于典科｜青岛大学｜学者主页

2026

Developing adverse outcome pathways underlying CAR activation-induced liver injuries using HepG2 spheroid model

Congying Jin, Y H Ma, Li Chen, Xiangbing Kong, Changqing Zhang, Meihua Zhang, Wanli Ma, Xiaoxiao Zhu, Honghui Guo, Luyao Jiang, Xia Li, Yuejie Tian, Dianke Yu, Yuan Jin

Archives of Toxicology

DOI

2025

piR-16404 drives ferroptotic liver injury via CASTOR1/mTORC1/GPX4 dysregulation in HepG2 cells and mice: a novel toxicity mechanism of N, N-dimethylformamide

Wanli Ma, Xiaoyu Huo, Ruoxi Li, Jingjing Xing, Lin Xu, Dianke Yu

Archives of Toxicology

DOI

2025

Corrigendum to “Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors” [Ecotoxicol. Environ. Saf., 287 (2024) 117266]

Yumei Ma, Chenlong Du, Yuzhen Liu, Meiyao Feng, Yingqing Shou, Dianke Yu, Yuan Jin

Ecotoxicology and Environmental Safety

DOI

2024

机器学习方法应用于化学物质毒性测试研究进展

冯驰原，首莹清，靳远，于典科

《中国药理学与毒理学杂志》

2024

Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor

Donghui Zhang, Xinya Liu, Lanchao Sun, Daochuan Li, Jingyue Du, Huizi Yang, Dianke Yu, Chuanhai Li

Toxicology

DOI

2024

Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors

Yumei Ma, Chenlong Du, Yuzhen Liu, Meiyao Feng, Yingqing Shou, Dianke Yu, Yuan Jin

Ecotoxicology and Environmental Safety

DOI

2024

Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk

Lanchao Sun, Xinya Liu, Jingyue Du, Huizi Yang, Yongfeng Lin, Dianke Yu, Chuanhai Li, Yuxin Zheng

Environmental Science & Technology

DOI

2024

New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM2.5-induced lung cancer

Lin Xu, Wanli Ma, Xiaoyu Huo, Jiao Luo, Ruoxi Li, Xiaoxiao Zhu, Xiangbin Kong, Kunming Zhao, Yuan Jin, Meihua Zhang, Xianshu Li, Ling Wang, Wei Han, Dianke Yu

Journal of Advanced Research

DOI

2024

Coke oven emissions exacerbate allergic asthma by promoting ferroptosis in airway epithelial cells

Xian Chen, Hongguang Chen, Pimei Zhang, Qiang Ju, Zhaoxu Wu, Nuo Xu, Qing Bi, Shuaishuai Yang, Jing Ji, Dianke Yu, Yanjie Zhao

Journal of Hazardous Materials

DOI

2024

piR-27222 mediates PM2.5-induced lung cancer by resisting cell PANoptosis through the WTAP/m6A axis

Wan‐Li Ma, Lin Xu, Yixuan Wang, Shen Chen, Daochuan Li, Xiaoyu Huo, Ruoxi Li, Xiaoxiao Zhu, Ningning Chen, Yuan Jin, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Wei Han, Dianke Yu

Environment International

DOI

2024

miR-145a-5p/SIK1/cAMP-dependent alteration of synaptic structural plasticity drives cognitive impairment induced by coke oven emissions

Zhaoxu Wu, Heng Zhang, Xian Chen, Pimei Zhang, Jiacheng Fang, Shuaishuai Yang, Hongguang Chen, Jing Ji, Lei Chen, Yuxin Zheng, Dianke Yu, Yanjie Zhao

Ecotoxicology and Environmental Safety

DOI

2024

Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation

Qinkai Lei, Chenlong Du, Yumei Ma, Yingqing Shou, Li Chen, Chiyuan Feng, Yuxin Zheng, Dianke Yu, Yuan Jin

Ecotoxicology and Environmental Safety

DOI

2024

LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma

Kunming Zhao, Xinyi Wang, Yaqiong Jin, Xiaoxiao Zhu, Tao You Zhou, Yongbo Yu, Xiaoying Ji, Yan Chang, Jiao Luo, Xin Ni, Yongli Guo, Dianke Yu

