百晓学者学者目录

余垚

副研究员、教授，复旦大学

精选作品

期刊论文

2026

苹果-葡萄复合果汁经马克斯克鲁维酵母有氧发酵的代谢物变化研究

陈仲泽，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

DOI

2026

Optimization and application of a tetracycline-inducible gene expression system in Kluyveromyces marxianus

Jingqi Wang, Baixiang Zhao, Junyuan Zeng, Jungang Zhou, Hong Lü, Yao Yu

Applied Microbiology and Biotechnology

DOI

2026

Systematic engineering of COPII machinery and cell wall remodeling enables gram-level secretion of recombinant human serum albumin with native-like structural features in Kluyveromyces marxianus

Xin Lu, Lunqiang Zhao, Hong Chen, Xinwei Wu, Wei Zhao, Jie Zhou, Yao Yu, Hong Lu

Bioresource Technology

DOI

2025

水产养殖中酵母类产品的研究热点与趋势分析

杨威，段进坤，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

DOI

2025

马克斯克鲁维酵母在食品生物技术中的应用及相关专利分布

陈莹，宋坤锋，莫文娟，余垚，周峻岗，吕红

《复旦学报(自然科学版)》

DOI

2025

马克斯克鲁维酵母重组蛋白高产突变株的转录组分析

吴若男，尹安琪，余垚，周峻岗，吕红

《复旦学报(自然科学版)》

DOI

2025

生物技术类通识课程改革中校企协同实践模式的探索

王婧淇，吴若男，余垚

《高校生物学教学研究(电子版)》

2025

Characterization and optimization of mnn11Δ-mediated enhancement in heterologous protein production in Kluyveromyces marxianus

Shihao Zhou, Pingping Wu, Haiyan Ren, Jungang Zhou, Yao Yu, Hong Lü

Microbial Cell Factories

DOI

2025

Enhancing recombinant protein production through Cre-loxP mediated chromosomal rearrangement evolution in Kluyveromyces marxianus

Haiyan Ren, Qiyuan Zou, Kunfeng Song, Yao Yu, Jungang Zhou, Wenjuan Mo, Hong Lü

Communications Biology

DOI

2025

Metabolic engineering of Kluyveromyces marxianus to produce myo-inositol from starch

Qing Lan, Pingping Wu, Yao Yu, Jungang Zhou, Hong Lü

Bioresource Technology

DOI

2025

Alien Chromosome Serves as a Novel Platform for Multiple Gene Expression in Kluyveromyces marxianus

Yilin Lyu, Jungang Zhou, Yao Yu, Hong Lü

Microorganisms

DOI

2024

大豆血红蛋白在马克斯克鲁维酵母中的重组表达及条件优化

田甜，鲁心怡，曾俊源，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

2024

遗传上位效应的教学实验设计与实践

石译，余垚，吕奕琳，吕红

《遗传》

2024

Characterization and optimization of 5´ untranslated region containing poly-adenine tracts in Kluyveromyces marxianus using machine-learning model

Junyuan Zeng, Kunfeng Song, Jingqi Wang, Haimei Wen, Jungang Zhou, Ting Ni, Hong Lü, Yao Yu

Microbial Cell Factories

DOI

2024

Design and practice of educational experiments on genetic epistasis.

Yi Shi, Yao Yu, Yanyan Lu, Hong Lü

PubMed

DOI

2024

High-Yield Expressed Human Ferritin Heavy-Chain Nanoparticles in K. marxianus for Functional Food Development

Xinyi Lu, Liping Liu, Haibo Zhang, Haifang Lu, Haifang Lu, Tian Tian, Bing Du, Li Pan, Yao Yu, Jungang Zhou, Hong Lü, Hong Lü

Foods

DOI

2024

Efficient and markerless gene integration with SlugCas9-HF in Kluyveromyces marxianus

Huanyu Zhou, Tian Tian, Jingtong Liu, Hong Lü, Yao Yu, Yongming Wang

Communications Biology

DOI

2024

Coupling thermotolerance and high production of recombinant protein by CYR1N1546K mutation via cAMP signaling cascades

Haiyan Ren, Qing Lan, Shihao Zhou, Yilin Lyu, Yao Yu, Jungang Zhou, Wenjuan Mo, Hong Lü

