徐晓莉｜中国药科大学｜学者主页

2026

Leveraging digital-green finance synergies to accelerate biodiversity conservation and sustainability

Hongyu Guo, Mbarek Rahmoune, Ahmed Imran Hunjra, Xiaoli Xu

Research In International Business And Finance，Vol. 83

DOI

2026

国家科技成果转移转化示范区设立如何影响新质生产力发展水平？

徐晓莉，李瑞雪，朱富显

《软科学》，Vol. 40, No. 2

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2026

全国统一大市场建设与创新成果流动——来自异地专利转移的证据

徐晓莉，黄林智，李瑞雪，李明明

《金融发展研究》，No. 5

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2026

数字产业链韧性的社会期望落差效应研究——兼议提振预期与扩大内需的经济后果

李明明，陈晶，徐晓莉

《软科学》，Vol. 40, No. 7

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2026

Small-molecule modulators of the necroptotic pathway: A medicinal chemistry perspective

De-Chang Li, Nannan Chen, Qi-Dong You, Xiaoli Xu

European Journal of Medicinal Chemistry

DOI

2026

Halogen-methyl hybridization unlocks orally bioavailable STING agonist for tumor immunotherapy

Guo-Feng Xin, Qiangsheng Zhu, Nannan Chen, Lin-Lin Li, Ye-Ling Zhou, Si-Shuo Liu, Si-Jia Gong, Bei-Duo Wu, Yin-Quan Huang, Qidong You, Xiaoli Xu

European Journal of Medicinal Chemistry

DOI

2026

A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders

Yifan Zhang, Linlin Li, Jiayi Xu, Chun-Chen Che, Jiaqing Jia, Haohao Lu, Qidong You, Xiaoli Xu

Molecules

DOI

2026

Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders

Hui Li, Wei Zheng, Wenjing Bian, M T Li, Zhidan Fan, Ziwen Feng, X Q Liu, Shiduo Zhang, Haohao Lu, Yinquan Huang, Jiaqing Jia, Yifan Zhang, Linlin Li, Chun-Chen Che, Haiguo Yu, Yibei Xiao, Qidong You, Xiaoli Xu

Nature Communications

DOI

2026

Discovery of a non-nucleotide STING agonist with antitumor activity

Shu Wang, Nannan Chen, Wenjing Bian, Tiantian Liu, Xiaoli Xu, Yibei Xiao, Qidong You, Ziwen Feng, Xuan Liu

Results in Chemistry

DOI

2026

An Overview of Small-Molecule Agents for the Treatment of Dermatomyositis

Xuechun Liu, Ziwen Feng, Chun-Chen Che, Guofeng Xin, Linlin Li, Qidong You, Xiaoli Xu

Current Topics in Medicinal Chemistry

DOI

2025

二元政策组合能否提升企业突破式创新效率？——兼论技术创新与转化

李双圆，徐晓莉

《软科学》，Vol. 39, No. 8

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2025

金融科技与企业突破式绿色创新效率——兼论金融科技与科技金融的协同效应

李双圆，徐晓莉

《金融监管研究》，No. 7

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2025

新质生产力提升产业链供应链韧性的机制研究

李明明，陈晶，徐晓莉，朱富显

《南京财经大学学报》，No. 2

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2025

核酸模式识别机制及其化学干预的研究进展

贾佳庆，李辉，尤启冬，徐晓莉

《中国药科大学学报》

2025

Call for Papers: Pharmaceutical Innovation and Global Health: Breakthroughs and Future─Celebrating the 90th Anniversary of China Pharmaceutical University

Hai Qian, Hongbin Sun, Can Zhang, Peng Yang, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2025

HSP90 Mediates Targeted Degradation of Nonclient Protein PARP1 for Breast Cancer Treatment

Wei Liu, Jianfeng Liu, Huangliang Shu, Lixiao Zhang, Xingyu Yin, Xiaoli Xu, Qidong You, Lei Wang

Journal of Medicinal Chemistry

DOI

2025

Structural Optimization of Pyrazole Compounds as Hsp90 Regulators with Enhanced Antitumor Activity

Ziwen Feng, Li Li, Shi-Duo Zhang, Wang Ying-ji, Jia-Yue Pei, Nannan Chen, Bei-Duo Wu, Qiuling Zheng, Qidong You, Xiaoke Guo, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2024

Can heterogeneous environmental policies mitigate ESG divergence? -Based on corporate green innovation and bleaching green behavioral options

