李顺来｜北京化工大学｜学者主页

2026

一类简化型嘌呤核苷衍生物的设计与合成研究

李顺来，王铭显，徐方明，于明武，杜洪光

《化学研究与应用》

2024

Essential Structural Profile of Novel Adenosine Derivatives as Antiplatelet Aggregation Inhibitors based on 3D-QSAR Analysis

Shunlai Li, Pengyu Zheng, Yajing Ren, Hongguang Du

Letters in Drug Design & Discovery

DOI

2023

Synthesis of 6-Alkylamino-2-alkylthio(alkoxy) Purine Derivatives: Antiplatelet Aggregation Activity Evaluation and 3D-QSAR Analysis

Shunlai Li, Pengyu Zheng, Yajing Ren, Hongguang Du

Russian Journal of Bioorganic Chemistry

DOI

2022

Synthesis of novel purine derivatives: Antiplatelet aggregation activity evaluation and 3D‐QSAR analysis

Shunlai Li, Yajing Ren, Qiwen He, Yongji Wei, Hongguang Du

Journal of Heterocyclic Chemistry

DOI

2021

Synthesis of novel acyclic and multiple phenyl iron tetraamino ligand catalysts and its catalytic activity for degradation of dye wastewater by H2O2

Shunlai Li, Run Zhou, Weijing Zhao, Hongguang Du

Applied Organometallic Chemistry

DOI

2020

Synthesis, anti‐platelet aggregation activity evaluation and structure–activity relationships of a series of novel purine derivatives

Shunlai Li, Cheng Zhou, Mingwu Yu, Qiwen He, Hongguang Du

Journal of Heterocyclic Chemistry

DOI

2020

Essential Structural Profile of Novel Adenosine Derivatives as Antiplatelet Aggregation Inhibitors Based on 3D-QSAR Analysis Using CoMFA, CoMSIA, and SOMFA

Shunlai Li, XueFeng Bao, Chenghu Lu, Chaorui Ren, Guo‐Cheng Liu, Hongguang Du

Russian Journal of Bioorganic Chemistry

DOI

2020

Synthesis of a simplified iron(III) tetraamido macrocyclic ligand (FeIII-TAML) catalyst and its catalytic activity for degradation of dye wastewater by H2O2

Shunlai Li, Liaoyuan Wang, Run Zhou, Cheng Zhou, Hongguang Du

Journal of Coordination Chemistry

DOI

2019

巴氟替尼中间体(R)-3-二甲氨基吡咯烷的合成

李顺来，李秀秀，任朝瑞，杜洪光

《合成化学》

DOI

2018

新型腺嘌呤类化合物的抗血小板凝集3D-QSAR研究

李顺来，徐芳明，黄衍均，杜洪光

《计算机与应用化学》

2018

3D-QSAR Studies on New Benzothiazole-Based Dual Functional Inhibitors of BCR-ABL Kinase Including the T315I Mutant

Shunlai Li, Chaorui Ren, Chenghu Lu, Xiuxiu Li, Hongguang Du

Letters in Drug Design & Discovery

DOI

2017

一类新型6-烷氨基-2-烷硫基嘌呤核苷衍生物抗血小板凝集的3D-QSAR研究

李顺来，陆成虎，杜洪光

《北京化工大学学报(自然科学版)》

2017

Expedient synthesis of 2-alkylthio-N6-aryladenosines from guanosine

Miao Tian, Ning Chen, Fangming Xu, Xiuxiu Li, Shunlai Li, Hongguang Du

Journal of Sulfur Chemistry

DOI

2017

Front Cover: Silver‐Catalyzed Direct C6–H Arylation of Purines and Purine Nucleosides with Arylboronic Acids (Eur. J. Org. Chem. 24/2017)

Miao Tian, Mingwu Yu, Tingting Shi, Junbin Hu, Shunlai Li, Jiaxi Xu, Ning Chen, Hongguang Du