Cell Death and Disease

DOI

2023

Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease

Ningning Chen, Jiao Luo, Tao Zhou, Yingqing Shou, Chenlong Du, Ge Song, Lin Xu, Kunming Zhao, Yuan Jin, Chuanhai Li, Dianke Yu

Biochemical Pharmacology

DOI

2023

Functional polymorphisms in Benzo(a)Pyrene-induced toxicity pathways associated with the risk on laryngeal squamous cell carcinoma

Lin Xu, Xueying Sun, Yiyi Wang, Tao Zhou, Jingjing Jia, Mai Zhang, Pengyuan Zhou, Yixiao Wang, Youshuo Wang, Yingqing Shou, Xiaoyu Huo, Xiaoying Ji, Jing Chen, Dianke Yu

Food and Chemical Toxicology

DOI

2023

An entropy weight method to integrate big omics and mechanistically evaluate DILI

Yuan Jin, Yingqing Shou, Qinkai Lei, Chenlong Du, Lin Xu, Ningning Chen, Wanli Ma, Xiaoxiao Zhu, Shuya Zhou, Yuxin Zheng, Dianke Yu

Hepatology

DOI

2023

Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter

Jiao Luo, Yanan Ji, Ningning Chen, Ge Song, Shuyue Zhou, Xuan Niu, Dianke Yu

iScience

DOI

2023

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Jiao Luo, Ge Song, Ningning Chen, Mengyue Xie, Xuan Niu, Shuyue Zhou, Yanan Ji, Xiaoxiao Zhu, Wanli Ma, Qianqian Zhang, Dianke Yu

Cell Death Discovery

DOI

2023

Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk

Lin Xu, Yanting Li, Wanli Ma, Xueying Sun, Rongrong Fan, Yuan Jin, Ningning Chen, Xiaoxiao Zhu, Huan Guo, Kunming Zhao, Jiao Luo, Chuanhai Li, Yuxin Zheng, Dianke Yu

Journal of Hazardous Materials

DOI

2023

Toxicity and risk priority ranking of polybrominated diphenyl ethers (PBDEs): A relative receptor-bound concentration approach

Xinya Liu, Lanchao Sun, Shangning Wu, Penghao Wang, Zhaoze Wang, Mengfan Zhai, Jiayi Xu, Donghui Zhang, Dianke Yu, Chuanhai Li

The Science of The Total Environment

DOI

2023

MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1

Yuzhen Liu, Heyuan Guan, Meiyao Feng, Chenlong Du, Qianqian Zhang, Yingqing Shou, Guangshuai Qi, Dianke Yu, Yuan Jin

Ecotoxicology and Environmental Safety

DOI

2023

Carbon dots induce pathological damage to the intestine via causing intestinal flora dysbiosis and intestinal inflammation

Mengmeng Jia, Bingcheng Yi, Xian Chen, Yongzhi Xu, Xinkai Xu, Zhaoxu Wu, Jing Ji, Jinglong Tang, Dianke Yu, Yuxin Zheng, Qihui Zhou, Yanjie Zhao

Journal of Nanobiotechnology

DOI

2023

Genomic Characterization Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B

Rongrong Fan, Lin Xu, Bowen Cui, Daochuan Li, Xueying Sun, Yuan Qi, Jianan Rao, Kai Wang, Cheng Wang, Kunming Zhao, Yanjie Zhao, Juncheng Dai, Wen Chen, Hongbing Shen, Yu Liu, Dianke Yu

Environmental Science & Technology

DOI

2023

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Chuanhai Li, Lidan Jiang, Donghui Zhang, Yuan Qi, Xinyi Wang, Yuan Jin, Xinya Liu, Yongfeng Lin, Jiao Luo, Lin Xu, Kunming Zhao, Dianke Yu

Environment International

DOI

2023

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

Donghui Zhang, Xinya Liu, Yuan Qi, Yongfeng Lin, Kunming Zhao, Yuan Jin, Jiao Luo, Lin Xu, Dianke Yu, Chuanhai Li

The Science of The Total Environment

DOI

2022

The path via pathway-based approaches towards safety assessment: A concise review

Yuan Jin, Guangshuai Qi, Meiyao Feng, Dianke Yu

Toxicology and Applied Pharmacology

DOI

2022

Identification of miRNAs involved in liver injury induced by chronic exposure to cadmium

