孙逊｜复旦大学｜学者主页

2025

Discovery of a deuterated TNF-α small molecule modulator for potential treatment of ulcerative colitis

Tong Song, Mengxiao Zhuang, Zhi Ying Dorothy Wong, Ge Xu, Mei‐Lin Tang, Buyu Kou, Xun Sun

European Journal of Medicinal Chemistry

DOI

2025

Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer

Kunlin Liu, Chenhao Zhu, Yongxi Liang, Delin Min, Zijun Jin, Xun Sun

Journal of Medicinal Chemistry

DOI

2025

A Medicinal Chemistry Perspective on Protein Tyrosine Phosphatase Nonreceptor Type 2 in Tumor Immunology

Qi Huang, Linghao Hu, Haowen Chen, Bingjie Yang, Xun Sun, Mingliang Wang

Journal of Medicinal Chemistry

DOI

2025

Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)

Jianwu Lu, Yinfei Shi, Kongcheng Huang, Yuebin Liu, Shun Yuan, Xiaolong Yang, Yansheng Xu, Xun Sun, Taizhi Wu

Organic Process Research & Development

DOI

2024

Development of a Triphenylmethyl Alkylation Pre-Column Derivatization Method for HPLC Quantitative Analysis of Chemically Unstable Halogenated Compounds

Jianwu Lu, Yinfei Shi, Xiaoxia Ye, Shun Yuan, Xiaolong Yang, Xun Sun, Taizhi Wu

ACS Omega

DOI

2023

FD-1050@NPs-cRGD: A novel NIR-II fluorophore for triple-negative breast cancer imaging

Hulin Fan, Wei Wu, Zhongjian Chen, Quangang Zhu, Xun Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2023

Improved Synthetic Process of Baloxavir Marboxil Intermediate 3-Benzyloxy-4-oxo-4H-pyran-2-carboxylic Acid

Kongcheng Huang, Jianwu Lu, Xiaoxu Wang, Yinfei Shi, Kaimike Yang, Shun Yuan, Yinquan Wang, Han Sun, Yuebin Liu, Xun Sun, Taizhi Wu

Organic Process Research & Development

DOI

2023

Discovery of novel tubulin CBSI ( R )-9k from the indanone scaffold for the treatment of colorectal cancer

Zhipeng Huo, Delin Min, Shijie Zhang, Mei‐Lin Tang, Xun Sun

RSC Medicinal Chemistry

DOI

2022

Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer

Yongxi Liang, Delin Min, Hulin Fan, Kunlin Liu, Juchuanli Tu, Xue‐Yan He, Bingjie Liu, Lu Zhou, Suling Liu, Xun Sun

Acta Pharmaceutica Sinica B

DOI

2022

Discovery of First-in-Class TAK1–MKK3 Protein–Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production

Mei‐Lin Tang, Haidong Li, Jin-Feng Ning, Xiaoyan Shen, Xun Sun

Journal of Medicinal Chemistry

DOI

2022

Discovery of pyrimidine-bridged CA-4 CBSIs for the treatment of cervical cancer in combination with cisplatin with significantly reduced nephrotoxicity

Zhipeng Huo, Kunlin Liu, Xi Zhang, Yongxi Liang, Xun Sun

European Journal of Medicinal Chemistry

DOI

2022

Strategic design of lysine-targeted irreversible covalent NDM-1 inhibitors

Youzhen Ma, Yongxi Liang, Menglu Guo, Delin Min, Lulu Zheng, Yun Tang, Xun Sun

Chinese Chemical Letters

DOI

2022

Identification, Synthesis, and Comprehension of an Imidazole N-3 Regioisomeric Impurity of Olmesartan Medoxomil Key Intermediate

Jianwu Lu, Xiao Li, Shun Yuan, Yinquan Wang, Han Sun, Wei‐Zhao Weng, Yinfei Shi, Xiaoxu Wang, Kongcheng Huang, Xun Sun, Taizhi Wu

Organic Process Research & Development

DOI

2021

TMSOTf-mediated approach to 1,3-oxazin-2-one skeleton through one-pot successive reduction-[4 + 2] cyclization process of imides with ynamides

Chen-Chen Zhang, Zhipeng Huo, Mei‐Lin Tang, Yongxi Liang, Xun Sun

Tetrahedron Letters

DOI

2021

A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation

Baohui Yuan, He Liu, Xiaoliang Dong, Xiaohua Pan, Xun Sun, Jia Teng Sun, Li‐Long Pan