European Journal of Organic Chemistry

DOI

2017

Silver‐Catalyzed Direct C6–H Arylation of Purines and Purine Nucleosides with Arylboronic Acids

Miao Tian, Mingwu Yu, Tingting Shi, Junbin Hu, Shunlai Li, Jiaxi Xu, Ning Chen, Hongguang Du

European Journal of Organic Chemistry

DOI

2016

Synthesis, Antiplatelet Aggregation Activity Evaluation and 3D‐QSAR of a Series of Novel 6‐Alkylamino(Alkoxyl)‐2‐Propylthio‐8‐Azapurine Nucleosides

Hongguang Du, Mingwu Yu, C. E. Deng, Chenghu Lu, Shunlai Li

Journal of Heterocyclic Chemistry

DOI

2016

ChemInform Abstract: Purinyl N3‐Directed Palladium‐Catalyzed C—H Alkoxylation of N9‐Arylpurines: A Late‐Stage Strategy to Synthesize N9‐(ortho‐Alkoxyl)arylpurines.

Mingwu Yu, Zhiqian Wang, Miao Tian, Chenghu Lu, Shunlai Li, Hongguang Du

ChemInform

DOI

2016

Synthesis of 8-alkoxy-6-alkylamino-2-alkylthiopurine nucleosides with a straightforward multiple-functionalization strategy

Hongguang Du, Xiaoyang Sun, Mingwu Yu, Miao Tian, Shunlai Li, Zhiqian Wang

Tetrahedron Letters

DOI

2016

Purinyl N3-Directed Palladium-Catalyzed C–H Alkoxylation of N9-Arylpurines: A Late-Stage Strategy to Synthesize N9-(ortho-Alkoxyl)arylpurines

Mingwu Yu, Zhiqian Wang, Miao Tian, Chenghu Lu, Shunlai Li, Hongguang Du

The Journal of Organic Chemistry

DOI

2016

ChemInform Abstract: Copper‐Catalyzed Intramolecular Alkoxylation of Purine Nucleosides: One‐Step Synthesis of 5′‐O,8‐Cyclopurine Nucleosides.

Mingwu Yu, Zhiqian Wang, Junbin Hu, Shunlai Li, Hongguang Du

ChemInform

DOI

2015

6-烷氨基-2-乙硫基嘌呤核苷化合物的合成及抗血小板聚集活性研究

王子健，李顺来，于明武，骆媛，王帅，王永安，杜洪光

《有机化学》

2015

Copper-Catalyzed Intramolecular Alkoxylation of Purine Nucleosides: One-Step Synthesis of 5′-O,8-Cyclopurine Nucleosides

Mingwu Yu, Zhiqian Wang, Junbin Hu, Shunlai Li, Hongguang Du

The Journal of Organic Chemistry

DOI

2013

一类伊马替尼衍生物酪氨酸激酶抑制剂作用模式的理论研究

李顺来，孙墨林，何茂芋，杜洪光

《计算机与应用化学》

2013

6-烷氧基-2-丙硫基-8-氮杂嘌呤核苷的合成及抗血小板凝聚活性评价

邓聪迩，李顺来，刘祥伟，杜洪光

《有机化学》

2013

合成3-羟基-2-(4-吡啶基)-1H-茚-1-酮的工艺改进

李顺来，汪阿鹏，王新磊，杜洪光

《合成化学》

2013

6-取代氨基-2-烷硫基腺苷化合物的合成及抗血小板凝聚活性

魏永吉，李顺来，于明武，杜洪光

《高等学校化学学报》

2013

3D‐QSAR Study on a Series of VEGFR‐2 Kinase Inhibitors: 3‐Pyrrole Substituted Indolin‐2‐Ones Compounds

Shunlai Li, Rutao Zhang, Hongguang Du

Journal of Chemistry

DOI

2013

Synthesis of 6-Alkoxyl-2-propylthio-8-azapurine Nucleosides and Their Antiplatelet Aggregation Activity Evaluation

