张德楠｜哈尔滨医科大学｜学者主页

2026

Lineage-Specific CagA Binding Mechanics and Microenvironmental Rewiring in East Asian Gastric Carcinogenesis

Hong-Bo Xie, Denan Zhang, Lei Liu, Qing Jin, Xiu-Jie Chen

Molecules

DOI

2026

GRIP-Lung: Generative Model of Response to Drug-Induced Perturbation in Lung Cancer

Zhijin Fu, Yanjiao Li, Z. Du, Denan Zhang, Lei Liu, Qing Jin, Xiu-Jie Chen, Hong-Bo Xie

International Journal of Molecular Sciences

DOI

2026

KAN-PROSPECT: a Kolmogorov–Arnold Networks–integrated framework for predicting the effects and adverse reactions of natural products via transfer learning

Z. Du, Zhijun Wang, Yu Chen, Boyou Li, Xin Wan, Tian-yang Ren, Hao-Wei Chen, Lei Liu, Qing Jin, Yong-Le Zhang, Ya-Nan Zhang, Junge Bai, Hong-Bo Xie, Xiu-Jie Chen, Xuekun Ren, Denan Zhang

Scientific Reports

DOI

2025

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Meizhu Xiao, Zhijin Fu, Yanjiao Li, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Xiu-Jie Chen, Hong-Bo Xie

Discover Oncology

DOI

2024

Predicting drug synergy using a network propagation inspired machine learning framework.

Qing Jin, Xianze Zhang, Di Huo, Hong-Bo Xie, Denan Zhang, Lei Liu, Ya-Shuang Zhao, Xiu-Jie Chen

Briefings in Functional Genomics

DOI

2024

A deep learning drug screening framework for integrating local-global characteristics: A novel attempt for limited data

Ying Wang, Yangguang Su, Kairui Zhao, Di Huo, Z. Du, Zhi-Jun Wang, Hong-Bo Xie, Lei Liu, Qing Jin, Xuekun Ren, Xiu-Jie Chen, Denan Zhang

Heliyon

DOI

2024

Decoding temporal heterogeneity in NSCLC through machine learning and prognostic model construction

Junpeng Cheng, Meizhu Xiao, Qing-Kang Meng, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Zhijin Fu, Yanjiao Li, Xiu-Jie Chen, Hong-Bo Xie

World Journal of Surgical Oncology

DOI

2024

DAPredict: a database for drug action phenotype prediction

Qing-Kang Meng, Yiyang Cai, Kun Zhou, Fei Xu, Di Huo, Hong-Bo Xie, Meini Yu, Denan Zhang, Xiu-Jie Chen

Database J. Biol. Databases Curation

DOI

2024

Impact of Hashimoto’s thyroiditis on the tumor microenvironment in papillary thyroid cancer: insights from single-cell analysis

Hongzhe Ma, Guoqi Li, Di Huo, Yangguang Su, Qing Jin, Yangxu Lu, Yan-Yan Sun, Denan Zhang, Xiu-Jie Chen

Frontiers in Endocrinology

DOI

2023

Integrating multiple machine learning algorithms for prognostic prediction of gastric cancer based on immune-related lncRNAs

Guo-Qi Li, Di Huo, Naifu Guo, Yi Li, Hongzhe Ma, Lei Liu, Hongbo M. Xie, Denan Zhang, Bo Qu, Xiu-Jie Chen

Frontiers in Genetics

DOI

2023

Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population

Yangguang Su, Ying Wang, Zhuo Qu, Jia-Xin Liu, Xuekun Ren, Denan Zhang, Xiu-Jie Chen

Frontiers in Pharmacology

DOI

2022

Computational Prediction of Drug Phenotypic Effects Based on Substructure-Phenotype Associations

Jing-Bo Yang, Denan Zhang, Yiyang Cai, Kexin Yu, Mingming Li, Lei Liu, Xiu-Jie Chen

IEEE/ACM Transactions on Computational Biology & Bioinformatics

DOI

2022

Exploring Precise Medication Strategies for OSCC Based on Single-Cell Transcriptome Analysis from a Dynamic Perspective

Qing-Kang Meng, Feng Wu, Guo-Qi Li, Fei Xu, Lei Liu, Denan Zhang, Yangxu Lu, Hongbo M. Xie, Xiu-Jie Chen

Cancers

DOI

2021

Precision treatment exploration of breast cancer based on heterogeneity analysis of lncRNAs at the single-cell level

Yan Zhang, Denan Zhang, Qing-Kang Meng, Zi-Hao Liu, Hongbo M. Xie, Lei Liu, Fei Xu, Xiu-Jie Chen

BMC Cancer

DOI

2020

CHG: A Systematically Integrated Database of Cancer Hallmark Genes

Denan Zhang, Di Huo, Hongbo M. Xie, Lingxiang Wu, Juan Zhang, Lei Liu, Qing Jin, Xiu-Jie Chen

Frontiers in Genetics

DOI

2020

Computational drug repositioning based on the relationships between substructure-indication

Jing-Bo Yang, Denan Zhang, Leiyu Liu, Guoqi Li, Yiyang Cai, Yan Zhang, Hongbo Jin, Xiu-Jie Chen

Briefings Bioinform.