Xinhang Jiang, Wenxue Li, Mingxue Tan, Ping Guo, Xiaoling Liu, Xinhong Pan, Dianke Yu, Yaqin Pang, Daochuan Li, Qing Wang, Wen Chen, Liping Chen

Toxicology

DOI

2022

Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM2.5-induced lung cancer development

Wanli Ma, Lin Xu, Xueying Sun, Yuan Qi, Shen Chen, Daochuan Li, Yuan Jin, Ningning Chen, Xiaoxiao Zhu, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

Environmental Pollution

DOI

2022

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2022

Identifying microRNAs that drive BaP-induced pulmonary effects: Multiple patterns of mechanisms underlying activation of the toxicity pathways

Yuan Jin, Qianqian Zhang, Yuzhen Liu, Heyuan Guan, Yingqing Shou, Chenlong Du, Jiao Luo, Kunming Zhao, Chuanhai Li, Lin Xu, Wanli Ma, Ningning Chen, Yuxin Zheng, Dianke Yu

Environment International

DOI

2022

Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests

Yangchun Zhang, Ziqi Liu, Ziwei Wang, Huan Gao, Yuqing Wang, Mengxing Cui, Honghao Peng, Yongmei Xiao, Yuan Jin, Dianke Yu, Wen Chen, Qing Wang

Journal of Hazardous Materials

DOI

2022

Roles of H19/miR-29a-3p/COL1A1 axis in COE-induced lung cancer

Heng Zhang, Xinmei Li, Mengmeng Jia, Jing Ji, Zhaoxu Wu, Xian Chen, Dianke Yu, Yuxin Zheng, Yanjie Zhao

Environmental Pollution

DOI

2022

miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer

Ningning Chen, Jiao Luo, Yufei Hou, Yanan Ji, Mengyue Xie, Ge Song, Dianke Yu

Biochemical Pharmacology

DOI

2022

Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure

Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng, Daochuan Li, Wen Chen

Particle and Fibre Toxicology

DOI

2022

N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro

Lin Xu, Wanli Ma, Yuan Jin, Xueying Sun, Ningning Chen, Xiaoxiao Zhu, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

The Science of The Total Environment

DOI

2022

CpG site-specific methylation as epi-biomarkers for the prediction of health risk in PAHs-exposed populations

Lizhu Ye, Zhini He, Daochuan Li, Liping Chen, Shen Chen, Ping Guo, Dianke Yu, Lu Ma, Yong Niu, Huawei Duan, Xiumei Xing, Yongmei Xiao, Xiao‐Wen Zeng, Qing Wang, Guang‐Hui Dong, Michael Aschner, Yuxin Zheng, Wen Chen

Journal of Hazardous Materials

DOI

2022

GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation

Siying Tang, Daochuan Li, Hao Ding, Menghui Jiang, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Rui Chen, Yuxin Zheng, Jin‐Mei Piao

Ecotoxicology and Environmental Safety

DOI

2021

系统毒理学研究进展

靳远，刘玉真，戚光帅，于典科

《环境与职业医学》

DOI

2021

经口六价铬暴露毒作用模式中关键毒性通路的生物信息学分析

蒋欣航，王紫微，彭慧，徐驰，于典科，靳远，陈丽萍，陈雯

《环境与职业医学》

DOI

2021

PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A

Lin Xu, Wendi Chen, Jing Chen, Yuan Jin, Wanli Ma, Guangshuai Qi, Xueying Sun, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2021

Corrigendum to “SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes” [Environ. Pollut. 261 (2020) 114160]

Ping Guo, Shen Chen, Daochuan Li, Jinmiao Zhang, Jiao Luo, Aihua Zhang, Dianke Yu, Michael S. Bloom, Liping Chen, Wen Chen

Environmental Pollution

DOI

2021

Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers

Shen Chen, Daochuan Li, Dianke Yu, Miao Li, Lizhu Ye, Jiang Yue, Shijie Tang, Rui Zhang, Chi Xu, Shuyun Jiang, Ziwei Wang, Michael Aschner, Yuxin Zheng, Liping Chen, Wen Chen

Journal of Hazardous Materials

DOI

2021

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Yuan Jin, Guangshuai Qi, Yingqing Shou, Daochuan Li, Yuzhen Liu, Heyuan Guan, Qianqian Zhang, Shen Chen, Jiao Luo, Lin Xu, Chuanhai Li, Wanli Ma, Ningning Chen, Yuxin Zheng, Dianke Yu