Communications Biology

DOI

2024

Transfer of disulfide bond formation modules via yeast artificial chromosomes promotes the expression of heterologous proteins in Kluyveromyces marxianus

Pingping Wu, Wenjuan Mo, Tian Tian, Kunfeng Song, Yilin Lyu, Haiyan Ren, Jungang Zhou, Yao Yu, Hong Lü

mLife

DOI

2023

马克斯克鲁维酵母发酵苹果酒的化学成分与抗氧化活性

兰青，张志勇，余垚，周峻岗，吕红

《食品与发酵工业》

DOI

2023

基于文献和专利分析非葡萄酒类果酒技术领域发展现状

陈莹，张志勇，余垚，周峻岗，吕红

《食品与发酵工业》

DOI

2023

以生物技术关联人类社会发展的新视角设计通识课跨学科的课堂讨论

吕红，吴若男，余垚

《高校生物学教学研究(电子版)》

2022

马克斯克鲁维酵母FIM1基因组分析

罗通宇，曾俊源，吕奕琳，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

2022

Establishment of a Cre-loxP System Based on a Leaky LAC4 Promoter and an Unstable panARS Element in Kluyveromyces marxianus

Haiyan Ren, Anqi Yin, Pingping Wu, Huanyu Zhou, Jungang Zhou, Yao Yu, Hong Lü

Microorganisms

DOI

2022

Downregulation of ammonium uptake improves the growth and tolerance of Kluyveromyces marxianus at high temperature

Yi Ai, Tongyu Luo, Yao Yu, Jungang Zhou, Hong Lü

MicrobiologyOpen

DOI

2022

Comparative metabolome and transcriptome analyses of the properties of Kluyveromyces marxianus and Saccharomyces yeasts in apple cider fermentation

Zhiyong Zhang, Qing Lan, Yao Yu, Jungang Zhou, Hong Lü

Food Chemistry Molecular Sciences

DOI

2022

Characterization of essential elements for improved episomal expressions in Kluyveromyces marxianus

Pingping Wu, Jungang Zhou, Yao Yu, Hong Lü

Biotechnology Journal

DOI

2022

Meiosis-Based Laboratory Evolution of the Thermal Tolerance in Kluyveromyces marxianus

Li Wu, Yilin Lyu, Pingping Wu, Tongyu Luo, Junyuan Zeng, Tianfang Shi, Jungang Zhou, Yao Yu, Hong Lü

Frontiers in Bioengineering and Biotechnology

DOI

2021

Characterization and optimization of the LAC4 upstream region for low‐leakage expression in Kluyveromyces marxianus

Benxin Liu, Pingping Wu, Jungang Zhou, Anqi Yin, Yao Yu, Hong Lü

Yeast

DOI

2021

Comparative Genomic and Transcriptomic Analysis Reveals Specific Features of Gene Regulation in Kluyveromyces marxianus

Yao Yu, Wenjuan Mo, Haiyan Ren, Xianmei Yang, Wanlin Lu, Tongyu Luo, Junyuan Zeng, Jungang Zhou, Ji Qi, Hong Lü

Frontiers in Microbiology

DOI

2021

Investigation of Kluyveromyces marxianus as a novel host for large‐scale production of porcine parvovirus virus‐like particles

Deqiang Yang, Lei Chen, Jinkun Duan, Yao Yu, Jungang Zhou, Hong Lü

Microbial Cell Factories

DOI

2021

Characterization and modulation of endoplasmic reticulum stress response target genes in Kluyveromyces marxianus to improve secretory expressions of heterologous proteins

Tianfang Shi, Jungang Zhou, Aijuan Xue, Hong Lü, Yungang He, Yao Yu

Biotechnology for Biofuels

DOI

2021

A Single Vaccination of IBDV Subviral Particles Generated by Kluyveromyces marxianus Efficiently Protects Chickens against Novel Variant and Classical IBDV Strains

Deqiang Yang, Lixia Zhang, Jinkun Duan, Qiang Huang, Yao Yu, Jungang Zhou, Hong Lü

Vaccines

DOI

2021

Coordinately express hemicellulolytic enzymes in Kluyveromyces marxianus to improve the saccharification and ethanol production from corncobs

Qing Lan, Yitong Duan, Pingping Wu, Xueyin Li, Yao Yu, Bo Shi, Jungang Zhou, Hong Lü

