zhen Wu

DOI

2017

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

Jun Wu, Mingtao Ao, Rui Shao, Hui-ru Wang, Diao Yu, Meijuan Fang, Xiang Gao, Zhen Wu, Qiang Zhou, Yu-hua Xue

Scientific Reports

DOI

2017

Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment

Xiao-Yan Wang, Xia Yan, Meijuan Fang, Zhen Wu, Dong Wang, Ying-Kun Qiu

Natural Product Research

DOI

2017

hPPARα活性化の分子機構【Powered by NICT】

Bowen Tang, Boqun Li, Yuqing Qian, Mingtao Ao, Kaiqiang Guo, Meijuan Fang, Zhen Wu

2017

The effect of V155M mutation on the complex of hSTING and 2′3′-cGAMP: an in silico study case

Bowen Tang, Baicun Li, Boqun Li, Zan Li, Jing-Bo Qin, Xiaoxiao Zhou, Ying-Kun Qiu, Zhen Wu, Meijuan Fang

DOI

2017

Comprehensive two-dimensional normal-phase liquid chromatography × reversed-phase liquid chromatography for analysis of toad skin.

Jia-Fu Li, Xia Yan, Yun-Long Wu, Meijuan Fang, Zhen Wu, Ying-Kun Qiu

Analytica Chimica Acta

DOI

2016

A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5

Wei Li, Xi-Xiang Tang, Xia Yan, Zhen Wu, Zhi-Wei Yi, Meijuan Fang, Xin Su, Ying-Kun Qiu

Natural Product Research

DOI

2016

Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression

Xia Yan, Yunpin Zhou, Xi-Xiang Tang, Xiu-Xiu Liu, Zhi-Wei Yi, Meijuan Fang, Zhen Wu, Fuhu Jiang, Ying-Kun Qiu

Marine Drugs

DOI

2016

Novel N-Substituted 2-(2-(Adamantan-1-yl)-1H-Indol-3-yl)-2-Oxoacetamide Derivatives: Synthesis and Biological Evaluation

Hong Hu, Xudong Yu, Fei Wang, Chunrong Lin, Jin-Zhang Zeng, Ying-Kun Qiu, Meijuan Fang, Zhen Wu

Molecules

DOI

2016

Synthesis, structure–activity relationship studies and biological evaluation of novel 2,5‐disubstituted indole derivatives as anticancer agents

Hong-Yu Hu, Jun Wu, Mingtao Ao, Hui-ru Wang, Tongtong Zhou, Yuhua Xue, Ying-Kun Qiu, Meijuan Fang, Zhen Wu

Chemical Biology and Drug Design

DOI

2016

Biosynthetic Functional Gene Analysis of Bis-Indole Metabolites from 25D7, a Clone Derived from a Deep-Sea Sediment Metagenomic Library

Xiang-Bo Yan, Xi-Xiang Tang, D. Qin, Zhi-Wei Yi, Meijuan Fang, Zhen Wu, Ying-Kun Qiu

Marine Drugs

DOI

2016

分析及び分取包括的2次元液体クロマトグラフィーの組み合わせによる微生物代謝産物の新しいオンライン分離ワークフロー【Powered by NICT】

Xia Yan, Li-Juan Wang, Zhen Wu, Yun-Long Wu, Xiu-Xiu Liu, F. Chang, Meijuan Fang, Ying-Kun Qiu

2016

New on-line separation workflow of microbial metabolites via hyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography.

Xia Yan, Li-Juan Wang, Zhen Wu, Yun-Long Wu, Xiu-Xiu Liu, F. Chang, Meijuan Fang, Ying-Kun Qiu

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI

2015

Online polar two phase countercurrent chromatography×high performance liquid chromatography for preparative isolation of polar polyphenols from tea extract in a single step.

Wei-Bin Chen, Shu-Qi Li, Long-Jiang Chen, Meijuan Fang, Quan-Cheng Chen, Zhen Wu, Yun-Long Wu, Ying-Kun Qiu

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI

2015

On-line comprehensive two-dimensional normal-phase liquid chromatography × reversed-phase liquid chromatography for preparative isolation of Peucedanum praeruptorum.

Xin-Yuan Wang, Jia-Fu Li, Ya-Mei Jian, Zhen Wu, Meijuan Fang, Ying-Kun Qiu

Journal of Chromatography A

DOI

2015

On-line two-dimensional countercurrent chromatography×high performance liquid chromatography system with a novel fragmentary dilution and turbulent mixing interface for preparation of coumarins from Cnidium monnieri.