Journal of Hazardous Materials

DOI

2021

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532–3p/Acyl-CoA oxidase 1(ACOX1) pathway

Chuanhai Li, Lidan Jiang, Yuan Jin, Donghui Zhang, Jing Chen, Yuan Qi, Rongrong Fan, Jiao Luo, Lin Xu, Wanli Ma, Kunming Zhao, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2021

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

Xinmei Li, Heng Zhang, Lin Xu, Yuan Jin, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu, Yanjie Zhao

Frontiers in Molecular Biosciences

DOI

2021

PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury

Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Qiong Li, Haiyan Zhang, Rui Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Qun Zhao, Jianhui Liu, Gangfeng Ouyang, Michael Aschner, Yuxin Zheng, Lihua Zhang, Wen Chen, Daochuan Li

Journal of Hazardous Materials

DOI

2021

Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

Yangchun Zhang, Ziqi Liu, Qianmei He, Fei Wu, Yongmei Xiao, Wen Chen, Yuan Jin, Dianke Yu, Qing Wang

Frontiers in Genetics

DOI

2021

A toxicity pathway-based approach for modeling the mode of action framework of lead-induced neurotoxicity

Hehai Huang, Yuan Jin, Chuanying Chen, Meiyao Feng, Qing Wang, Daochuan Li, Wen Chen, Xiumei Xing, Dianke Yu, Yongmei Xiao

Environmental Research

DOI

2021

Effects of Real-Ambient PM2.5 Exposure on Lung Damage Modulated by Nrf2−/−

Hao Ding, Menghui Jiang, Daochuan Li, Yanjie Zhao, Dianke Yu, Rong Zhang, Wen Chen, Jingbo Pi, Rui Chen, Lianhua Cui, Yuxin Zheng, Jin‐Mei Piao

Frontiers in Pharmacology

DOI

2021

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease

Jiao Luo, Mengyue Xie, Yufei Hou, Wanli Ma, Yuan Jin, Jing Chen, Chuanhai Li, Kunming Zhao, Ningning Chen, Lin Xu, Yanan Ji, Qianqian Zhang, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2021

MicroRNA-760 resists ambient PM2.5-induced apoptosis in human bronchial epithelial cells through elevating heme-oxygenase 1 expression

Lin Xu, Qianwen Zhao, Daochuan Li, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Jing Chen, Kunming Zhao, Yuxin Zheng, Dianke Yu

Environmental Pollution

DOI

2021

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

Jiao Luo, Yufei Hou, Wanli Ma, Mengyue Xie, Yuan Jin, Lin Xu, Chuanhai Li, Ying Wang, Jing Chen, Wendi Chen, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2020

微小RNA在酒精致肝损伤中的作用机制研究进展

王序兵，赵艳洁，于典科

《环境与职业医学》

DOI

2020

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

Dongying Li, Leihong Wu, Bridgett Knox, Si Chen, William H. Tolleson, Fang Liu, Dianke Yu, Lei Guo, Weida Tong, Baitang Ning

Archives of Toxicology

DOI

2020

Nrf2 modulated the restriction of lung function via impairment of intrinsic autophagy upon real-ambient PM2.5 exposure

Menghui Jiang, Daochuan Li, Jin‐Mei Piao, Yanting Li, Liping Chen, Jianyu Li, Dianke Yu, Jingbo Pi, Rong Zhang, Rui Chen, Wen Chen, Yuxin Zheng

Journal of Hazardous Materials

DOI

2020

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

Yuan Jin, Meiyao Feng, Wanli Ma, Yanhong Wei, Guangshuai Qi, Jiao Luo, Lin Xu, Xinmei Li, Chuanhai Li, Wang Ying, Daochuan Li, Jing Chen, Yanjie Zhao, Yufei Hou, Qianwen Zhao, Lidan Jiang, Mengyue Xie, Yuxin Zheng, Dianke Yu

Environmental Pollution

DOI

2020

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity

Lin Xu, Qianwen Zhao, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Yufei Hou, Meiyao Feng, Ying Wang, Jing Chen, Jinquan Zhao, Yuxin Zheng, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2020