Biotechnology for Biofuels

DOI

2021

Protoplast transformation of Kluyveromyces marxianus

Yilin Lyu, Pingping Wu, Jungang Zhou, Yao Yu, Hong Lü

Biotechnology Journal

DOI

2021

Quantifying tagged mRNA export flux via nuclear pore complexes in single live cells

Yueyue Jing, Yilin Lv, Jingya Ye, Longfang Yao, Liwen Chen, Lan Mi, Yiyan Fei, Yao Yu, Biao Dong, Hong Lv, Jiong Ma

Biochemical and Biophysical Research Communications

DOI

2020

基因组整合与游离质粒联合应用介导阿魏酸酯酶A在马克斯克鲁维酵母中高效分泌表达

李雪莹，段懿桐，吴丽，莫文娟，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

DOI

2020

GH43家族β-D-木糖苷酶RuXyn1在马克斯克鲁维酵母中的表达及其应用

段懿桐，李雪莹，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

DOI

2020

Improving the expression of a heterologous protein by genome shuffling in Kluyveromyces marxianus

Li Wu, Mengzhu Wang, Genhan Zha, Jungang Zhou, Yao Yu, Hong Lü

Journal of Biotechnology

DOI

2020

A protocol of rapid laboratory evolution by genome shuffling in Kluyveromyces marxianus

Li Wu, Mengzhu Wang, Genhan Zha, Jungang Zhou, Yao Yu, Hong Lü

MethodsX

DOI

2019

CSFV E2蛋白主要抗原区域在马克斯克鲁维酵母中的表达及小鼠免疫

朱培霞，陈蕾，段进坤，刘洋，莫文娟，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

DOI

2019

Kluyveromyces marxianus developing ethanol tolerance during adaptive evolution with significant improvements of multiple pathways

Wenjuan Mo, Mengzhu Wang, Rongrong Zhan, Yao Yu, Yungang He, Hong Lü

Biotechnology for Biofuels

DOI

2018

犬细小病毒病毒样颗粒在马克斯克鲁维酵母中的表达及免疫原性研究

陈蕾，段进坤，朱培霞，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

2018

Efficient production of porcine circovirus virus-like particles using the nonconventional yeast Kluyveromyces marxianus

Jinkun Duan, Deqiang Yang, Lei Chen, Yao Yu, Jungang Zhou, Hong Lü

Applied Microbiology and Biotechnology

DOI

2018

Mutational Mtc6p attenuates autophagy and improves secretory expression of heterologous proteins in Kluyveromyces marxianus

Yang Liu, Wenjuan Mo, Tianfang Shi, Mengzhu Wang, Jungang Zhou, Yao Yu, Wen-Shan Yew, Hong Lü

Microbial Cell Factories

DOI

2018

Improved secretory expression of lignocellulolytic enzymes in Kluyveromyces marxianus by promoter and signal sequence engineering

Jungang Zhou, Peixia Zhu, Xiaoyue Hu, Hong Lü, Yao Yu

Biotechnology for Biofuels

DOI

2017

马克斯克鲁维酵母表达系统菊粉酶启动子的改造及活性研究

胡晓悦，周峻岗，余垚，吕红，HU Xiaoyu

《复旦学报(自然科学版)》

2017

对分课堂教学模式在通识课程“改变生活的生物技术”中的应用

刘明秋，余垚，吕红

《高校生物学教学研究(电子版)》

2017

Epe1 contributes to activation of AMPK by promoting phosphorylation of AMPK alpha subunit, Ssp2

Yongyi Chen, Xiaoyue Hu, Chao Guo, Yao Yu, Hong Lü

Scientific Reports

DOI

2016

一种针对马克斯克鲁维酵母(Kluyveromyces marxianus)的无痕基因组改造方法

郭超，陈勇毅，周峻岗，余垚，吕红

《复旦学报(自然科学版)》

2016

Set3 contributes to heterochromatin integrity by promoting transcription of subunits of Clr4-Rik1-Cul4 histone methyltransferase complex in fission yeast

Yao Yu, Huan Zhou, Xiaolong Deng, Wenchao Wang, Hong Lü

Scientific Reports

DOI

2015

Genome‐wide screen of fission yeast mutants for sensitivity to 6‐azauracil, an inhibitor of transcriptional elongation