Conger Deng, Shunlai Li, Xiangwei Liu, Hongguang Du

Chinese Journal of Organic Chemistry

DOI

2011

N6-烷基-2-烷氧基腺苷化合物的合成及抗血小板凝集活性

吴兆军，李顺来，丁忠仁，杜洪光

《有机化学》

2011

一类来氟米特类似物二氢乳清酸脱氢酶抑制剂作用模式的理论研究

李顺来，王新磊，杜洪光

《计算机与应用化学》

2011

内-9-甲基-9-氮杂二环[3.3.1]壬-3-烷胺的合成工艺改进

李顺来，张汝涛，王军，杜洪光

《合成化学》

2011

无环嘌呤核苷化合物2-(2-(6-氨基-2-烷硫基-9H-嘌呤-9-基)乙基)丙二酸二甲酯的合成

王馨悦，李顺来，杜洪光

《北京化工大学学报(自然科学版)》

2011

一类双氯芬酸类似物环氧合酶抑制剂作用模式的理论研究

李顺来，王存铎，李秀艳，杜洪光

《北京化工大学学报(自然科学版)》

2011

3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide

Shunlai Li, Mao-Yu He, Hongguang Du

International Journal of Molecular Sciences

DOI

2008

新型二芳基取代-1，2，4-三唑类化合物的抗炎构效关系和分子对接研究

李秀艳，郑艳，李顺来，杜洪光

《计算机与应用化学》

2008

COX-2/DHODH双重抑制剂存在可行性的初步对接虚拟筛选研究

李顺来，李秀艳，杜洪光

《北京化工大学学报(自然科学版)》

2007

三环类环氧合酶抑制剂的三维定量构效关系研究

李顺来，郑艳，尹文刚

《北京化工大学学报(自然科学版)》

2006

新型1,5-二芳基咪唑类选择性COX-2抑制剂的抗炎构效关系

汪凤颖，李顺来

《北京化工大学学报(自然科学版)》

2006

新型1,5-二芳基咪唑类制剂的分子对接研究

李顺来，郑艳，汪凤颖

《北京化工大学学报(自然科学版)》

2006

Self-Organizing Molecular Field Analysis on a New Series of COX-2 Selective Inhibitors: 1,5-Diarylimidazoles

Shunlai Li, Yan Zheng

International Journal of Molecular Sciences

DOI

2004

一类新型罗非昔布开环衍生物抗炎构效关系

汪凤颖，李顺来，冯文林

《北京化工大学学报(自然科学版)》

2004

三环类环氧合酶-2选择性抑制剂的构效关系

汪凤颖，李顺来，王清

《药学进展》

精选作品

期刊论文

一类简化型嘌呤核苷衍生物的设计与合成研究

Essential Structural Profile of Novel Adenosine Derivatives as Antiplatelet Aggregation Inhibitors based on 3D-QSAR Analysis

Synthesis of 6-Alkylamino-2-alkylthio(alkoxy) Purine Derivatives: Antiplatelet Aggregation Activity Evaluation and 3D-QSAR Analysis

Synthesis of novel purine derivatives: Antiplatelet aggregation activity evaluation and 3D‐QSAR analysis

Synthesis of novel acyclic and multiple phenyl iron tetraamino ligand catalysts and its catalytic activity for degradation of dye wastewater by H2O2

Synthesis, anti‐platelet aggregation activity evaluation and structure–activity relationships of a series of novel purine derivatives

Essential Structural Profile of Novel Adenosine Derivatives as Antiplatelet Aggregation Inhibitors Based on 3D-QSAR Analysis Using CoMFA, CoMSIA, and SOMFA

Synthesis of a simplified iron(III) tetraamido macrocyclic ligand (FeIII-TAML) catalyst and its catalytic activity for degradation of dye wastewater by H2O2