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis

Liping Chen, Ping Guo, Wenxue Li, Fei Fang, Wei Zhu, Junling Fan, Fangping Wang, Yuanyuan Gao, Qun Zhao, Qing Wang, Yongmei Xiao, Xiumei Xing, Daochuan Li, Tieliu Shi, Dianke Yu, Michael Aschner, Lihua Zhang, Wen Chen

Hepatology

DOI

2020

Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Xiao‐Wen Zeng, Guang‐Hui Dong, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen

Particle and Fibre Toxicology

DOI

2020

MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway

Xubing Wang, Yanjie Zhao, Jiao Min Luo, Lin Xu, Xinmei Li, Yuan Jin, Chuanhai Li, Meiyao Feng, Ying Wang, Jing Chen, Yufei Hou, Qianwen Zhao, Jinquan Zhao, Baitang Ning, Yuxin Zheng, Dianke Yu

Molecular Pharmacology

DOI

2020

Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China

Shen Chen, Daochuan Li, Xiaonen Wu, Liping Chen, Bin Zhang, Yafei Tan, Dianke Yu, Yong Niu, Huawei Duan, Qiong Li, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen

Environment International

DOI

2020

MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells

Xiaoju Ma, Xue Zhang, Jiao Luo, Boxuan Liang, Jing Peng, Chuanying Chen, Hongyu Guo, Qing Wang, Xiumei Xing, Qifei Deng, Hehai Huang, Qilong Liao, Wen Chen, Qiansheng Hu, Dianke Yu, Yongmei Xiao

Toxicology in Vitro

DOI

2020

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

Dianke Yu, Jing Chen, Si Chen, Lin Xu, Leihong Wu, Dongying Li, Jiao Luo, Yuan Jin, Yanjie Zhao, Bridgett Knox, William H. Tolleson, Xubing Wang, Lei Guo, Weida Tong, Baitang Ning

Drug Metabolism and Disposition

DOI

2020

SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes

Ping Guo, Shen Chen, Daochuan Li, Jinmiao Zhang, Jiao Luo, Aihua Zhang, Dianke Yu, Michael S. Bloom, Liping Chen, Wen Chen

Environmental Pollution

DOI

2019

Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics

Baitang Ning, Dianke Yu, Ai‐Ming Yu

Biochemical Pharmacology

DOI

2019

The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure

Shen Chen, Daochuan Li, Haiyan Zhang, Dianke Yu, Rui Chen, Bin Zhang, Yafei Tan, Yong Niu, Huawei Duan, Bixian Mai, She-Jun Chen, Jian Zhen Yu, Tiangang Luan, Liping Chen, Xiumei Xing, Qiong Li, Yongmei Xiao, Guang‐Hui Dong, Yujie Niu, Michael Aschner, Rong Zhang, Yuxin Zheng, Wen Chen

Environment International

DOI

2019

FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation

Zhini He, Rui Zhang, Shen Chen, Liping Chen, Huiyao Li, Lizhu Ye, Qiong Li, Ziwei Wang, Qing Wang, Huawei Duan, Yong Niu, Yongmei Xiao, Guang‐Hui Dong, Daochuan Li, Dianke Yu, Yuxin Zheng, Xiumei Xing, Wen Chen

Environmental Pollution

DOI

2018

DNA damage‐induced apoptosis and mitogen‐activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells

Si Chen, Zhen Ren, Dianke Yu, Baitang Ning, Lei Guo

Environmental and Molecular Mutagenesis

DOI

2017

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

Dianke Yu, Leihong Wu, Pritmohinder S. Gill, William H. Tolleson, Si Chen, Jinchun Sun, Bridgett Knox, Yaqiong Jin, Wenming Xiao, Huixiao Hong, Yong Wang, Zhen Ren, Lei Guo, Nan Mei, Yongli Guo, Xi Yang, Leming M. Shi, Yinting Chen, Linjuan Zeng, Kostiantyn Dreval, Volodymyr Tryndyak, Igor P. Pogribny, Hong Fang, Tieliu Shi, Sandra S. McCullough, Sudeepa Bhattacharyya, Laura K. Schnackenberg, William B. Mattes, Richard D. Beger, Laura Phillips James, Weida Tong, Baitang Ning