Frontiers in Cardiovascular Medicine

DOI

2021

A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis

Zhengnan Ren, Jun Yang, Mengya Zhang, Yiwen Huang, Dong-xiao Song, Xun Sun, Li‐Long Pan, Jia Teng Sun

Acta Pharmacologica Sinica

DOI

2021

LMR‐101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ‐aminobutyric acid type A receptors

Yi Zhao, Long An, Shupan Guo, Xiaoxing Huang, Huajie Tian, Li Liu, Tao Chen, Xun Sun, Qibing Mei, Rutao Wang

Epilepsia

DOI

2020

白藜芦醇二聚体Quadrangularin A和Pallidol合成方法学研究

韩吉来，唐美麟，孙逊

《有机化学》

2020

Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity

Zhengyu Liu, Mei‐Lin Tang, Jin-Feng Ning, Yunpeng Hao, Lu Zhou, Xun Sun

European Journal of Medicinal Chemistry

DOI

2020

A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine

Renwu Li, Lingling Yan, Xun Sun, Weiping Zheng

Bioorganic & Medicinal Chemistry

DOI

2020

A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process

Yongxi Liang, Mei‐Lin Tang, Zhipeng Huo, Chenchen Zhang, Xun Sun

Molecules

DOI

2019

An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma

Chenlei Wen, Ke Huang, Lu-Lu Jiang, Xiongxiong Lu, Yuting Dai, Min-Min Shi, Xiao-Mei Tang, Qingbing Wang, Xiaodan Zhang, Peng‐Hui Wang, Huiti Li, Xiaoxue Ruan, Liwen Wang, Xinjing Wang, Qian Wang, Wei Lü, Xiaoqiang Xiang, Xun Sun, Yanhui Xu, Luhua Lai, Qian Zhan, Hongwei Li, Chenghong Peng, Jing Chen, Jin-Yan Huang, Deyong Ye, Sai‐Juan Chen, Chen Ying Zhu, Min Li, Yuan Fang, Baiyong Shen, Lu Zhou

Proceedings of the National Academy of Sciences

DOI

2019

Design, synthesis and biological evaluation of novel indone derivatives as selective ERβ modulators

Xixi Liu, Mei‐Lin Tang, Zhong Chen, Yun Tang, Jianming Yu, Xun Sun

Medicinal Chemistry Research

DOI

2019

Novel Mercapto Propionamide Derivatives with Potent New Delhi Metallo-β-Lactamase-1 Inhibitory Activity and Low Toxicity

Zhi Qiang Meng, Mei‐Lin Tang, Liting Yu, Yongxi Liang, Jilai Han, ChenChen Zhang, Fupin Hu, Jianming Yu, Xun Sun

ACS Infectious Diseases

DOI

2018

Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes

Liting Yu, Mei‐Lin Tang, Chang‐Mei Si, Zhi Qiang Meng, Yongxi Liang, Jilai Han, Xun Sun

Organic Letters

DOI

2018

Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis

Yongwei Jiang, Liang Xu, Wei Guo Fu, Hua Lin, Jianming Yu, Xun Sun

Tetrahedron

DOI

2018

Diastereoselective approach to trans -5-hydroxy-6-substitutedethanone-2-piperidinones: Scalable syntheses of (+)-febrifugine and (+)-halofuginone

Chen Wang, Yi-Wen Liu, Zhu Zhou, Chang‐Mei Si, Xun Sun, Bang‐Guo Wei

Tetrahedron

DOI

2018

Approach to Chiral 1-Substituted Isoquinolone and 3-Substituted Isoindolin-1-one by Addition–Cyclization Process

Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang‐Mei Si, Xun Sun, Bang‐Guo Wei

The Journal of Organic Chemistry

DOI

2017

Effective approach to ureas through organocatalyzed one-pot process

Mingliang Wang, Jilai Han, Xiaojia Si, Yimin Hu, Jidong Zhu, Xun Sun

Tetrahedron Letters

DOI

2017

Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3- c ]pyridine derivatives as potent and selective CYP17 inhibitors

Mingliang Wang, Yanjia Fang, Shoulai Gu, Fangfang Chen, Zheng‐Jiang Zhu, Xun Sun, Jidong Zhu