Shuangyuan Li, Xiaoli Xu, Fuxian Zhu

Sustainable Futures，Vol. 80

DOI

2024

中国新质生产力指标构建与时空演进

朱富显，李瑞雪，徐晓莉，孙家昌

《工业技术经济》，Vol. 43, No. 3

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2024

长三角新质生产力涌现的动态识别与驱动因子捕捉——基于多时点SNA与QCA分析

朱富显，徐晓莉，李瑞雪，童乔莉

《金融发展研究》，No. 10

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2024

平台经济金融化对实体企业“脱虚向实”的影响

徐晓莉，谭其宇

《华东经济管理》，Vol. 38, No. 8

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2024

Protein-protein interactions in cGAS-STING pathway: a medicinal chemistry perspective

Shi-Duo Zhang, Hui Li, Ye-Ling Zhou, Xuechun Liu, De-Chang Li, Chuan-Feng Hao, Qidong You, Xiaoli Xu

Future Medicinal Chemistry

DOI

2024

An updated patent review of stimulator of interferon genes agonists (2021 – present)

Guo-Feng Xin, Nannan Chen, Lin-Lin Li, Xuechun Liu, Chun-Chen Che, Bei-Duo Wu, Qidong You, Xiaoli Xu

Expert Opinion on Therapeutic Patents

DOI

2023

Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor

Nannan Chen, Han Zhang, Qiangsheng Zhu, Ting Zeng, Wei Dai, Ye-Ling Zhou, Guo-Feng Xin, Bei-Duo Wu, Si-Jia Gong, Zhengyu Jiang, Qidong You, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2023

Imidazo[1,2-a]Pyridine Derivatives as Novel Dual-Target Inhibitors of ABCB1 and ABCG2 for Reversing Multidrug Resistance

Hui Li, Shenglie Zhang, Yan-Han Jia, Qian Li, Ziwen Feng, Shi-Duo Zhang, Wei Zheng, Ye-Ling Zhou, Linlin Li, Xuechun Liu, Yaqiong Chen, Hui Peng, Qidong You, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2023

Inhibitors of Stimulator of Interferon Genes from 2019 to July 2022: An Overview of the Structure and Bioactivity

Feng Xu, Xinjian Tian, Qiangsheng Zhu, Ziwen Feng, Hui Joyce Li, Wei Dai, Ye-Ling Zhou, Qidong You, Xiaoli Xu

Current Drug Targets

DOI

2022

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

Sinan Ma, Jianai Ji, Yuanyuan Tong, Yuxuan Zhu, Junwei Dou, Xian Zhang, Shicheng Xu, Tianbao Zhu, Xiaoli Xu, Qidong You, Zhengyu Jiang

Acta Pharmaceutica Sinica B

DOI

2022

Medicinal chemistry perspective on cGAS-STING signaling pathway with small molecule inhibitors

Xinjian Tian, Feng Xu, Qiangsheng Zhu, Ziwen Feng, Wei Dai, Ye-Ling Zhou, Qidong You, Xiaoli Xu

European Journal of Medicinal Chemistry

DOI

2022

Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective

Qiangsheng Zhu, Nannan Chen, Xinjian Tian, Ye-Ling Zhou, Qidong You, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2022

Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis

Xuetao Chen, Fanying Meng, Jingtian Zhang, Zijian Zhang, Xuan Ye, Weikun Zhang, Yuanyuan Tong, Xinrui Ji, Rujun Xu, Xiaoli Xu, Qidong You, Zhengyu Jiang

European Journal of Medicinal Chemistry

DOI

2021

“网络课程学习+课堂授课+临床用药案例讨论”三维立体的临床药学专业《药物化学》教学模式研究

徐晓莉，向华，江程

《药学研究》

DOI

2021

Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects

Shicheng Xu, An-ping Guo, Nannan Chen, Wei Dai, Huanaoyu Yang, Wenqin Xie, Mengjie Wang, Qidong You, Xiaoli Xu

European Journal of Medicinal Chemistry

DOI

2021

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification

Li Li, Nannan Chen, Dandan Xia, Shicheng Xu, Wei Dai, Yuanyuan Tong, Lei Wang, Zhengyu Jiang, Qidong You, Xiaoli Xu

Cell chemical biology

DOI

2021

Agonist of stimulator of interferon genes as antitumor agents: a patent review (2008-2020)