Huan Zhou, Qi Liu, Tianfang Shi, Yao Yu, Hong Lü

Yeast

DOI

2015

Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast

Xiaolong Deng, Huan Zhou, Guiping Zhang, Wenchao Wang, Langyong Mao, Xing Zhou, Yao Yu, Hong Lü

Scientific Reports

DOI

2014

裂殖酵母SAGA各亚基亚细胞荧光定位分析

周幸，周楠，余垚，吕红

《遗传》

2014

sgf73+在裂殖酵母中的大规模遗传筛选

郭雨辰，雷秉坤，邓小龙，余垚，吕红

《遗传》

2014

组蛋白H3K4甲基转移酶复合物亚基Ash2参与裂殖酵母产孢

王文超，周欢，余垚，吕红

《遗传》

2014

“改变生活的生物技术”通识教育课程建设的探索与实践

吕红，余垚，刘明秋

《高校生物学教学研究(电子版)》

2014

[Ash2, a subunit of histone H3K4 methyltransferase complex, is involved in the sporulation in Schizosaccharomyces pombe].

Wenchao Wang, Huan Zhou, Yao Yu, Hong Lv

PubMed

DOI

2014

Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Yuchen Guo, Bingkun Lei, Xiaolong Deng, Yao Yu, Hong Lv

PubMed

DOI

2014

Subcellular fluorescence localization analysis of all SAGA subunits in fission yeast (Schizosaccharomyces pombe)

Xing Zhou, Nan Zhou, Yao Yu, Hong Lv

Hereditas (Beijing)

DOI

2013

裂殖酵母SAGA复合物亚基Spt20参与钙调蛋白磷酸酶调节的Cl-胞内平衡

周楠，雷秉坤，周幸，余垚，吕红

《遗传》

2013

裂殖酵母Cnb1参与胞质分裂过程

范洁琼，邓小龙，冯碧薇，王继峰，余垚，吕红

《遗传》

2013

SAGA complex subunit Spt20 involves in the calcineurin-mediated Cl- homeostasis in Schizosaccharomyces pombe

Nan Zhou, Bingkun Lei, Xing Zhou, Yao Yu, Hong Lv

Hereditas (Beijing)

DOI

2013

Cnb1 involved in cytokinesis in Schizosaccharomyces pombe

Jie-Qiong FAN, Xiaolong Deng, Bi-Wei Feng, Jifeng Wang, Yao Yu, Hong Lv

Hereditas (Beijing)

DOI

2012

Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library

Xian Ming Pan, Bingkun Lei, Nan Zhou, Bi-Wei Feng, Wei Yao, Xin Zhao, Yao Yu, Hong Lü

BMC Genomics

DOI

2007

人类组织特异性DNA聚合酶POLλ2基因的克隆、表达纯化和鉴定

谷福，游淳，刘建平，程鏖，余垚，王翔，万大方，顾建人，袁汉英，李育阳，吕红

《中国科学:生命科学》

2005

1.人类多巴胺应答基因-1，DRG-1功能的初步鉴定 2.人类基因LASS2与其酵母同源基因LAG1的功能互补研究

余垚

《复旦大学》

2005

Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p

Yao Yu, Hong Lü, Hui Pan, Junhao Ma, Zhi-Jie Ding, Yuyang Li

Microbiological Research

DOI

2004

细胞周期末期促进复合物亚基CDC16Hs与DNA双链断端修复蛋白Ku80相互作用

余垚，丁志杰，马俊豪，吕红，李育阳

《复旦学报(自然科学版)》

会议论文

2016

裂殖酵母Set3蛋白通过调控CLRC亚基的转录促进异染色质基因沉默

余垚

《第九届中国模式真菌研讨会》

2013

Tip60及其辅助因子ING5介导的乙酰化修饰对基因表达的精密调控

余垚，吕红

《中国遗传学会第九次全国会员代表大会暨学术研讨会》

2011

模式酵母基因组稳定性维持的分子机制

潘贤，雷秉坤，冯碧薇，周楠，余垚，吕红

《中国的遗传学研究——遗传学进步推动中国西部经济与社会发展——2011年中国遗传学会大会》

研究方向

酵母分子遗传学遗传工程合成生物学

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