European Journal of Medicinal Chemistry

DOI

2017

A practical approach to asymmetric synthesis of dolastatin 10

Wen Yan Zhou, Xiao-Di Nie, Yu Zhang, Chang‐Mei Si, Zhu Zhou, Xun Sun, Bang-Guo Wei

Organic & Biomolecular Chemistry

DOI

2016

An efficient method for synthesis of bexagliflozin and its carbon-13 labeled analogue

Ge Zhi Xu, Baihua Xu, Yanli Song, Xun Sun

Tetrahedron Letters

DOI

2016

An enantioselective total synthesis of tubulysin V

Wei Tao, Wen Zhou, Zhu Zhou, Chang‐Mei Si, Xun Sun, Bang‐Guo Wei

Tetrahedron

DOI

2016

Differential metabolism of 3FDT and docetaxel in RLMs, rats, and HLMs

Mei‐Lin Tang, Lu Zhou, Jun Chang, Zhuo-Han Hu, Qin Yan, Xun Sun

European Journal of Medicinal Chemistry

DOI

2016

Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis

Song Jiao, Peng Peng, Jun Chang, Mingming Liu, Jianming Yu, Lu Zhou, Xun Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2016

Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents

Mei‐Lin Tang, Zhong Chen, Zhengyu Liu, Peng Peng, Xinhua Liu, Xun Sun

European Journal of Medicinal Chemistry

DOI

2016

A Concise and Practical Semisynthesis of Ecteinascidin 743 and (–)‐Jorumycin

Shanghu Xu, Guan Wang, Jinjin Zhu, Chuang Shen, Zhezhou Yang, Jun Yu, Zhong Li, Tanghuan Lin, Xun Sun, Fuli Zhang

European Journal of Organic Chemistry

DOI

2016

Sulfoxide‐Based Enantioselective Nazarov Cyclization: Divergent Syntheses of (+)‐Isopaucifloral F, (+)‐Quadrangularin A, and (+)‐Pallidol

Mei‐Lin Tang, Peng Peng, Zhengyu Liu, Jian Zhang, Jianming Yu, Xun Sun

Chemistry - A European Journal

DOI

2016

Novel fluorinated docetaxel analog for anti-hepatoma: Molecular docking and biological evaluation

Yunpeng Hao, Zheng-yu Liu, Cheng Xie, Lu Zhou, Xun Sun

European Journal of Pharmaceutical Sciences

DOI

2016

Divergent copper-mediated dimerization and hydroxylation of benzamides involving C–H bond functionalization

Mingliang Wang, Yimin Hu, Zhe Jiang, Hong C. Shen, Xun Sun

Organic & Biomolecular Chemistry

DOI

2015

Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives

Xiaodong Hao, Jun Chang, Boyin Qin, Chen Zhong, Zhi‐Bo Chu, Jin Yan Huang, Wen‐Jiang Zhou, Xun Sun

European Journal of Medicinal Chemistry

DOI

2015

Chemical Constituents of Cordyceps cicadae

Zhi‐Bo Chu, Jun Chang, Ying Zhu, Xun Sun

Natural Product Communications

DOI

2015

ChemInform Abstract: Two Novel Isoquinoline Alkaloids from the Seedling of Corydalis decumbens.

Jun Chang, Zhi‐Bo Chu, Song Jiao, Lin Jin, Xun Sun

ChemInform

DOI

2015

Fluorination of 2-substituted benzo[b]furans with Selectfluor™

Mingliang Wang, Xixi Liu, Lu Zhou, Jidong Zhu, Xun Sun

Organic & Biomolecular Chemistry

DOI

2014

具有穿膜功能的嵌合型AVPI-低分子量鱼精蛋白/DNA共给药系统的抗肿瘤研究

谭娇，王雅萍，王慧欣，梁剑铭，张梦，孙逊，黄永焯

《药学学报》

2014

Two novel isoquinoline alkaloids from the seedling of Corydalis decumbens

Jun Chang, Zhi‐Bo Chu, Song Jiao, Lin Jin, Xun Sun

Tetrahedron Letters

DOI

2014

Design, Synthesis, and Biological Evaluation of Deuterated C-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes

Ge Zhi Xu, Binhua Lv, Jacques Y. Roberge, Baihua Xu, Jiyan Du, Jiajia Dong, Yuanwei Chen, Kun Peng, Lili Zhang, Xinxing Tang, Yan Feng, Min Xu, Wei Guo Fu, Wenbin Zhang, Liangcheng Zhu, Zhongping Deng, Zelin Sheng, Ajith A. Welihinda, Xun Sun

Journal of Medicinal Chemistry

DOI

2013

Design, synthesis and cytotoxicity of novel 3′-N-alkoxycarbonyl docetaxel analogs

Jun Chang, Xiaodong Hao, Yunpeng Hao, Hongfu Lu, Jianming Yu, Xun Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2013

Synthesis and in vitro antitumor activity of novel iridium(III) complexes with enantiopure C2-symmetrical vicinal diamine ligands

Qing Yang, Jun Chang, Song Jiao, Meng-Ting Qian, Jianming Yu, Xun Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2013

Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells

Zhong Chen, Xinhua Liu, Jun Chang, Jianming Yu, Xun Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2013

Neuroprotective effects of mercaptoethylleonurine and mercaptoethylguanidine analogs on hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells

Zhao-Lin Que, Wen‐Jiang Zhou, Jun Chang, Xinhua Liu, Jianming Yu, Xun Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2013

Synthesis and biological evaluation of novel neuroprotective agents for paraquat-induced apoptosis in human neuronal SH-SY5Y cells

Zhong Chen, Xinhua Liu, Xiaodong Hao, Jun Chang, Xun Sun

European Journal of Medicinal Chemistry

DOI

2013

Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs

Jun Chang, Yunpeng Hao, Xiaodong Hao, Hongfu Lu, Jianming Yu, Xun Sun

Molecules

DOI

2013

Mitochondrial-targeted prodrug cancer therapy using a rhodamine B labeled fluorinated docetaxel

Cheng Xie, Jun Chang, Xiaodong Hao, Jianming Yu, Hongrui Liu, Xun Sun

European Journal of Pharmaceutics and Biopharmaceutics

DOI

2013

Inside Cover: Design, Synthesis, and Antibacterial Activity of Demethylvancomycin Analogues against Drug‐Resistant Bacteria (ChemMedChem 6/2013)

Jun Chang, Si‐Ji Zhang, Yongwei Jiang, Liang Xu, Jianming Yu, Wen‐Jiang Zhou, Xun Sun

ChemMedChem

DOI

2013

Design, Synthesis, and Antibacterial Activity of Demethylvancomycin Analogues against Drug‐Resistant Bacteria

Jun Chang, Si‐Ji Zhang, Yongwei Jiang, Liang Xu, Jianming Yu, Wen‐Jiang Zhou, Xun Sun

ChemMedChem

DOI

2013

Synthesis and Cytotoxic Evaluation of Novel Platinum(II) Complexes with C2‐Asymmetric and C2‐Symmetric Chiral Vicinal Diamines

Chen Zhang, Hongrui Liu, Qing Yang, Jun Chang, Xun Sun

Chinese Journal of Chemistry

DOI

2012

Synthesis and antibacterial activity against Clostridium difficile of novel demethylvancomycin derivatives

Si‐Ji Zhang, Qing Yang, Liang Xu, Jun Chang, Xun Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2011

Concise total syntheses of (±)isopaucifloral F, (±)quadrangularin A, and (±)pallidol

Zhong Chen, Jun Zhu, Jun Chang, Xun Sun

Tetrahedron Letters

DOI

2011

Synthesis, cytotoxicity, metabolic stability and pharmacokinetic evaluation of fluorinated docetaxel analogs

Hongfu Lu, Cheng Xie, Jun Chang, Guo‐Qiang Lin, Xun Sun

European Journal of Medicinal Chemistry

DOI

2011

(1S,2S,3R,4S,5R,7S,8S,10R,13S)-2-Debenzoyl-10-deacetyl-2-(3-fluorobenzoyl)-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III ethyl acetate monosolvate monohydrate

Chen Zhang, Cheng Xie, Jun Chang, Hongfu Lu, Xun Sun

Acta Crystallographica Section E Structure Reports Online

DOI

2008

Nickel-catalyzed organozinc-induced unexpected 1,3-migration of tert-butyl from sulfur to carbon in N-tert-butanesulfinyl iminoacetates

Xun Sun, Wei Zheng, Bang‐Guo Wei

Tetrahedron Letters

DOI

2008

Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues

Hongfu Lu, Xun Sun, Liang Xu, Liguang Lou, Guo‐Qiang Lin

European Journal of Medicinal Chemistry

DOI

2008

ChemInform Abstract: Nickel‐Catalyzed Organozinc‐Induced Unexpected 1,3‐Migration of tert‐Butyl from Sulfur to Carbon in N‐tert‐Butanesulfinyl Iminoacetates.