Nannan Chen, Han Zhang, Qidong You, Xiaoli Xu

Expert Opinion on Therapeutic Patents

DOI

2020

Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery

Lei Wang, Xiaoli Xu, Zhengyu Jiang, Qidong You

Acta Pharmaceutica Sinica B

DOI

2020

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core

Qiuyue Zhang, Xuexuan Wu, Jianrui Zhou, Lixiao Zhang, Xiaoli Xu, Lianshan Zhang, Qidong You, Lei Wang

European Journal of Medicinal Chemistry

DOI

2020

Discovery and Optimization of Small Molecules Targeting the Protein–Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer

Lei Wang, Jingsheng Jiang, Lixiao Zhang, Qiuyue Zhang, Jianrui Zhou, Li Li, Xiaoli Xu, Qidong You

Journal of Medicinal Chemistry

DOI

2020

An updated patent review of anticancer Hsp90 inhibitors (2013-present)

Li Li, Nannan Chen, Qidong You, Xiaoli Xu

Expert Opinion on Therapeutic Patents

DOI

2019

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

Han Zhang, Qidong You, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2019

Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions

Li Li, Lei Wang, Qidong You, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2019

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Lei Wang, Lixiao Zhang, Li Li, Jingsheng Jiang, Zhen Zheng, Jialin Shang, Chengxiang Wang, Weilin Chen, Qichao Bao, Xiaoli Xu, Zhengyu Jiang, Jian Zhang, Qidong You

Science Advances

DOI

2018

Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis

Fen Jiang, An-ping Guo, Jia-chen Xu, Qidong You, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2017

基于均相时间分辨荧光技术(HTRF)的HSP90-HOP相互作用抑制剂活性测试方法的构建及其应用

王慧洁，周子涵，徐嘉辰，姜奋，尤启冬，徐晓莉

《药学学报》

DOI

2017

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway

Xiaoli Xu, Yingrui Yang, Xiaofei Mo, Jinlian Wei, Xiaojin Zhang, Qidong You

European Journal of Medicinal Chemistry

DOI

2017

Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors

Fen Jiang, An-ping Guo, Jia-cheng Xu, Huijie Wang, Xiaofei Mo, Qidong You, Xiaoli Xu

European Journal of Medicinal Chemistry

DOI

2017

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction

Lei Wang, Li Li, Zihan Zhou, Zhengyu Jiang, Qidong You, Xiaoli Xu

European Journal of Medicinal Chemistry

DOI

2017

Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5

Weilin Chen, Dong‐Dong Li, Zhihui Wang, Xiaoli Xu, Xiaojin Zhang, Zhengyu Jiang, Xiaoke Guo, Qidong You

Bioorganic Chemistry

DOI

2016

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90

Fen Jiang, Huijie Wang, Yuhui Jin, Qiong Zhang, Zhihui Wang, Jian-Min Jia, Fang Liu, Lei Wang, Qichao Bao, Dongdong Li, Qidong You, Xiaoli Xu

Journal of Medicinal Chemistry

DOI

2016

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity

Dong‐Dong Li, Weilin Chen, Zhihui Wang, Yi-Yue Xie, Xiaoli Xu, Zhengyu Jiang, Xiaojin Zhang, Qidong You, Xiaoke Guo

European Journal of Medicinal Chemistry

DOI

2016

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5

Dong‐Dong Li, Weilin Chen, Xiaoli Xu, Fen Jiang, Lei Wang, Yi-Yue Xie, Xiaojin Zhang, Xiaoke Guo, Qidong You, Hao-Peng Sun

European Journal of Medicinal Chemistry

DOI

2016

Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators

Lei Wang, Li Li, Weitao Fu, Zhengyu Jiang, Qidong You, Xiaoli Xu

Bioorganic & Medicinal Chemistry

DOI

2016

Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo

Xiaoli Xu, Yue Wu, Mingyang Hu, Xiang Li, Qichao Bao, Jinlei Bian, Qidong You, Xiaojin Zhang

Scientific Reports

DOI

2016

Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification

Weilin Chen, Zhihui Wang, Taotao Feng, Dong‐Dong Li, Chu-Hui Wang, Xiaoli Xu, Xiaojin Zhang, Qidong You, Xiaoke Guo

Bioorganic & Medicinal Chemistry

DOI

2016

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

Chao Zhang, Hui-Jie Wang, Qichao Bao, Lei Wang, Tian-kun Guo, Weilin Chen, Lili Xu, Hai-Shan Zhou, Jinlei Bian, Yingrui Yang, Hao-Peng Sun, Xiaoli Xu, Qidong You

