李少伟｜厦门大学｜学者主页

2026

基于mRNA平台的人类免疫缺陷病毒1疫苗策略

刘佩，方中岳，陈欣欣，李少伟，顾颖

《生物化学与生物物理进展》

2026

Nature Biomedical Engineering

DOI

2024

表位结构指导免疫优势转移的HPV交叉疫苗的理性设计（英文）

王致萍，王大宁，陈洁，高飞，江雅楠，杨澄宇，钱兹英，池鑫，张姝玥，许钰洁，卢一涵，沈璟佳，张承宗，李瑾瑾，周立志，李婷婷，郑清炳，俞海，李少伟，夏宁邵，顾颖

Science Bulletin

2024

假病毒包装系统发展及新兴应用

葛慧敏，蒋雯玲，方中岳，李少伟，顾颖

《病毒学报》

2024

An insect cell-derived extracellular vesicle-based gB vaccine elicits robust adaptive immune responses against Epstein-Barr virus

Qian Wu, Kai-Yun Chen, Wenhui Xue, Guo-Song Wang, Yan-Bo Yang, Shaowei Li, Ning-Shao Xia, Yi-Xin Chen

Science China Life Sciences

DOI

2024

Lizhi Zhou, Yue Ma, Kaihang Wang, Tingting Chen, Yang Huang, Liqin Liu, Yuqian Li, Jie Sun, Yi-Sha Hu, Ting-Ting Li, Z. Kong, Ying-Bin Wang, Q. Zheng, Qinjian Zhao, Jun Zhang, Ying Gu, Hai-tao Yu, N. Xia, Shaowei Li

Applied Microbiology and Biotechnology

DOI

2021

Qiong Huang, Shaowei Li, Xingbin Hu, Mengting Sun, Qijing Wu, Hui-Ru Dai, Yujing Tan, F. Sun, Chunlin Wang, X. Rong, W. Liao, Jianjun Peng, Jianjun Xiao, Li Huang, Jiao Wang, B. Liang, Kelin Lin, Yajing Liu, Min Shi

Journal of experimental & clinical cancer research : CR

DOI

2020

Unraveling metabolism heterogeneity in colorectal cancer and its implications in pan-cancer cohort.

Qijing Wu, Qiong Huang, Mengting Sun, B. Liang, Xingbin Hu, D. Zeng, Chunlin Wang, X. Rong, Zhen-Zhen Wu, Shaowei Li, Ling Wang, Z. Yao, Yajing Liu, F. Sun, W. Liao, Min Shi

DOI

2020

黄芳，李少伟，顾颖

《中国病原生物学杂志》

2018

人CD4胞外区蛋白在杆状病毒-昆虫细胞系统中的表达纯化及性质鉴定

乔佳明，张芝晴，张振勇，李少伟，夏宁邵，顾颖

《中国免疫学杂志》

2018

人乳头瘤病毒样颗粒组装研究进展

史晶洁，宋硕，王大宁，李智海，夏宁邵，李少伟

《病毒学报》

2018

杨超，张芝晴，沈鸿霖，高双全，李少勇，李少伟，夏宁邵，顾颖

《病毒学报》

2017

Zhen-Yong Zhang, Ting-Ting Li, Jiaming Qiao, Yuyun Zhang, Shuangquan Gao, Qiaobin Yao, Zekai Li, Zhi-Qing Zhang, Ying Gu, N. Xia, Shaowei Li

DOI

2017

Xin Wang, Min Li, Shaowei Li, Ting Wu, Jun Zhang, N. Xia, Qinjian Zhao

Expert Review of Vaccines

DOI

2016

HIV-1 Capsid as a Target for Antiviral Therapy

Zhi-Qing Zhang, Feng Zhang, Chao Yang, Jia-Long Qi, Shuangquan Gao, Shaowei Li, Ying Gu, N. Xia

DOI

2016

[Expression,Purification,Structure Determination and Immunogenicity Assay of Hepatitis E Virus Capsid Protein p495 Derived from Baculovirus-based Insect Cell].

Qingshan Lin, Jie Jiang, Ting-Ting Li, Yuyun Zhang, Zhen-Yong Zhang, Minghua Zheng, Kaihang Wang, Q. Zheng, Hai Yu, Ying Gu, N. Xia, Shaowei Li

Bing du xue bao = Chinese journal of virology

2016

Quantitative and epitope-specific antigenicity analysis of the human papillomavirus 6 capsid protein in aqueous solution or when adsorbed on particulate adjuvants.

Min Li, Xin Wang, Lu Cao, Zhijie Lin, M. Wei, Mu-Jin Fang, Shaowei Li, Jun Zhang, N. Xia, Qinjian Zhao

Vaccine

DOI

2016

[Preparation and Cryo-EM Structure Determination of Human Papillomavirus 16 Pseudovirion Derived from Suspension-adapted HEK293 Cells].