Dong Wang, Long-Jiang Chen, Jing-Lan Liu, Xin-Yuan Wang, Yun-Long Wu, Meijuan Fang, Zhen Wu, Ying-Kun Qiu

Journal of Chromatography A

DOI

2015

Corrigendum to "Two-dimensional countercurrent chromatography×high performance liquid chromatography with heart-cutting and stop-and-go techniques for preparative isolation of coumarin derivatives from Peucedanum praeruptorum Dunn" [J. Chromatogr. A 1374 (2014) 156-163].

Jing-Lan Liu, Xin-Yuan Wang, Ling-ling Zhang, Meijuan Fang, Yun-Long Wu, Zhen Wu, Ying-Kun Qiu

Journal of Chromatography A

DOI

2014

Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

Xiang-Bo Yan, Xi-Xiang Tang, Lin Chen, Zhi-Wei Yi, Meijuan Fang, Zhen Wu, Ying-Kun Qiu

Marine Drugs

DOI

2014

Two-dimensional preparative liquid chromatography system for preparative separation of minor amount components from complicated natural products.

Ying-Kun Qiu, Fangfang Chen, Ling-ling Zhang, Xia Yan, Lin Chen, Meijuan Fang, Zhen Wu

Analytica Chimica Acta

DOI

2014

6-[(7-chloroquinoline-4-oxyl) phenolic ether]-2-naphthamide derivative as well as preparation method and application thereof

Fei Wang, Kaiqiang Guo, Jing-Yi Hong, Qiang Ma, Gu-Rao Cha, 古丽娜热哈力木, Meijuan Fang, Zhen Wu

2014

Two-dimensional countercurrent chromatography × high performance liquid chromatography for preparative isolation of toad venom.

Ying-Kun Qiu, Xia Yan, Meijuan Fang, Lin Chen, Zhen Wu, Yu-Fen Zhao

Journal of Chromatography A

DOI

2014

Two-dimensional countercurrent chromatography×high performance liquid chromatography with heart-cutting and stop-and-go techniques for preparative isolation of coumarin derivatives from Peucedanum praeruptorum Dunn.

Jing-Lan Liu, Xin-Yuan Wang, Ling-ling Zhang, Meijuan Fang, Yun-Long Wu, Zhen Wu, Ying-Kun Qiu

Journal of Chromatography A

DOI

精选作品

期刊论文

Structure-Based Design and Optimization of Bi-Aryl Amide Derivatives as Nur77 Ligands for Nur77-Bcl-2-Dependent Apoptotic Cancer Therapy.

Corrigendum to "Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl-pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment" [Bioorg. Chem. 162 (2025) 108577].

Design, synthesis, and evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as anti-HCC agents targeting Nur77.

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma.

基于激酶的蛋白水解靶向嵌合体研究进展

Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy

Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy.

Inhibition of Nur77 expression and translocation by compound B6 reduces ER stress and alleviates cigarette smoke-induced inflammation and injury in bronchial epithelial cells

Discovery of new DHA ethanolamine derivatives as potential anti-inflammatory agents targeting Nur77.

Discovery of 5-(Pyrimidin-2-ylamino)-1H-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer.

The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma

Design, synthesis, and evaluation of novel benzoylhydrazone derivatives as Nur77 modulators with potent antitumor activity against hepatocellular carcinoma

Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors.

Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling

Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the in vivo anti-obesity effect of the DPA-EA and DHA-EA mixture prepared from algae oil

Identification and characterization of 7-azaindole derivatives as inhibitors of the SARS-CoV-2 spike-hACE2 protein interaction

Identification of potential ATP-competitive cyclin-dependent kinase 1 inhibitors: De novo drug generation, molecular docking, and molecular dynamics simulation

The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9

Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo.

Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77.

Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma.

Design, synthesis, and biological evaluation of (E)-N'-substitute-4-((4-pyridylpyrimidin-2-yl)amino)benzohydrazide derivatives as novel potential CDK9 inhibitors

AI-Aided Design of Novel Targeted Covalent Inhibitors against SARS-CoV-2

Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors.

Synthesis, SAR study, and bioactivity evaluation of a series of Quinoline-Indole-Schiff base derivatives: Compound 10E as a new Nur77 exporter and autophagic death inducer.

Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities.

Synthesis and Antiproliferative Activity of New Thiosemicarboxamide Derivatives

Anti-inflammatory sesquiterpenoids from the heartwood of Juniperus formosana Hayata.

Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent

Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1/AMPK/ PPARα pathway via targeting nicotinamide N-methyltransferase.

Synthesis and biological evaluation of (3/4-(pyrimidin-2-ylamino)benzoyl)-based hydrazine-1-carboxamide/carbothioamide derivatives as novel RXRα antagonists

Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77.

Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.

Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors.

Glycine metabolomic changes induced by anticancer agents in A549 cells

Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents.

New cyclopentenoneacrylic acid derivatives from a marine-derived fungus Trichoderma atroviride H548

A self-attention based message passing neural network for predicting molecular lipophilicity and aqueous solubility

4-取代-1-(2-甲基-6-(吡啶-3-基)-烟酰)氨基脲类衍生物合成与生物活性研究（英文）

Insights into the stereoselectivity of human SETD7 methyltransferase

Two New Cytotoxic Compounds from a Deep-Sea Penicillum citreonigrum XT20-134

New β-Lactone with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus MCCC3A00957.

Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors.

苯胺基喹唑啉类酪氨酸激酶抑制剂的电喷雾质谱裂解规律

重组人组织激肽释放酶结合蛋白抗氧化活性及抗凝活性分析

采用原研制剂制备米诺膦酸片及体外溶出度的一致性考察

Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1

Moringa oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPARα.

pDNA-巯基壳聚糖纳米粒的制备及Box-Behnken效应面法工艺优化

吲哚-3-乙醛酰胺类化合物的合成及生物活性研究进展

Synthesis and biological evaluation of 1-(2-(adamantane-1-yl)-1H-indol-5-yl)-3-substituted urea/thiourea derivatives as anticancer agents

Development of an on-line mixed-mode gel liquid chromatography×reversed phase liquid chromatography method for separation of water extract from Flos Carthami.

The molecular mechanism of hPPARα activation

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment

hPPARα活性化の分子機構【Powered by NICT】

The effect of V155M mutation on the complex of hSTING and 2′3′-cGAMP: an in silico study case

Comprehensive two-dimensional normal-phase liquid chromatography × reversed-phase liquid chromatography for analysis of toad skin.

A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5

Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression

Novel N-Substituted 2-(2-(Adamantan-1-yl)-1H-Indol-3-yl)-2-Oxoacetamide Derivatives: Synthesis and Biological Evaluation

Synthesis, structure–activity relationship studies and biological evaluation of novel 2,5‐disubstituted indole derivatives as anticancer agents

Biosynthetic Functional Gene Analysis of Bis-Indole Metabolites from 25D7, a Clone Derived from a Deep-Sea Sediment Metagenomic Library

分析及び分取包括的2次元液体クロマトグラフィーの組み合わせによる微生物代謝産物の新しいオンライン分離ワークフロー【Powered by NICT】

New on-line separation workflow of microbial metabolites via hyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography.

Online polar two phase countercurrent chromatography×high performance liquid chromatography for preparative isolation of polar polyphenols from tea extract in a single step.

On-line comprehensive two-dimensional normal-phase liquid chromatography × reversed-phase liquid chromatography for preparative isolation of Peucedanum praeruptorum.

On-line two-dimensional countercurrent chromatography×high performance liquid chromatography system with a novel fragmentary dilution and turbulent mixing interface for preparation of coumarins from Cnidium monnieri.

Corrigendum to "Two-dimensional countercurrent chromatography×high performance liquid chromatography with heart-cutting and stop-and-go techniques for preparative isolation of coumarin derivatives from Peucedanum praeruptorum Dunn" [J. Chromatogr. A 1374 (2014) 156-163].

Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone

Two-dimensional preparative liquid chromatography system for preparative separation of minor amount components from complicated natural products.

6-[(7-chloroquinoline-4-oxyl) phenolic ether]-2-naphthamide derivative as well as preparation method and application thereof

Two-dimensional countercurrent chromatography × high performance liquid chromatography for preparative isolation of toad venom.

Two-dimensional countercurrent chromatography×high performance liquid chromatography with heart-cutting and stop-and-go techniques for preparative isolation of coumarin derivatives from Peucedanum praeruptorum Dunn.

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