Oncotarget

DOI

2016

Optimization and biological evaluation of celastrol derivatives as Hsp90–Cdc37 interaction disruptors with improved druglike properties

Fen Jiang, Hui-Jie Wang, Qichao Bao, Lei Wang, Yuhui Jin, Qiong Zhang, Di Maria Jiang, Qidong You, Xiaoli Xu

Bioorganic & Medicinal Chemistry

DOI

2016

Structure–activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity

Xiaoli Xu, Yue Wu, Mingyang Hu, Xiang Li, Congying Gu, Qidong You, Xiaojin Zhang

Bioorganic & Medicinal Chemistry

DOI

2016

Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents

Jinlian Wei, Yingrui Yang, Mengchen Lu, Yonghua Lei, Lili Xu, Zhengyu Jiang, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Haopeng Sun, Qidong You

Mini-Reviews in Medicinal Chemistry

DOI

2016

Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential

Jinlian Wei, Yingrui Yang, Yali Li, Xiaofei Mo, Xiaoke Guo, Xiaojin Zhang, Xiaoli Xu, Zhengyu Jiang, Qidong You

Bioorganic & Medicinal Chemistry

DOI

2016

Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function

Lei Wang, Li Li, Kai Gu, Xiaoli Xu, Yuan Sun, Qidong You

Current Drug Targets

DOI

2016

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors

Bahidja Cherfaoui, Tian-kun Guo, Hao-Peng Sun, Wei-Lin Cheng, Fang Liu, Fen Jiang, Xiaoli Xu, Qidong You

Bioorganic & Medicinal Chemistry

DOI

2016

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells

Xiaoli Xu, Qichao Bao, Jian-Min Jia, Fang Liu, Xiaoke Guo, Ming-ye Zhang, Jinlian Wei, Mengchen Lu, Lili Xu, Xiaojin Zhang, Qidong You, Hao-Peng Sun

Scientific Reports

DOI

2016

Discovery of novel chemical scaffolds as RhoA inhibitors using virtual screening, synthesis, and bioactivity evaluation

Chao Zhang, Huijie Wang, Qichao Bao, Jinlei Bian, Yingrui Yang, Qidong You, Xiaoli Xu

RSC Advances

DOI

2016

Betulinic acid acetate, an antiproliferative natural product, suppresses client proteins of heat shock protein pathways through a CDC37-binding mechanism

Qichao Bao, Lu Wang, Lei Wang, Xiaoli Xu, Fen Jiang, Fang Liu, Xiaojin Zhang, Xiaoke Guo, Qidong You, Hao-Peng Sun

RSC Advances

DOI

2015

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline

Taotao Feng, Dong‐Dong Li, Hai Wang, Jian Zhuang, Fang Liu, Qichao Bao, Yonghua Lei, Weilin Chen, Xiaojin Zhang, Xiaoli Xu, Haopeng Sun, Qidong You, Xiaoke Guo

European Journal of Medicinal Chemistry

DOI

2015

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Zhengyu Jiang, Lili Xu, Mengchen Lu, Zhiyun Chen, Zhenwei Yuan, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Hao-Peng Sun, Qidong You

Journal of Medicinal Chemistry

DOI

2015

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure–Activity Relationship Study

Lili Xu, Junfeng Zhu, Xiaoli Xu, Jie Zhu, Li Li, Meiyang Xi, Zhengyu Jiang, Ming-Ye Zhang, Fang Liu, Mengchen Lu, Qichao Bao, Qi Li, Chao Zhang, Jinlian Wei, Xiaojin Zhang, Lianshan Zhang, Qidong You, Hao-Peng Sun

Journal of Medicinal Chemistry

DOI

2015

Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening

Yao Chen, Zongliang Liu, Tingming Fu, Wei Li, Xiaoli Xu, Hao-peng Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2015

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1)

Jinlei Bian, Lili Xu, Bang Deng, Qian Xue, Jun Yan Fan, Xiuwen Yang, Fang Liu, Xiaoli Xu, Xiaoke Guo, Xiang Li, Haopeng Sun, Qidong You, Xiaojin Zhang

Bioorganic & Medicinal Chemistry Letters

DOI

2015

Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction

Lei Wang, Qichao Bao, Xiaoli Xu, Fen Jiang, Kai Gu, Zhengyu Jiang, Xiaojin Zhang, Xiaoke Guo, Qidong You, Hao-Peng Sun