Archives of Toxicology

DOI

2017

The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p

Yinting Chen, Linjuan Zeng, Yong Wang, William H. Tolleson, Bridgett Knox, Si Chen, Zhen Ren, Lei Guo, Nan Mei, Feng Qian, Kaihong Huang, David Liu, Weida Tong, Dianke Yu, Baitang Ning

Biochemical Pharmacology

DOI

2017

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

Linjuan Zeng, Yinting Chen, Yong Wang, Li‐Rong Yu, Bridgett Knox, Jiwei Chen, Tieliu Shi, Si Chen, Zhen Ren, Lei Guo, Yuanfeng Wu, David Liu, Kaihong Huang, Weida Tong, Dianke Yu, Baitang Ning

Biochemical Pharmacology

DOI

精选作品

期刊论文

Developing adverse outcome pathways underlying CAR activation-induced liver injuries using HepG2 spheroid model

piR-16404 drives ferroptotic liver injury via CASTOR1/mTORC1/GPX4 dysregulation in HepG2 cells and mice: a novel toxicity mechanism of N, N-dimethylformamide

Corrigendum to “Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors” [Ecotoxicol. Environ. Saf., 287 (2024) 117266]

机器学习方法应用于化学物质毒性测试研究进展

Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor

Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors

Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk

New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM2.5-induced lung cancer

Coke oven emissions exacerbate allergic asthma by promoting ferroptosis in airway epithelial cells

piR-27222 mediates PM2.5-induced lung cancer by resisting cell PANoptosis through the WTAP/m6A axis

miR-145a-5p/SIK1/cAMP-dependent alteration of synaptic structural plasticity drives cognitive impairment induced by coke oven emissions

Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation

LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma

Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease

Functional polymorphisms in Benzo(a)Pyrene-induced toxicity pathways associated with the risk on laryngeal squamous cell carcinoma

An entropy weight method to integrate big omics and mechanistically evaluate DILI

Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk

Toxicity and risk priority ranking of polybrominated diphenyl ethers (PBDEs): A relative receptor-bound concentration approach

MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1

Carbon dots induce pathological damage to the intestine via causing intestinal flora dysbiosis and intestinal inflammation

Genomic Characterization Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

The path via pathway-based approaches towards safety assessment: A concise review

Identification of miRNAs involved in liver injury induced by chronic exposure to cadmium

Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM2.5-induced lung cancer development

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Identifying microRNAs that drive BaP-induced pulmonary effects: Multiple patterns of mechanisms underlying activation of the toxicity pathways

Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests

Roles of H19/miR-29a-3p/COL1A1 axis in COE-induced lung cancer

miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer

Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure

N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro

CpG site-specific methylation as epi-biomarkers for the prediction of health risk in PAHs-exposed populations

GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM2.5 exposure disturbed thyroid hormone homeostasis regulation

系统毒理学研究进展

经口六价铬暴露毒作用模式中关键毒性通路的生物信息学分析

PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A

Corrigendum to “SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes” [Environ. Pollut. 261 (2020) 114160]

Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532–3p/Acyl-CoA oxidase 1(ACOX1) pathway

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury

Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

A toxicity pathway-based approach for modeling the mode of action framework of lead-induced neurotoxicity

Effects of Real-Ambient PM2.5 Exposure on Lung Damage Modulated by Nrf2−/−

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease

MicroRNA-760 resists ambient PM2.5-induced apoptosis in human bronchial epithelial cells through elevating heme-oxygenase 1 expression

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

微小RNA在酒精致肝损伤中的作用机制研究进展

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

Nrf2 modulated the restriction of lung function via impairment of intrinsic autophagy upon real-ambient PM2.5 exposure

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis

Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway

Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China

MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes

Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics

The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure

FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation

DNA damage‐induced apoptosis and mitogen‐activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells

Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans

The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

会议论文

基于生物活性等效浓度构建“体外-体内外推”模型及在新污染物毒性风险评估中的应用

tRNA来源的小RNA片段在二甲基甲酰胺致肝损伤中的作用机制研究

基于PBTK模型和体外实验评估镉暴露的健康风险

苯并芘靶器官毒性分析及相关毒性通路研究

hsa-miR-1301-3p通过调节ADH6,ALDH5A1和ALDH8A1的表达调控酒精肝损伤的机制研究

HSA-miR-1301-3p对酒精代谢酶的调控机制研究