孙晓

2026

网络药理学与分子对接技术在中药抗脓毒症急性肺损伤中的作用

《生命的化学》

2026

生物类专业无机化学与分析化学课程思政教学改革探索——以山东第一医科大学为例

《中国教育技术装备》

2024

肝素生物测定法的研究进展

《药物生物技术》

2023

人促红素注射液生物学活性体外法的ELISA验证

《药物生物技术》

2023

G-Quadruplex Structures Are Key Modulators of Somatic Structural Variants in Cancers

Cancer Research

DOI

2022

实验病理学在药品监管中的建设与发展初探

《中国新药杂志》

2022

阴道用中药原位凝胶的研究进展

《中草药》

2022

Radiogenomics analysis reveals the associations of dynamic contrast-enhanced–MRI features with gene expression characteristics, PAM50 subtypes, and prognosis of breast cancer

Frontiers in Oncology

DOI

2021

Classification of Mild Cognitive Impairment With Multimodal Data Using Both Labeled and Unlabeled Samples

IEEE/ACM Transactions on Computational Biology & Bioinformatics

DOI

2021

Brain-Specific Gene Expression and Quantitative Traits Association Analysis for Mild Cognitive Impairment

Biomedicines

DOI

2021

Predicting Conversion from MCI to AD Combining Multi-Modality Data and Based on Molecular Subtype

Brain Science

DOI

2021

Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome

International Journal of Molecular Sciences

DOI

2021

Direct genome-wide identification of G-quadruplex structures by whole-genome resequencing

Nature Communications

DOI

2021

Inferring single cell expression profiles from overlapped pooling sequencing data with compressed sensing strategy

Nucleic Acids Research

DOI

2021

[A review on integration methods for single-cell data].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

DOI

2021

From Cellular Infiltration Assessment to a Functional Gene Set-Based Prognostic Model for Breast Cancer

Frontiers in Immunology

DOI

2020

六叶龙胆化学成分研究

《中国药学杂志》

2020

Effect for Human Genomic Variation During the BMP4-Induced Conversion From Pluripotent Stem Cells to Trophoblast

Frontiers in Genetics

DOI

2020

Corrigendum: Effect for Human Genomic Variation During the BMP4-Induced Conversion From Pluripotent Stem Cells to Trophoblast

Frontiers in Genetics

DOI

2020

Sample-specific perturbation of gene interactions identifies breast cancer subtypes

Briefings Bioinform.

DOI

2020

Molecular Subtyping of Mild Cognitive Impairment based on Genetic Polymorphism and Gene Expression

The journal of prevention of Alzheimer's disease

DOI

2020

Cooperative binding of transcription factors in the human genome.

Genomics

DOI

2020

DeconPeaker, a Deconvolution Model to Identify Cell Types Based on Chromatin Accessibility in ATAC-Seq Data of Mixture Samples

Frontiers in Genetics

DOI

2020

A deconvolution method and its application in analyzing the cellular fractions in acute myeloid leukemia samples

BMC Genomics

DOI

2020

Prognostic gene expression signature revealed the involvement of mutational pathways in cancer genome

Journal of Cancer

DOI

2020

Whole Genome Identification of Potential G-Quadruplexes and Analysis of the G-Quadruplex Binding Domain for SARS-CoV-2

bioRxiv

DOI

2019

超高效液相色谱-串联质谱法测定抗疲劳类保健食品及补肾壮阳类中成药中15种添加药物

《药物分析杂志》

DOI

2019

Quantitative Trait Module-Based Genetic Analysis of Alzheimer’s Disease

International Journal of Molecular Sciences

DOI

2019

DNMHMM: An approach to identify the differential nucleosome regions in multiple cell types based on a Hidden Markov Model

Biosyst.

DOI

2019

Evaluation of single-cell classifiers for single-cell RNA sequencing data sets

Briefings Bioinform.

DOI

2019

Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure

Epigenetics

DOI

2019

Two Distinct Subtypes Revealed in Blood Transcriptome of Breast Cancer Patients With an Unsupervised Analysis

Frontiers in Oncology

DOI

2019

Enhancer LncRNAs Influence Chromatin Interactions in Different Ways

Frontiers in Genetics

DOI

2019

Comprehensive identification of survival-associated genes for cancers

bioRxiv

DOI

2018

Nucleosome Positioning of Intronless Genes in the Human Genome

IEEE/ACM Transactions on Computational Biology & Bioinformatics

DOI

2018

Prediction of microRNA-binding residues in protein using a Laplacian support vector machine based on sequence information

J. Bioinform. Comput. Biol.

DOI

2018

Nucleosome Positioning and Its Role in Gene Regulation in Yeast

DOI

2018

Efficient inference of single cell expression profiles with overlapping pooling and compressed sensing

bioRxiv

DOI

2018

Classification of Alzheimer's Disease Based on Stacked Denoising Autoencoder

2018 4th Annual International Conference on Network and Information Systems for Computers (ICNISC)

DOI

2017

头孢拉定二水合物的晶型及其特性

《中国抗生素杂志》

2017

The accessible chromatin landscape during conversion of human embryonic stem cells to trophoblast by bone morphogenetic protein 4†

Biology of Reproduction

DOI

2017

The application of next-generation sequencing techniques in studying transcriptional regulation in embryonic stem cells.