RSC Advances

DOI

2015

Discovery of new scaffolds from approved drugs as acetylcholinesterase inhibitors

Yao Chen, Xiaoli Xu, Tingming Fu, Wei Li, Zongliang Liu, Haopeng Sun

RSC Advances

DOI

2015

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Jinlei Bian, Qian Xue, Bang Deng, Xiaoli Xu, Xiaoke Guo, Yalou Wang, Xiang Li, Haopeng Sun, Qidong You, Xiaojin Zhang

RSC Advances

DOI

2015

Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach

Taotao Feng, Weilin Chen, Dong‐Dong Li, Hongzhi Lin, Fang Liu, Qichao Bao, Yonghua Lei, Xiaojin Zhang, Xiaoli Xu, Xiaoke Guo, Qidong You, Haopeng Sun

RSC Advances

DOI

2014

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1)

Jinlei Bian, Bang Deng, Lili Xu, Xiaoli Xu, Nan Wang, Tianhan Hu, Zeyu Yao, Jianyao Du, Li Yang, Yonghua Lei, Xiang Li, Haopeng Sun, Xiaojin Zhang, Qidong You

European Journal of Medicinal Chemistry

DOI

2014

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening

Hao-Peng Sun, Jianmin Jia, Fen Jiang, Xiaoli Xu, Fang Liu, Xiaoke Guo, Bahidja Cherfaoui, Hao‐Ze Huang, Yang Pan, Qidong You

European Journal of Medicinal Chemistry

DOI

2014

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Zhengyu Jiang, Mengchen Lu, Lili Xu, Tingting Yang, Meiyang Xi, Xiaoli Xu, Xiaoke Guo, Xiaojin Zhang, Qidong You, Hao-Peng Sun

Journal of Medicinal Chemistry

DOI

2014

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Jian-Min Jia, Fang Liu, Xiaoli Xu, Xiaoke Guo, Fen Jiang, Bahidja Cherfaoui, Hao-Peng Sun, Qidong You

Bioorganic & Medicinal Chemistry Letters

DOI

2013

Indenoisoquinoline derivatives as topoisomerase I inhibitors that suppress angiogenesis by affecting the HIF signaling pathway

Xiaoli Xu, Fang Liu, Shengmiao Zhang, Jianmin Jia, Zhiyu Li, Xiaoke Guo, Yong Yang, Haopeng Sun, Qidong You

Biomedicine & Pharmacotherapy

DOI

2013

3-Aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as Potent Nrf2/ARE Inducers in Human Cancer Cells and AOM-DSS Treated Mice

Meiyang Xi, Jian-min Jia, Hao-peng Sun, Zhongying Sun, Jiewei Jiang, Yajing Wang, Min‐Ye Zhang, Junfeng Zhu, Lili Xu, Zhengyu Jiang, Xin Xue, Ming Ye, Xi Yang, Yuan Gao, Lei Tao, Xiaoke Guo, Xiaoli Xu, Qinglong Guo, Xiaojin Zhang, Rong Hu, Qidong You

Journal of Medicinal Chemistry

DOI

2013

Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors

Xin Xue, Jinlian Wei, Lili Xu, Meiyang Xi, Xiaoli Xu, Fang Liu, Xiaoke Guo, Lei Wang, Xiaojin Zhang, Mingye Zhang, Mengchen Lu, Hao-Peng Sun, Qidong You

Journal of Chemical Information and Modeling

DOI

2013

Discovery and Design of Tricyclic Scaffolds as Protein Kinase CK2 (CK2) Inhibitors through a Combination of Shape-Based Virtual Screening and Structure-Based Molecular Modification

Haopeng Sun, Xiaoli Xu, Xiaowen Wu, Xiaojin Zhang, Fang Liu, Jianmin Jia, Xiaoke Guo, Jingjie Huang, Zhengyu Jiang, Taotao Feng, Hongxi Chu, You Zhou, Shenglie Zhang, Zongliang Liu, Qidong You

Journal of Chemical Information and Modeling

DOI

2013

Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening

Jianmin Jia, Xiaoli Xu, Fang Liu, Xiaoke Guo, Zhang MingYe, Mengchen Lu, Lili Xu, Jinlian Wei, Jia Zhu, Shenglie Zhang, Shengmiao Zhang, Haopeng Sun, Qidong You