Xun Sun, Wei Zheng, Bang‐Guo Wei

ChemInform

DOI

2008

(2S)-Ethyl 2-[(Ss)-benzylsulfinylamino]-3,3-dimethylbutanoate

Wei Zheng, Xun Sun, Jie Sun, Bang‐Guo Wei

Acta Crystallographica Section E Structure Reports Online

DOI

2008

ChemInform Abstract: Toward the Synthesis of Caraphenol C (VI): Substituent Effect on the Nazarov Cyclization of 2‐Arylchalcones.

Jun Zhu, Zhong Chen, Hongfu Lu, Guang‐Yu Li, Xun Sun

ChemInform

DOI

2008

ChemInform Abstract: A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides.

Xun Sun, Jun Zhu, Chen Zhong, Ken‐Ji Izumi, Chen Zhang

ChemInform

DOI

2006

Convenient Synthesis of Indene Derivatives via Intramolecular Friedel-Crafts Cyclization of Tetraaryl Substituted 1,3-Butadienes

Xun Sun, Ken-Ji Izumi, Chang‐Qi Hu, Guo‐Qiang Lin

Chinese Journal of Chemistry

DOI

2004

天然多羟基酚类化合物Pallidol的全合成和Baicalein的结构改造

孙逊

《复旦大学》

2003

黄芩苷元的Mannich反应

孙逊，胡昌奇，黄晓东，董纪昌

《有机化学》

精选作品

期刊论文

Discovery of a deuterated TNF-α small molecule modulator for potential treatment of ulcerative colitis

Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer

A Medicinal Chemistry Perspective on Protein Tyrosine Phosphatase Nonreceptor Type 2 in Tumor Immunology

Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)

Development of a Triphenylmethyl Alkylation Pre-Column Derivatization Method for HPLC Quantitative Analysis of Chemically Unstable Halogenated Compounds

FD-1050@NPs-cRGD: A novel NIR-II fluorophore for triple-negative breast cancer imaging

Improved Synthetic Process of Baloxavir Marboxil Intermediate 3-Benzyloxy-4-oxo-4H-pyran-2-carboxylic Acid

Discovery of novel tubulin CBSI ( R )-9k from the indanone scaffold for the treatment of colorectal cancer

Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer

Discovery of First-in-Class TAK1–MKK3 Protein–Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production

Discovery of pyrimidine-bridged CA-4 CBSIs for the treatment of cervical cancer in combination with cisplatin with significantly reduced nephrotoxicity

Strategic design of lysine-targeted irreversible covalent NDM-1 inhibitors

Identification, Synthesis, and Comprehension of an Imidazole N-3 Regioisomeric Impurity of Olmesartan Medoxomil Key Intermediate

TMSOTf-mediated approach to 1,3-oxazin-2-one skeleton through one-pot successive reduction-[4 + 2] cyclization process of imides with ynamides

A Novel Resveratrol Analog Upregulates SIRT1 Expression and Ameliorates Neointima Formation

A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis

LMR‐101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on γ‐aminobutyric acid type A receptors

白藜芦醇二聚体Quadrangularin A和Pallidol合成方法学研究

Novel octapeptide-DTX prodrugs targeting MMP-7 as effective agents for the treatment of colorectal cancer with lower systemic toxicity

A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine

A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process

An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma

Design, synthesis and biological evaluation of novel indone derivatives as selective ERβ modulators

Novel Mercapto Propionamide Derivatives with Potent New Delhi Metallo-β-Lactamase-1 Inhibitory Activity and Low Toxicity

Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes

Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis

Diastereoselective approach to trans -5-hydroxy-6-substitutedethanone-2-piperidinones: Scalable syntheses of (+)-febrifugine and (+)-halofuginone

Approach to Chiral 1-Substituted Isoquinolone and 3-Substituted Isoindolin-1-one by Addition–Cyclization Process