Yi chuan = Hereditas

DOI

2017

Efficient identification of SNPs in pooled DNA samples using a dual mononucleotide addition-based sequencing method

Zeitschrift für Induktive Abstammungs- und Vererbungslehre

DOI

2017

An approach of identifying differential nucleosome regions in multiple samples

BMC Genomics

DOI

2017

Histone modifications influence skipped exons inclusion

J. Bioinform. Comput. Biol.

DOI

2016

Combinatorial pooled sequencing: experiment design and decoding

Quantitative Biology

DOI

2016

DNABP: Identification of DNA-Binding Proteins Based on Feature Selection Using a Random Forest and Predicting Binding Residues

PLoS ONE

DOI

2016

An accurate clone-based haplotyping method by overlapping pool sequencing

Nucleic Acids Research

DOI

2016

Ehapp2: Estimate haplotype frequencies from pooled sequencing data with prior database information

J. Bioinform. Comput. Biol.

DOI

2016

組合せプールされた配列:実験設計と復号化【Powered by NICT】

2016

Comparison of the experimental methods in haplotype sequencing via next generation sequencing

Quantitative Biology

DOI

2015

HPLC-QTOF-MS法测定风湿骨痛胶囊中9个乌头类生物碱的含量

《药物分析杂志》

2015

染色质构象解析技术——Hi-C及染色质构象信息提取

DOI

2015

PRBP: Prediction of RNA-Binding Proteins Using a Random Forest Algorithm Combined with an RNA-Binding Residue Predictor

IEEE/ACM Transactions on Computational Biology & Bioinformatics

DOI

2015

Accurate estimation of haplotype frequency from pooled sequencing data and cost-effective identification of rare haplotype carriers by overlapping pool sequencing

Bioinform.

DOI

2015

Sequence and Structure Analysis of Biological Molecules Based on Computational Methods

BioMed Research International

DOI

2015

A Novel Cylindrical Representation for Characterizing Intrinsic Properties of Protein Sequences

Journal of Chemical Information and Modeling

DOI

2015

Sequence-Based Prediction of RNA-Binding Proteins Using Random Forest with Minimum Redundancy Maximum Relevance Feature Selection

BioMed Research International

DOI

2014

Quantitative group testing-based overlapping pool sequencing to identify rare variant carriers

BMC Bioinformatics

DOI

2014

A Novel Method for Detecting Contaminated Sample Based on Illumina Sequencing Data

DOI

2014

Sequence-based predictor of ATP-binding residues using random forest and mRMR-IFS feature selection.

Journal of Theoretical Biology

DOI

2014

A dynamic programming algorithm for nucleosome positions alignment

International Conference on Systems Biology

DOI

2014

Nucleosome organization in the vicinity of transcription factor binding sites in the human genome

BMC Genomics

DOI

2013

The nucleosome regulates the usage of polyadenylation sites in the human genome

BMC Genomics

DOI

2013

Quantitative analysis reveals increased histone modifications and a broad nucleosome-free region bound by histone acetylases in highly expressed genes in human CD4+ T cells.

Genomics

DOI

2013

The Patterns of Histone Modifications in the Vicinity of Transcription Factor Binding Sites in Human Lymphoblastoid Cell Lines

PLoS ONE

DOI

2013

Identification of Novel MicroRNAs in Primates by Using the Synteny Information and Small RNA Deep Sequencing Data

International Journal of Molecular Sciences

DOI

2013

Non-Coding Sequences Regulating Eukaryotic Gene Expression

DOI

2013

Identifying Rare Variants With Optimal Depth of Coverage and Cost‐Effective Overlapping Pool Sequencing

Genetic Epidemiology

DOI

2013

Patterns of Nucleosome and Chromatin Modifications and Their Effects on Chromatin States

DOI

2013

Nucleosome Distribution near the 3′ Ends of Genes in the Human Genome

Bioscience, biotechnology and biochemistry

DOI

2012

Sequence-Based Prediction of DNA-Binding Residues in Proteins with Conservation and Correlation Information

IEEE/ACM Transactions on Computational Biology & Bioinformatics

DOI

2012

Nucleosome organization in sequences of alternative events in human genome

Biosyst.

DOI

2012

Next-generation sequencing data processing: Analysis of unmapped reads and extremely high mapped peaks

International Conference on BioMedical Engineering and Informatics

DOI

2012

Prediction of autism susceptibility genes based on association rules

Journal of Neuroscience Research

DOI

2011

Prediction of RNA‐binding residues in proteins from primary sequence using an enriched random forest model with a novel hybrid feature

Proteins: Structure, Function, and Bioinformatics

DOI

2011

Predicting DNA-Binding Residues of Proteins Using Random Forest and Evolutionary Information Combined with Conservation Information

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2011

MicroRNA Genes Derived from Repetitive Elements and Expanded by Segmental Duplication Events in Mammalian Genomes

PLoS ONE

DOI

2011

Role of 10-11 bp periodicities of eukaryotic DNA sequence in nucleosome positioning

Biosyst.