Da-Ning Wang, Ya-Jing Liu, Q. Zheng, Zhihai Li, F. Fan, Xin-Lin Liu, Shuo Song, Ying Gu, N. Xia, Shaowei Li

Bing du xue bao = Chinese journal of virology

2016

Real-time stability of a hepatitis E vaccine (Hecolin®) demonstrated with potency assays and multifaceted physicochemical methods.

Xiao Zhang, M. Wei, Guang Sun, Xin Wang, Min Li, Zhijie Lin, Zhongyi Li, Yufang Li, Mu-Jin Fang, Jun Zhang, Shaowei Li, N. Xia, Qinjian Zhao

Vaccine

DOI

2016

Mutant of HPV33 (human papilloma virus 33) L1 protein

Shaowei Li, Shuo Song, Zhihai Li, Yunbing Li, Hai Yu, Ning Xia

2016

夏宁邵，张军，李少伟，葛胜祥，李益民，吴文翰

《病毒学报》

2015

Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody

Da-Ning Wang, Zhihai Li, Jieqiong Xiao, Jun-Qi Wang, Li Zhang, Ya-Jing Liu, F. Fan, Lu Xin, M. Wei, Z. Kong, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li, N. Xia

PLoS ONE

DOI

Qinjian Zhao, Shaowei Li, Hai Yu, N. Xia, Y. Modis

Trends in Biotechnology

DOI

2012

Shaowei Li, Cuiling Song, Chunyan Yang, Ying Gu, Wen-Xin Luo, Ning-Shao Xia

2012

Hepatitis E vaccine development

Ting Wu, Shaowei Li, Jun Zhang, M. Ng, N. Xia, Qinjian Zhao

Human Vaccines & Immunotherapeutics

DOI

2012

Hepatitis E virus: neutralizing sites, diagnosis, and protective immunity

Jun Zhang, Shaowei Li, Ting Wu, Qinjian Zhao, M. Ng, N. Xia

Reviews in Medical Virology

DOI

2011

HIV-1 gp160截短蛋白在酿酒酵母中的表达

杨坤宇，李少伟，张毅，李庶甘，何芳萍，林庆山，周正，张军，夏宁邵

《生命科学研究》

2011

抗H5亚型禽流感病毒单链抗体在毕赤酵母中的分泌型表达和生物活性分析

何芳萍，林庆山，李少伟，魏旻希，陈振钦，罗文新，陈毅歆，张军，夏宁邵

《病毒学报》

Fang-Ping He, Qingshan Lin, Shaowei Li, M. Wei, Zhenqin Chen, Wenxin Luo, Yi-Xin Chen, Jun Zhang, N. Xia

Bing du xue bao = Chinese journal of virology

2010

A novel potential neutralizing epitope of hepatitis E virus

Zi-Zheng Zheng, Ming Tang, J. Miao, Min Zhao, Hui Huang, Jing-xian Li, Hai Yu, Shaowei Li, Jun Zhang, N. Xia

DOI

2009

人乳头瘤病毒16型病毒样颗粒的制备及其免疫原性研究

魏旻希，李少伟，黄博，沈文通，苏永在，张春华，顾颖，杜海莲，张军，夏宁邵

《病毒学报》

2009

大肠杆菌来源的人乳头瘤病毒11型病毒样颗粒的制备及其免疫原性

杨春燕，李少伟，王晋，魏旻希，黄博，庄玉娣，李仲艺，潘晖榕，张军，夏宁邵

《微生物学报》

2009

Expression and purification of soluble HIV-1 envelope glycoprotein gp160 mutant from Saccharomyces cerevisiae.

Kun-Yu Yang, Shaowei Li, Fang-Ping He, Jian-Nan Zhang, M. Wei, Hui-Rong Pan, Chunyan Yang, Jun-Hui Xiong, Jun Zhang, N. Xia

Journal of Bioscience and Bioengineering

DOI

2008

Cytosporone B is an agonist for nuclear orphan receptor Nur77

Yan-yan Zhan, Xiping Du, Hang‐zi Chen, Jingjing Liu, Bixing Zhao, Danhong Huang, Guideng Li, Qingyan Xu, Mingqing Zhang, Bart C. Weimer, Dong Chen, Zhe Cheng, Lianru Zhang, Qinxi Li, Shaowei Li, Zhonghui Zheng, Siyang Song, Yaojian Huang, Zhiyun Ye, Wen‐Jin Su, Sheng‐Cai Lin, Yuemao Shen, Qiao Wu

基于mRNA平台的人类免疫缺陷病毒1疫苗策略

重新思考新一代疫苗策略

Fruquintinib alternating with bevacizumab plus capecitabine as maintenance therapy after first-line treatment in metastatic colorectal cancer (mCRC): A multicenter, open-label, phase II study.