Effective approach to ureas through organocatalyzed one-pot process

Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3- c ]pyridine derivatives as potent and selective CYP17 inhibitors

A practical approach to asymmetric synthesis of dolastatin 10

An efficient method for synthesis of bexagliflozin and its carbon-13 labeled analogue

An enantioselective total synthesis of tubulysin V

Differential metabolism of 3FDT and docetaxel in RLMs, rats, and HLMs

Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis

Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents

A Concise and Practical Semisynthesis of Ecteinascidin 743 and (–)‐Jorumycin

Sulfoxide‐Based Enantioselective Nazarov Cyclization: Divergent Syntheses of (+)‐Isopaucifloral F, (+)‐Quadrangularin A, and (+)‐Pallidol

Novel fluorinated docetaxel analog for anti-hepatoma: Molecular docking and biological evaluation

Divergent copper-mediated dimerization and hydroxylation of benzamides involving C–H bond functionalization

Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives

Chemical Constituents of Cordyceps cicadae

ChemInform Abstract: Two Novel Isoquinoline Alkaloids from the Seedling of Corydalis decumbens.

Fluorination of 2-substituted benzo[b]furans with Selectfluor™

具有穿膜功能的嵌合型AVPI-低分子量鱼精蛋白/DNA共给药系统的抗肿瘤研究

Two novel isoquinoline alkaloids from the seedling of Corydalis decumbens

Design, Synthesis, and Biological Evaluation of Deuterated C-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes

Design, synthesis and cytotoxicity of novel 3′-N-alkoxycarbonyl docetaxel analogs

Synthesis and in vitro antitumor activity of novel iridium(III) complexes with enantiopure C2-symmetrical vicinal diamine ligands

Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells

Neuroprotective effects of mercaptoethylleonurine and mercaptoethylguanidine analogs on hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells

Synthesis and biological evaluation of novel neuroprotective agents for paraquat-induced apoptosis in human neuronal SH-SY5Y cells

Synthesis and Anti-HBV Activity of Novel 3′-N-phenylsulfonyl Docetaxel Analogs

Mitochondrial-targeted prodrug cancer therapy using a rhodamine B labeled fluorinated docetaxel

Inside Cover: Design, Synthesis, and Antibacterial Activity of Demethylvancomycin Analogues against Drug‐Resistant Bacteria (ChemMedChem 6/2013)

Design, Synthesis, and Antibacterial Activity of Demethylvancomycin Analogues against Drug‐Resistant Bacteria

Synthesis and Cytotoxic Evaluation of Novel Platinum(II) Complexes with C2‐Asymmetric and C2‐Symmetric Chiral Vicinal Diamines

Synthesis and antibacterial activity against Clostridium difficile of novel demethylvancomycin derivatives

Concise total syntheses of (±)isopaucifloral F, (±)quadrangularin A, and (±)pallidol

Synthesis, cytotoxicity, metabolic stability and pharmacokinetic evaluation of fluorinated docetaxel analogs

(1S,2S,3R,4S,5R,7S,8S,10R,13S)-2-Debenzoyl-10-deacetyl-2-(3-fluorobenzoyl)-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III ethyl acetate monosolvate monohydrate

Nickel-catalyzed organozinc-induced unexpected 1,3-migration of tert-butyl from sulfur to carbon in N-tert-butanesulfinyl iminoacetates

Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues

ChemInform Abstract: Nickel‐Catalyzed Organozinc‐Induced Unexpected 1,3‐Migration of tert‐Butyl from Sulfur to Carbon in N‐tert‐Butanesulfinyl Iminoacetates.

(2S)-Ethyl 2-[(Ss)-benzylsulfinylamino]-3,3-dimethylbutanoate

ChemInform Abstract: Toward the Synthesis of Caraphenol C (VI): Substituent Effect on the Nazarov Cyclization of 2‐Arylchalcones.

ChemInform Abstract: A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides.

Convenient Synthesis of Indene Derivatives via Intramolecular Friedel-Crafts Cyclization of Tetraaryl Substituted 1,3-Butadienes

天然多羟基酚类化合物Pallidol的全合成和Baicalein的结构改造

黄芩苷元的Mannich反应

会议论文

线粒体靶向的抗肝癌四氟代多烯紫杉醇前药的研究

具有神经保护作用的新型白藜芦醇二聚体的设计合成及活性研究

研究方向