曹雄｜南方医科大学｜学者主页

2026

Treatment with perampanel alleviates depression-like behavior in mice via modulating GluN2B expression to improve excitatory synaptic transmission

Jin-Ming Liu, Yan-lin Zhang, Fang Guo, Bin-Wu Li, Hu Chen, Yuye Mo, Jiangwei Kong, Xiaohui Tan, Weibin Wu, Xiong Cao

Translational Psychiatry

2026

A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility

Jijin Wu, Xiao-Han Tong, Rui-Zhe Sun, Yang Tan, Bing-Jie Liu, Xianwei Liu, Chunxiao Chen, Weng-Hei Hong, Ying Sun, Yun Liu, Han Li, Zihao Wang, Yu-Chao Li, Xiong Cao, Xiaodan Huang, Qian Tao, Lu Huang, Tian-Ming Gao, Chao-Ran Ren, Song Lin

Nature Communications

DOI

2026

The gut microbiota alleviates depression by remodeling gut-brain energy metabolism.

Cheng-lin Lu, Jing Ren, Yueshiyuan Lei, Xiao-Ying Lian, Hao-Ran Jiang, Fang Guo, Liang-Yu Chen, Jia-Wen Mo, Hongyu Mao, Jun Fan, Guangyan Wu, Wan-Qian Ye, You-Lu Wen, Haitao Sun, Yan He, Jiu-Bo Zhao, Xiong Cao

Cell Metabolism

DOI

2026

Riluzole Restores Circuit and Behavioral Function Altered by Allele-Specific Expression-Mediated LINC02449-CPLX1 Dysregulation.

Chaoying Ni, Jin-Ming Liu, Tengfei Yang, Zhiying Deng, Xiaohui Wu, Shu-Fen Li, Hannah Xue, Zhong-Ju Wang, Xiong Cao, Cunyou Zhao

Schizophrenia bulletin

DOI

2026

Newborn neurons compete with neuronal ensembles to moderate behavioral responses to stress.

Can Zhang, Su-Fen Wei, Yaping Wang, Jia-Qi Nie, Qi Wang, Fu-Ling Wu, Ming-Feng Huang, Wei-Zhong Cai, Liang Chen, Jin-Ming Liu, Fang Guo, Xiao-Shan Lin, Shu-Ji Li, Xiang-Na Guo, Siqiang Ren, Xiong Cao

Cell Reports

DOI

2025

[Review] An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features

Cheng-Lin Lu, Jing Ren, Xiong Cao

Biological Psychiatry，Vol. 97, No. 3

DOI

2025

Astrocytes: a potential avenue for depression and cancer

Cheng-lin Lu, Xiong Cao

Brain Behavior and Immunity Integrative

DOI

2025

Gain of Alternative Allele Expression of LINC02449 at rs149707223 in Schizophrenia and Bipolar Disorder: Inducing Synaptic Transmission and Behavioral Deficits in Mice

Tengfei Yang, Jin-Ming Liu, Qiaqi Chen, Zhiying Deng, Chaoying Ni, Yunqian Wang, Yuting Lan, Ting-Yun Jiang, Shu-Fen Li, Meijun Jiang, Hong Xue, Xiong Cao, Zhong-Ju Wang, Cunyou Zhao

Nature Communications

DOI

2025

Synaptic Protein Lactylation: A Novel Mechanism Underlying Physical Exercise-mediated Stress Resilience

Can-Yuan Zhang, Su-Fen Wei, Xiong Cao

Neuroscience Bulletin

DOI

2025

Astrocytic glucocorticoid receptors in the ventral hippocampus modulate anxiety-like behaviors.