巴氟替尼中间体(R)-3-二甲氨基吡咯烷的合成

新型腺嘌呤类化合物的抗血小板凝集3D-QSAR研究

3D-QSAR Studies on New Benzothiazole-Based Dual Functional Inhibitors of BCR-ABL Kinase Including the T315I Mutant

一类新型6-烷氨基-2-烷硫基嘌呤核苷衍生物抗血小板凝集的3D-QSAR研究

Expedient synthesis of 2-alkylthio-N6-aryladenosines from guanosine

Front Cover: Silver‐Catalyzed Direct C6–H Arylation of Purines and Purine Nucleosides with Arylboronic Acids (Eur. J. Org. Chem. 24/2017)

Silver‐Catalyzed Direct C6–H Arylation of Purines and Purine Nucleosides with Arylboronic Acids

Synthesis, Antiplatelet Aggregation Activity Evaluation and 3D‐QSAR of a Series of Novel 6‐Alkylamino(Alkoxyl)‐2‐Propylthio‐8‐Azapurine Nucleosides

ChemInform Abstract: Purinyl N3‐Directed Palladium‐Catalyzed C—H Alkoxylation of N9‐Arylpurines: A Late‐Stage Strategy to Synthesize N9‐(ortho‐Alkoxyl)arylpurines.

Synthesis of 8-alkoxy-6-alkylamino-2-alkylthiopurine nucleosides with a straightforward multiple-functionalization strategy

Purinyl N3-Directed Palladium-Catalyzed C–H Alkoxylation of N9-Arylpurines: A Late-Stage Strategy to Synthesize N9-(ortho-Alkoxyl)arylpurines

ChemInform Abstract: Copper‐Catalyzed Intramolecular Alkoxylation of Purine Nucleosides: One‐Step Synthesis of 5′‐O,8‐Cyclopurine Nucleosides.

6-烷氨基-2-乙硫基嘌呤核苷化合物的合成及抗血小板聚集活性研究

Copper-Catalyzed Intramolecular Alkoxylation of Purine Nucleosides: One-Step Synthesis of 5′-O,8-Cyclopurine Nucleosides

一类伊马替尼衍生物酪氨酸激酶抑制剂作用模式的理论研究

6-烷氧基-2-丙硫基-8-氮杂嘌呤核苷的合成及抗血小板凝聚活性评价

合成3-羟基-2-(4-吡啶基)-1H-茚-1-酮的工艺改进

6-取代氨基-2-烷硫基腺苷化合物的合成及抗血小板凝聚活性

3D‐QSAR Study on a Series of VEGFR‐2 Kinase Inhibitors: 3‐Pyrrole Substituted Indolin‐2‐Ones Compounds

Synthesis of 6-Alkoxyl-2-propylthio-8-azapurine Nucleosides and Their Antiplatelet Aggregation Activity Evaluation

N6-烷基-2-烷氧基腺苷化合物的合成及抗血小板凝集活性

一类来氟米特类似物二氢乳清酸脱氢酶抑制剂作用模式的理论研究

内-9-甲基-9-氮杂二环[3.3.1]壬-3-烷胺的合成工艺改进

无环嘌呤核苷化合物2-(2-(6-氨基-2-烷硫基-9H-嘌呤-9-基)乙基)丙二酸二甲酯的合成

一类双氯芬酸类似物环氧合酶抑制剂作用模式的理论研究

3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide

新型二芳基取代-1，2，4-三唑类化合物的抗炎构效关系和分子对接研究

COX-2/DHODH双重抑制剂存在可行性的初步对接虚拟筛选研究

三环类环氧合酶抑制剂的三维定量构效关系研究

新型1,5-二芳基咪唑类选择性COX-2抑制剂的抗炎构效关系

新型1,5-二芳基咪唑类制剂的分子对接研究

Self-Organizing Molecular Field Analysis on a New Series of COX-2 Selective Inhibitors: 1,5-Diarylimidazoles

一类新型罗非昔布开环衍生物抗炎构效关系

三环类环氧合酶-2选择性抑制剂的构效关系

研究方向