PLoS ONE

DOI

2013

Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives

You Lang Zhou, Xiaoli Xu, Yuan Sun, Huaping Wang, Haopeng Sun, Qidong You

Bioorganic & Medicinal Chemistry Letters

DOI

2012

新型6-芳基茚并异喹啉酮衍生物的合成及抗肿瘤活性研究

王天麟，向华，徐晓莉，肖红，尤启冬

《中国药物化学杂志》

2010

Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents

Rong-geng Fu, Qidong You, Lei Yang, WU Wu-tong, Cheng Jiang, Xiaoli Xu

Bioorganic & Medicinal Chemistry

DOI

1993

肾脱氢二肽酶抑制剂西司他丁的合成

徐晓莉，张致平，刘浚

《中国医药工业杂志》

精选作品

期刊论文

Leveraging digital-green finance synergies to accelerate biodiversity conservation and sustainability

国家科技成果转移转化示范区设立如何影响新质生产力发展水平？

全国统一大市场建设与创新成果流动——来自异地专利转移的证据

数字产业链韧性的社会期望落差效应研究——兼议提振预期与扩大内需的经济后果

Small-molecule modulators of the necroptotic pathway: A medicinal chemistry perspective

Halogen-methyl hybridization unlocks orally bioavailable STING agonist for tumor immunotherapy

A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders

Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders

Discovery of a non-nucleotide STING agonist with antitumor activity

An Overview of Small-Molecule Agents for the Treatment of Dermatomyositis

二元政策组合能否提升企业突破式创新效率？——兼论技术创新与转化

金融科技与企业突破式绿色创新效率——兼论金融科技与科技金融的协同效应

新质生产力提升产业链供应链韧性的机制研究

核酸模式识别机制及其化学干预的研究进展

Call for Papers: Pharmaceutical Innovation and Global Health: Breakthroughs and Future─Celebrating the 90th Anniversary of China Pharmaceutical University

HSP90 Mediates Targeted Degradation of Nonclient Protein PARP1 for Breast Cancer Treatment

Structural Optimization of Pyrazole Compounds as Hsp90 Regulators with Enhanced Antitumor Activity

Can heterogeneous environmental policies mitigate ESG divergence? -Based on corporate green innovation and bleaching green behavioral options

中国新质生产力指标构建与时空演进

长三角新质生产力涌现的动态识别与驱动因子捕捉——基于多时点SNA与QCA分析

平台经济金融化对实体企业“脱虚向实”的影响

Protein-protein interactions in cGAS-STING pathway: a medicinal chemistry perspective

An updated patent review of stimulator of interferon genes agonists (2021 – present)

Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor

Imidazo[1,2-a]Pyridine Derivatives as Novel Dual-Target Inhibitors of ABCB1 and ABCG2 for Reversing Multidrug Resistance

Inhibitors of Stimulator of Interferon Genes from 2019 to July 2022: An Overview of the Structure and Bioactivity

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

Medicinal chemistry perspective on cGAS-STING signaling pathway with small molecule inhibitors

Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective

Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis

“网络课程学习+课堂授课+临床用药案例讨论”三维立体的临床药学专业《药物化学》教学模式研究

Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification

Agonist of stimulator of interferon genes as antitumor agents: a patent review (2008-2020)

Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core

Discovery and Optimization of Small Molecules Targeting the Protein–Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer

An updated patent review of anticancer Hsp90 inhibitors (2013-present)

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis

基于均相时间分辨荧光技术(HTRF)的HSP90-HOP相互作用抑制剂活性测试方法的构建及其应用

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway

Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction

Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5

Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators

Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo

Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

Optimization and biological evaluation of celastrol derivatives as Hsp90–Cdc37 interaction disruptors with improved druglike properties

Structure–activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity

Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents

Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential

Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells

Discovery of novel chemical scaffolds as RhoA inhibitors using virtual screening, synthesis, and bioactivity evaluation

Betulinic acid acetate, an antiproliferative natural product, suppresses client proteins of heat shock protein pathways through a CDC37-binding mechanism

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure–Activity Relationship Study

Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1)

Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction

Discovery of new scaffolds from approved drugs as acetylcholinesterase inhibitors

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1)

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Indenoisoquinoline derivatives as topoisomerase I inhibitors that suppress angiogenesis by affecting the HIF signaling pathway

3-Aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as Potent Nrf2/ARE Inducers in Human Cancer Cells and AOM-DSS Treated Mice