Rethinking Next-Generation Vaccine Strategies

Chitosan as a Vaccine Adjuvant: From Material Determinants to Innate Immune Activation and Formulation Optimization

Conformational dynamics of pneumococcal polysaccharide conjugates drive UV-vis quantification errors and a strategy to enable UV-vis spectrophotometer quantification

Molecular basis of host ATP level modulation by actin-dependent secreted bacterial ATPase and its metaeffector

Public antibody clonotypes and deep learning identify SARS-CoV-2 and HIV broadly neutralizing antibodies in immune repertoires

Structural basis and immunogenic efficacy of porcine circovirus type 3 virus-like particle

Structural and biochemical characterization of neutralizing antibodies targeting human papillomavirus type 45

An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein as a novel antiviral strategy

LNP-based delivery of a Toll-like receptor 9 agonist elicits potent adjuvant effects and antitumor immunity

A modular nanoparticle display strategy for varicella-zoster virus gE based on a licensed protein scaffold

人乳头瘤病毒16型感染上皮细胞过程的研究进展

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Efficacy and safety of fruquintinib alternating with bevacizumab plus capecitabine as maintenance therapy after first-line treatment in metastatic colorectal cancer (mCRC): A multicenter, open-label, phase II study.

Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation

Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer

Identification of a stromal immunosuppressive barrier orchestrated by SPP1+/C1QC+ macrophages and CD8+ exhausted T cells driving gastric cancer immunotherapy resistance

Montanide ISA-51: a promising adjuvant in cancer vaccine immunotherapy

Research Progress on Varicella-Zoster Virus Vaccines

Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests

Advancing mRNA vaccines: A comprehensive review of design, delivery, and efficacy in infectious diseases.

Author Correction: Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests

Multi-epitope transplantation enables cross-type neutralization of phylogenetically distant HPV11/6/53 in mice

Antibodies elicited by hepatitis E vaccination in humans confer cross-genus protection against rat hepatitis E virus.

Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites

A single residue switch mediates the broad neutralization of Rotaviruses

Targeting HIV-1 immune escape mechanisms: Key advances and challenges in HIV-1 vaccine design.

Broad neutralizing antibody response of a monomeric spike–based SARS-CoV-2 bivalent vaccine against diverse variants

Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice

A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion

Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion

Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections

表位结构指导免疫优势转移的HPV交叉疫苗的理性设计（英文）

假病毒包装系统发展及新兴应用

An insect cell-derived extracellular vesicle-based gB vaccine elicits robust adaptive immune responses against Epstein-Barr virus

戊型肝炎流行病学特征及疫苗研发进展

Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer

Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer.

Tumor microenvironment RNA test to predict immunotherapy outcomes in advanced gastric cancer: The TIMES001 trial.

Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.

Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2

WHO International Standards for antibodies to HPV6 HPV11 HPV31 HPV33 HPV45 HPV52 and HPV58

Risedronate-functionalized manganese-hydroxyapatite amorphous particles: A potent adjuvant for subunit vaccines and cancer immunotherapy.

Structural insight into broadening SARS-CoV-2 neutralization by an antibody cocktail harbouring both NTD and RBD potent antibodies

A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein

Characterization of a triple-type chimeric vaccine against human papillomavirus types 18, 45, and 59.

Comprehensive Overview of Broadly Neutralizing Antibodies against SARS-CoV-2 Variants

A cryptic site in class 5 epitope of SARS-CoV-2 RBD maintains highly conservation across natural isolates

Glycoprotein E-Displaying Nanoparticles Induce Robust Neutralizing Antibodies and T-Cell Response against Varicella Zoster Virus

Structural basis for the synergetic neutralization of hepatitis E virus by antibody–antibody interaction

Structural biology of the human papillomavirus

Structural insights into activation mechanisms on NADase of the bacterial DSR2 anti-phage defense system

Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design

Examination of antagonistic metabolic reactions and nicotinamide/methylnicotinamide as a biomarker in gastric cancer.

Rational design of a cross-type HPV vaccine through immunodominance shift guided by a cross-neutralizing antibody.

Precision and correlation of ED50 and endpoint titer method in measuring HPV vaccine immunogenicity.

Micronanoparticled risedronate exhibits potent vaccine adjuvant effects.

In-depth review of delivery carriers associated with vaccine adjuvants: current status and future perspectives

Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions

Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16

Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection

Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant

Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

Current progress in the development of prophylactic and therapeutic vaccines

PET/CT Imaging of Activated Cancer-Associated Fibroblasts Predict Response to PD-1 Blockade in Gastric Cancer Patients

Corrigendum: PET/Ct Imaging of Activated Cancer-Associated Fibroblasts Predict Response to PD-1 Blockade in Gastric Cancer Patients

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion

Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail.

Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses

A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity

Characterization of an Escherichia coli-derived triple-type chimeric vaccine against human papillomavirus types 39, 68 and 70

Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylation

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

Genetic engineering of baculovirus-insect cell system to improve protein production

Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209