DOI

2011

A novel 2D graphical representation of protein sequence based on individual amino acid

DOI

2011

Analysis of Nucleosome Positioning in The Vicinity of Sites of Nucleotide Polymorphism in Human Genome*: Analysis of Nucleosome Positioning in The Vicinity of Sites of Nucleotide Polymorphism in Human Genome*

DOI

2011

A novel method for quantitatively predicting non-covalent interactions from protein and nucleic acid sequence.

Journal of Molecular Graphics and Modelling

DOI

2011

Notice of RetractionDynamic Nucleosome Positioning around Functional Transcription Factor Binding Sites in the Promoters of Inducible NF-kappaB Target Genes

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2011

Patterns of Nucleosome Positioning and The Relationship between Positioning and DNA Methylation

2011

Notice of RetractionChromatin Organization in Different Types of Splicing Events

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2010

Global analysis of in vivo EGR1‐binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing

Electrophoresis

DOI

2010

Origin and evolution of a placental-specific microRNA family in the human genome

BMC Evolutionary Biology

DOI

2010

Umap: Use Unique Sequence for Alignment of Short Sequence Reads and SNP Detection

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2010

Causal Relationship of Histone Modifications and Gene Expression Indicated by Variable Bayeasian Network Methods

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2010

Analysis of Similarities/Dissimilarities of DNA Sequences Based on a Novel Graphical Representation

2010

Identification of common microRNA-mRNA regulatory biomodules in human epithelial cancers

Chinese science bulletin = Kexue tongbao

DOI

2010

Gene Sequences Analysis Using a New Graphical Representation of DNA Sequence

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2010

Genome-Wide Identification of Orthologs of miR-1302 Genes in Placental Mammals

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2010

Nucleosomes Are Well Positioned at Both Ends of Exons

LSMS/ICSEE

DOI

2010

Meta-analysis of cancer gene-profiling data.

Methods in molecular biology

DOI

2010

Reannotation of protein‐coding genes based on an improved graphical representation of DNA sequence

Journal of Computational Chemistry

DOI

2009

SVM-Based Approach for Predicting DNA-Binding Residues in Proteins from Amino Acid Sequences

2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing

DOI

2009

Mechanism-anchored profiling derived from epigenetic networks predicts outcome in acute lymphoblastic leukemia

BMC Bioinformatics

DOI

2009

TN curve: A novel 3D graphical representation of DNA sequence based on trinucleotides and its applications

Journal of Theoretical Biology

DOI

2008

Comparability of gene expression in human blood, immune and carcinoma cells

Applied Mathematics and Computation

DOI

2008

Prediction of DNA-binding residues in proteins from amino acid sequences using a random forest model with a hybrid feature

Bioinform.

DOI

2008

Characteristics of nucleosome core DNA and their applications in predicting nucleosome positions.

Biophysical Journal

DOI

2008

Evaluation of FORS-D Analysis: A Comparison with the Statistically Significant Stem-loop Potential

Biochemical Genetics

DOI

2007

Quantitative Estimation of siRNAs Gene Silencing Capability by Random Forest Regression Model

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2007

Support Vector Machine for Prediction of DNA-Binding Domains in Protein-DNA Complexes

Life System Modeling and Simulation

DOI

2007

MiPred: classification of real and pseudo microRNA precursors using random forest prediction model with combined features

Nucleic Acids Res.

DOI

2007

Meta-analysis of several gene lists for distinct types of cancer: A simple way to reveal common prognostic markers

BMC Bioinformatics

DOI

2007

gWord: A Tool for Genome-Wide Word Search and Count

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2007

RFRCDB-siRNA: Improved design of siRNAs by random forest regression model coupled with database searching

Comput. Methods Programs Biomed.

DOI

2007

Base-Base Correlation a Novel Sequence Feature and its Applications

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2007

Studies of Hurst Index for Different Regions of Genes

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2006

Support Vector Machine for Prediction of siRNA Silencing Efficacy

2006

A sequence feature based searching system for nucleotide database

2005

Expression profiles of mouse dendritic cell sarcoma are similar to those of hematopoietic stem cells or progenitors by clustering and principal component analyses.

Biochemical and Biophysical Research Communications - BBRC

DOI

2005

Classifying Genomic Sequences by Sequence Feature Analysis

Genomics, Proteomics & Bioinformatics

DOI

2001

IDENTIFY GENE SPLICED SITES BASED ON BP NN

2019

BALB/c小鼠LLNA:BrdU-ELISA法对化学物刺激性和致敏作用验证评价探索性研究

《中国药理学会药检药理专业委员会第十六届（2019年）学术年会论文集》

DOI

2026

ConsultMind:Towards Automated Diagnostic Consultation via Uncertainty-Aware Reasoning

arXiv preprint

2026

MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounters

arXiv preprint

2026

Lung-R1: A Knowledge Graph-Guided LLM for Pulmonary Diagnostic Reasoning

arXiv preprint

2026

MentalSeek-Dx: Towards Progressive Hypothetico-Deductive Reasoning for Real-world Psychiatric Diagnosis

arXiv preprint