Cheng-lin Lu, Jing Ren, Wei Wang, Liang Chen, Xiao-Ying Lian, Xiong Cao

Brain Research Bulletin

DOI

2025

Gut microbiota regulates innate anxiety through neural activity of medial prefrontal cortex in male mice

Jing Ren, Xiao-Ying Lian, Wan-Qian Ye, You-Lu Wen, Cheng-lin Lu, Xiong Cao

Frontiers in Neuroscience

DOI

2025

Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC

You-Lu Wen, Fang Guo, Ting-Ting Gu, Yan Zeng, Xiong Cao

Genes to Cells

DOI

2025

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Jiaming Liu, Jia-Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng-Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng-lin Lu, Chuanjun Tong, Ed X. Wu, Qiu-gen Hu, Xiong Cao, Yan-Qiu Feng

Advancement of science

DOI

2024

Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors

Jia-Wen Mo, Peng-Li Kong, Li Ding, Jun Fan, Jing Ren, Cheng-lin Lu, Fang Guo, Liang Chen, Ran Mo, Qiu Zhong, You-Lu Wen, Ting-Ting Gu, Qian-Wen Wang, Shu-Ji Li, Ting Guo, Tian-Ming Gao, Xiong Cao

Advancement of science

DOI

2024

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice

Fang Guo, Jun Fan, Jin-Ming Liu, Peng-Li Kong, Jing Ren, Jia-Wen Mo, Cheng-lin Lu, Qiu Zhong, Liang Chen, Hao Jiang, Can Zhang, You-Lu Wen, Ting-Ting Gu, Shu-Ji Li, Ying-Ying Fang, Bing-Xing Pan, Tian-Ming Gao, Xiong Cao

Nature Communications

DOI

2023

O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission

Jun Fan, Fang Guo, Ran Mo, Liang Chen, Jia-Wen Mo, Cheng-lin Lu, Jing Ren, Qiuling Zhong, Xiao-Jing Kuang, You-Lu Wen, Ting-Ting Gu, Jin-Ming Liu, Shu-Ji Li, Ying-Ying Fang, Cunyou Zhao, Tian-Ming Gao, Xiong Cao

Journal of Clinical Investigation

DOI

2022

Glucocorticoid Receptor-Dependent Astrocytes Mediate Stress Vulnerability

Cheng-Lin Lu, Jing Ren, Jia-Wen Mo, Jun Fan, Fang Guo, Liang-Yu Chen, You-Lu Wen, Shu-Ji Li, Ying-Ying Fang, Zhao-Fa Wu, Yu-Long Li, Tian-Ming Gao, Xiong Cao

Biological Psychiatry，Vol. 92, No. 30

DOI

2022

A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors

Jing Ren, Cheng-lin Lu, Jie Huang, Jun Fan, Fang Guo, Jia-Wen Mo, Wei-Yuan Huang, Peng-Li Kong, Xiao-Wen Li, Li-Rong Sun, Xiang-Dong Sun, Xiong Cao

Journal of Neuroscience

DOI

2022

Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression

Jiaming Liu, Jia-Wen Mo, Xunda Wang, Ziqi An, Shuangyang Zhang, Can Zhang, P. Yi, Alex T. L. Leong, Jing Ren, Liang Chen, Ran Mo, Yuanyao Xie, Qian-Jin Feng, Wu-Fan Chen, Tian-Ming Gao, Ed X. Wu, Yanqiu Feng, Xiong Cao

Science Advances

DOI

2022

PPARγ Dysfunction in the Medial Prefrontal Cortex Mediates High-Fat Diet-Induced Depression

C. Fu, Xinyi Zhang, Liu Xu, Huibing Huang, Shuang Xu, Qiaoqi Wu, Zhen Wang, X. Gu, Lifang Lin, Song Lin, Ying-Ying Fang, Xiong Cao, Xuemin Wang

Molecular Neurobiology

DOI

2022

P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress

Xiao-Jing Kuang, Can Zhang, Bing Yan, Weihua Cai, Cheng-lin Lu, Ling Xie, Shu-Ji Li, Peng-Li Kong, Jun Fan, Shu-Min Pan, Ting Guo, Xiong Cao