DOI

2020

Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis

Lei Liu, Zhuo Shao, Jiaxuan Lv, Fei Xu, Sibo Ren, Qing Jin, Jing-Bo Yang, Weifang Ma, Hongbo M. Xie, Denan Zhang, Xiu-Jie Chen

Frontiers in Bioengineering and Biotechnology

DOI

2018

Biological evaluation and energetic analyses of novel GSK‐3β inhibitors

Denan Zhang, Lei Liu, Lin Pang, Qing Jin, Kehui Ke, M. Hu, Jing-Bo Yang, Weifang Ma, Hongbo M. Xie, Xiu-Jie Chen

Journal of Cellular Biochemistry

DOI

2018

Predicting hepatocellular carcinoma through cross-talk genes identified by risk pathways

Lei Liu, Lin Pang, Yunfeng Wang, M. Hu, Zhuo Shao, Di Huo, Denan Zhang, Hongbo M. Xie, Jing-Bo Yang, Qiuqi Liu, Xiu-Jie Chen

OncoTarget

DOI

2018

Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network

Lei Liu, Xiu-Jie Chen, Chunyu Hu, Denan Zhang, Zhuo Shao, Qing Jin, Jing-Bo Yang, Hongbo M. Xie, Bo Liu, M. Hu, Kehui Ke

Scientific Reports

DOI

2017

Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins

Hongbo M. Xie, Diheng Zeng, Xiu-Jie Chen, Di Huo, Lei Liu, Denan Zhang, Qing Jin, Kehui Ke, M. Hu

OncoTarget

DOI

2017

Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities study

Hongbo M. Xie, Haixia Wen, Denan Zhang, Lei Liu, Bo Liu, Qiuqi Liu, Qing Jin, Kehui Ke, M. Hu, Xiu-Jie Chen

OncoTarget

DOI

2016

Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues

Xiu-Jie Chen, Lei Liu, Yunfeng Wang, Bo Liu, Diheng Zeng, Qing Jin, Mengjian Li, Denan Zhang, Qiuqi Liu, Hongbo M. Xie

OncoTarget

DOI

2016

In silico drug repositioning for the treatment of Alzheimer's disease using molecular docking and gene expression data

Hongbo M. Xie, Haixia Wen, Mingze Qin, J. Xia, Denan Zhang, Lei Liu, Bo Liu, Qiuqi Liu, Qing Jin, Xiu-Jie Chen

DOI

2016

IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering

Lingxiang Wu, Xiu-Jie Chen, Denan Zhang, Wubing Zhang, Leiyu Liu, Hongzhe Ma, Jing-Bo Yang, Hongbo M. Xie, Bo Liu, Qing Jin

PLoS ONE

DOI

2014

基于高通量数据的转录调控预测分析与调控网络构建研究

张德楠

《哈尔滨工业大学》

2014

新一代高通量测序Chip-seq数据正规化方法研究

张德楠，王亚东

《智能计算机与应用》

2014

Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data

Denan Zhang, Guohua Wang, Ya-Dong Wang

BMC Bioinformatics

DOI

2010

Signal Transducers and Activators of Transcription-1 (STAT1) Regulates microRNA Transcription in Interferon γ-Stimulated HeLa Cells

Guohua Wang, Ya-Dong Wang, Mingxiang Teng, Denan Zhang, Lang Li, Yunlong Liu

PLoS ONE

DOI

张德楠

精选作品

期刊论文

Lineage-Specific CagA Binding Mechanics and Microenvironmental Rewiring in East Asian Gastric Carcinogenesis

GRIP-Lung: Generative Model of Response to Drug-Induced Perturbation in Lung Cancer

KAN-PROSPECT: a Kolmogorov–Arnold Networks–integrated framework for predicting the effects and adverse reactions of natural products via transfer learning

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Predicting drug synergy using a network propagation inspired machine learning framework.

A deep learning drug screening framework for integrating local-global characteristics: A novel attempt for limited data

Decoding temporal heterogeneity in NSCLC through machine learning and prognostic model construction

DAPredict: a database for drug action phenotype prediction

Impact of Hashimoto’s thyroiditis on the tumor microenvironment in papillary thyroid cancer: insights from single-cell analysis

Integrating multiple machine learning algorithms for prognostic prediction of gastric cancer based on immune-related lncRNAs

Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population

Computational Prediction of Drug Phenotypic Effects Based on Substructure-Phenotype Associations

Exploring Precise Medication Strategies for OSCC Based on Single-Cell Transcriptome Analysis from a Dynamic Perspective

Precision treatment exploration of breast cancer based on heterogeneity analysis of lncRNAs at the single-cell level

CHG: A Systematically Integrated Database of Cancer Hallmark Genes

Computational drug repositioning based on the relationships between substructure-indication

Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis

Biological evaluation and energetic analyses of novel GSK‐3β inhibitors

Predicting hepatocellular carcinoma through cross-talk genes identified by risk pathways

Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network

Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins

Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities study

Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues

In silico drug repositioning for the treatment of Alzheimer's disease using molecular docking and gene expression data

IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering

基于高通量数据的转录调控预测分析与调控网络构建研究

新一代高通量测序Chip-seq数据正规化方法研究

Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data

Signal Transducers and Activators of Transcription-1 (STAT1) Regulates microRNA Transcription in Interferon γ-Stimulated HeLa Cells

研究方向