Theranostics

DOI

2021

柴胡桂枝汤通过sirt1-p53信号通路产生抗抑郁作用

葛鑫宇，郭芳，范俊，陈宝田，于林，任静，李纪强，卢成林，莫嘉文，李树基，袁乐欣，胡号应，刘赟，周晓，崔娟，朱志敏，曹雄

《南方医科大学学报》

2021

Proteomic Profiling of Astrocytic O-GlcNAc Transferase-Related Proteins in the Medial Prefrontal Cortex

Jun Fan, Qiu Zhong, Ran Mo, Cheng-lin Lu, Jing Ren, Jia-Wen Mo, Fang Guo, You-Lu Wen, Xiong Cao

Frontiers in Molecular Neuroscience

DOI

2019

Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors

W. Xiong, Xiong Cao, Yuanning Zeng, Xihe Qin, Minzhen Zhu, Jing Ren, Zhou Wu, Qi-Yuan Huang, Yuan Zhang, Meng-Yao Wang, Lian-Wan Chen, G. Turecki, N. Mechawar, Wen-Jun Chen, Guoliang Yi, Xin-Hong Zhu

Journal of Neuroscience

DOI

2017

α2‐glycine receptors modulate adult hippocampal neurogenesis and spatial memory

Mingkuan Lin, W. Xiong, Shu-Ji Li, Zhi Gong, Xiong Cao, Xiao-Jing Kuang, Yuan Zhang, Tian-Ming Gao, N. Mechawar, Ce Liu, Xin-Hong Zhu

Developmental Neurobiology

DOI

2016

加强推进重大精神疾病的研究

曹雄，高天明

《中国科学:生命科学》

2016

Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes*

Yue Zhang, Song Xu, Kangyan Liang, Kai Li, Zhipeng Zou, Cui-Lan Yang, K. Tan, Xiong Cao, Yu Jiang, Tian-Ming Gao, Xiao-Chun Bai

Journal of Biological Chemistry

DOI

2013

Store-Operated Ca2+ Channels Blockers Inhibit Lipopolysaccharide Induced Astrocyte Activation

Jian-Hua Li, Shen-Ting Zhao, Cui-Ying Wu, Xiong Cao, Miao-Ru Peng, Shu-Ji Li, Xiao-ai Liu, Tian-Ming Gao

Neurochemical Research

DOI

2013

Astrocyte-derived ATP modulates depressive-like behaviors

Xiong Cao, Liang-ping Li, Qian Wang, Qiong Wu, Hong-hai Hu, Meng Zhang, Ying-Ying Fang, Jie Zhang, Shu-Ji Li, W. Xiong, Hua-Cheng Yan, Yu-Bo Gao, Ji-Hong Liu, Xiao-Wen Li, Li-Rong Sun, Yuanning Zeng, Xin-Hong Zhu, Tian-Ming Gao

Nature Medicine

DOI

2013

Astrocytic Adenosine 5′‐Triphosphate Release Regulates the Proliferation of Neural Stem Cells in the Adult Hippocampus

Xiong Cao, Liang-ping Li, Xihe Qin, Shu-Ji Li, Meng Zhang, Qian Wang, Hong-hai Hu, Ying-Ying Fang, Yu-Bo Gao, Xiao-Wen Li, Li-Rong Sun, W. Xiong, Tian-Ming Gao, Xin-Hong Zhu

Stem Cells

DOI

2011

Promoting Adult Hippocampal Neurogenesis: A Novel Strategy for Antidepressant Drug Screening

Hua Yan, Xiong Cao, Tianming Gao, Xinhong Zhu

Current Medicinal Chemistry

DOI

2010

Fuzi polysaccharide-1 produces antidepressant-like effects in mice

Hua-Cheng Yan, Hong-Da Qu, Li-Rong Sun, Shu-Ji Li, Xiong Cao, Ying-Ying Fang, Wei Jie, Jonathan C. Bean, Wei-Kang Wu, Xin-Hong Zhu, Tian-Ming Gao

International Journal Of Neuropsychopharmacology，Vol. 130, No. 5

DOI

2010

抑郁症动物模型的研究进展(英文)

严华成，曹雄，Manas Das，朱心红，高天明

Neuroscience Bulletin

2010

Behavioral animal models of depression

Hua-Cheng Yan, Xiong Cao, M. Das, Xin-Hong Zhu, Tian-Ming Gao

Neuroscience Bulletin

DOI

2008

马钱子复合生物碱成分抑制成年大鼠海马神经前体细胞的分裂作用

龚芝，孙丽荣，曹雄，李树基，朱心红，高天明

《南方医科大学学报》

Brain-wide spatiotemporally distinct traveling waves drive anxiety-like behaviors in mice

Jiaming Liu, Jia-Wen Mo, Xunda Wang, Yinuo Ma, Peng-Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng-lin Lu, Chuanjun Tong, Ed X. Wu, Qiu-gen Hu, Xiong Cao, Yanqiu Feng

ISMRM Annual Meeting

DOI

精选作品

期刊论文

Treatment with perampanel alleviates depression-like behavior in mice via modulating GluN2B expression to improve excitatory synaptic transmission

A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility

The gut microbiota alleviates depression by remodeling gut-brain energy metabolism.

Riluzole Restores Circuit and Behavioral Function Altered by Allele-Specific Expression-Mediated LINC02449-CPLX1 Dysregulation.

Newborn neurons compete with neuronal ensembles to moderate behavioral responses to stress.

[Review] An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features

Astrocytes: a potential avenue for depression and cancer

Gain of Alternative Allele Expression of LINC02449 at rs149707223 in Schizophrenia and Bipolar Disorder: Inducing Synaptic Transmission and Behavioral Deficits in Mice

Synaptic Protein Lactylation: A Novel Mechanism Underlying Physical Exercise-mediated Stress Resilience

Astrocytic glucocorticoid receptors in the ventral hippocampus modulate anxiety-like behaviors.

Gut microbiota regulates innate anxiety through neural activity of medial prefrontal cortex in male mice

Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Lysosomal TFEB‐TRPML1 Axis in Astrocytes Modulates Depressive‐like Behaviors

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice

O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission

Glucocorticoid Receptor-Dependent Astrocytes Mediate Stress Vulnerability

A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors

Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression

PPARγ Dysfunction in the Medial Prefrontal Cortex Mediates High-Fat Diet-Induced Depression

P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress

柴胡桂枝汤通过sirt1-p53信号通路产生抗抑郁作用

Proteomic Profiling of Astrocytic O-GlcNAc Transferase-Related Proteins in the Medial Prefrontal Cortex

Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors

α2‐glycine receptors modulate adult hippocampal neurogenesis and spatial memory

加强推进重大精神疾病的研究

Neuronal mTORC1 Is Required for Maintaining the Nonreactive State of Astrocytes*

Store-Operated Ca2+ Channels Blockers Inhibit Lipopolysaccharide Induced Astrocyte Activation

Astrocyte-derived ATP modulates depressive-like behaviors

Astrocytic Adenosine 5′‐Triphosphate Release Regulates the Proliferation of Neural Stem Cells in the Adult Hippocampus

Promoting Adult Hippocampal Neurogenesis: A Novel Strategy for Antidepressant Drug Screening

Fuzi polysaccharide-1 produces antidepressant-like effects in mice

抑郁症动物模型的研究进展(英文)

Behavioral animal models of depression

马钱子复合生物碱成分抑制成年大鼠海马神经前体细胞的分裂作用

Brain-wide spatiotemporally distinct traveling waves drive anxiety-like behaviors in mice

会议论文

胆碱能受体激动剂抑制小胶质细胞活化并保护脑缺血大鼠海马神经元迟发性死亡

研究方向